Match tier
Listed
Presence
Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-10-05
Joseph Hunter Holthoff
Assistant Professor
Also affiliated: University of Arkansas Medical Center (2016–2023); University of Arkansas System (2023); Central Arkansas Veterans Healthcare System (2022–2026)
Internal Med, College of Medicine
7 h-index
38 pubs
803 cited
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Joseph H. Holthoff, Assistant Professor in Internal Medicine at the University of Arkansas for Medical Sciences, focuses his research on understanding and identifying biomarkers for acute kidney injury (AKI). His work has led to publications identifying SOD1 as a novel prognostic biomarker for AKI following cardiothoracic surgery and investigating urinary complement C3 and vitamin D-binding protein as predictors of adverse outcomes in similar patient populations. Holthoff also studies the role of specific molecules, such as Esm-1 and IGFBP-1, in the pathophysiology and clinical prognosis of kidney diseases, including diabetic kidney disease and AKI. His research extends to exploring unconventional therapies for challenging kidney conditions and examining the effectiveness of different dialysis methods for specific medical emergencies, such as hypermagnesemia. Holthoff collaborates with researchers at his institution, including Nithin Karakala and Fatima Ayub, with whom he has co-authored multiple publications.
Metrics
- h-index: 7
- Publications: 38
- Citations: 803
Positions
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Assistant Professor publications 2006–2026University of Arkansas for Medical Sciences Internal Med, College of Medicine Institutional directory
Selected Publications
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Diabetic kidney disease within the framework of cardio-kidney-metabolic health: a paradigm shift (2026)
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Aldosterone in Diabetic Kidney Disease: From Mineralocorticoid Receptor Antagonism to Aldosterone Synthase Inhibition (2026)
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A rare case of primary hyperaldosteronism with parathyroid hyperplasia and papillary thyroid carcinoma (2026)
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Perfusion Under Pressure: Reversing Anuric AKI with Targeted Intra-Abdominal Pressure (IAP) Reduction (2025)
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The Second Slice Tells the Story: Evolving Cryoglobulinemia in Mesangial Glomerulonephritis (2025)
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Dialysate Sodium (2025)
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SGLT2 Inhibitors as a Therapeutic Option for Both Acute and Chronic Refractory Hypomagnesemia in Diabetic and Nondiabetic Patients: A Multicenter Case Series (2025)
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Plasma Cell–Directed Rescue With Bortezomib in Refractory Antiphospholipase A2 Receptor–Positive Membranous Nephropathy (2025)
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The role of IGFBP-1 in the clinical prognosis and pathophysiology of acute kidney injury (2025)
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Breaking Barriers: Unconventional Therapy Treats a Challenging Case of Primary Membranous Nephropathy (2024)
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New Mutation Associated with Polycystic Kidney Disease Type I: A Case Report (2024)
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Urine Chemistry: A Valuable Link Binding Kidney Physiology to Patient Care (2024)
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Urinary Complement C3 and Vitamin D-Binding Protein Predict Adverse Outcomes in Patients with Acute Kidney Injury after Cardiac Surgery (2024)
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New Mutation Associated with Polycystic Kidney Disease Type I: A Case Report (2024)
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I Am the Lucky Third: Spontaneous Resolution of High-Risk Membranous Nephropathy (2023)
Grants & Funding
As listed on this researcher's institutional profile.
- Investigating the mechanism of protection of IGFBP-1 in a murine model of acute kidney injury Dialysis Clinic, Inc. Principal Investigator
- Preclinical evaluation of resveratrol in sepsis-induced renal injury NIH Principal Investigator
Collaboration Network
Top Collaborators
Philip R. Mayeux
University of Arkansas for Medical Sciences
9 shared publications
In database
- Resveratrol improves renal microcirculation, protects the tubular epithelium, and prolongs survival in a mouse model of sepsis-induced acute kidney injury
- Development of Oxidative Stress in the Peritubular Capillary Microenvironment Mediates Sepsis-Induced Renal Microcirculatory Failure and Acute Kidney Injury
- Peritubular capillary dysfunction and renal tubular epithelial cell stress following lipopolysaccharide administration in mice
- Resveratrol, a dietary polyphenolic phytoalexin, is a functional scavenger of peroxynitrite
- Rolipram Improves Renal Perfusion and Function during Sepsis in the Mouse
Showing 5 of 9 shared publications
Nithin Karakala
University of Arkansas for Medical Sciences
8 shared publications
In database
- SOD1 is a novel prognostic biomarker of acute kidney injury following cardiothoracic surgery
- Urinary Complement C3 and Vitamin D-Binding Protein Predict Adverse Outcomes in Patients with Acute Kidney Injury after Cardiac Surgery
- The role of IGFBP-1 in the clinical prognosis and pathophysiology of acute kidney injury
- The Drug that Keeps Giving: Hypomagnesemia Fixed by SGLT2 Inhibitor
- Urine Chemistry: A Valuable Link Binding Kidney Physiology to Patient Care
Showing 5 of 8 shared publications
John M. Arthur
Central Arkansas Veterans Healthcare System
