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Listed
Presence
Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-10-08
Isabelle Racine Miousse
Federal Grant PI
High Impact
Assistant Professor
Also affiliated: Montreal General Hospital (2009); McGill University Health Centre (2008–2009); Arkansas Children's Nutrition Center (2013–2014); McGill University (2006–2012)
Biochemistry & Molecular Biology, College of Medicine
30 h-index
93 pubs
3,095 cited
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Isabelle R. Miousse's research focuses on the metabolic and molecular mechanisms underlying cellular responses to radiation and cancer. She investigates how dietary interventions, particularly methionine restriction, can modulate these responses. Her work has explored the role of methionine metabolism in acute radiation injury, specifically in the gut, and its potential to enhance the efficacy of immune checkpoint inhibitors in colorectal cancer models.
Miousse also studies the radioprotective properties of gamma-tocotrienol, examining its effects on intestinal and hematopoietic injury induced by various forms of radiation in nonhuman primate models. Her research group has characterized methionine dependence in melanoma cells and investigated the impact of dietary methionine deficiency on immune cell genetic instability in murine models.
With a career h-index of 29 and over 3,000 citations, Miousse has secured federal funding for her work on methionine metabolism and radiation response. She actively collaborates with researchers at the University of Arkansas for Medical Sciences, including Sarita Garg, Lauren C. Morehead, Alan J. Tackett, and Katherine Wallis.
Metrics
- h-index: 30
- Publications: 93
- Citations: 3,095
Positions
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Assistant Professor 2018–presentUniversity of Arkansas for Medical Sciences Biochemistry & Molecular Biology, College of Medicine Institutional directory
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Postdoctoral Fellow 2013–2018University of Arkansas for Medical Sciences Environmental and Occupational Health ORCID
Selected Publications
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<scp>DZNep</scp> : A Methyltransferase Modulator for Disease Mitigation (2026)
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Abstract 4378: Live attenuated MMR vaccines modulate tumor immune cell infiltration and synergize with standard of care to prolong survival in preclinical HCC models (2026)
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Pancreatic tumor microenvironment reprogramming via alloantigen-expressing virotherapy elicits tumor rejection and improves immunotherapy response (2026)
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Multimodal reprogramming of the tumor microenvironment by MMR and dual checkpoint blockade in hepatocellular carcinoma models (2025)
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Exposure to a Single Dose of Space-Relevant Proton Radiation Alters the Intestinal One-Carbon Metabolism Pathway and Microbiome in Mice (2025)
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Enhancing Rectal Cancer Radiosensitivity and Gut Protection through Methionine Restriction (2025)
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GLP-1 receptor agonists in the context of cancer: the road ahead (2025)
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Abstract 950: Engineered oncolytic vesiculovirus downsizes pancreatic tumor and boosts immune response (2025)
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Enhancing Neoadjuvant Virotherapy’s Effectiveness by Targeting Stroma to Improve Resectability in Pancreatic Cancer (2024)
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Rescue of Methionine Dependence by Cobalamin in a Human Colorectal Cancer Cell Line (2024)
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Modulation of Hematopoietic Injury by a Promising Radioprotector, Gamma-Tocotrienol, in Rhesus Macaques Exposed to Partial-Body Radiation (2023)
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Climate Change and New Challenges for Rural Communities: Particulate Matter Matters (2023)
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Resveratrol induces major histocompatibility complex class I antigen presentation in a STING-dependent and independent manner in melanoma (2023)
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Increased Response to Immune Checkpoint Inhibitors with Dietary Methionine Restriction in a Colorectal Cancer Model (2023)
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Characterization of methionine dependence in melanoma cells (2023)
Federal Grants 1 $153,000 total
NIH
Contact PI
Aug 2025 - Jul 2027
Methionine metabolism in the acute response to radiation in the gut
Grants & Funding
As listed on this researcher's institutional profile. Federal awards with verified records are shown above.
