T
Tyrone A. Washington Data-verified
Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.
Federal Grant PI
High Impact
Associate Professor
faculty
26 h-index
165 pubs
2,066 cited
Research Areas
Links
Biography and Research Information
OverviewAI-generated summary
Tyrone A. Washington's research focuses on skeletal muscle physiology and the impact of various conditions, including disuse atrophy and cancer cachexia, on muscle function and metabolism. His work investigates sex-based differences in these responses, examining how male and female mice and rats are differentially affected by these physiological challenges. A significant portion of his research explores the mechanisms underlying muscle regeneration and the potential for exercise and regenerative strategies to counteract detrimental effects.
Washington has published extensively on these topics, with his scholarship metrics indicating an h-index of 26 and over 2,000 total citations across 166 publications. He has received federal funding, including a $434,793 award from the NIH/National Institute of Arthritis and Musculoskeletal and Skin Diseases for research on regenerative and rehabilitation strategies following volumetric muscle loss injury. He leads a research group at the University of Arkansas at Fayetteville and collaborates with several colleagues within the institution, including Eleanor R. Schrems, Francielly Morena da Silva, Ana Regina Cabrera, and Nicholas P. Greene.
Metrics
- h-index: 26
- Publications: 165
- Citations: 2,066
Selected Publications
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American College of Sports Medicine Position Stand. Resistance Training Prescription for Muscle Function, Hypertrophy, and Physical Performance in Healthy Adults: An Overview of Reviews (2026)
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Skeletal muscle methylome-transcriptome disruptions during the onset and progression of colorectal cancer-induced cachexia (2025)
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Transcriptomic analysis demonstrates moderators of muscle quality are altered in age-related sarcopenic obesity (2025)
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Unravelling the diversity observed in cancer cachexia (2025)
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Aerobic Exercise Training Does Not Attenuate Fibrosis In Autologous Repaired Vml-injured Skeletal Muscle (2025)
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Promoting mitochondrial fusion is protective against cancer-induced muscle detriments in males and females (2025)
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Global mitophagy inhibition via BNIP3 ablation is not sufficient to alleviate skeletal muscle impairments in male and female tumor-bearing mice (2025)
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Myocellular adaptations to short‐term weighted wheel‐running exercise are largely conserved during C26‐tumour induction in male and female mice (2025)
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Transcriptional analysis of cancer cachexia: conserved and unique features across preclinical models and biological sex (2024)
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Mitochondrial antioxidant SkQ1 attenuates C26 cancer-induced muscle wasting in males and improves muscle contractility in female tumor-bearing mice (2024)
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Supplemental table 6 (2023)
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Supplemental table 1 (2023)
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Supplemental table 3 (2023)
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Supplemental table 2 (2023)
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Supplemental table 4 (2023)
Federal Grants 1 $434,793 total
NIH/National Institute of Arthritis and Musculoskeletal and Skin Diseases
Contact PI
Aug 2024 - Jul 2027
Collaboration Network
Top Collaborators
Nicholas P. Greene
University of Arkansas at Fayetteville
39 shared publications
In database
- Female mice may have exacerbated catabolic signalling response compared to male mice during development and progression of disuse atrophy
- Mitochondrial aberrations during the progression of disuse atrophy differentially affect male and female mice
- Development of metabolic and contractile alterations in development of cancer cachexia in female tumor-bearing mice
- Exercise Counteracts the Deleterious Effects of Cancer Cachexia
- The time-course of cancer cachexia onset reveals biphasic transcriptional disruptions in female skeletal muscle distinct from males
Showing 5 of 39 shared publications
Eleanor R. Schrems
University of Arkansas at Fayetteville
31 shared publications
In database
- Development of metabolic and contractile alterations in development of cancer cachexia in female tumor-bearing mice
