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Listed
Presence
Current · Arkansas
Last published
2021
Sources
OpenAlex · ORCID
Refreshed
2026-10-07
J
John E. Seng
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Also affiliated: University of Minnesota (1997–1998); United States Food and Drug Administration (1994–1996); Charles River Laboratories (United States) (2003–2010); Minnesota Oncology (2012–2017)
16 h-index
28 pubs
894 cited
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
John E. Seng's research focuses on the effects of dietary interventions, particularly caloric restriction, on rodent models. His work has investigated how different levels of dietary restriction influence aging, survival rates, and the expression of drug and carcinogen metabolizing enzymes in rodents. This research has implications for understanding mutagenesis and cancer development in experimental studies. Seng has also examined the toxicity profiles of various substances, including stabilized compacted DNA nanoparticles and hydrolyzed aqueous olive pulp extract, in murine models. He has published on the use of dietary control to reduce experimental variability in animal assays, emphasizing the importance of standardization in research. His scholarship metrics include an h-index of 16, with 28 total publications and 894 total citations.
Metrics
- h-index: 16
- Publications: 28
- Citations: 894
Selected Publications
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Plasma Metabolomics in a Nonhuman Primate Model of Abdominal Radiation Exposure (2021)
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Total Body Irradiation in the “Hematopoietic” Dose Range Induces Substantial Intestinal Injury in Non-Human Primates (2015)
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Toxicokinetics of chloral hydrate in ad libitum-fed, dietary-controlled, and calorically restricted male B6C3F1 mice following short-term exposure (2003)
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Dietary controlled carcinogenicity study of chloral hydrate in male B6C3F1 mice (2003)
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Body weight considerations in the B6C3F1 mouse and the use of dietary control to standardize background tumor incidence in chronic bioassays (2003)
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A Mechanistic Basis for the Beneficial Effects of Caloric Restriction On Longevity and Disease: Consequences for the Interpretation of Rodent Toxicity Studies (1998)
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FDA Points-to-Consider Documents: The Need for Dietary Control for the Reduction of Experimental Variability within Animal Assays and the Use of Dietary Restriction to Achieve Dietary Control (1996)
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Effects of Caloric Restriction on Expression of Testicular Cytochrome P450 Enzymes Associated with the Metabolic Activation of Carcinogens (1996)
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Purification and characterization of an amidase from an acrylamide-degrading Rhodococcus sp (1994)
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Effects of caloric restriction on rodent drug and carcinogen metabolizing enzymes: implications for mutagenesis and cancer (1993)
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Cellular Localization of Cytochrome P45011A1 in Testes of Mature Sprague-Dawley Rats1 (1991)
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Potentiation of carbon tetrachloride hepatotoxicity by phenylpropanolamine (1991)
Collaboration Network
Top Collaborators
Julian E.A. Leakey
National Center for Toxicological Research
9 shared publications
In database
- Purification and characterization of an amidase from an acrylamide-degrading Rhodococcus sp
- Effects of caloric restriction on rodent drug and carcinogen metabolizing enzymes: implications for mutagenesis and cancer
- FDA Points-to-Consider Documents: The Need for Dietary Control for the Reduction of Experimental Variability within Animal Assays and the Use of Dietary Restriction to Achieve Dietary Control
- Effects of Caloric Restriction on Expression of Testicular Cytochrome P450 Enzymes Associated with the Metabolic Activation of Carcinogens
- Dietary controlled carcinogenicity study of chloral hydrate in male B6C3F1 mice
