Biography and Research Information
OverviewAI-generated summary
Daniel Fil investigates the molecular mechanisms underlying disease, with a focus on cancer and neurological conditions. His work includes studying the effects of specific compounds on cancer stem cells, as demonstrated in his 2021 publication on salinomycin analogs and breast cancer models. He also examines genetic mutations that lead to neurodegenerative disorders, such as his 2023 study on the neurobehavioral deficits associated with a specific mutant frataxin in mice. Additionally, Fil's research extends to the immune system, exploring how chemical inhibition impacts T cell function and how genetic factors influence antigen presentation in melanoma. His publications also touch upon the role of specific genes in the development of the enteric nervous system in mice.
Metrics
- h-index: 12
- Publications: 45
- Citations: 475
Selected Publications
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685 EZH2 inhibition impairs CD8+ CAR-T cell persistence (2025)
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691 ATF6 activation promotes ICB response in melanoma (2025)
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762 CD28 costimulation induces PCK2 to support T cell effector function in metabolically hostile environments (2025)
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236 Manipulating the DNA damage response to combat T cell exhaustion and improve immunotherapy response (2025)
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277 Proteome turnover dynamics analysis uncovers E3 ligases that enhance T-cell persistence during exhaustion (2025)
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392 Donor-intrinsic proteomic programs shape CAR-T cell persistence across a longitudinal killing assay (2025)
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Comprehensive Analysis of Proteome Turnover Dynamics During T Cell Exhaustion (2025)
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EZH2 loss during metabolic stress drives restoration of MHC class I machinery in melanoma (2025)
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1132 Enhancing melanoma therapy efficacy by protecting EZH2 activity in T cells (2024)
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538 ATF6 activation in melanoma promotes anti-tumor immunity and improves ICB therapy response (2024)
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929 Proteomic analysis reveals differential modulation of the DNA damage response in exhausted T cells (2024)
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932 Defining the role for PCK2 in T-cell metabolic plasticity (2024)
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Design and validation of cell-based potency assays for frataxin supplementation treatments (2024)
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Abstract 584: Synergistic action of ATF6 and EZH2 in sensing metabolic stress to boost anti-tumor immunity (2024)
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536 EZH2 senses metabolic stress to restore MHC-I antigen presentation and ICB response in metastatic melanoma (2023)
Collaboration Network
Top Collaborators
Brian Koss
University of Arkansas for Medical Sciences
20 shared publications
In database
- Chemical inhibition of <scp>DNA‐PKcs</scp> impairs the activation and cytotoxicity of <scp>CD4</scp><sup>+</sup> helper and <scp>CD8</scp><sup>+</sup> effector T cells
- Resveratrol induces major histocompatibility complex class I antigen presentation in a STING-dependent and independent manner in melanoma
- 1020 Proteomic analysis of T cell exhaustion unveils differential modulation of the DNA damage response
- 1211 Defining the role of PCK2 in T cell metabolic plasticity in Glioblastoma
- EZH2 loss during metabolic stress drives restoration of MHC class I machinery in melanoma
Showing 5 of 20 shared publications
Lora J. Rogers
University of Arkansas for Medical Sciences
12 shared publications
In database
- Chemical inhibition of <scp>DNA‐PKcs</scp> impairs the activation and cytotoxicity of <scp>CD4</scp><sup>+</sup> helper and <scp>CD8</scp><sup>+</sup> effector T cells
- 1020 Proteomic analysis of T cell exhaustion unveils differential modulation of the DNA damage response
- 1211 Defining the role of PCK2 in T cell metabolic plasticity in Glioblastoma
- 255 Functional and multi-omic characterization of CAR T cells across healthy donors
- 304 Discovering T cell proteome turnover dynamics to enhance persistence in solid tumors
Showing 5 of 12 shared publications
Sydnye L. Shuttleworth
University of Arkansas for Medical Sciences
12 shared publications
In database
- 1020 Proteomic analysis of T cell exhaustion unveils differential modulation of the DNA damage response
- 1211 Defining the role of PCK2 in T cell metabolic plasticity in Glioblastoma
- 304 Discovering T cell proteome turnover dynamics to enhance persistence in solid tumors
- 932 Defining the role for PCK2 in T-cell metabolic plasticity
- 929 Proteomic analysis reveals differential modulation of the DNA damage response in exhausted T cells
Showing 5 of 12 shared publications
Alan J. Tackett
University of Arkansas for Medical Sciences
10 shared publications
In database
- Resveratrol induces major histocompatibility complex class I antigen presentation in a STING-dependent and independent manner in melanoma
- EZH2 loss during metabolic stress drives restoration of MHC class I machinery in melanoma
- 304 Discovering T cell proteome turnover dynamics to enhance persistence in solid tumors
