N
Nicholas P. Greene Data-verified
Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.
Federal Grant PI
High Impact
Associate Professor
faculty
29 h-index
186 pubs
3,857 cited
Research Areas
Links
Biography and Research Information
OverviewAI-generated summary
Nicholas P. Greene's research focuses on skeletal muscle physiology, with a particular emphasis on the molecular mechanisms underlying muscle atrophy and adaptation. His work investigates how conditions such as cancer cachexia and disuse impact muscle at the cellular and molecular levels, examining factors like mitochondrial stress and transcriptional disruptions. Greene has explored sex-based differences in the development of muscle atrophy and the response to stimuli like exercise and aging.
His federally funded work includes a $313,850 grant from the NIH/National Institute of Arthritis and Musculoskeletal and Skin Diseases for the "DEVELOPMENT OF TARGETED APPROACHES IN PREVENTION OF CANCER-CACHEXIA." Greene has authored or co-authored 187 publications with a total of 3,827 citations, and maintains an h-index of 28. He is recognized as a high-impact researcher and a federal grant principal investigator. Greene actively collaborates with researchers at the University of Arkansas at Fayetteville, including Francielly Morena da Silva, Tyrone A. Washington, Ana Regina Cabrera, and Eleanor R. Schrems, with whom he shares numerous publications.
Metrics
- h-index: 29
- Publications: 186
- Citations: 3,857
Selected Publications
-
The Age‐Dependent Resident Myonuclear Multi‐Omic Response to an Acute Skeletal Muscle Hypertrophic Stimulus in Mice (2026)
-
Exercise-induced antioxidant programming in oxidative muscle: a critical IL1β-NBR1-p62 axis (2026)
-
Skeletal muscle methylome-transcriptome disruptions during the onset and progression of colorectal cancer-induced cachexia (2025)
-
The Age-Dependent Resident Myonuclear Multi-Omic Response to a Skeletal Muscle Hypertrophic Stimulus (2025)
-
Mitochondrial-targeted plastoquinone therapy prevents early onset muscle weakness that occurs before atrophy during ovarian cancer (2025)
-
Sustained Accumulation of Molecular Clock Suppressors Period 1 and Period 2 Promotes C2C12 Myotube Atrophy Through an Autocrine-Mediated Mechanism With Relevance to Androgen Deprivation-Induced Limb Muscle Mass Loss (2025)
-
Myocellular adaptations to short‐term weighted wheel‐running exercise are largely conserved during C26‐tumour induction in male and female mice (2025)
-
Landscape of Clinical Trials in Cancer Cachexia: Assessment of Trends From 1995-2024 (2025)
-
The 24-hour molecular landscape after exercise in humans reveals MYC is sufficient for muscle growth (2024)
-
Transcriptional analysis of cancer cachexia: conserved and unique features across preclinical models and biological sex (2024)
-
Mitochondrial-targeted plastoquinone therapy ameliorates early onset muscle weakness that precedes ovarian cancer cachexia in mice (2024)
-
Mitochondrial antioxidant SkQ1 attenuates C26 cancer-induced muscle wasting in males and improves muscle contractility in female tumor-bearing mice (2024)
-
Muscle weakness and mitochondrial stress occur before severe metastasis in a novel mouse model of ovarian cancer cachexia (2024)
-
Exploring heterogeneity: a dive into preclinical models of cancer cachexia (2024)
-
Muscle weakness and mitochondrial stress occur before metastasis in a novel mouse model of ovarian cancer cachexia (2024)
Federal Grants 1 $313,850 total
NIH/National Institute of Arthritis and Musculoskeletal and Skin Diseases
Contact PI
Jul 2020 - Jun 2026
DEVELOPMENT OF TARGETED APPROACHES IN PREVENTION OF CANCER-CACHEXIA
Collaboration Network
Top Collaborators
Francielly Morena da Silva
University of Arkansas at Fayetteville
27 shared publications
In database
- Multi-transcriptome analysis following an acute skeletal muscle growth stimulus yields tools for discerning global and MYC regulatory networks
- Female mice may have exacerbated catabolic signalling response compared to male mice during development and progression of disuse atrophy
- A molecular signature defining exercise adaptation with ageing and <i>in vivo</i> partial reprogramming in skeletal muscle
- Development of metabolic and contractile alterations in development of cancer cachexia in female tumor-bearing mice
- The time-course of cancer cachexia onset reveals biphasic transcriptional disruptions in female skeletal muscle distinct from males
Showing 5 of 27 shared publications
Tyrone A. Washington
University of Arkansas at Fayetteville
24 shared publications
In database
- Female mice may have exacerbated catabolic signalling response compared to male mice during development and progression of disuse atrophy
- Mitochondrial aberrations during the progression of disuse atrophy differentially affect male and female mice
- Development of metabolic and contractile alterations in development of cancer cachexia in female tumor-bearing mice
- Exercise Counteracts the Deleterious Effects of Cancer Cachexia
- The time-course of cancer cachexia onset reveals biphasic transcriptional disruptions in female skeletal muscle distinct from males
Showing 5 of 24 shared publications
Ana Regina Cabrera
University of Arkansas at Fayetteville
23 shared publications
In database