6 shared publications
In database
- Plasma Cell–Directed Rescue With Bortezomib in Refractory Antiphospholipase A2 Receptor–Positive Membranous Nephropathy
- SOD1 is a novel prognostic biomarker of acute kidney injury following cardiothoracic surgery
- Urinary Complement C3 and Vitamin D-Binding Protein Predict Adverse Outcomes in Patients with Acute Kidney Injury after Cardiac Surgery
- The role of IGFBP-1 in the clinical prognosis and pathophysiology of acute kidney injury
- Breaking Barriers: Unconventional Therapy Treats a Challenging Case of Primary Membranous Nephropathy
Showing 5 of 6 shared publications
Neriman Gökden
University of Arkansas for Medical Sciences
5 shared publications
In database
- Resveratrol improves renal microcirculation, protects the tubular epithelium, and prolongs survival in a mouse model of sepsis-induced acute kidney injury
- Development of Oxidative Stress in the Peritubular Capillary Microenvironment Mediates Sepsis-Induced Renal Microcirculatory Failure and Acute Kidney Injury
- Peritubular capillary dysfunction and renal tubular epithelial cell stress following lipopolysaccharide administration in mice
- Rolipram Improves Renal Perfusion and Function during Sepsis in the Mouse
- The role of IGFBP-1 in the clinical prognosis and pathophysiology of acute kidney injury
Fatima Ayub
Central Arkansas Veterans Healthcare System
5 shared publications
In database
- Plasma Cell–Directed Rescue With Bortezomib in Refractory Antiphospholipase A2 Receptor–Positive Membranous Nephropathy
- I Am the Lucky Third: Spontaneous Resolution of High-Risk Membranous Nephropathy
- SGLT2 Inhibitors as a Therapeutic Option for Both Acute and Chronic Refractory Hypomagnesemia in Diabetic and Nondiabetic Patients: A Multicenter Case Series
- Dialysate Sodium
- Aldosterone in Diabetic Kidney Disease: From Mineralocorticoid Receptor Antagonism to Aldosterone Synthase Inhibition
Luis A. Juncos
University of Arkansas for Medical Sciences
4 shared publications
In database
- Plasma Cell–Directed Rescue With Bortezomib in Refractory Antiphospholipase A2 Receptor–Positive Membranous Nephropathy
- SOD1 is a novel prognostic biomarker of acute kidney injury following cardiothoracic surgery
- The role of IGFBP-1 in the clinical prognosis and pathophysiology of acute kidney injury
- The Role of Esm-1 in Diabetic Kidney Disease: More Than Just a Biomarker
Kathryn A. Seely
University of Arkansas for Medical Sciences (US)
3 shared publications
- Resveratrol improves renal microcirculation, protects the tubular epithelium, and prolongs survival in a mouse model of sepsis-induced acute kidney injury
- Development of Oxidative Stress in the Peritubular Capillary Microenvironment Mediates Sepsis-Induced Renal Microcirculatory Failure and Acute Kidney Injury
- Renal microcirculatory perfusion in a pediatric model of sepsis‐induced acute kidney injury in the rat
Samuel T. Burns
University of Arkansas for Medical Sciences (US)
3 shared publications
- Resveratrol, a dietary polyphenolic phytoalexin, is a functional scavenger of peroxynitrite
- The dietary antioxidant resveratrol is a functional scavenger of peroxynitrite in vitro
- Renal microcirculatory perfusion in a pediatric model of sepsis‐induced acute kidney injury in the rat
Christian Herzog
Central Arkansas Veterans Healthcare System
3 shared publications
In database
- SOD1 is a novel prognostic biomarker of acute kidney injury following cardiothoracic surgery
- The role of IGFBP-1 in the clinical prognosis and pathophysiology of acute kidney injury
- Urine Mass Spectrometry Can Distinguish Prerenal and Intrarenal AKI
Fatima Ayub
University of Arkansas for Medical Sciences
3 shared publications
In database
- Urinary Complement C3 and Vitamin D-Binding Protein Predict Adverse Outcomes in Patients with Acute Kidney Injury after Cardiac Surgery
- The Drug that Keeps Giving: Hypomagnesemia Fixed by SGLT2 Inhibitor
- Hemodialysis Is More Effective Than Continuous Venovenous Hemodialysis for Treatment of Hypermagnesemia due to Epsom Salt Ingestion
Md R. Hasan
Arkansas Department of Health (US)
3 shared publications
- The Drug that Keeps Giving: Hypomagnesemia Fixed by SGLT2 Inhibitor
- I Am the Lucky Third: Spontaneous Resolution of High-Risk Membranous Nephropathy
- SGLT2 Inhibitors as a Therapeutic Option for Both Acute and Chronic Refractory Hypomagnesemia in Diabetic and Nondiabetic Patients: A Multicenter Case Series
Manisha Singh
Central Arkansas Veterans Healthcare System
3 shared publications
In database
- New Mutation Associated with Polycystic Kidney Disease Type I: A Case Report
- New Mutation Associated with Polycystic Kidney Disease Type I: A Case Report
- SGLT2 Inhibitors as a Therapeutic Option for Both Acute and Chronic Refractory Hypomagnesemia in Diabetic and Nondiabetic Patients: A Multicenter Case Series
Elina Pathak
University of Arkansas for Medical Sciences (US)
2 shared publications
- Development of Oxidative Stress in the Peritubular Capillary Microenvironment Mediates Sepsis-Induced Renal Microcirculatory Failure and Acute Kidney Injury
- Sirtuin 1 enzyme activity and autophagy proteins are increased in the kidney during murine sepsis
Kellie A. Woodling
National Center for Toxicological Research
2 shared publications
In database
- Resveratrol, a dietary polyphenolic phytoalexin, is a functional scavenger of peroxynitrite
- The dietary antioxidant resveratrol is a functional scavenger of peroxynitrite in vitro
Daniel R. Doerge
National Center for Toxicological Research
2 shared publications
In database
- Resveratrol, a dietary polyphenolic phytoalexin, is a functional scavenger of peroxynitrite
- The dietary antioxidant resveratrol is a functional scavenger of peroxynitrite in vitro
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