M
Marjan Boerma Institution-verified
Sourced from institutional research profiles (UAMS TRI or ARA).
Federal Grant PI
High Impact
Professor
faculty
37 h-index
221 pubs
5,167 cited
Research Areas
Biography and Research Information
OverviewAI-generated summary
Marjan Boerma investigates the biological mechanisms underlying cardiovascular injury caused by cancer therapies, such as chemotherapy and radiation. Using pre-clinical research models, Boerma's work assesses cardiac function, tissue structure, and molecular changes in response to these treatments, with the goal of identifying potential interventions to mitigate these side effects. This research is supported by federal funding, including a $1.47 million grant from the NIH/National Institute of General Medical Sciences for the "Center for Studies of Host Response to Cancer Therapy" and a $1.15 million grant for "COBRE Phase III." Additional NIH funding supports the development of a biomarker assay for radiation injury ($395,650) and research into the protein C pathway's role in mitigating radiation-induced vascular dysfunction ($588,106).
Boerma's research group has published extensively on topics related to radiation-induced heart disease, including the association between cancer radiation therapy and atrial fibrillation, and the role of Toll-like receptor 4 (TLR4) in radiation-induced heart disease. Work also extends to other treatment-related toxicities, such as the impact of chemotherapeutic agents on the heart. The group's publications also address methods for isolating extracellular vesicles for biomarker detection and the effects of genetic modifications on radiation exposure responses in various tissues. Boerma has a h-index of 37 and over 5,110 citations across 214 publications.
Metrics
- h-index: 37
- Publications: 221
- Citations: 5,167
Selected Publications
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Dataset for: Multi-organ acute and delayed effects following exposure to neutron radiation (2026)
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Multimodal reprogramming of the tumor microenvironment by MMR and dual checkpoint blockade in hepatocellular carcinoma models (2025)
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Adverse Outcome Pathways Applied to Space Radiation Research (2025)
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Sex-specific immune alterations in mice following long-term simulated microgravity and chronic irradiation (2025)
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A narrative review of metabolomics approaches in identifying biomarkers of doxorubicin-induced cardiotoxicity (2025)
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Long-term effects of combined exposures to simulated microgravity and galactic cosmic radiation on the mouse lung: sex-specific epigenetic reprogramming (2025)
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Distinct Urinary Metabolite Signatures Mirror In Vivo Oxidative Stress-Related Radiation Responses in Mice (2024)
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Sex-specific effects on the heart from combined exposure to simulated galactic cosmic radiation and hindlimb unloading (2024)
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<scp>AOP</scp> report: Development of an adverse outcome pathway for deposition of energy leading to abnormal vascular remodeling (2024)
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Pharmacologic or genetic interference with atrogene signaling protects against glucocorticoid-induced musculoskeletal and cardiac disease (2024)
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Deletion of myeloid HDAC3 promotes efferocytosis to ameliorate retinal ischemic injury (2024)
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Effects of confounding and effect-modifying lifestyle, environmental and medical factors on risk of radiation-associated cardiovascular disease (2024)
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Genetic Upregulation of Activated Protein C Mitigates Delayed Effects of Acute Radiation Exposure in the Mouse Plasma (2024)
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A Review of Numerical Models of Radiation Injury and Repair Considering Subcellular Targets and the Extracellular Microenvironment (2024)
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A Review of Numerical Models of Radiation Injury and Repair Considering Subcellular Targets and the Extracellular Microenvironment (2023)
Federal Grants 4 $3,602,703 total
NIH/National Institute of General Medical Sciences
Contact PI
Aug 2025 - May 2030
NIH/NIH Office of the Director
Contact PI
Feb 2020 - Jan 2026
Development of a minimally invasive biomarker assay to detect delayed radiation injury
NIH/NIH Office of the Director
Contact PI
Jun 2017 - Nov 2022
The Protein C Pathway in Mitigation of Radiation-Induced Endothelial and Vascular Dysfunction
NIH/National Institute of General Medical Sciences
Contact PI
Jun 2015 - May 2026
Grants & Funding
Collaboration Network
Top Collaborators
Vijayalakshmi Sridharan
University of Arkansas for Medical Sciences
16 shared publications
In database
- TLR4—A Pertinent Player in Radiation-Induced Heart Disease?