- Development of metabolic and contractile alterations in development of cancer cachexia in female tumor-bearing mice
- The time-course of cancer cachexia onset reveals biphasic transcriptional disruptions in female skeletal muscle distinct from males
- Females display relatively preserved muscle quality compared with males during the onset and early stages of C26-induced cancer cachexia
- Muscle miR-16 deletion results in impaired insulin sensitivity and contractile function in a sex-dependent manner
- The mechanosensitive gene <i>arrestin domain containing 2</i> regulates myotube diameter with direct implications for disuse atrophy with aging
Showing 5 of 23 shared publications
Kevin A. Murach
University of Arkansas at Fayetteville
20 shared publications
In database
- Multi-transcriptome analysis following an acute skeletal muscle growth stimulus yields tools for discerning global and MYC regulatory networks
- A molecular signature defining exercise adaptation with ageing and <i>in vivo</i> partial reprogramming in skeletal muscle
- Exercise Counteracts the Deleterious Effects of Cancer Cachexia
- The time-course of cancer cachexia onset reveals biphasic transcriptional disruptions in female skeletal muscle distinct from males
- Inflammation o'clock: interactions of circadian rhythms with inflammation‐induced skeletal muscle atrophy
Showing 5 of 20 shared publications
Seongkyun Lim
University of Arkansas at Fayetteville
19 shared publications
In database
- Multi-transcriptome analysis following an acute skeletal muscle growth stimulus yields tools for discerning global and MYC regulatory networks
- Female mice may have exacerbated catabolic signalling response compared to male mice during development and progression of disuse atrophy
- A molecular signature defining exercise adaptation with ageing and <i>in vivo</i> partial reprogramming in skeletal muscle
- Mitochondrial aberrations during the progression of disuse atrophy differentially affect male and female mice
- Development of metabolic and contractile alterations in development of cancer cachexia in female tumor-bearing mice
Showing 5 of 19 shared publications
Eleanor R. Schrems
University of Arkansas at Fayetteville
18 shared publications
In database
- Development of metabolic and contractile alterations in development of cancer cachexia in female tumor-bearing mice
- The time-course of cancer cachexia onset reveals biphasic transcriptional disruptions in female skeletal muscle distinct from males
- Females display relatively preserved muscle quality compared with males during the onset and early stages of C26-induced cancer cachexia
- Muscle miR-16 deletion results in impaired insulin sensitivity and contractile function in a sex-dependent manner
- Development of skeletal muscle fibrosis in a rodent model of cancer cachexia
Showing 5 of 18 shared publications
Megan E. Rosa‐Caldwell
University of Arkansas at Fayetteville
16 shared publications
In database
- Muscle weakness precedes atrophy during cancer cachexia and is linked to muscle-specific mitochondrial stress
- Female mice may have exacerbated catabolic signalling response compared to male mice during development and progression of disuse atrophy
- Mitochondrial aberrations during the progression of disuse atrophy differentially affect male and female mice
- Development of metabolic and contractile alterations in development of cancer cachexia in female tumor-bearing mice
- The time-course of cancer cachexia onset reveals biphasic transcriptional disruptions in female skeletal muscle distinct from males
Showing 5 of 16 shared publications
Ronald G. Jones
University of Arkansas at Fayetteville
10 shared publications
In database
- A molecular signature defining exercise adaptation with ageing and <i>in vivo</i> partial reprogramming in skeletal muscle
- The time-course of cancer cachexia onset reveals biphasic transcriptional disruptions in female skeletal muscle distinct from males
- The 24-hour molecular landscape after exercise in humans reveals MYC is sufficient for muscle growth
- Muscle weakness and mitochondrial stress occur before severe metastasis in a novel mouse model of ovarian cancer cachexia
- The 24-Hour Time Course of Integrated Molecular Responses to Resistance Exercise in Human Skeletal Muscle Implicates <i>MYC</i> as a Hypertrophic Regulator That is Sufficient for Growth
Showing 5 of 10 shared publications
J. William Deaver
University of Arkansas at Fayetteville (US)
9 shared publications
- Female mice may have exacerbated catabolic signalling response compared to male mice during development and progression of disuse atrophy
- Development of metabolic and contractile alterations in development of cancer cachexia in female tumor-bearing mice
- Females display relatively preserved muscle quality compared with males during the onset and early stages of C26-induced cancer cachexia
- Muscle miR-16 deletion results in impaired insulin sensitivity and contractile function in a sex-dependent manner
- The effect of diet-induced obesity on extracellular matrix remodeling during skeletal muscle regeneration
Showing 5 of 9 shared publications
Stavroula Tsitkanou
University of Arkansas at Fayetteville
9 shared publications
In database
- Muscle weakness precedes atrophy during cancer cachexia and is linked to muscle-specific mitochondrial stress
