Match tier
Institution-verified
Presence
Current · Arkansas
Last published
2026
Sources
Institutional record
Refreshed
2026-10-08
M
Marjan Boerma
Sourced from institutional research profiles (UAMS TRI or ARA).
Federal Grant PI
High Impact
Professor
Also affiliated: American Heart Association (2006); National Institutes of Health (2007); Loma Linda University (2015); University of Arkansas Medical Center (2006–2022); Leiden University Medical Center (2002–2005); Moffitt Cancer Center (2012); Central Arkansas Veterans Healthcare System (2005–2015); Arkansas Biosciences Institute (2006); John L. McClellan Memorial Veterans Hospital (2009); Charité - Universitätsmedizin Berlin (2012)
37 h-index
225 pubs
5,353 cited
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Marjan Boerma's research focuses on elucidating the biological mechanisms by which cancer therapies cause cardiovascular injury and identifying potential countermeasures. This work utilizes pre-clinical research models to investigate the cardiac side effects of radiation therapy, both alone and in combination with chemotherapeutic agents. Assessments include cardiac function, tissue structure, and molecular alterations in response to these treatments.
Boerma has received significant federal funding for this research, totaling $3,602,703 across four awards from the NIH. These grants support projects such as the development of minimally invasive biomarker assays for delayed radiation injury and the establishment of a center for studies on host response to cancer therapy. Collaborations within the University of Arkansas for Medical Sciences include work with Vijayalakshmi Sridharan, Igor Koturbash, Ashley Nemec-Bakk, and Rupak Pathak, evidenced by multiple shared publications.
With a career marked by extensive scholarship, Boerma has authored 224 publications with over 5,333 citations and maintains an h-index of 37. This productivity has led to recognition as a highly cited, high-impact researcher. Boerma leads an active research group and maintains a lab website, indicating ongoing research endeavors.
Metrics
- h-index: 37
- Publications: 225
- Citations: 5,353
Positions
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Professor 2021–presentUniversity of Arkansas for Medical Sciences Pharmaceutical Sciences Institutional directory
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Associate Professor 2012–2021University of Arkansas for Medical Sciences Pharmaceutical Sciences ORCID
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Assistant Professor 2006–2012University of Arkansas for Medical Sciences Pharmaceutical Sciences ORCID
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Postdoctoral Fellow 2004–2006University of Arkansas for Medical Sciences Surgery ORCID
Selected Publications
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Dual Targeting of EZH2 and LSD1 Suppresses Hepatocellular Carcinoma via Disruption of Sonic Hedgehog Signaling (2026)
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Dataset for: Multi-organ acute and delayed effects following exposure to neutron radiation (2026)
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Multimodal reprogramming of the tumor microenvironment by MMR and dual checkpoint blockade in hepatocellular carcinoma models (2025)
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Exposure to a Single Dose of Space-Relevant Proton Radiation Alters the Intestinal One-Carbon Metabolism Pathway and Microbiome in Mice (2025)
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Adverse Outcome Pathways Applied to Space Radiation Research (2025)
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Sex-specific immune alterations in mice following long-term simulated microgravity and chronic irradiation (2025)
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A narrative review of metabolomics approaches in identifying biomarkers of doxorubicin-induced cardiotoxicity (2025)
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Long-term effects of combined exposures to simulated microgravity and galactic cosmic radiation on the mouse lung: sex-specific epigenetic reprogramming (2025)
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Bridging Earth and Space: A Flexible and Resilient Federated Learning Framework Deployed on the International Space Station (2025)
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Distinct Urinary Metabolite Signatures Mirror In Vivo Oxidative Stress-Related Radiation Responses in Mice (2024)
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Sex-specific effects on the heart from combined exposure to simulated galactic cosmic radiation and hindlimb unloading (2024)
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AOP report: Development of an adverse outcome pathway for deposition of energy leading to abnormal vascular remodeling (2024)
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Pharmacologic or genetic interference with atrogene signaling protects against glucocorticoid-induced musculoskeletal and cardiac disease (2024)
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Deletion of myeloid HDAC3 promotes efferocytosis to ameliorate retinal ischemic injury (2024)
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Effects of confounding and effect-modifying lifestyle, environmental and medical factors on risk of radiation-associated cardiovascular disease (2024)
Federal Grants 4 $3,602,703 total
NIH
Contact PI
Aug 2025 - May 2030
NIH
Contact PI
Feb 2020 - Jan 2026
Development of a minimally invasive biomarker assay to detect delayed radiation injury
NIH
Contact PI
Jun 2017 - Nov 2022
The Protein C Pathway in Mitigation of Radiation-Induced Endothelial and Vascular Dysfunction
NIH
Contact PI
Jun 2015 - May 2026
Grants & Funding
As listed on this researcher's institutional profile. Federal awards with verified records are shown above.
