Biography and Research Information
OverviewAI-generated summary
Jingwei Shao studies targeted protein degradation utilizing PROTAC (proteolysis-targeting chimera) technology. Their work includes the development of O'PROTAC, a programmable oligonucleotide-based PROTAC system capable of degrading DNA-binding proteins like LEF1 and ERG. Shao has also investigated the role of inositol as a natural inhibitor of mitochondrial fission by targeting AMPK and explored CD36-mediated endocytosis of PROTACs. Further research has focused on the synthesis of PROTAC components, such as VH032 amine, and the identification of new cereblon ligands like 3-aminophthalic acid for O'PROTAC applications. Shao has a publication record of 11 papers with 331 citations and an h-index of 8. Key collaborators at the University of Arkansas for Medical Sciences include Anupreet Kharbanda and Phuc Tran.
Metrics
- h-index: 8
- Publications: 11
- Citations: 343
Selected Publications
-
CD36-mediated endocytosis of proteolysis-targeting chimeras (2025)
-
Feasible Column Chromatography-Free, Multi-Gram Scale Synthetic Process of VH032 Amine, Which Could Enable Rapid PROTAC Library Construction (2022)
-
3-Aminophthalic acid, a new cereblon ligand for targeted protein degradation by O’PROTAC (2022)
-
Inositol serves as a natural inhibitor of mitochondrial fission by directly targeting AMPK (2021)
-
Destruction of DNA‐Binding Proteins by Programmable Oligonucleotide PROTAC (O'PROTAC): Effective Targeting of LEF1 and ERG (2021)
Collaboration Network
Top Collaborators
Wei Yan
The University of Texas Health Science Center at San Antonio (US)
5 shared publications
- Destruction of DNA‐Binding Proteins by Programmable Oligonucleotide PROTAC (O'PROTAC): Effective Targeting of LEF1 and ERG
- Inositol serves as a natural inhibitor of mitochondrial fission by directly targeting AMPK
- CD36-mediated endocytosis of proteolysis-targeting chimeras
- 3-Aminophthalic acid, a new cereblon ligand for targeted protein degradation by O’PROTAC
- Feasible Column Chromatography-Free, Multi-Gram Scale Synthetic Process of VH032 Amine, Which Could Enable Rapid PROTAC Library Construction
Hongyu Li
The University of Texas Health Science Center at San Antonio (US)
5 shared publications
- Destruction of DNA‐Binding Proteins by Programmable Oligonucleotide PROTAC (O'PROTAC): Effective Targeting of LEF1 and ERG
- Inositol serves as a natural inhibitor of mitochondrial fission by directly targeting AMPK
- CD36-mediated endocytosis of proteolysis-targeting chimeras
- 3-Aminophthalic acid, a new cereblon ligand for targeted protein degradation by O’PROTAC
- Feasible Column Chromatography-Free, Multi-Gram Scale Synthetic Process of VH032 Amine, Which Could Enable Rapid PROTAC Library Construction
Yuqian Yan
Mayo Clinic (US)
3 shared publications
- Destruction of DNA‐Binding Proteins by Programmable Oligonucleotide PROTAC (O'PROTAC): Effective Targeting of LEF1 and ERG
- 3-Aminophthalic acid, a new cereblon ligand for targeted protein degradation by O’PROTAC
- Destruction of DNA‐Binding Proteins by Programmable Oligonucleotide PROTAC (O'PROTAC): Effective Targeting of LEF1 and ERG (Adv. Sci. 20/2021)
Donglin Ding
Mayo Clinic (US)
3 shared publications
- Destruction of DNA‐Binding Proteins by Programmable Oligonucleotide PROTAC (O'PROTAC): Effective Targeting of LEF1 and ERG
- 3-Aminophthalic acid, a new cereblon ligand for targeted protein degradation by O’PROTAC
- Destruction of DNA‐Binding Proteins by Programmable Oligonucleotide PROTAC (O'PROTAC): Effective Targeting of LEF1 and ERG (Adv. Sci. 20/2021)
Yunqian Pan
Mayo Clinic (US)
3 shared publications
- Destruction of DNA‐Binding Proteins by Programmable Oligonucleotide PROTAC (O'PROTAC): Effective Targeting of LEF1 and ERG
- 3-Aminophthalic acid, a new cereblon ligand for targeted protein degradation by O’PROTAC
- Destruction of DNA‐Binding Proteins by Programmable Oligonucleotide PROTAC (O'PROTAC): Effective Targeting of LEF1 and ERG (Adv. Sci. 20/2021)
