M
Megan E. Rosa‐Caldwell Data-verified
Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.
High Impact
Assistant Professor of Exercise Science
faculty
21 h-index
103 pubs
1,550 cited
Research Areas
Links
Biography and Research Information
OverviewAI-generated summary
Megan E. Rosa‐Caldwell's research focuses on understanding the physiological changes in skeletal muscle, particularly in the context of disease states such as cancer cachexia and disuse atrophy. Her work investigates the molecular and cellular mechanisms underlying muscle weakness and atrophy, with a specific interest in sex-based differences in these responses.
Recent publications from her laboratory have explored how mitochondrial stress contributes to muscle weakness during cancer cachexia. Additionally, her research has examined the differential impact of disuse atrophy on male and female mice, noting variations in catabolic signaling and mitochondrial aberrations. Her work also includes a systematic review on anorexia nervosa and its effects on muscle health. Rosa‐Caldwell collaborates with several researchers at the University of Arkansas at Fayetteville, including Tyrone A. Washington, Eleanor R. Schrems, Nicholas P. Greene, and Francielly Morena da Silva, with whom she has co-authored numerous publications.
With a career h-index of 21 and over 1,500 citations from more than 100 publications, Rosa‐Caldwell is recognized as a highly cited researcher. Her active laboratory website indicates ongoing research activities.
Metrics
- h-index: 21
- Publications: 103
- Citations: 1,550
Selected Publications
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Mitochondrial capacities and quality control following short‐ and long‐term weight restoration after simulated anorexia nervosa (2025)
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Divergent alterations in the skeletal muscle and serum proteome in a rodent model of anorexia nervosa and weight recovery (2025)
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Changes in muscle strength and moderators of protein turnover in a rodent model of anorexia nervosa and recovery (2025)
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Muscular Proteomic Alterations During Simulated Anorexia Nervosa Are Not Resolved Following Weight Recovery (2025)
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Electrical impedance myography as a marker of muscle mass in rats with simulated Anorexia Nervosa (2025)
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Brain Matter Alterations during Simulated Anorexia Nervosa and Following Weight Recovery in Rats (2025)
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Effects of Anorexia Nervosa on Muscle Quality Following Long-Term Recovery in Rats (2025)
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Systemic Proteomic Alterations in a Rodent Model of Anorexia Nervosa (2025)
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Muscle Alterations Persist Beyond Weight Restoration In A Rodent Model Of Anorexia Nervosa (2024)
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Predicting muscle function and mass with electrical impedance myography: A study in rat analogs of micro- and partial gravity (2024)
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A refined rodent model of anorexia nervosa: Simulating state‐specific effects of caloric restriction and weight restoration (2024)
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Supplemental table 6 (2023)
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Supplemental table 1 (2023)
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Supplemental table 3 (2023)
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Supplemental table 2 (2023)
Collaboration Network
Top Collaborators
Nicholas P. Greene
University of Arkansas at Fayetteville
23 shared publications
In database
- Muscle weakness precedes atrophy during cancer cachexia and is linked to muscle-specific mitochondrial stress
- Female mice may have exacerbated catabolic signalling response compared to male mice during development and progression of disuse atrophy
- Mitochondrial aberrations during the progression of disuse atrophy differentially affect male and female mice
- Development of metabolic and contractile alterations in development of cancer cachexia in female tumor-bearing mice
- The time-course of cancer cachexia onset reveals biphasic transcriptional disruptions in female skeletal muscle distinct from males
Showing 5 of 23 shared publications
Tyrone A. Washington
University of Arkansas at Fayetteville
20 shared publications
In database
- Female mice may have exacerbated catabolic signalling response compared to male mice during development and progression of disuse atrophy
