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Biography and Research Information
OverviewAI-generated summary
Anupreet Kharbanda's research focuses on the discovery and development of novel therapeutic agents, particularly for cancer treatment. This work involves the investigation of small molecules targeting specific protein kinases and signaling pathways implicated in various cancers. Kharbanda has published research on the development of inhibitors for FLT3 and its mutants in acute myeloid leukemia, as well as inhibitors for RET and TGFβ pathway components. The research also explores the potential of tocotrienols as an anti-breast cancer agent and the destruction of DNA-binding proteins using programmable oligonucleotide PROTACs (O'PROTACs). Collaborations include work with Yuet-Kin Leung, Brendan Frett, Phuc Tran, and Xiuqi Wang at the University of Arkansas for Medical Sciences. Kharbanda has an h-index of 12 with 16 total publications and 433 citations.
Metrics
- h-index: 12
- Publications: 16
- Citations: 444
Selected Publications
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Revisiting Aurora Kinase B: A promising therapeutic target for cancer therapy (2023)
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Discovery of N-Trisubstituted Pyrimidine Derivatives as Type I RET and RET Gatekeeper Mutant Inhibitors with a Novel Kinase Binding Pose (2022)
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Tocotrienols as an Anti-Breast Cancer Agent (2021)
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Destruction of DNA‐Binding Proteins by Programmable Oligonucleotide PROTAC (O'PROTAC): Effective Targeting of LEF1 and ERG (2021)
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Discovery of imidazo[1,2-a]pyridine-thiophene derivatives as FLT3 and FLT3 mutants inhibitors for acute myeloid leukemia through structure-based optimization of an NEK2 inhibitor (2021)
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Discovery of 4-aminoquinolines as highly selective TGFβR1 inhibitors with an attenuated MAP4K4 profile for potential applications in immuno-oncology (2021)
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Discovery and biological evaluation of phthalazines as novel non-kinase TGFβ pathway inhibitors (2021)
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Destruction of DNA-binding proteins by programmable O’PROTAC: Oligonucleotide-based PROTAC (2021)
Collaboration Network
Top Collaborators
Hongyu Li
University of Arkansas for Medical Sciences (US)
7 shared publications
- Destruction of DNA‐Binding Proteins by Programmable Oligonucleotide PROTAC (O'PROTAC): Effective Targeting of LEF1 and ERG
- Revisiting Aurora Kinase B: A promising therapeutic target for cancer therapy
- Discovery of imidazo[1,2-a]pyridine-thiophene derivatives as FLT3 and FLT3 mutants inhibitors for acute myeloid leukemia through structure-based optimization of an NEK2 inhibitor
- Discovery of N-Trisubstituted Pyrimidine Derivatives as Type I RET and RET Gatekeeper Mutant Inhibitors with a Novel Kinase Binding Pose
- Discovery and biological evaluation of phthalazines as novel non-kinase TGFβ pathway inhibitors
Showing 5 of 7 shared publications
Lingtian Zhang
University of Arkansas for Medical Sciences (US)
4 shared publications
- Discovery of imidazo[1,2-a]pyridine-thiophene derivatives as FLT3 and FLT3 mutants inhibitors for acute myeloid leukemia through structure-based optimization of an NEK2 inhibitor
- Discovery of N-Trisubstituted Pyrimidine Derivatives as Type I RET and RET Gatekeeper Mutant Inhibitors with a Novel Kinase Binding Pose
- Discovery and biological evaluation of phthalazines as novel non-kinase TGFβ pathway inhibitors
- Discovery of 4-aminoquinolines as highly selective TGFβR1 inhibitors with an attenuated MAP4K4 profile for potential applications in immuno-oncology
Yuet‐Kin Leung
University of Arkansas for Medical Sciences
4 shared publications
In database
- Discovery of imidazo[1,2-a]pyridine-thiophene derivatives as FLT3 and FLT3 mutants inhibitors for acute myeloid leukemia through structure-based optimization of an NEK2 inhibitor
- Discovery of N-Trisubstituted Pyrimidine Derivatives as Type I RET and RET Gatekeeper Mutant Inhibitors with a Novel Kinase Binding Pose
- Discovery and biological evaluation of phthalazines as novel non-kinase TGFβ pathway inhibitors
- Discovery of 4-aminoquinolines as highly selective TGFβR1 inhibitors with an attenuated MAP4K4 profile for potential applications in immuno-oncology
Brendan Frett
University of Arkansas for Medical Sciences
4 shared publications
In database
- Discovery of imidazo[1,2-a]pyridine-thiophene derivatives as FLT3 and FLT3 mutants inhibitors for acute myeloid leukemia through structure-based optimization of an NEK2 inhibitor
- Discovery of N-Trisubstituted Pyrimidine Derivatives as Type I RET and RET Gatekeeper Mutant Inhibitors with a Novel Kinase Binding Pose
- Discovery and biological evaluation of phthalazines as novel non-kinase TGFβ pathway inhibitors
- Discovery of 4-aminoquinolines as highly selective TGFβR1 inhibitors with an attenuated MAP4K4 profile for potential applications in immuno-oncology
Yuqian Yan
3 shared publications
