Rupak Pathak

Federal Grant PI High Impact

Associate Professor

UAMS

Last publication 2025 Last refreshed 2026-05-23

faculty

Radiation Health, College of Pharmacy

rpathak@uams.edu

23 h-index 98 pubs 1,284 cited

Research Areas

Links

ORCID Research Group UAMS TRI Profile

OverviewAI-generated summary

Rupak Pathak's research focuses on understanding the molecular mechanisms underlying radiation-induced tissue damage and the development of strategies to mitigate these effects. His work investigates the intricate biological responses to ionizing radiation, particularly in the context of cancer radiotherapy. Pathak's group studies the role of cellular components and signaling pathways in radiation resistance and toxicity, with a goal of improving patient outcomes.

His federally funded research, supported by a $693,302 NIH grant, specifically examines the involvement of platelets in radiation-induced immune dysregulation. This project aims to elucidate how radiation impacts immune function through platelet interactions, potentially leading to novel therapeutic targets. Pathak has a strong publication record in this area, with recent work exploring radiation-induced organ damage, such as bone loss in mice due to osteoclast activation, and intestinal normal tissue toxicity characterized by altered proteome profiles. He also investigates potential biomarkers and therapeutic approaches for radiation-induced liver damage and explores radioprotective effects of compounds like tocotrienols.

Pathak's scholarly contributions are recognized by his designation as a high-impact researcher, evidenced by an h-index of 23 and over 1,200 citations. He actively collaborates with colleagues at the University of Arkansas for Medical Sciences, including Martin Hauer-Jensen, Regina Lichti Binz, Marjan Boerma, and Igor Koturbash, with whom he has co-authored multiple publications. His research group is dedicated to advancing the understanding of radiation biology and its clinical implications.

Metrics

h-index: 23
Publications: 98
Citations: 1,284

Selected Publications

The hidden hand of endoplasmic reticulum stress in anticancer drug resistance (2025)

DOI OpenAlex
Geranylgeranyl Transferase Inhibitors Mitigate Intestinal Radiation Toxicity (2025)

DOI OpenAlex
Trimethylamine N-Oxide (TMAO) and cancer risk: Insights into a possible link (2025)

7 citations DOI OpenAlex
Exposure to a Single Dose of Space-Relevant Proton Radiation Alters the Intestinal One-Carbon Metabolism Pathway and Microbiome in Mice (2025)

DOI OpenAlex
591 Low kidney mass contributes to enhanced fractionated irradiation-induced renal hemodynamic dysfunction in mice (2025)

DOI OpenAlex
Current Insights into Molecular Mechanisms and Potential Biomarkers for Treating Radiation-Induced Liver Damage (2024)

14 citations DOI OpenAlex
G-Banding and Molecular Cytogenetics Detect Novel Translocations and Cryptic Aberrations in Human Immortal Endothelial Cells (2024)

DOI OpenAlex
Azido derivatives of sesquiterpene lactones: Synthesis, anticancer proliferation, and chemistry of nitrogen-centered radicals (2024)

1 citation DOI OpenAlex
Platelets, inflammation, and purinergic receptors in chronic kidney disease (2024)

12 citations DOI OpenAlex
Understanding the molecular mechanism responsible for developing therapeutic radiation-induced radioresistance of rectal cancer and improving the clinical outcomes of radiotherapy - A review (2024)

25 citations DOI OpenAlex
Protocol for preparation and staining of chromosomes isolated from mouse and human tissues for conventional and molecular cytogenetic analysis (2024)

4 citations DOI OpenAlex
Tocotrienols Provide Radioprotection to Multiple Organ Systems through Complementary Mechanisms of Antioxidant and Signaling Effects (2023)

9 citations DOI OpenAlex
Evaluating the effects of low-dose simulated galactic cosmic rays on murine hippocampal-dependent cognitive performance (2022)

7 citations DOI OpenAlex
Radiation-Induced Intestinal Normal Tissue Toxicity: Implications for Altered Proteome Profile (2022)

13 citations DOI OpenAlex
Cytogenetic and epigenetic aberrations in peripheral lymphocytes of northwest Arkansas Marshallese (2022)

9 citations DOI OpenAlex

View all publications on OpenAlex →

Federal Grants 1 $693,302 total

NIH/NIH Office of the Director Contact PI Jul 2022 - May 2027

Platelets in radiation-induced immune dysregulation

NIH Office of the Director $693,302 U01

Grants & Funding

Platelets in radiation-induced immune dysregulation NIH Principal Investigator
Effect of microgravity and GT3 on proton-induced genomic instability in endothelial cells National Aeronautics & Space Administration - Pass Through: Arkansas Space Grant Consortium Principal Investigator
Advanced Drug Development of Gamma-Tocotrienol as a Radiation Countermeasure in Rhesus Macaque Non-Human Primates Defense Threat Reduction Agency - Pass Through: Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. Co-Investigator
Ionizing radiation induced hematological malignancies NIH/Nat. Cancer Institute - Pass Through: University of Florida Principal Investigator
Team Leader for the Radiation Effects Team National Space Biomedical Research Institute - Pass Through: Baylor College of Medicine Co-Investigator
Center for Studies of Host Response to Cancer Therapy NIH Co-Investigator
Ionizing radiation induced hematological malignancies NIH Principal Investigator
Development of a fast and sensitive biodosimetry assay using molecular cytogenetics. NIH/Nat. Inst. of Allergy & Infectious Diseases - Pass Through: Columbia University Medical Center Principal Investigator