- Mitochondrial aberrations during the progression of disuse atrophy differentially affect male and female mice
- Development of metabolic and contractile alterations in development of cancer cachexia in female tumor-bearing mice
- The time-course of cancer cachexia onset reveals biphasic transcriptional disruptions in female skeletal muscle distinct from males
- Females display relatively preserved muscle quality compared with males during the onset and early stages of C26-induced cancer cachexia
Showing 5 of 20 shared publications
Seward B. Rutkove
Beth Israel Deaconess Medical Center (US)
19 shared publications
- Hindlimb suspension in Wistar rats: Sex‐based differences in muscle response
- Anorexia nervosa and muscle health: A systematic review of our current understanding and future recommendations for study
- The oestrous cycle and skeletal muscle atrophy: Investigations in rodent models of muscle loss
- Influence of gonadectomy on muscle health in micro- and partial-gravity environments in rats
- Sex differences in muscle health in simulated micro- and partial-gravity environments in rats
Showing 5 of 19 shared publications
Eleanor R. Schrems
University of Arkansas at Fayetteville
18 shared publications
In database
- Development of metabolic and contractile alterations in development of cancer cachexia in female tumor-bearing mice
- The time-course of cancer cachexia onset reveals biphasic transcriptional disruptions in female skeletal muscle distinct from males
- Females display relatively preserved muscle quality compared with males during the onset and early stages of C26-induced cancer cachexia
- Muscle miR-16 deletion results in impaired insulin sensitivity and contractile function in a sex-dependent manner
- Development of skeletal muscle fibrosis in a rodent model of cancer cachexia
Showing 5 of 18 shared publications
Francielly Morena da Silva
University of Arkansas at Fayetteville
15 shared publications
In database
- Female mice may have exacerbated catabolic signalling response compared to male mice during development and progression of disuse atrophy
- Development of metabolic and contractile alterations in development of cancer cachexia in female tumor-bearing mice
- The time-course of cancer cachexia onset reveals biphasic transcriptional disruptions in female skeletal muscle distinct from males
- Females display relatively preserved muscle quality compared with males during the onset and early stages of C26-induced cancer cachexia
- Muscle miR-16 deletion results in impaired insulin sensitivity and contractile function in a sex-dependent manner
Showing 5 of 15 shared publications
Ana Regina Cabrera
14 shared publications
In database
- Development of metabolic and contractile alterations in development of cancer cachexia in female tumor-bearing mice
- The time-course of cancer cachexia onset reveals biphasic transcriptional disruptions in female skeletal muscle distinct from males
- Females display relatively preserved muscle quality compared with males during the onset and early stages of C26-induced cancer cachexia
- Muscle miR-16 deletion results in impaired insulin sensitivity and contractile function in a sex-dependent manner
- PGC-1α overexpression is not sufficient to mitigate cancer cachexia in either male or female mice
Showing 5 of 14 shared publications
Ursula B. Kaiser
Brigham and Women's Hospital (US)
13 shared publications
- The oestrous cycle and skeletal muscle atrophy: Investigations in rodent models of muscle loss
- Influence of gonadectomy on muscle health in micro- and partial-gravity environments in rats
- Sex differences in muscle health in simulated micro- and partial-gravity environments in rats
- A refined rodent model of anorexia nervosa: Simulating state‐specific effects of caloric restriction and weight restoration
- Mitochondrial capacities and quality control following short‐ and long‐term weight restoration after simulated anorexia nervosa
Showing 5 of 13 shared publications
Kevin A. Murach
University of Arkansas at Fayetteville
13 shared publications
In database
- The time-course of cancer cachexia onset reveals biphasic transcriptional disruptions in female skeletal muscle distinct from males
- Biological sex divergence in transcriptomic profiles during the onset of hindlimb unloading-induced atrophy
- The Time-Course of Cancer Cachexia Onset Reveals Biphasic Transcriptional Disruptions in Female Skeletal Muscle Distinct from Males
- Mitochondrial capacities and quality control following short‐ and long‐term weight restoration after simulated anorexia nervosa
- Supplemental table 5
Showing 5 of 13 shared publications
