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Listed
Presence
Current · Arkansas
Last published
2025
Sources
OpenAlex · ORCID
Refreshed
2026-08-20
R
Rupak Pathak
Federal Grant PI
High Impact
Associate Professor
Also affiliated: Central Arid Zone Research Institute (2018); Uniformed Services University of the Health Sciences (2009); Saha Institute of Nuclear Physics (2007); Manipal Academy of Higher Education (2007); Massachusetts College of Pharmacy and Health Sciences (2025); University of Arkansas Medical Center (2021–2025); Central Arkansas Veterans Healthcare System (2013–2014); University of Applied Management Studies (2024); Arkansas Department of Agriculture (2018–2019); Maulana Abul Kalam Azad University of Technology, West Bengal (2007)
Faculty Researcher
Radiation Health, College of Pharmacy
23 h-index
98 pubs
1,320 cited
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Rupak Pathak's research investigates the molecular mechanisms underlying radiation-induced injuries and the development of strategies to mitigate these effects. His work focuses on understanding how ionizing radiation impacts various organ systems, including the intestines, liver, and bone, and how these changes contribute to long-term health consequences. Pathak has published research exploring the activation of mitochondrial function in osteoclasts following radiation exposure, leading to bone loss in mice, and the alterations in protein profiles associated with radiation-induced intestinal normal tissue toxicity.
His federally funded research, supported by a $636,257 NIH grant, specifically examines the role of platelets in radiation-induced immune dysregulation. This work aims to identify potential biomarkers and therapeutic targets for managing radiation damage. Pathak also investigates radioprotective mechanisms, such as the antioxidant and signaling effects of tocotrienols. His scholarly contributions are reflected in an h-index of 23 and over 1,300 citations across 98 publications. Pathak leads a research group at the University of Arkansas for Medical Sciences and collaborates with several colleagues, including Martin Hauer-Jensen, Regina Lichti Binz, Marjan Boerma, and Igor Koturbash.
Metrics
- h-index: 23
- Publications: 98
- Citations: 1,320
Selected Publications
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Gene Expression Profile of Gm20594 and Hapln1 in Mouse Cardiac Muscle Exposed to Microgravity and Space-like Chronic Low-Dose Radiation (2025)
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The hidden hand of endoplasmic reticulum stress in anticancer drug resistance (2025)
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Geranylgeranyl Transferase Inhibitors Mitigate Intestinal Radiation Toxicity (2025)
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Musculoskeletal miRNA profiling after exposure to simulated space stressors in mice (2025)
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Trimethylamine N-Oxide (TMAO) and cancer risk: Insights into a possible link (2025)
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Exposure to a Single Dose of Space-Relevant Proton Radiation Alters the Intestinal One-Carbon Metabolism Pathway and Microbiome in Mice (2025)
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Sex-specific immune alterations in mice following long-term simulated microgravity and chronic irradiation (2025)
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591 Low kidney mass contributes to enhanced fractionated irradiation-induced renal hemodynamic dysfunction in mice (2025)
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Current Insights into Molecular Mechanisms and Potential Biomarkers for Treating Radiation-Induced Liver Damage (2024)
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G-Banding and Molecular Cytogenetics Detect Novel Translocations and Cryptic Aberrations in Human Immortal Endothelial Cells (2024)
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Azido derivatives of sesquiterpene lactones: Synthesis, anticancer proliferation, and chemistry of nitrogen-centered radicals (2024)
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Platelets, inflammation, and purinergic receptors in chronic kidney disease (2024)
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Understanding the molecular mechanism responsible for developing therapeutic radiation-induced radioresistance of rectal cancer and improving the clinical outcomes of radiotherapy - A review (2024)
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Protocol for preparation and staining of chromosomes isolated from mouse and human tissues for conventional and molecular cytogenetic analysis (2024)
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Tocotrienols Provide Radioprotection to Multiple Organ Systems through Complementary Mechanisms of Antioxidant and Signaling Effects (2023)
Federal Grants 1 $636,257 total
NIH
Contact PI
Jul 2022 - May 2027
Grants & Funding
As listed on this researcher's institutional profile. Federal awards with verified records are shown above.