Showing 5 of 9 shared publications
William T. Allaben
National Center for Toxicological Research (US)
5 shared publications
- FDA Points-to-Consider Documents: The Need for Dietary Control for the Reduction of Experimental Variability within Animal Assays and the Use of Dietary Restriction to Achieve Dietary Control
- Total Body Irradiation in the “Hematopoietic” Dose Range Induces Substantial Intestinal Injury in Non-Human Primates
- Dietary controlled carcinogenicity study of chloral hydrate in male B6C3F1 mice
- Body weight considerations in the B6C3F1 mouse and the use of dietary control to standardize background tumor incidence in chronic bioassays
- Toxicokinetics of chloral hydrate in ad libitum-fed, dietary-controlled, and calorically restricted male B6C3F1 mice following short-term exposure
Ronald Wilson Hart
National Center for Toxicological Research (US)
3 shared publications
- Effects of caloric restriction on rodent drug and carcinogen metabolizing enzymes: implications for mutagenesis and cancer
- FDA Points-to-Consider Documents: The Need for Dietary Control for the Reduction of Experimental Variability within Animal Assays and the Use of Dietary Restriction to Achieve Dietary Control
- A Mechanistic Basis for the Beneficial Effects of Caloric Restriction On Longevity and Disease: Consequences for the Interpretation of Rodent Toxicity Studies
Martin Hauer‐Jensen
University of Arkansas for Medical Sciences
2 shared publications
In database
- Total Body Irradiation in the “Hematopoietic” Dose Range Induces Substantial Intestinal Injury in Non-Human Primates
- Plasma Metabolomics in a Nonhuman Primate Model of Abdominal Radiation Exposure
Jay Gandy
University of Arkansas for Medical Sciences
2 shared publications
In database
- Effects of Caloric Restriction on Expression of Testicular Cytochrome P450 Enzymes Associated with the Metabolic Activation of Carcinogens
- Cellular Localization of Cytochrome P45011A1 in Testes of Mature Sprague-Dawley Rats1
Angelo Turturro
National Center for Toxicological Research (US)
2 shared publications
- FDA Points-to-Consider Documents: The Need for Dietary Control for the Reduction of Experimental Variability within Animal Assays and the Use of Dietary Restriction to Achieve Dietary Control
- Effects of Caloric Restriction on Expression of Testicular Cytochrome P450 Enzymes Associated with the Metabolic Activation of Carcinogens
Andrew Parkinson
University of Kansas Medical Center (US)
2 shared publications
- Effects of Caloric Restriction on Expression of Testicular Cytochrome P450 Enzymes Associated with the Metabolic Activation of Carcinogens
- Cellular Localization of Cytochrome P45011A1 in Testes of Mature Sprague-Dawley Rats1
Mohamed S. Nawaz
National Center for Toxicological Research (US)
1 shared publication
- Purification and characterization of an amidase from an acrylamide-degrading Rhodococcus sp
Ashraf Ali Khan
National Center for Toxicological Research
1 shared publication
In database
- Purification and characterization of an amidase from an acrylamide-degrading Rhodococcus sp
Paul H. Siitonen
National Center for Toxicological Research (US)
1 shared publication
- Purification and characterization of an amidase from an acrylamide-degrading Rhodococcus sp
Carl E. Cerniglia
National Center for Toxicological Research
1 shared publication
In database
- Purification and characterization of an amidase from an acrylamide-degrading Rhodococcus sp
Junru Wang
University of Arkansas for Medical Sciences (US)
1 shared publication
- Total Body Irradiation in the “Hematopoietic” Dose Range Induces Substantial Intestinal Injury in Non-Human Primates
Lijian Shao
University of Arkansas for Medical Sciences (US)
1 shared publication
- Total Body Irradiation in the “Hematopoietic” Dose Range Induces Substantial Intestinal Injury in Non-Human Primates
Howard P. Hendrickson
University of Arkansas for Medical Sciences (US)
1 shared publication
- Total Body Irradiation in the “Hematopoietic” Dose Range Induces Substantial Intestinal Injury in Non-Human Primates
Liya Liu
University of Arkansas for Medical Sciences (US)
1 shared publication
- Total Body Irradiation in the “Hematopoietic” Dose Range Induces Substantial Intestinal Injury in Non-Human Primates
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