Lauren Breithaupt
Massachusetts General Hospital (US)
13 shared publications
- Anorexia nervosa and muscle health: A systematic review of our current understanding and future recommendations for study
- Identification of State Markers in Anorexia Nervosa: Replication and Extension of Inflammation-Associated Biomarkers Using Multiplex Profiling
- Identification of State Markers in Anorexia Nervosa: Replication and Extension of Inflammation Associated Biomarkers Using Multiplex Profiling in Anorexia Nervosa and Atypical Anorexia Nervosa
- A refined rodent model of anorexia nervosa: Simulating state‐specific effects of caloric restriction and weight restoration
- Mitochondrial capacities and quality control following short‐ and long‐term weight restoration after simulated anorexia nervosa
Showing 5 of 13 shared publications
Seongkyun Lim
University of Arkansas at Fayetteville
10 shared publications
In database
- Female mice may have exacerbated catabolic signalling response compared to male mice during development and progression of disuse atrophy
- Mitochondrial aberrations during the progression of disuse atrophy differentially affect male and female mice
- Development of metabolic and contractile alterations in development of cancer cachexia in female tumor-bearing mice
- The time-course of cancer cachexia onset reveals biphasic transcriptional disruptions in female skeletal muscle distinct from males
- Females display relatively preserved muscle quality compared with males during the onset and early stages of C26-induced cancer cachexia
Showing 5 of 10 shared publications
Marie Mortreux
Beth Israel Deaconess Medical Center (US)
9 shared publications
- Hindlimb suspension in Wistar rats: Sex‐based differences in muscle response
- The oestrous cycle and skeletal muscle atrophy: Investigations in rodent models of muscle loss
- Influence of gonadectomy on muscle health in micro- and partial-gravity environments in rats
- Sex differences in muscle health in simulated micro- and partial-gravity environments in rats
- Adaptation to full weight‐bearing following disuse in rats: The impact of biological sex on musculoskeletal recovery
Showing 5 of 9 shared publications
Dong‐Min Sung
Beth Israel Deaconess Medical Center (US)
9 shared publications
- Hindlimb suspension in Wistar rats: Sex‐based differences in muscle response
- The oestrous cycle and skeletal muscle atrophy: Investigations in rodent models of muscle loss
- Influence of gonadectomy on muscle health in micro- and partial-gravity environments in rats
- Sex differences in muscle health in simulated micro- and partial-gravity environments in rats
- Adaptation to full weight‐bearing following disuse in rats: The impact of biological sex on musculoskeletal recovery
Showing 5 of 9 shared publications
Stavroula Tsitkanou
9 shared publications
In database
- Muscle weakness precedes atrophy during cancer cachexia and is linked to muscle-specific mitochondrial stress
- Females display relatively preserved muscle quality compared with males during the onset and early stages of C26-induced cancer cachexia
- Biological sex divergence in transcriptomic profiles during the onset of hindlimb unloading-induced atrophy
- Supplemental table 5
- Supplemental table 4
Showing 5 of 9 shared publications
Jacob L. Brown
University of Arkansas at Fayetteville (US)
6 shared publications
- Female mice may have exacerbated catabolic signalling response compared to male mice during development and progression of disuse atrophy
- Mitochondrial aberrations during the progression of disuse atrophy differentially affect male and female mice
- Development of skeletal muscle fibrosis in a rodent model of cancer cachexia
- Effects of PGC-1α overexpression on the myogenic response during skeletal muscle regeneration
- PGC-1α overexpression is not sufficient to mitigate cancer cachexia in either male or female mice
Showing 5 of 6 shared publications
Michael P. Wiggs
Baylor University (US)
6 shared publications
- Muscle weakness precedes atrophy during cancer cachexia and is linked to muscle-specific mitochondrial stress
- Female mice may have exacerbated catabolic signalling response compared to male mice during development and progression of disuse atrophy
- Mitochondrial aberrations during the progression of disuse atrophy differentially affect male and female mice
- Development of metabolic and contractile alterations in development of cancer cachexia in female tumor-bearing mice
- Females display relatively preserved muscle quality compared with males during the onset and early stages of C26-induced cancer cachexia
Showing 5 of 6 shared publications
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