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Biography and Research Information
OverviewAI-generated summary
Mohamed A. Sadek investigates neuroprotective agents and their effects on neurodegenerative diseases, particularly experimental autoimmune encephalomyelitis (EAE)-induced multiple sclerosis in mice. His research has explored the therapeutic potential of compounds like Semaglutide, examining its impact on EAE through the PI3K/Akt/GSK-3β pathway. Additionally, Sadek has studied the neuroprotective effects of curcumin, focusing on its role in mitigating cognitive and physical impairments in EAE models via the AMPK/SIRT1 pathway. His work also extends to the fabrication and evaluation of drug delivery systems, such as PEGylated terpesomes for curcumin, aiming for enhanced hepatoprotective activity. Sadek has also contributed to reviews on bioactive compounds like orientin and morusin, and has published on cerebrovascular function in headache disorders using transcranial Doppler studies. His scholarship metrics include an h-index of 4 and 120 total citations across 8 publications.
Metrics
- h-index: 6
- Publications: 13
- Citations: 189
Selected Publications
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Morusin as a drug candidate: opportunities, limitations, and the path toward clinical translation (2025)
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A Comprehensive Review on Pulmonary Fibrosis (PF): Histological Spectrum, Diagnosis, Risk Factors, Pathogenesis, Molecular Pathophysiology, and Current Treatment Options (2025)
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Integrative sleep management: from molecular pathways to conventional and herbal treatments (2025)
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Orientin: a comprehensive review of a promising bioactive flavonoid (2025)
Collaboration Network
Top Collaborators
Nesrine S. El Sayed
Cairo University (EG)
3 shared publications
- Semaglutide, a novel glucagon-like peptide-1 agonist, amends experimental autoimmune encephalomyelitis-induced multiple sclerosis in mice: Involvement of the PI3K/Akt/GSK-3β pathway
- Neuroprotective effect of curcumin against experimental autoimmune encephalomyelitis-induced cognitive and physical impairments in mice: an insight into the role of the AMPK/SIRT1 pathway
- Repositioning of a nutraceutical, scoparone, in the management of MK-801-induced schizophrenia-like behavior in Mice: An insight into SIRT1/PGC-1α/TFAM pathway
Mostafa A. Rabie
Cairo University (EG)
3 shared publications
- Semaglutide, a novel glucagon-like peptide-1 agonist, amends experimental autoimmune encephalomyelitis-induced multiple sclerosis in mice: Involvement of the PI3K/Akt/GSK-3β pathway
- Neuroprotective effect of curcumin against experimental autoimmune encephalomyelitis-induced cognitive and physical impairments in mice: an insight into the role of the AMPK/SIRT1 pathway
- Repositioning of a nutraceutical, scoparone, in the management of MK-801-induced schizophrenia-like behavior in Mice: An insight into SIRT1/PGC-1α/TFAM pathway
Eman M. Khedr
Aswan University (EG)
2 shared publications
- Cerebrovascular function in tension-type headache and migraine with or without aura: Transcranial Doppler study
- Cerebrovascular reactivity after functional activation of the Brain using Photic Stimulation in Migraine and Tension Type Headache: a transcranial doppler Ultrasonography Study
Mohammed A. Abbas
2 shared publications
- Cerebrovascular function in tension-type headache and migraine with or without aura: Transcranial Doppler study
- Cerebrovascular reactivity after functional activation of the Brain using Photic Stimulation in Migraine and Tension Type Headache: a transcranial doppler Ultrasonography Study
Ayman Gamea
South Valley University (EG)
2 shared publications
- Cerebrovascular function in tension-type headache and migraine with or without aura: Transcranial Doppler study
- Cerebrovascular reactivity after functional activation of the Brain using Photic Stimulation in Migraine and Tension Type Headache: a transcranial doppler Ultrasonography Study
Ahmed F. Zaki
South Valley University (EG)
2 shared publications
- Cerebrovascular function in tension-type headache and migraine with or without aura: Transcranial Doppler study
- Cerebrovascular reactivity after functional activation of the Brain using Photic Stimulation in Migraine and Tension Type Headache: a transcranial doppler Ultrasonography Study
Esraa A. Kandil
Cairo University (EG)
2 shared publications
- Semaglutide, a novel glucagon-like peptide-1 agonist, amends experimental autoimmune encephalomyelitis-induced multiple sclerosis in mice: Involvement of the PI3K/Akt/GSK-3β pathway
- Neuroprotective effect of curcumin against experimental autoimmune encephalomyelitis-induced cognitive and physical impairments in mice: an insight into the role of the AMPK/SIRT1 pathway
Helmy M. Sayed
Cairo University (EG)
2 shared publications
- Semaglutide, a novel glucagon-like peptide-1 agonist, amends experimental autoimmune encephalomyelitis-induced multiple sclerosis in mice: Involvement of the PI3K/Akt/GSK-3β pathway
- Neuroprotective effect of curcumin against experimental autoimmune encephalomyelitis-induced cognitive and physical impairments in mice: an insight into the role of the AMPK/SIRT1 pathway
Rana M. ElBishbishy
Cairo University (EG)
2 shared publications
- PEGylated terpesomes of curcumin for prominent hepatoprotective activity: Fabrication, optimization, biochemical analysis and in vivo evaluation
- Integrative sleep management: from molecular pathways to conventional and herbal treatments
Ahmed M. El‐Dessouki
Ahram Canadian University (EG)
2 shared publications
- Integrative sleep management: from molecular pathways to conventional and herbal treatments
- Morusin as a drug candidate: opportunities, limitations, and the path toward clinical translation
Riham A. El‐Shiekh
Cairo University (EG)
2 shared publications
- Integrative sleep management: from molecular pathways to conventional and herbal treatments
- Morusin as a drug candidate: opportunities, limitations, and the path toward clinical translation
Abdurrahman M. Fahmy
Cairo University (EG)
1 shared publication
- PEGylated terpesomes of curcumin for prominent hepatoprotective activity: Fabrication, optimization, biochemical analysis and in vivo evaluation
Bander Balkhi
King Saud University (SA)
1 shared publication
- PEGylated terpesomes of curcumin for prominent hepatoprotective activity: Fabrication, optimization, biochemical analysis and in vivo evaluation
Sadek Ahmed
Cairo University (EG)
1 shared publication
- PEGylated terpesomes of curcumin for prominent hepatoprotective activity: Fabrication, optimization, biochemical analysis and in vivo evaluation
Yasmina M. Ebrahim
Cairo University (EG)
1 shared publication
- Integrative sleep management: from molecular pathways to conventional and herbal treatments
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