Isabelle R. Miousse

Federal Grant PI High Impact

Assistant Professor

UAMS

Also affiliated: Centre Hospitalier Universitaire de Grenoble (2009); McGill University Health Centre (2008–2009); Center for Environmental Health (2015); Winthrop Rockefeller Foundation (2025); Arkansas Children's Nutrition Center (2013–2014); Arkansas Department of Health (2014–2015); McGill University (2006–2012)

Faculty Researcher

Biochemistry & Molecular Biology, College of Medicine

29 h-index 93 pubs 3,059 cited

Research Areas

Biomedical Subjects

Links

ORCID Lab Website Research Group UAMS TRI Profile

OverviewAI-generated summary

Isabelle R. Miousse's research focuses on the metabolic and molecular mechanisms underlying cellular responses to radiation and cancer. She investigates how dietary interventions, particularly methionine restriction, can modulate these responses. Her work has explored the role of methionine metabolism in acute radiation injury, specifically in the gut, and its potential to enhance the efficacy of immune checkpoint inhibitors in colorectal cancer models.

Miousse also studies the radioprotective properties of gamma-tocotrienol, examining its effects on intestinal and hematopoietic injury induced by various forms of radiation in nonhuman primate models. Her research group has characterized methionine dependence in melanoma cells and investigated the impact of dietary methionine deficiency on immune cell genetic instability in murine models.

With a career h-index of 29 and over 3,000 citations, Miousse has secured federal funding for her work on methionine metabolism and radiation response. She actively collaborates with researchers at the University of Arkansas for Medical Sciences, including Sarita Garg, Lauren C. Morehead, Alan J. Tackett, and Katherine Wallis.

Metrics

h-index: 29
Publications: 93
Citations: 3,059

Selected Publications

<scp>DZNep</scp> : A Methyltransferase Modulator for Disease Mitigation (2026)

Environmental and Molecular Mutagenesis DOI OpenAlex
Abstract 4378: Live attenuated MMR vaccines modulate tumor immune cell infiltration and synergize with standard of care to prolong survival in preclinical HCC models (2026)

Cancer Research DOI OpenAlex
Pancreatic tumor microenvironment reprogramming via alloantigen-expressing virotherapy elicits tumor rejection and improves immunotherapy response (2026)

Journal for ImmunoTherapy of Cancer DOI OpenAlex
Multimodal reprogramming of the tumor microenvironment by MMR and dual checkpoint blockade in hepatocellular carcinoma models (2025)

Frontiers in Immunology 1 citation DOI OpenAlex
Exposure to a Single Dose of Space-Relevant Proton Radiation Alters the Intestinal One-Carbon Metabolism Pathway and Microbiome in Mice (2025)

Radiation Research DOI OpenAlex
Enhancing Rectal Cancer Radiosensitivity and Gut Protection through Methionine Restriction (2025)

Research Square DOI OpenAlex
GLP-1 receptor agonists in the context of cancer: the road ahead (2025)

American Journal of Physiology-Cell Physiology 15 citations DOI OpenAlex
Abstract 950: Engineered oncolytic vesiculovirus downsizes pancreatic tumor and boosts immune response (2025)

Cancer Research DOI OpenAlex
Enhancing Neoadjuvant Virotherapy’s Effectiveness by Targeting Stroma to Improve Resectability in Pancreatic Cancer (2024)

Biomedicines 5 citations DOI OpenAlex
Rescue of Methionine Dependence by Cobalamin in a Human Colorectal Cancer Cell Line (2024)

Nutrients 7 citations DOI OpenAlex
Modulation of Hematopoietic Injury by a Promising Radioprotector, Gamma-Tocotrienol, in Rhesus Macaques Exposed to Partial-Body Radiation (2023)

Radiation Research 10 citations DOI OpenAlex
Climate Change and New Challenges for Rural Communities: Particulate Matter Matters (2023)

Sustainability 7 citations DOI OpenAlex
Resveratrol induces major histocompatibility complex class I antigen presentation in a STING-dependent and independent manner in melanoma (2023)

Molecular Immunology 5 citations DOI OpenAlex
Increased Response to Immune Checkpoint Inhibitors with Dietary Methionine Restriction in a Colorectal Cancer Model (2023)

Cancers 31 citations DOI OpenAlex
Characterization of methionine dependence in melanoma cells (2023)

Molecular Omics 11 citations DOI OpenAlex

View all publications on OpenAlex →

Federal Grants 1 $153,000 total

NIH Contact PI Aug 2025 - Jul 2027

Methionine metabolism in the acute response to radiation in the gut

NIH Office of the Director $153,000 R21

Grants & Funding

As listed on this researcher's institutional profile. Federal awards with verified records are shown above.

Team Leader for the Radiation Effects Team National Space Biomedical Research Institute via Baylor College of Medicine Co-Investigator
Synergizing methionine restriction with radiation therapy in KRAS mutant rectal cancer UAMS Cancer Institute Team Award Co-Investigator
Center for Studies of Host Response to Cancer Therapy NIH Co-Investigator
Methionine restriction as an adjuvant therapy in melanoma NIH/Nat. Inst. of General Medical Sciences via University of Arkansas at Fayetteville Principal Investigator
Decreasing methionine intake to improve survival in patients with metastatic melanoma UAMS CTSA Other
Methionine and autophagy in metastatic melanoma Barton Endowment, UAMS college of Medicine Principle Investigator