- Team Leader for the Radiation Effects Team National Space Biomedical Research Institute via Baylor College of Medicine Co-Investigator
- Synergizing methionine restriction with radiation therapy in KRAS mutant rectal cancer UAMS Cancer Institute Team Award Co-Investigator
- Center for Studies of Host Response to Cancer Therapy NIH Co-Investigator
- Methionine restriction as an adjuvant therapy in melanoma NIH/Nat. Inst. of General Medical Sciences via University of Arkansas at Fayetteville Principal Investigator
- Decreasing methionine intake to improve survival in patients with metastatic melanoma UAMS CTSA Other
- Methionine and autophagy in metastatic melanoma Barton Endowment, UAMS college of Medicine Principle Investigator
Collaboration Network
Top Collaborators
Igor Koturbash
University of Arkansas for Medical Sciences
37 shared publications
In database
- Pediatric Exposures to Ionizing Radiation: Carcinogenic Considerations
- Effects of ionizing radiation on DNA methylation: from experimental biology to clinical applications
- Response of transposable elements to environmental stressors
- Short-term exposure to engineered nanomaterials affects cellular epigenome
- <i>In vivo</i>epigenetic effects induced by engineered nanomaterials: A case study of copper oxide and laser printer-emitted engineered nanoparticles
Showing 5 of 37 shared publications
Martin Hauer‐Jensen
University of Arkansas for Medical Sciences
20 shared publications
In database
- Short-term dietary methionine supplementation affects one-carbon metabolism and DNA methylation in the mouse gut and leads to altered microbiome profiles, barrier function, gene expression and histomorphology
- Radiation-induced changes in DNA methylation of repetitive elements in the mouse heart
- Densely ionizing radiation affects DNA methylation of selective LINE-1 elements
- Effects of low-dose oxygen ions and protons on cardiac function and structure in male C57BL/6J mice
- A priming dose of protons alters the early cardiac cellular and molecular response to 56Fe irradiation
Showing 5 of 20 shared publications
Sarita Garg
University of Arkansas for Medical Sciences
17 shared publications
In database
- Short-term dietary methionine supplementation affects one-carbon metabolism and DNA methylation in the mouse gut and leads to altered microbiome profiles, barrier function, gene expression and histomorphology
- Increased Response to Immune Checkpoint Inhibitors with Dietary Methionine Restriction in a Colorectal Cancer Model
- Effects of Gamma-Tocotrienol on Intestinal Injury in a GI-Specific Acute Radiation Syndrome Model in Nonhuman Primate
- Methionine dietary supplementation potentiates ionizing radiation-induced gastrointestinal syndrome
- Gamma-Tocotrienol Modulates Total-Body Irradiation-Induced Hematopoietic Injury in a Nonhuman Primate Model
Showing 5 of 17 shared publications
Alan J. Tackett
University of Arkansas for Medical Sciences
14 shared publications
In database
- Short-term dietary methionine supplementation affects one-carbon metabolism and DNA methylation in the mouse gut and leads to altered microbiome profiles, barrier function, gene expression and histomorphology
- Densely ionizing radiation affects DNA methylation of selective LINE-1 elements
- Inter-Strain Differences in LINE-1 DNA Methylation in the Mouse Hematopoietic System in Response to Exposure to Ionizing Radiation
- Increased Response to Immune Checkpoint Inhibitors with Dietary Methionine Restriction in a Colorectal Cancer Model
- Characterization of methionine dependence in melanoma cells
Showing 5 of 14 shared publications
Charles M. Skinner
University of Arkansas for Medical Sciences
12 shared publications
In database
- Short-term dietary methionine supplementation affects one-carbon metabolism and DNA methylation in the mouse gut and leads to altered microbiome profiles, barrier function, gene expression and histomorphology
- Radiation-induced changes in DNA methylation of repetitive elements in the mouse heart
- Densely ionizing radiation affects DNA methylation of selective LINE-1 elements
- Modulation of dietary methionine intake elicits potent, yet distinct, anticancer effects on primary versus metastatic tumors
- Methionine dietary supplementation potentiates ionizing radiation-induced gastrointestinal syndrome
Showing 5 of 12 shared publications
Rupak Pathak
University of Arkansas for Medical Sciences
11 shared publications
In database
- Short-term dietary methionine supplementation affects one-carbon metabolism and DNA methylation in the mouse gut and leads to altered microbiome profiles, barrier function, gene expression and histomorphology
- Densely ionizing radiation affects DNA methylation of selective LINE-1 elements
- Inter-Strain Differences in LINE-1 DNA Methylation in the Mouse Hematopoietic System in Response to Exposure to Ionizing Radiation
- Methionine dietary supplementation potentiates ionizing radiation-induced gastrointestinal syndrome
- Combined exposure to protons and 56Fe leads to overexpression of Il13 and reactivation of repetitive elements in the mouse lung
Showing 5 of 11 shared publications
Marjan Boerma
Winthrop Rockefeller Foundation
11 shared publications
In database
- Radiation-induced changes in DNA methylation of repetitive elements in the mouse heart
- Effects of low-dose oxygen ions and protons on cardiac function and structure in male C57BL/6J mice
