Rupak Pathak
Associate Professor
University of Arkansas for Medical Sciences
faculty
Radiation Health, College of Pharmacy
Research Areas
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Biography and Research Information
OverviewAI-generated summary
Rupak Pathak, Associate Professor in Radiation Health at the University of Arkansas for Medical Sciences, focuses his research on the biological effects of ionizing radiation and the development of strategies to mitigate associated toxicities. His work investigates the molecular mechanisms underlying radiation-induced damage in normal tissues, including the liver and intestines, and explores potential therapeutic interventions. Pathak also studies the development of radioresistance in cancer and its implications for treatment outcomes.
His federally funded research portfolio, totaling over $4.2 million across five awards, includes projects focused on developing biomarker assays for delayed radiation injury, understanding host responses to cancer therapy, and investigating the role of platelets in radiation-induced immune dysregulation. Pathak leads a research group and has a notable publication record, with 102 total publications and an h-index of 23. He frequently collaborates with researchers at the University of Arkansas for Medical Sciences, including Martin Hauer-Jensen, Regina Lichti Binz, Marjan Boerma, and Igor Koturbash.
Metrics
- h-index: 23
- Publications: 102
- Citations: 1,250
Selected Publications
- The hidden hand of endoplasmic reticulum stress in anticancer drug resistance (2025) DOI
- Geranylgeranyl Transferase Inhibitors Mitigate Intestinal Radiation Toxicity (2025) DOI
- Exposure to a Single Dose of Space-Relevant Proton Radiation Alters the Intestinal One-Carbon Metabolism Pathway and Microbiome in Mice (2025) DOI
- 591 Low kidney mass contributes to enhanced fractionated irradiation-induced renal hemodynamic dysfunction in mice (2025) DOI
- Current Insights into Molecular Mechanisms and Potential Biomarkers for Treating Radiation-Induced Liver Damage (2024) DOI
- G-Banding and Molecular Cytogenetics Detect Novel Translocations and Cryptic Aberrations in Human Immortal Endothelial Cells (2024) DOI
- Azido derivatives of sesquiterpene lactones: Synthesis, anticancer proliferation, and chemistry of nitrogen-centered radicals (2024) DOI
- Platelets, inflammation, and purinergic receptors in chronic kidney disease (2024) DOI
- Understanding the molecular mechanism responsible for developing therapeutic radiation-induced radioresistance of rectal cancer and improving the clinical outcomes of radiotherapy - A review (2024) DOI
- Protocol for preparation and staining of chromosomes isolated from mouse and human tissues for conventional and molecular cytogenetic analysis (2024) DOI
- Tocotrienols Provide Radioprotection to Multiple Organ Systems through Complementary Mechanisms of Antioxidant and Signaling Effects (2023) DOI
- Evaluating the effects of low-dose simulated galactic cosmic rays on murine hippocampal-dependent cognitive performance (2022) DOI
- Radiation-Induced Intestinal Normal Tissue Toxicity: Implications for Altered Proteome Profile (2022) DOI
- Cytogenetic and epigenetic aberrations in peripheral lymphocytes of northwest Arkansas Marshallese (2022) DOI
- Molecular Cytogenetics Reveals Mosaicism in Human Umbilical Vein Endothelial Cells (2022) DOI
Federal Grants 5 $4,296,005 total
Development of a minimally invasive biomarker assay to detect delayed radiation injury
The Protein C Pathway in Mitigation of Radiation-Induced Endothelial and Vascular Dysfunction
Grants & Funding
- Platelets in radiation-induced immune dysregulation NIH Principal Investigator
- Effect of microgravity and GT3 on proton-induced genomic instability in endothelial cells National Aeronautics & Space Administration - Pass Through: Arkansas Space Grant Consortium Principal Investigator
- Advanced Drug Development of Gamma-Tocotrienol as a Radiation Countermeasure in Rhesus Macaque Non-Human Primates Defense Threat Reduction Agency - Pass Through: Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. Co-Investigator
- Ionizing radiation induced hematological malignancies NIH/Nat. Cancer Institute - Pass Through: University of Florida Principal Investigator
- Team Leader for the Radiation Effects Team National Space Biomedical Research Institute - Pass Through: Baylor College of Medicine Co-Investigator
- Center for Studies of Host Response to Cancer Therapy NIH Co-Investigator
- Ionizing radiation induced hematological malignancies NIH Principal Investigator
- Development of a fast and sensitive biodosimetry assay using molecular cytogenetics. NIH/Nat. Inst. of Allergy & Infectious Diseases - Pass Through: Columbia University Medical Center Principal Investigator
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