- Effect of microgravity and GT3 on proton-induced genomic instability in endothelial cells National Aeronautics & Space Administration via Arkansas Space Grant Consortium Principal Investigator
- Advanced Drug Development of Gamma-Tocotrienol as a Radiation Countermeasure in Rhesus Macaque Non-Human Primates Defense Threat Reduction Agency via Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. Co-Investigator
- Ionizing radiation induced hematological malignancies NIH/Nat. Cancer Institute via University of Florida Principal Investigator
- Team Leader for the Radiation Effects Team National Space Biomedical Research Institute via Baylor College of Medicine Co-Investigator
- Center for Studies of Host Response to Cancer Therapy NIH Co-Investigator
- Ionizing radiation induced hematological malignancies NIH Principal Investigator
- Development of a fast and sensitive biodosimetry assay using molecular cytogenetics. NIH/Nat. Inst. of Allergy & Infectious Diseases via Columbia University Medical Center Principal Investigator
- Safeguarding vascular endothelial damage during deep-space missions by newly designed water-soluble vitamin E formulation National Aeronautics & Space Administration via University of Arkansas at Little Rock Principal Investigator
- Effect of microgravity and GT3 on radiation-induced genomic instability in endothelial cells Arkansas Space Grant Consortium via University of Arkansas at Little Rock Principal Investigator
- Arkansas Center for Health Disparities (ARCHD): An NIMHD COE NIH Co-Investigator
- Studies of Endothelial Dysfunction under Simulated Space Environment National Aeronautics & Space Administration via Arkansas Space Grant Consortium Principal Investigator
- Advanced Development of Gamma-Tocotrienol as a Radiation Countermeasure US Department of Defense via Armed Forces Radiobiology Research Institute Co-Investigator
- Tocotrienol as a countermeasure against high-energy charged particle-induced carcinogenesis, cardiovascular disease, and central nervous system effects- Resubmission National Aeronautics & Space Administration Co-Investigator
- Preventing immune system dysregulation during deep-space missions by Tocofexol, a modified isomer of vitamin E - AA request National Aeronautics & Space Administration via Arkansas Space Grant Consortium Principal Investigator
Collaboration Network
Top Collaborators
Regina Lichti Binz
University of Arkansas for Medical Sciences
6 shared publications
In database
- Dietary Methionine Deficiency Enhances Genetic Instability in Murine Immune Cells
- Cytogenetic and epigenetic aberrations in peripheral lymphocytes of northwest Arkansas Marshallese
- Evaluating the effects of low-dose simulated galactic cosmic rays on murine hippocampal-dependent cognitive performance
- Molecular Cytogenetics Reveals Mosaicism in Human Umbilical Vein Endothelial Cells
- Protocol for preparation and staining of chromosomes isolated from mouse and human tissues for conventional and molecular cytogenetic analysis
Showing 5 of 6 shared publications
Martin Hauer‐Jensen
University of Arkansas for Medical Sciences
5 shared publications
In database
- Dietary Methionine Deficiency Enhances Genetic Instability in Murine Immune Cells
- Cytogenetic and epigenetic aberrations in peripheral lymphocytes of northwest Arkansas Marshallese
- Methods for induction and assessment of intestinal permeability in rodent models of radiation injury
- Plasma Metabolomics in a Nonhuman Primate Model of Abdominal Radiation Exposure
- Exposure to a Single Dose of Space-Relevant Proton Radiation Alters the Intestinal One-Carbon Metabolism Pathway and Microbiome in Mice
Marjan Boerma
University of Arkansas for Medical Sciences
5 shared publications
In database
- Cytogenetic and epigenetic aberrations in peripheral lymphocytes of northwest Arkansas Marshallese
- Mitigation of late cardiovascular effects of oxygen ion radiation by γ-tocotrienol in a mouse model
- Plasma Metabolomics in a Nonhuman Primate Model of Abdominal Radiation Exposure
- Exposure to a Single Dose of Space-Relevant Proton Radiation Alters the Intestinal One-Carbon Metabolism Pathway and Microbiome in Mice
- Geranylgeranyl Transferase Inhibitors Mitigate Intestinal Radiation Toxicity
Igor Koturbash
University of Arkansas for Medical Sciences
4 shared publications
In database
- Dietary Methionine Deficiency Enhances Genetic Instability in Murine Immune Cells