- Exercise Counteracts the Deleterious Effects of Cancer Cachexia
- Females display relatively preserved muscle quality compared with males during the onset and early stages of C26-induced cancer cachexia
- Mitochondrial antioxidant SkQ1 attenuates C26 cancer-induced muscle wasting in males and improves muscle contractility in female tumor-bearing mice
- Biological sex divergence in transcriptomic profiles during the onset of hindlimb unloading-induced atrophy
Showing 5 of 9 shared publications
Landen W. Saling
University of Arkansas at Fayetteville
8 shared publications
In database
- Development of metabolic and contractile alterations in development of cancer cachexia in female tumor-bearing mice
- Females display relatively preserved muscle quality compared with males during the onset and early stages of C26-induced cancer cachexia
- Muscle miR-16 deletion results in impaired insulin sensitivity and contractile function in a sex-dependent manner
- Development of skeletal muscle fibrosis in a rodent model of cancer cachexia
- Growth Differentiation Factor 5 Is A Paracrine Regulator In Sarcopenic Obesity
Showing 5 of 8 shared publications
Michael P. Wiggs
Baylor University (US)
7 shared publications
- Muscle weakness precedes atrophy during cancer cachexia and is linked to muscle-specific mitochondrial stress
- Female mice may have exacerbated catabolic signalling response compared to male mice during development and progression of disuse atrophy
- Mitochondrial aberrations during the progression of disuse atrophy differentially affect male and female mice
- Development of metabolic and contractile alterations in development of cancer cachexia in female tumor-bearing mice
- Females display relatively preserved muscle quality compared with males during the onset and early stages of C26-induced cancer cachexia
Showing 5 of 7 shared publications
Luca J. Delfinis
York University (CA)
7 shared publications
- Muscle weakness precedes atrophy during cancer cachexia and is linked to muscle-specific mitochondrial stress
- Muscle weakness and mitochondrial stress occur before severe metastasis in a novel mouse model of ovarian cancer cachexia
- Mitochondrial antioxidant SkQ1 attenuates C26 cancer-induced muscle wasting in males and improves muscle contractility in female tumor-bearing mice
- Muscle weakness and mitochondrial stress occur before metastasis in a novel mouse model of ovarian cancer cachexia
- Mitochondrial-targeted plastoquinone therapy prevents early onset muscle weakness that occurs before atrophy during ovarian cancer
Showing 5 of 7 shared publications
Yuan Wen
University of Kentucky (US)
7 shared publications
- Multi-transcriptome analysis following an acute skeletal muscle growth stimulus yields tools for discerning global and MYC regulatory networks
- A molecular signature defining exercise adaptation with ageing and <i>in vivo</i> partial reprogramming in skeletal muscle
- The 24-hour molecular landscape after exercise in humans reveals MYC is sufficient for muscle growth
- The 24-Hour Time Course of Integrated Molecular Responses to Resistance Exercise in Human Skeletal Muscle Implicates <i>MYC</i> as a Hypertrophic Regulator That is Sufficient for Growth
- At the Nexus Between Epigenetics and Senescence: The Effects of Senolytic ( <scp>BI01</scp> ) Administration on <scp>DNA</scp> Methylation Clock Age and the Methylome in Aged and Regenerated Skeletal Muscle
Showing 5 of 7 shared publications
Sabin Khadgi
University of Arkansas at Fayetteville
7 shared publications
In database
- Multi-transcriptome analysis following an acute skeletal muscle growth stimulus yields tools for discerning global and MYC regulatory networks
- A molecular signature defining exercise adaptation with ageing and <i>in vivo</i> partial reprogramming in skeletal muscle
- The 24-hour molecular landscape after exercise in humans reveals MYC is sufficient for muscle growth
- Mitochondrial antioxidant SkQ1 attenuates C26 cancer-induced muscle wasting in males and improves muscle contractility in female tumor-bearing mice
- The 24-Hour Time Course of Integrated Molecular Responses to Resistance Exercise in Human Skeletal Muscle Implicates <i>MYC</i> as a Hypertrophic Regulator That is Sufficient for Growth
Showing 5 of 7 shared publications
Similar Researchers
Based on overlapping research topics
Ruqaiza Muhyudin
University of Arkansas at Fayetteville
Muscle Physiology and Disorders
Mitochondrial Function and Pathology
Cancer-related molecular mechanisms research
Calvin Peterson
University of Arkansas at Fayetteville
Muscle Physiology and Disorders
Mitochondrial Function and Pathology
Cancer-related molecular mechanisms research
Landen W. Saling
University of Arkansas at Fayetteville
Muscle Physiology and Disorders
Mitochondrial Function and Pathology
Cancer-related molecular mechanisms research
Pieter J. Koopmans
University of Arkansas at Fayetteville
Muscle Physiology and Disorders
Mitochondrial Function and Pathology
Cancer-related molecular mechanisms research
Ronald G. Jones
University of Arkansas at Fayetteville
Muscle Physiology and Disorders
Mitochondrial Function and Pathology
Cancer-related molecular mechanisms research
Eleanor R. Schrems
University of Arkansas at Fayetteville
Muscle Physiology and Disorders
Mitochondrial Function and Pathology
Cancer-related molecular mechanisms research