- The time-course of cancer cachexia onset reveals biphasic transcriptional disruptions in female skeletal muscle distinct from males
- Females display relatively preserved muscle quality compared with males during the onset and early stages of C26-induced cancer cachexia
- Muscle miR-16 deletion results in impaired insulin sensitivity and contractile function in a sex-dependent manner
- Development of skeletal muscle fibrosis in a rodent model of cancer cachexia
Showing 5 of 31 shared publications
Francielly Morena da Silva
University of Arkansas at Fayetteville
28 shared publications
In database
- Female mice may have exacerbated catabolic signalling response compared to male mice during development and progression of disuse atrophy
- Development of metabolic and contractile alterations in development of cancer cachexia in female tumor-bearing mice
- The time-course of cancer cachexia onset reveals biphasic transcriptional disruptions in female skeletal muscle distinct from males
- Females display relatively preserved muscle quality compared with males during the onset and early stages of C26-induced cancer cachexia
- Muscle miR-16 deletion results in impaired insulin sensitivity and contractile function in a sex-dependent manner
Showing 5 of 28 shared publications
Ana Regina Cabrera
University of Arkansas at Fayetteville
27 shared publications
In database
- Development of metabolic and contractile alterations in development of cancer cachexia in female tumor-bearing mice
- The time-course of cancer cachexia onset reveals biphasic transcriptional disruptions in female skeletal muscle distinct from males
- Females display relatively preserved muscle quality compared with males during the onset and early stages of C26-induced cancer cachexia
- Muscle miR-16 deletion results in impaired insulin sensitivity and contractile function in a sex-dependent manner
- Mitochondrial antioxidant SkQ1 attenuates C26 cancer-induced muscle wasting in males and improves muscle contractility in female tumor-bearing mice
Showing 5 of 27 shared publications
Megan E. Rosa‐Caldwell
University of Arkansas at Fayetteville
20 shared publications
In database
- Female mice may have exacerbated catabolic signalling response compared to male mice during development and progression of disuse atrophy
- Mitochondrial aberrations during the progression of disuse atrophy differentially affect male and female mice
- Development of metabolic and contractile alterations in development of cancer cachexia in female tumor-bearing mice
- The time-course of cancer cachexia onset reveals biphasic transcriptional disruptions in female skeletal muscle distinct from males
- Females display relatively preserved muscle quality compared with males during the onset and early stages of C26-induced cancer cachexia
Showing 5 of 20 shared publications
Seongkyun Lim
University of Arkansas at Fayetteville
20 shared publications
In database
- Female mice may have exacerbated catabolic signalling response compared to male mice during development and progression of disuse atrophy
- Mitochondrial aberrations during the progression of disuse atrophy differentially affect male and female mice
- Development of metabolic and contractile alterations in development of cancer cachexia in female tumor-bearing mice
- The time-course of cancer cachexia onset reveals biphasic transcriptional disruptions in female skeletal muscle distinct from males
- Females display relatively preserved muscle quality compared with males during the onset and early stages of C26-induced cancer cachexia
Showing 5 of 20 shared publications
Kevin A. Murach
University of Arkansas at Fayetteville
19 shared publications
In database
- Exercise Counteracts the Deleterious Effects of Cancer Cachexia
- The time-course of cancer cachexia onset reveals biphasic transcriptional disruptions in female skeletal muscle distinct from males
- Mitochondrial antioxidant SkQ1 attenuates C26 cancer-induced muscle wasting in males and improves muscle contractility in female tumor-bearing mice
- Transcriptional analysis of cancer cachexia: conserved and unique features across preclinical models and biological sex
- Biological sex divergence in transcriptomic profiles during the onset of hindlimb unloading-induced atrophy
Showing 5 of 19 shared publications
Stavroula Tsitkanou
University of Arkansas at Fayetteville
14 shared publications
In database
- Exercise Counteracts the Deleterious Effects of Cancer Cachexia
- Females display relatively preserved muscle quality compared with males during the onset and early stages of C26-induced cancer cachexia
- Mitochondrial antioxidant SkQ1 attenuates C26 cancer-induced muscle wasting in males and improves muscle contractility in female tumor-bearing mice
- Biological sex divergence in transcriptomic profiles during the onset of hindlimb unloading-induced atrophy