- Destruction of DNA‐Binding Proteins by Programmable Oligonucleotide PROTAC (O'PROTAC): Effective Targeting of LEF1 and ERG
- Destruction of DNA-binding proteins by programmable O’PROTAC: Oligonucleotide-based PROTAC
- Destruction of DNA‐Binding Proteins by Programmable Oligonucleotide PROTAC (O'PROTAC): Effective Targeting of LEF1 and ERG (Adv. Sci. 20/2021)
Dejie Wang
3 shared publications
- Destruction of DNA‐Binding Proteins by Programmable Oligonucleotide PROTAC (O'PROTAC): Effective Targeting of LEF1 and ERG
- Destruction of DNA-binding proteins by programmable O’PROTAC: Oligonucleotide-based PROTAC
- Destruction of DNA‐Binding Proteins by Programmable Oligonucleotide PROTAC (O'PROTAC): Effective Targeting of LEF1 and ERG (Adv. Sci. 20/2021)
Yundong He
3 shared publications
- Destruction of DNA‐Binding Proteins by Programmable Oligonucleotide PROTAC (O'PROTAC): Effective Targeting of LEF1 and ERG
- Destruction of DNA-binding proteins by programmable O’PROTAC: Oligonucleotide-based PROTAC
- Destruction of DNA‐Binding Proteins by Programmable Oligonucleotide PROTAC (O'PROTAC): Effective Targeting of LEF1 and ERG (Adv. Sci. 20/2021)
Yunqian Pan
3 shared publications
- Destruction of DNA‐Binding Proteins by Programmable Oligonucleotide PROTAC (O'PROTAC): Effective Targeting of LEF1 and ERG
- Destruction of DNA-binding proteins by programmable O’PROTAC: Oligonucleotide-based PROTAC
- Destruction of DNA‐Binding Proteins by Programmable Oligonucleotide PROTAC (O'PROTAC): Effective Targeting of LEF1 and ERG (Adv. Sci. 20/2021)
Wei Yan
University of Arkansas for Medical Sciences (US)
3 shared publications
- Destruction of DNA‐Binding Proteins by Programmable Oligonucleotide PROTAC (O'PROTAC): Effective Targeting of LEF1 and ERG
- Discovery of N-Trisubstituted Pyrimidine Derivatives as Type I RET and RET Gatekeeper Mutant Inhibitors with a Novel Kinase Binding Pose
- Destruction of DNA-binding proteins by programmable O’PROTAC: Oligonucleotide-based PROTAC
Haojie Huang
3 shared publications
- Destruction of DNA‐Binding Proteins by Programmable Oligonucleotide PROTAC (O'PROTAC): Effective Targeting of LEF1 and ERG
- Destruction of DNA-binding proteins by programmable O’PROTAC: Oligonucleotide-based PROTAC
- Destruction of DNA‐Binding Proteins by Programmable Oligonucleotide PROTAC (O'PROTAC): Effective Targeting of LEF1 and ERG (Adv. Sci. 20/2021)
Phuc Tran
University of Arkansas for Medical Sciences
3 shared publications
In database
- Discovery of N-Trisubstituted Pyrimidine Derivatives as Type I RET and RET Gatekeeper Mutant Inhibitors with a Novel Kinase Binding Pose
- Discovery and biological evaluation of phthalazines as novel non-kinase TGFβ pathway inhibitors
- Discovery of 4-aminoquinolines as highly selective TGFβR1 inhibitors with an attenuated MAP4K4 profile for potential applications in immuno-oncology
Naga Rajiv Lakkaniga
Indian Institute of Technology Dhanbad (IN)
3 shared publications
- Revisiting Aurora Kinase B: A promising therapeutic target for cancer therapy
- Discovery of imidazo[1,2-a]pyridine-thiophene derivatives as FLT3 and FLT3 mutants inhibitors for acute myeloid leukemia through structure-based optimization of an NEK2 inhibitor
- Discovery of N-Trisubstituted Pyrimidine Derivatives as Type I RET and RET Gatekeeper Mutant Inhibitors with a Novel Kinase Binding Pose
Jaideep B. Bharate
University of Arkansas for Medical Sciences
2 shared publications
In database
- Discovery of imidazo[1,2-a]pyridine-thiophene derivatives as FLT3 and FLT3 mutants inhibitors for acute myeloid leukemia through structure-based optimization of an NEK2 inhibitor
- Discovery of N-Trisubstituted Pyrimidine Derivatives as Type I RET and RET Gatekeeper Mutant Inhibitors with a Novel Kinase Binding Pose
Xiuqi Wang
University of Arkansas for Medical Sciences
2 shared publications
In database
- Discovery of imidazo[1,2-a]pyridine-thiophene derivatives as FLT3 and FLT3 mutants inhibitors for acute myeloid leukemia through structure-based optimization of an NEK2 inhibitor
- Discovery of N-Trisubstituted Pyrimidine Derivatives as Type I RET and RET Gatekeeper Mutant Inhibitors with a Novel Kinase Binding Pose
Jingwei Shao
2 shared publications
In database
- Destruction of DNA‐Binding Proteins by Programmable Oligonucleotide PROTAC (O'PROTAC): Effective Targeting of LEF1 and ERG
- Destruction of DNA‐Binding Proteins by Programmable Oligonucleotide PROTAC (O'PROTAC): Effective Targeting of LEF1 and ERG (Adv. Sci. 20/2021)
Similar Researchers
Based on overlapping research topics
Phuc Tran
University of Arkansas for Medical Sciences
Drug Discovery
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Brendan Frett
University of Arkansas for Medical Sciences
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Baha’a Jabali
University of Arkansas for Medical Sciences
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Gunaganti Naresh
University of Arkansas for Medical Sciences
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University of Arkansas for Medical Sciences
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Yuntao Dai
University of Arkansas at Fayetteville
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Molecular Biology Techniques and Applications