- ABI C. OBrien NIH COBRE FY26 Y4 State of Arkansas
- Effects of Chronic and Single-dose Charged Particle Exposure on Cardiac Function and Structure in Multiple Animal Models National Aeronautics & Space Administration
- Platelets in radiation-induced immune dysregulation NIH/Nat. Inst. of Allergy & Infectious Diseases
- Impact of hemodynamics on efferocytosis in endothelial cells NIH/Nat. Heart, Lung & Blood Institute
- Metabolomics Based Prediction of Delayed Effects of Acute Radiation Exposure NIH/Nat. Inst. of Allergy & Infectious Diseases via Nelson Scientific Labs, LLC
- Tocotrienol as a countermeasure against high-energy charged particle-induced carcinogenesis, cardiovascular disease, and central nervous system effects- Resubmission National Aeronautics & Space Administration
- Advanced development of multi-omics based assays to predict late radiation organinjuries - the DEARE-Watch project NIH
- Team Leader for the Radiation Effects Team National Space Biomedical Research Institute via Baylor College of Medicine
- Role of TLR4 in Radiation-induced Cardiomyopathy/Upstate NY US Department of Defense via SUNY Upstate Medical University
- Phosphodiesterase inhibitors and tocols in radiation-induced heart disease American Cancer Society, Inc.
- Role of Senescent Cells in Radiation-induced Pulmonary Fibrosis NIH
- Center for Musculoskeletal Disease Research (CMDR) NIH/Nat. Inst. of General Medical Sciences
- COBRE Phase III _ Boerma NIH/Nat. Inst. of General Medical Sciences
- Center for Molecular Interactions in Cancer (CMIC) NIH
- Integration of in-silico and in-vivo Models for Determining Preclinical Indicators and/or Integrated Biomarkers of Radiation-Induced Vascular Dysfunction National Aeronautics & Space Administration via Louisiana State University
- Photobiomodulation to Ameliorate Neuronal Degeneration and Cognitive Decline after Mixed Field Irradiation - Continuation National Aeronautics & Space Administration
- Radiation-Induced Heart Disease: Mechanisms and Interventions NIH
- Oral Interleukin 11 as a Countermeasure against Radiation Injury to Gut NIH
- Center for Research on Cardiac and Vascular Effects of Space Radiation National Space Biomedical Research Institute
- MRNA translational Control of Cell Cycle Progression American Cancer Society, Inc.
