P.A.L. Wight

High Impact

Researcher

University of Arkansas for Medical Sciences

faculty

24 h-index 113 pubs 3,485 cited

Research Areas

Neuroscience and Neuropharmacology Research Neurological disorders and treatments Gene expression and cancer classification Birth, Development, and Health Molecular Biology Techniques and Applications Health and Medical Research Impacts Immune Response and Inflammation

Links

ORCID Lab Website

Is this your profile? Verify and claim your profile

OverviewAI-generated summary

P.A.L. Wight's research program investigates the molecular mechanisms that regulate myelin gene expression, with a particular focus on the proteolipid protein 1 (PLP1) gene. This work has been supported by a grant from the National Institute of Neurological Disorders and Stroke (NINDS) for $321,999, aimed at elucidating these regulatory mechanisms in both human and mouse models. Studies have examined the role of splice variants and regulatory elements, including an intronic enhancer, in controlling PLP1 expression during early postnatal brain development.

The research also extends to the function of PLP1 in the enteric nervous system and its potential modulation by ethanol, as explored in the context of fetal alcohol spectrum disorders. Investigations have utilized transgenic mouse models, such as PLP1-lacZ mice, to track gene expression patterns and identify key regulatory sequences. This work contributes to understanding neurodevelopmental processes and the impact of environmental factors on brain health.

Wight has published 113 papers, accumulating over 3,485 citations, and holds an h-index of 24. Key collaborators at the University of Arkansas for Medical Sciences include Pankaj Patyal and Daniel Fil, with whom multiple shared publications exist. The researcher maintains an active laboratory website.

Metrics

  • h-index: 24
  • Publications: 113
  • Citations: 3,485

Selected Publications

  • Plp1 in the enteric nervous system is preferentially expressed during early postnatal development in mouse as DM20, whose expression appears reliant on an intronic enhancer (2023) DOI
  • PLP1-lacZ transgenic mice reveal that splice variants containing “human-specific” exons are relatively minor in comparison to the archetypal transcript and that an upstream regulatory element bolsters expression during early postnatal brain development (2023) DOI
  • Ethanol modulation of hippocampal neuroinflammation, myelination, and neurodevelopment in a postnatal mouse model of fetal alcohol spectrum disorders (2021) DOI

Federal Grants 1 $321,999 total

NIH/National Institute of Neurological Disorders and Stroke Contact PI Apr 2019 - Mar 2026

Elucidation of Mechanisms Controlling Human and Mouse Myelin PLP1 Gene Expression

National Institute of Neurological Disorders and Stroke $321,999 R01

Collaborators

Researchers in the database who share publications

Pankaj Patyal University of Arkansas for Medical Sciences 2 shared publications Daniel Fil University of Arkansas for Medical Sciences 2 shared publications Paul D. Drew University of Arkansas for Medical Sciences 1 shared publication Victoria M. Niedzwiedz‐Massey University of Arkansas for Medical Sciences 1 shared publication James C. Douglas University of Arkansas for Medical Sciences 1 shared publication Cynthia J.M. Kane University of Arkansas for Medical Sciences 1 shared publication Tonya Rafferty University of Arkansas for Medical Sciences 1 shared publication

Similar Researchers

Based on overlapping research topics

David W. Donley Harding University Main Campus
Neuroscience and Neuropharmacology Research Neurological disorders and treatments Molecular Biology Techniques and Applications
Good match 5 shared topics
Bryan E. White University of Arkansas for Medical Sciences
Neuroscience and Neuropharmacology Research Neurological disorders and treatments Molecular Biology Techniques and Applications
Good match 4 shared topics
Paavan Atluri University of Arkansas at Fayetteville
Neuroscience and Neuropharmacology Research Neurological disorders and treatments Molecular Biology Techniques and Applications
Good match 4 shared topics
U Thaung Shwe University of Arkansas for Medical Sciences
Neuroscience and Neuropharmacology Research Neurological disorders and treatments Molecular Biology Techniques and Applications
Good match 4 shared topics
Victoria M. Niedzwiedz‐Massey University of Arkansas for Medical Sciences
Neuroscience and Neuropharmacology Research Neurological disorders and treatments Birth, Development, and Health
Good match 4 shared topics
Hui-Ming Chang University of Arkansas for Medical Sciences
Neuroscience and Neuropharmacology Research Molecular Biology Techniques and Applications Health and Medical Research Impacts
Good match 4 shared topics