Haojie Huang
WinnMed (US)
3 shared publications
- Destruction of DNA‐Binding Proteins by Programmable Oligonucleotide PROTAC (O'PROTAC): Effective Targeting of LEF1 and ERG
- 3-Aminophthalic acid, a new cereblon ligand for targeted protein degradation by O’PROTAC
- Destruction of DNA‐Binding Proteins by Programmable Oligonucleotide PROTAC (O'PROTAC): Effective Targeting of LEF1 and ERG (Adv. Sci. 20/2021)
Bo‐Syong Pan
Wake Forest University (US)
3 shared publications
- Inositol serves as a natural inhibitor of mitochondrial fission by directly targeting AMPK
- CD36-mediated endocytosis of proteolysis-targeting chimeras
- Feasible Column Chromatography-Free, Multi-Gram Scale Synthetic Process of VH032 Amine, Which Could Enable Rapid PROTAC Library Construction
Dejie Wang
2 shared publications
- Destruction of DNA‐Binding Proteins by Programmable Oligonucleotide PROTAC (O'PROTAC): Effective Targeting of LEF1 and ERG
- Destruction of DNA‐Binding Proteins by Programmable Oligonucleotide PROTAC (O'PROTAC): Effective Targeting of LEF1 and ERG (Adv. Sci. 20/2021)
Yundong He
2 shared publications
- Destruction of DNA‐Binding Proteins by Programmable Oligonucleotide PROTAC (O'PROTAC): Effective Targeting of LEF1 and ERG
- Destruction of DNA‐Binding Proteins by Programmable Oligonucleotide PROTAC (O'PROTAC): Effective Targeting of LEF1 and ERG (Adv. Sci. 20/2021)
Anupreet Kharbanda
2 shared publications
In database
- Destruction of DNA‐Binding Proteins by Programmable Oligonucleotide PROTAC (O'PROTAC): Effective Targeting of LEF1 and ERG
- Destruction of DNA‐Binding Proteins by Programmable Oligonucleotide PROTAC (O'PROTAC): Effective Targeting of LEF1 and ERG (Adv. Sci. 20/2021)
Che-Chia Hsu
Wake Forest University (US)
2 shared publications
- Inositol serves as a natural inhibitor of mitochondrial fission by directly targeting AMPK
- CD36-mediated endocytosis of proteolysis-targeting chimeras
Rajesh Manne
Wake Forest University (US)
2 shared publications
- Inositol serves as a natural inhibitor of mitochondrial fission by directly targeting AMPK
- CD36-mediated endocytosis of proteolysis-targeting chimeras
Zhong‐Zhu Chen
Chongqing University of Arts and Sciences (CN)
2 shared publications
- Inositol serves as a natural inhibitor of mitochondrial fission by directly targeting AMPK
- High-throughput Approaches to Detect Cytokines and Chemokines Secretion by Both Autophagy and Endosome Vesicle Fusion of HBMEC by Knocking Down the NLRP2 Gene
Hui‐Kuan Lin
Duke University (US)
2 shared publications
- Inositol serves as a natural inhibitor of mitochondrial fission by directly targeting AMPK
- CD36-mediated endocytosis of proteolysis-targeting chimeras
Phuc Tran
University of Arkansas for Medical Sciences
2 shared publications
In database
- CD36-mediated endocytosis of proteolysis-targeting chimeras
- 3-Aminophthalic acid, a new cereblon ligand for targeted protein degradation by O’PROTAC
Similar Researchers
Based on overlapping research topics
Allison C. Farrar
Hendrix College
Molecular Biology Techniques and Applications
Cancer-related molecular mechanisms research
Mitochondrial Function and Pathology
Phuc Tran
University of Arkansas for Medical Sciences
Molecular Biology Techniques and Applications
Protein Degradation and Inhibitors
Cancer-related molecular mechanisms research
Mari K. Davidson
University of Arkansas for Medical Sciences
Molecular Biology Techniques and Applications
Cancer-related molecular mechanisms research
Drug Delivery Systems
Sures Thallapuranam
University of Arkansas at Fayetteville
Molecular Biology Techniques and Applications
Drug Delivery Systems
Computational Drug Discovery Methods
Nathan Avaritt
University of Arkansas for Medical Sciences
Molecular Biology Techniques and Applications
Cancer-related molecular mechanisms research
Computational Drug Discovery Methods
Fengping Lv
University of Arkansas for Medical Sciences
Molecular Biology Techniques and Applications
Protein Degradation and Inhibitors
Computational Drug Discovery Methods