Collaboration Network
Top Collaborators
Martin Hauer‐Jensen
National Institutes of Health
54 shared publications
In database
- Significance of endothelial dysfunction in the pathogenesis of early and delayed radiation enteropathy
- Effects of ionizing radiation on the heart
- Radiation damage to the gastrointestinal tract: mechanisms, diagnosis, and management
- γ-Tocotrienol Ameliorates Intestinal Radiation Injury and Reduces Vascular Oxidative Stress after Total-Body Irradiation by an HMG-CoA Reductase-Dependent Mechanism
- Prevention and Treatment of Functional and Structural Radiation Injury in the Rat Heart by Pentoxifylline and Alpha-Tocopherol
Showing 5 of 54 shared publications
Vijayalakshmi Sridharan
University of Arkansas for Medical Sciences
53 shared publications
In database
- Effects of ionizing radiation on the heart
- Space-type radiation induces multimodal responses in the mouse gut microbiome and metabolome
- Impact of Spaceflight and Artificial Gravity on the Mouse Retina: Biochemical and Proteomic Analysis
- Spaceflight induces oxidative damage to blood‐brain barrier integrity in a mouse model
- Radiation-Induced Alterations in Mitochondria of the Rat Heart
Showing 5 of 53 shared publications
Amrita K. Cheema
Georgetown University (US)
21 shared publications
- Effects of ionizing radiation on the heart
- Sulforaphane prevents age‐associated cardiac and muscular dysfunction through Nrf2 signaling
- Space-type radiation induces multimodal responses in the mouse gut microbiome and metabolome
- Plasma metabolite biomarkers predictive of radiation induced cardiotoxicity
- One-carbon metabolism and ionizing radiation: a multifaceted interaction
Showing 5 of 21 shared publications
Igor Koturbash
University of Arkansas for Medical Sciences
21 shared publications
In database
- Effects of ionizing radiation on the heart
- Space-type radiation induces multimodal responses in the mouse gut microbiome and metabolome
- Radiation-induced changes in DNA methylation of repetitive elements in the mouse heart
- Effects of low-dose oxygen ions and protons on cardiac function and structure in male C57BL/6J mice
- A priming dose of protons alters the early cardiac cellular and molecular response to 56Fe irradiation
Showing 5 of 21 shared publications
Rupak Pathak
University of Arkansas for Medical Sciences
18 shared publications
In database
- Reduction of Radiation-Induced Vascular Nitrosative Stress by the Vitamin E Analog γ-Tocotrienol: Evidence of a Role for Tetrahydrobiopterin
- C/EBPδ Deficiency Sensitizes Mice to Ionizing Radiation-Induced Hematopoietic and Intestinal Injury
- The Vitamin E Analog Gamma-Tocotrienol (GT3) Suppresses Radiation-Induced Cytogenetic Damage
- Thrombomodulin Contributes to Gamma Tocotrienol-Mediated Lethality Protection and Hematopoietic Cell Recovery in Irradiated Mice
- Characterization of Transgenic Gfrp Knock-In Mice: Implications for Tetrahydrobiopterin in Modulation of Normal Tissue Radiation Responses
Showing 5 of 18 shared publications
Xiao Wen Mao
Loma Linda University (US)
14 shared publications
- Effects of ionizing radiation on the heart
- Impact of Spaceflight and Artificial Gravity on the Mouse Retina: Biochemical and Proteomic Analysis
- Spaceflight induces oxidative damage to blood‐brain barrier integrity in a mouse model
- Characterization of mouse ocular response to a 35-day spaceflight mission: Evidence of blood-retinal barrier disruption and ocular adaptations
- Acute Effect of Low-Dose Space Radiation on Mouse Retina and Retinal Endothelial Cells
Showing 5 of 14 shared publications
Gregory A. Nelson
Loma Linda University (US)
13 shared publications
- Effects of ionizing radiation on the heart
- Space-type radiation induces multimodal responses in the mouse gut microbiome and metabolome
- Radiation-induced changes in DNA methylation of repetitive elements in the mouse heart
- Acute Effect of Low-Dose Space Radiation on Mouse Retina and Retinal Endothelial Cells
- Combined Effects of Low-Dose Proton Radiation and Simulated Microgravity on the Mouse Retina and the Hematopoietic System
Showing 5 of 13 shared publications
Yaoxiang Li
Georgetown University (US)
13 shared publications
- Plasma metabolite biomarkers predictive of radiation induced cardiotoxicity
- An optimized method for the isolation of urinary extracellular vesicles for molecular phenotyping: detection of biomarkers for radiation exposure
- Identification of Plasma Lipidome Changes Associated with Low Dose Space-Type Radiation Exposure in a Murine Model
- Urinary Metabolomics for the Prediction of Radiation-Induced Cardiac Dysfunction
- Effects of proton and oxygen ion irradiation on cardiovascular function and structure in a rabbit model
Showing 5 of 13 shared publications
Antiño R. Allen
University of Arkansas for Medical Sciences
12 shared publications
In database