- Cytogenetic and epigenetic aberrations in peripheral lymphocytes of northwest Arkansas Marshallese
- Methods for induction and assessment of intestinal permeability in rodent models of radiation injury
- Exposure to a Single Dose of Space-Relevant Proton Radiation Alters the Intestinal One-Carbon Metabolism Pathway and Microbiome in Mice
Isabelle R. Miousse
University of Arkansas for Medical Sciences
3 shared publications
In database
- Dietary Methionine Deficiency Enhances Genetic Instability in Murine Immune Cells
- Plasma Metabolomics in a Nonhuman Primate Model of Abdominal Radiation Exposure
- Exposure to a Single Dose of Space-Relevant Proton Radiation Alters the Intestinal One-Carbon Metabolism Pathway and Microbiome in Mice
Enoch K. Larrey
University of Arkansas for Medical Sciences
3 shared publications
In database
- Radiation-Induced Intestinal Normal Tissue Toxicity: Implications for Altered Proteome Profile
- Azido derivatives of sesquiterpene lactones: Synthesis, anticancer proliferation, and chemistry of nitrogen-centered radicals
- Geranylgeranyl Transferase Inhibitors Mitigate Intestinal Radiation Toxicity
Antara Banerjee
Chettinad Academy of Research and Education (IN)
3 shared publications
- Understanding the molecular mechanism responsible for developing therapeutic radiation-induced radioresistance of rectal cancer and improving the clinical outcomes of radiotherapy - A review
- Current Insights into Molecular Mechanisms and Potential Biomarkers for Treating Radiation-Induced Liver Damage
- Trimethylamine N-Oxide (TMAO) and cancer risk: Insights into a possible link
Surajit Pathak
Chettinad Academy of Research and Education (IN)
3 shared publications
- Understanding the molecular mechanism responsible for developing therapeutic radiation-induced radioresistance of rectal cancer and improving the clinical outcomes of radiotherapy - A review
- Current Insights into Molecular Mechanisms and Potential Biomarkers for Treating Radiation-Induced Liver Damage
- Trimethylamine N-Oxide (TMAO) and cancer risk: Insights into a possible link
Vijayalakshmi Sridharan
University of Arkansas for Medical Sciences
2 shared publications
In database
- Mitigation of late cardiovascular effects of oxygen ion radiation by γ-tocotrienol in a mouse model
- Exposure to a Single Dose of Space-Relevant Proton Radiation Alters the Intestinal One-Carbon Metabolism Pathway and Microbiome in Mice
Reid D. Landes
University of Arkansas for Medical Sciences
2 shared publications
In database
- Cytogenetic and epigenetic aberrations in peripheral lymphocytes of northwest Arkansas Marshallese
- Mitigation of late cardiovascular effects of oxygen ion radiation by γ-tocotrienol in a mouse model
Laura Ewing
University of Arkansas for Medical Sciences
2 shared publications
In database
- Cytogenetic and epigenetic aberrations in peripheral lymphocytes of northwest Arkansas Marshallese
- Methods for induction and assessment of intestinal permeability in rodent models of radiation injury
Stepan Melnyk
University of Arkansas for Medical Sciences
2 shared publications
In database
- Methods for induction and assessment of intestinal permeability in rodent models of radiation injury
- Exposure to a Single Dose of Space-Relevant Proton Radiation Alters the Intestinal One-Carbon Metabolism Pathway and Microbiome in Mice
Kimberly J. Krager
University of Arkansas for Medical Sciences
2 shared publications
In database
- Ionizing Radiation Activates Mitochondrial Function in Osteoclasts and Causes Bone Loss in Young Adult Male Mice
- Tocotrienols Provide Radioprotection to Multiple Organ Systems through Complementary Mechanisms of Antioxidant and Signaling Effects
Nükhet Aykin‐Burns
University of Arkansas for Medical Sciences
2 shared publications
In database
- Ionizing Radiation Activates Mitochondrial Function in Osteoclasts and Causes Bone Loss in Young Adult Male Mice
- Tocotrienols Provide Radioprotection to Multiple Organ Systems through Complementary Mechanisms of Antioxidant and Signaling Effects
Charles M. Skinner
University of Arkansas for Medical Sciences
2 shared publications
In database
- Cytogenetic and epigenetic aberrations in peripheral lymphocytes of northwest Arkansas Marshallese
- Exposure to a Single Dose of Space-Relevant Proton Radiation Alters the Intestinal One-Carbon Metabolism Pathway and Microbiome in Mice
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