- A priming dose of protons alters the early cardiac cellular and molecular response to 56Fe irradiation
- One-carbon metabolism and ionizing radiation: a multifaceted interaction
- Changes in one-carbon metabolism and DNA methylation in the hearts of mice exposed to space environment-relevant doses of oxygen ions (16O)
Showing 5 of 11 shared publications
Lauren C. Morehead
University of Arkansas for Medical Sciences
10 shared publications
In database
- Increased Response to Immune Checkpoint Inhibitors with Dietary Methionine Restriction in a Colorectal Cancer Model
- Differences in cell death in methionine versus cysteine depletion
- Characterization of methionine dependence in melanoma cells
- Increased response to immune checkpoint inhibitors with dietary methionine restriction
- Increased Response to Immune Checkpoint Inhibitors with Dietary Methionine Restriction
Showing 5 of 10 shared publications
Katherine Wallis
University of Arkansas for Medical Sciences
9 shared publications
In database
- Sex-Specific Effects of Dietary Methionine Restriction on the Intestinal Microbiome
- Increased Response to Immune Checkpoint Inhibitors with Dietary Methionine Restriction in a Colorectal Cancer Model
- Differences in cell death in methionine versus cysteine depletion
- Increased response to immune checkpoint inhibitors with dietary methionine restriction
- Increased Response to Immune Checkpoint Inhibitors with Dietary Methionine Restriction
Showing 5 of 9 shared publications
Laura Ewing
8 shared publications
In database
- MicroRNAs as biomarkers for liver injury: Current knowledge, challenges and future prospects
- Methionine dietary supplementation potentiates ionizing radiation-induced gastrointestinal syndrome
- Safety assessment of the dietary supplement OxyELITE™ Pro (New Formula) in inbred and outbred mouse strains
- Decaffeinated Green Tea Extract Does Not Elicit Hepatotoxic Effects and Modulates the Gut Microbiome in Lean B6C3F1 Mice
- DNA Methylation in Radiation-Induced Carcinogenesis: Experimental Evidence and Clinical Perspectives
Showing 5 of 8 shared publications
Vijayalakshmi Sridharan
University of Arkansas for Medical Sciences
7 shared publications
In database
- Radiation-induced changes in DNA methylation of repetitive elements in the mouse heart
- Effects of low-dose oxygen ions and protons on cardiac function and structure in male C57BL/6J mice
- A priming dose of protons alters the early cardiac cellular and molecular response to 56Fe irradiation
- Changes in one-carbon metabolism and DNA methylation in the hearts of mice exposed to space environment-relevant doses of oxygen ions (16O)
- Impact of obesity on the toxicity of a multi-ingredient dietary supplement, OxyELITE Pro™ (New Formula), using the novel NZO/HILtJ obese mouse model: Physiological and mechanistic assessments
Showing 5 of 7 shared publications
Kristy Kutanzi
University of Arkansas for Medical Sciences
7 shared publications
In database
- Pediatric Exposures to Ionizing Radiation: Carcinogenic Considerations
- Effects of ionizing radiation on DNA methylation: from experimental biology to clinical applications
- Densely ionizing radiation affects DNA methylation of selective LINE-1 elements
- Modulation of dietary methionine intake elicits potent, yet distinct, anticancer effects on primary versus metastatic tumors
- Inter-Strain Differences in LINE-1 DNA Methylation in the Mouse Hematopoietic System in Response to Exposure to Ionizing Radiation
Showing 5 of 7 shared publications
Gregory A. Nelson
Loma Linda University (US)
6 shared publications
- Radiation-induced changes in DNA methylation of repetitive elements in the mouse heart
- Densely ionizing radiation affects DNA methylation of selective LINE-1 elements
- Effects of low-dose oxygen ions and protons on cardiac function and structure in male C57BL/6J mice
- A priming dose of protons alters the early cardiac cellular and molecular response to 56Fe irradiation
- Combined exposure to protons and 56Fe leads to overexpression of Il13 and reactivation of repetitive elements in the mouse lung
Showing 5 of 6 shared publications
Stepan Melnyk
University of Arkansas for Medical Sciences
6 shared publications
In database
- Short-term exposure to engineered nanomaterials affects cellular epigenome
- Short-term dietary methionine supplementation affects one-carbon metabolism and DNA methylation in the mouse gut and leads to altered microbiome profiles, barrier function, gene expression and histomorphology
- One-carbon metabolism and ionizing radiation: a multifaceted interaction
- Methionine dietary supplementation potentiates ionizing radiation-induced gastrointestinal syndrome
- Methylsulfonylmethane Serves as a Donor of Methyl Groups for Methylation of DNA in Human Liver HepaRG Cells
Showing 5 of 6 shared publications
Marie‐Cécile G. Chalbot
University of Arkansas for Medical Sciences (US)
6 shared publications
- Response of transposable elements to environmental stressors
- Epigenetic alterations induced by ambient particulate matter in mouse macrophages
- Dose-response analysis of epigenetic, metabolic, and apical endpoints after short-term exposure to experimental hepatotoxicants
- Climate Change and New Challenges for Rural Communities: Particulate Matter Matters
- Analysis of the Ambient Particulate Matter-induced Chromosomal Aberrations Using an <em>In Vitro</em> System
Showing 5 of 6 shared publications
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