- Behavioral effects of space radiation: A comprehensive review of animal studies
- 5-Fluorouracil chemotherapy upregulates cytokines and alters hippocampal dendritic complexity in aged mice
- Long-Term Changes in Cognition and Physiology after Low-Dose 16O Irradiation
- Early effects of 16O radiation on neuronal morphology and cognition in a murine model
- Late Effects of 1H + 16O on Short-Term and Object Memory, Hippocampal Dendritic Morphology and Mutagenesis
Showing 5 of 12 shared publications
Qiang Fu
National Institutes of Health
11 shared publications
In database
- Significance of endothelial dysfunction in the pathogenesis of early and delayed radiation enteropathy
- Radiation damage to the gastrointestinal tract: mechanisms, diagnosis, and management
- γ-Tocotrienol Ameliorates Intestinal Radiation Injury and Reduces Vascular Oxidative Stress after Total-Body Irradiation by an HMG-CoA Reductase-Dependent Mechanism
- Comparative gene expression profiling in three primary human cell lines after treatment with a novel inhibitor of Rho kinase or atorvastatin
- Radiation responses in skin and connective tissues: effect on wound healing and surgical outcome
Showing 5 of 11 shared publications
Eduardo G. Moros
Moffitt Cancer Center (US)
11 shared publications
- Radiation-Induced Alterations in Mitochondria of the Rat Heart
- Cardiac Inflammation after Local Irradiation Is Influenced by the Kallikrein-Kinin System
- Effects of Late Administration of Pentoxifylline and Tocotrienols in an Image-Guided Rat Model of Localized Heart Irradiation
- A Tocotrienol-Enriched Formulation Protects against Radiation-Induced Changes in Cardiac Mitochondria without Modifying Late Cardiac Function or Structure
- Advanced Small Animal Conformal Radiation Therapy Device
Showing 5 of 11 shared publications
Junru Wang
University of Arkansas for Medical Sciences (US)
11 shared publications
- Significance of endothelial dysfunction in the pathogenesis of early and delayed radiation enteropathy
- Radiation damage to the gastrointestinal tract: mechanisms, diagnosis, and management
- Comparative gene expression profiling in three primary human cell lines after treatment with a novel inhibitor of Rho kinase or atorvastatin
- Pharmacological Induction of Transforming Growth Factor-Beta1 in Rat Models Enhances Radiation Injury in the Intestine and the Heart
- The Somatostatin Analog SOM230 (Pasireotide) Ameliorates Injury of the Intestinal Mucosa and Increases Survival after Total-Body Irradiation by Inhibiting Exocrine Pancreatic Secretion
Showing 5 of 11 shared publications
Isabelle R. Miousse
Winthrop Rockefeller Foundation
11 shared publications
In database
- Radiation-induced changes in DNA methylation of repetitive elements in the mouse heart
- Effects of low-dose oxygen ions and protons on cardiac function and structure in male C57BL/6J mice
- A priming dose of protons alters the early cardiac cellular and molecular response to 56Fe irradiation
- One-carbon metabolism and ionizing radiation: a multifaceted interaction
- Changes in one-carbon metabolism and DNA methylation in the hearts of mice exposed to space environment-relevant doses of oxygen ions (16O)
Showing 5 of 11 shared publications
Maohua Cao
11 shared publications
- Effects of low-dose oxygen ions and protons on cardiac function and structure in male C57BL/6J mice
- Effects of local irradiation combined with sunitinib on early remodeling, mitochondria, and oxidative stress in the rat heart
- Effects of low-dose rate γ-irradiation combined with simulated microgravity on markers of oxidative stress, DNA methylation potential, and remodeling in the mouse heart
- Late Administration of a Palladium Lipoic Acid Complex (POLY-MVA) Modifies Cardiac Mitochondria but Not Functional or Structural Manifestations of Radiation-Induced Heart Disease in a Rat Model
- Effects of single-dose protons or oxygen ions on function and structure of the cardiovascular system in male Long Evans rats
Showing 5 of 11 shared publications
Reid D. Landes
University of Arkansas for Medical Sciences
11 shared publications
In database
- Effects of low-dose oxygen ions and protons on cardiac function and structure in male C57BL/6J mice
- Simultaneous exposure to chronic irradiation and simulated microgravity differentially alters immune cell phenotype in mouse thymus and spleen
- Changes in one-carbon metabolism and DNA methylation in the hearts of mice exposed to space environment-relevant doses of oxygen ions (16O)
- Effects of single-dose protons or oxygen ions on function and structure of the cardiovascular system in male Long Evans rats
- Sex-dependent effects of genetic upregulation of activated protein C on delayed effects of acute radiation exposure in the mouse heart, small intestine, and skin
Showing 5 of 11 shared publications
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