- Sex-dependent effects of genetic upregulation of activated protein C on delayed effects of acute radiation exposure in the mouse heart, small intestine, and skin
- The M2 Gene Is a Determinant of Reovirus-Induced Myocarditis
- Effects of low-dose oxygen ions on cardiac function and structure in female C57BL/6J mice
- Effects of Simulated 5-Ion Galactic Cosmic Radiation on Function and Structure of the Mouse Heart
Showing 5 of 16 shared publications
Yaoxiang Li
Georgetown University (US)
9 shared publications
- An optimized method for the isolation of urinary extracellular vesicles for molecular phenotyping: detection of biomarkers for radiation exposure
- Urinary Metabolomics for the Prediction of Radiation-Induced Cardiac Dysfunction
- Effects of proton and oxygen ion irradiation on cardiovascular function and structure in a rabbit model
- Effects of Whole and Partial Heart Irradiation on Collagen, Mast Cells, and Toll-like Receptor 4 in the Mouse Heart
- Analysis of the urinary metabolic profiles in irradiated rats treated with Activated Protein C (APC), a potential mitigator of radiation toxicity
Showing 5 of 9 shared publications
Amrita K. Cheema
Georgetown University (US)
9 shared publications
- An optimized method for the isolation of urinary extracellular vesicles for molecular phenotyping: detection of biomarkers for radiation exposure
- Urinary Metabolomics for the Prediction of Radiation-Induced Cardiac Dysfunction
- Effects of proton and oxygen ion irradiation on cardiovascular function and structure in a rabbit model
- Effects of Whole and Partial Heart Irradiation on Collagen, Mast Cells, and Toll-like Receptor 4 in the Mouse Heart
- Analysis of the urinary metabolic profiles in irradiated rats treated with Activated Protein C (APC), a potential mitigator of radiation toxicity
Showing 5 of 9 shared publications
Igor Koturbash
University of Arkansas for Medical Sciences
8 shared publications
In database
- Cytogenetic and epigenetic aberrations in peripheral lymphocytes of northwest Arkansas Marshallese
- A Review of Numerical Models of Radiation Injury and Repair Considering Subcellular Targets and the Extracellular Microenvironment
- Effects of proton and oxygen ion irradiation on cardiovascular function and structure in a rabbit model
- Sex-specific effects on the heart from combined exposure to simulated galactic cosmic radiation and hindlimb unloading
- A Review of Numerical Models of Radiation Injury and Repair Considering Subcellular Targets and the Extracellular Microenvironment
Showing 5 of 8 shared publications
Shivani Bansal
Georgetown University (US)
8 shared publications
- An optimized method for the isolation of urinary extracellular vesicles for molecular phenotyping: detection of biomarkers for radiation exposure
- Urinary Metabolomics for the Prediction of Radiation-Induced Cardiac Dysfunction
- Effects of Whole and Partial Heart Irradiation on Collagen, Mast Cells, and Toll-like Receptor 4 in the Mouse Heart
- Analysis of the urinary metabolic profiles in irradiated rats treated with Activated Protein C (APC), a potential mitigator of radiation toxicity
- An optimized method for the isolation of urinary extracellular vesicles for molecular phenotyping: detection of biomarkers for radiation exposure
Showing 5 of 8 shared publications
Reid D. Landes
University of Arkansas for Medical Sciences (US)
7 shared publications
- Sex-dependent effects of genetic upregulation of activated protein C on delayed effects of acute radiation exposure in the mouse heart, small intestine, and skin
- Effects of low-dose oxygen ions on cardiac function and structure in female C57BL/6J mice
- Cytogenetic and epigenetic aberrations in peripheral lymphocytes of northwest Arkansas Marshallese
- Differential Recovery of Small Intestinal Segments after Partial-Body Irradiation in Non-Human Primates
- Effects of Simulated 5-Ion Galactic Cosmic Radiation on Function and Structure of the Mouse Heart
Showing 5 of 7 shared publications
José A. Fernández
Scripps Research Institute (US)
7 shared publications
- An optimized method for the isolation of urinary extracellular vesicles for molecular phenotyping: detection of biomarkers for radiation exposure
- Sex-dependent effects of genetic upregulation of activated protein C on delayed effects of acute radiation exposure in the mouse heart, small intestine, and skin
- Urinary Metabolomics for the Prediction of Radiation-Induced Cardiac Dysfunction
- Analysis of the urinary metabolic profiles in irradiated rats treated with Activated Protein C (APC), a potential mitigator of radiation toxicity
- An optimized method for the isolation of urinary extracellular vesicles for molecular phenotyping: detection of biomarkers for radiation exposure
Showing 5 of 7 shared publications
John H. Griffin
Scripps Research Institute (US)
7 shared publications
- An optimized method for the isolation of urinary extracellular vesicles for molecular phenotyping: detection of biomarkers for radiation exposure
- Sex-dependent effects of genetic upregulation of activated protein C on delayed effects of acute radiation exposure in the mouse heart, small intestine, and skin