- Promoting mitochondrial fusion is protective against cancer-induced muscle detriments in males and females
Showing 5 of 14 shared publications
Richard Perry
Colorado State University (US)
10 shared publications
- The effect of autologous repair and voluntary wheel running on force recovery in a rat model of volumetric muscle loss
- Development of skeletal muscle fibrosis in a rodent model of cancer cachexia
- The effect of diet-induced obesity on extracellular matrix remodeling during skeletal muscle regeneration
- Effects of PGC-1α overexpression on the myogenic response during skeletal muscle regeneration
- Nandrolone supplementation does not improve functional recovery in an aged animal model of volumetric muscle loss injury
Showing 5 of 10 shared publications
Landen W. Saling
University of Arkansas at Fayetteville
10 shared publications
In database
- Development of metabolic and contractile alterations in development of cancer cachexia in female tumor-bearing mice
- Females display relatively preserved muscle quality compared with males during the onset and early stages of C26-induced cancer cachexia
- Muscle miR-16 deletion results in impaired insulin sensitivity and contractile function in a sex-dependent manner
- Development of skeletal muscle fibrosis in a rodent model of cancer cachexia
- Growth Differentiation Factor 5 Is A Paracrine Regulator In Sarcopenic Obesity
Showing 5 of 10 shared publications
J. William Deaver
University of Arkansas at Fayetteville (US)
9 shared publications
- Female mice may have exacerbated catabolic signalling response compared to male mice during development and progression of disuse atrophy
- Development of metabolic and contractile alterations in development of cancer cachexia in female tumor-bearing mice
- Females display relatively preserved muscle quality compared with males during the onset and early stages of C26-induced cancer cachexia
- Muscle miR-16 deletion results in impaired insulin sensitivity and contractile function in a sex-dependent manner
- The effect of diet-induced obesity on extracellular matrix remodeling during skeletal muscle regeneration
Showing 5 of 9 shared publications
Wesley S. Haynie
University of Arkansas at Fayetteville
7 shared publications
In database
- Mitochondrial aberrations during the progression of disuse atrophy differentially affect male and female mice
- Development of metabolic and contractile alterations in development of cancer cachexia in female tumor-bearing mice
- The effect of autologous repair and voluntary wheel running on force recovery in a rat model of volumetric muscle loss
- Development of skeletal muscle fibrosis in a rodent model of cancer cachexia
- Effects of PGC-1α overexpression on the myogenic response during skeletal muscle regeneration
Showing 5 of 7 shared publications
Jacob L. Brown
University of Arkansas at Fayetteville (US)
6 shared publications
- Female mice may have exacerbated catabolic signalling response compared to male mice during development and progression of disuse atrophy
- Mitochondrial aberrations during the progression of disuse atrophy differentially affect male and female mice
- Development of skeletal muscle fibrosis in a rodent model of cancer cachexia
- Effects of PGC-1α overexpression on the myogenic response during skeletal muscle regeneration
- PGC-1α overexpression is not sufficient to mitigate cancer cachexia in either male or female mice
Showing 5 of 6 shared publications
Ronald G. Jones
University of Arkansas at Fayetteville
6 shared publications
In database
- The time-course of cancer cachexia onset reveals biphasic transcriptional disruptions in female skeletal muscle distinct from males
- Transcriptional analysis of cancer cachexia: conserved and unique features across preclinical models and biological sex
- The Time-Course of Cancer Cachexia Onset Reveals Biphasic Transcriptional Disruptions in Female Skeletal Muscle Distinct from Males
- Skeletal muscle methylome-transcriptome disruptions during the onset and progression of colorectal cancer-induced cachexia
- Mitochondria-Targeted Antioxidant SkQ1 Improves Muscle Contractility in Female C26 Tumor-Bearing Mice
Showing 5 of 6 shared publications
David E. Lee
University of Arkansas at Fayetteville (US)
5 shared publications
- Female mice may have exacerbated catabolic signalling response compared to male mice during development and progression of disuse atrophy
- Mitochondrial aberrations during the progression of disuse atrophy differentially affect male and female mice
- Muscle miR-16 deletion results in impaired insulin sensitivity and contractile function in a sex-dependent manner
- Development of skeletal muscle fibrosis in a rodent model of cancer cachexia
- Effects of PGC-1α overexpression on the myogenic response during skeletal muscle regeneration
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