- Urinary Metabolomics for the Prediction of Radiation-Induced Cardiac Dysfunction
- Analysis of the urinary metabolic profiles in irradiated rats treated with Activated Protein C (APC), a potential mitigator of radiation toxicity
- An optimized method for the isolation of urinary extracellular vesicles for molecular phenotyping: detection of biomarkers for radiation exposure
Showing 5 of 7 shared publications
Paari Dominic
Louisiana State University Health Sciences Center Shreveport (US)
6 shared publications
- Cancer Radiation Therapy May Be Associated With Atrial Fibrillation
- Effects of low-dose oxygen ions on cardiac function and structure in female C57BL/6J mice
- Mitigation of late cardiovascular effects of oxygen ion radiation by γ-tocotrienol in a mouse model
- The Inverse Correlation Between the Duration of Lifetime Occupational Radiation Exposure and the Prevalence of Atrial Arrhythmia
- Abstract P098: Effects Of Occupational Radiation Exposure On The Prevalence Of Hypertension And Its Complications
Showing 5 of 6 shared publications
Rupak Pathak
6 shared publications
In database
- Cytogenetic and epigenetic aberrations in peripheral lymphocytes of northwest Arkansas Marshallese
- Differential Recovery of Small Intestinal Segments after Partial-Body Irradiation in Non-Human Primates
- Mitigation of late cardiovascular effects of oxygen ion radiation by γ-tocotrienol in a mouse model
- Platelet glycoprotein Ibα provides radiation protection
- Plasma Metabolomics in a Nonhuman Primate Model of Abdominal Radiation Exposure
Showing 5 of 6 shared publications
Ashley Nemec-Bakk
University of Arkansas for Medical Sciences
6 shared publications
In database
- Effects of low-dose oxygen ions on cardiac function and structure in female C57BL/6J mice
- Effects of Simulated 5-Ion Galactic Cosmic Radiation on Function and Structure of the Mouse Heart
- Mitigation of late cardiovascular effects of oxygen ion radiation by γ-tocotrienol in a mouse model
- Effects of proton and oxygen ion irradiation on cardiovascular function and structure in a rabbit model
- Sex-specific effects on the heart from combined exposure to simulated galactic cosmic radiation and hindlimb unloading
Showing 5 of 6 shared publications
Meth Jayatilake
Georgetown University (US)
6 shared publications
- An optimized method for the isolation of urinary extracellular vesicles for molecular phenotyping: detection of biomarkers for radiation exposure
- Urinary Metabolomics for the Prediction of Radiation-Induced Cardiac Dysfunction
- An optimized method for the isolation of urinary extracellular vesicles for molecular phenotyping: detection of biomarkers for radiation exposure
- Distinct Urinary Metabolite Signatures Mirror In Vivo Oxidative Stress-Related Radiation Responses in Mice
- An optimized method for the isolation of urinary extracellular vesicles for molecular phenotyping: detection of biomarkers for radiation exposure
Showing 5 of 6 shared publications
Sunil Bansal
Georgetown University (US)
6 shared publications
- An optimized method for the isolation of urinary extracellular vesicles for molecular phenotyping: detection of biomarkers for radiation exposure
- Urinary Metabolomics for the Prediction of Radiation-Induced Cardiac Dysfunction
- Analysis of the urinary metabolic profiles in irradiated rats treated with Activated Protein C (APC), a potential mitigator of radiation toxicity
- An optimized method for the isolation of urinary extracellular vesicles for molecular phenotyping: detection of biomarkers for radiation exposure
- An optimized method for the isolation of urinary extracellular vesicles for molecular phenotyping: detection of biomarkers for radiation exposure
Showing 5 of 6 shared publications
Maohua Cao
5 shared publications
- Sex-dependent effects of genetic upregulation of activated protein C on delayed effects of acute radiation exposure in the mouse heart, small intestine, and skin
- Effects of low-dose oxygen ions on cardiac function and structure in female C57BL/6J mice
- Late Health Effects of Partial Body Irradiation Injury in a Minipig Model Are Associated with Changes in Systemic and Cardiac IGF-1 Signaling
- Mitigation of late cardiovascular effects of oxygen ion radiation by γ-tocotrienol in a mouse model
- Effects of proton and oxygen ion irradiation on cardiovascular function and structure in a rabbit model
Kimberly J. Krager
University of Arkansas for Medical Sciences
5 shared publications
In database
- TLR4—A Pertinent Player in Radiation-Induced Heart Disease?
- Sex-dependent effects of genetic upregulation of activated protein C on delayed effects of acute radiation exposure in the mouse heart, small intestine, and skin
- Small animal models of localized heart irradiation
- Effects of Whole and Partial Heart Irradiation on Collagen, Mast Cells, and Toll-like Receptor 4 in the Mouse Heart
- Multimodal reprogramming of the tumor microenvironment by MMR and dual checkpoint blockade in hepatocellular carcinoma models
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