- 536 EZH2 senses metabolic stress to restore MHC-I antigen presentation and ICB response in metastatic melanoma
- Abstract 584: Synergistic action of ATF6 and EZH2 in sensing metabolic stress to boost anti-tumor immunity
Showing 5 of 10 shared publications
Megan R. Reed
University of Arkansas for Medical Sciences
8 shared publications
In database
- Single and double modified salinomycin analogs target stem-like cells in 2D and 3D breast cancer models
- EZH2 loss during metabolic stress drives restoration of MHC class I machinery in melanoma
- 536 EZH2 senses metabolic stress to restore MHC-I antigen presentation and ICB response in metastatic melanoma
- Abstract 584: Synergistic action of ATF6 and EZH2 in sensing metabolic stress to boost anti-tumor immunity
- 538 ATF6 activation in melanoma promotes anti-tumor immunity and improves ICB therapy response
Showing 5 of 8 shared publications
Billie Heflin
University of Arkansas for Medical Sciences
8 shared publications
In database
- Resveratrol induces major histocompatibility complex class I antigen presentation in a STING-dependent and independent manner in melanoma
- EZH2 loss during metabolic stress drives restoration of MHC class I machinery in melanoma
- 536 EZH2 senses metabolic stress to restore MHC-I antigen presentation and ICB response in metastatic melanoma
- Abstract 584: Synergistic action of ATF6 and EZH2 in sensing metabolic stress to boost anti-tumor immunity
- 538 ATF6 activation in melanoma promotes anti-tumor immunity and improves ICB therapy response
Showing 5 of 8 shared publications
Katherine Wallis
University of Arkansas for Medical Sciences
8 shared publications
In database
- Resveratrol induces major histocompatibility complex class I antigen presentation in a STING-dependent and independent manner in melanoma
- 932 Defining the role for PCK2 in T-cell metabolic plasticity
- 929 Proteomic analysis reveals differential modulation of the DNA damage response in exhausted T cells
- 538 ATF6 activation in melanoma promotes anti-tumor immunity and improves ICB therapy response
- 236 Manipulating the DNA damage response to combat T cell exhaustion and improve immunotherapy response
Showing 5 of 8 shared publications
Jessica L Kelliher
University of Arkansas for Medical Sciences (US)
8 shared publications
- 1020 Proteomic analysis of T cell exhaustion unveils differential modulation of the DNA damage response
- 304 Discovering T cell proteome turnover dynamics to enhance persistence in solid tumors
- 932 Defining the role for PCK2 in T-cell metabolic plasticity
- 929 Proteomic analysis reveals differential modulation of the DNA damage response in exhausted T cells
- Comprehensive Analysis of Proteome Turnover Dynamics During T Cell Exhaustion
Showing 5 of 8 shared publications
Jacob L Edmondson
University of Arkansas for Medical Sciences
8 shared publications
In database
- 536 EZH2 senses metabolic stress to restore MHC-I antigen presentation and ICB response in metastatic melanoma
- Abstract 584: Synergistic action of ATF6 and EZH2 in sensing metabolic stress to boost anti-tumor immunity
- 932 Defining the role for PCK2 in T-cell metabolic plasticity
- 538 ATF6 activation in melanoma promotes anti-tumor immunity and improves ICB therapy response
- 1132 Enhancing melanoma therapy efficacy by protecting EZH2 activity in T cells
Showing 5 of 8 shared publications
Michael Bauer
University of Arkansas for Medical Sciences
7 shared publications
In database
- 1211 Defining the role of PCK2 in T cell metabolic plasticity in Glioblastoma
- EZH2 loss during metabolic stress drives restoration of MHC class I machinery in melanoma
- 255 Functional and multi-omic characterization of CAR T cells across healthy donors
- 304 Discovering T cell proteome turnover dynamics to enhance persistence in solid tumors
- 932 Defining the role for PCK2 in T-cell metabolic plasticity
Showing 5 of 7 shared publications
Lauren C. Morehead
University of Arkansas for Medical Sciences
3 shared publications
In database
- Chemical inhibition of <scp>DNA‐PKcs</scp> impairs the activation and cytotoxicity of <scp>CD4</scp><sup>+</sup> helper and <scp>CD8</scp><sup>+</sup> effector T cells
- Resveratrol induces major histocompatibility complex class I antigen presentation in a STING-dependent and independent manner in melanoma
- EZH2 loss during metabolic stress drives restoration of MHC class I machinery in melanoma
Latambria Hampton
University of Arkansas for Medical Sciences
3 shared publications
In database
- 1020 Proteomic analysis of T cell exhaustion unveils differential modulation of the DNA damage response
- 1211 Defining the role of PCK2 in T cell metabolic plasticity in Glioblastoma
- 932 Defining the role for PCK2 in T-cell metabolic plasticity
Aaron J. Storey
Arkana Laboratories
3 shared publications
In database
- 304 Discovering T cell proteome turnover dynamics to enhance persistence in solid tumors
- Comprehensive Analysis of Proteome Turnover Dynamics During T Cell Exhaustion
- 277 Proteome turnover dynamics analysis uncovers E3 ligases that enhance T-cell persistence during exhaustion
Nathan L. Avaritt
University of Arkansas for Medical Sciences
3 shared publications
In database
- EZH2 loss during metabolic stress drives restoration of MHC class I machinery in melanoma
- 538 ATF6 activation in melanoma promotes anti-tumor immunity and improves ICB therapy response
- 691 ATF6 activation promotes ICB response in melanoma
Thomas A. Williams
University of Arkansas for Medical Sciences
3 shared publications
In database
- 236 Manipulating the DNA damage response to combat T cell exhaustion and improve immunotherapy response
- 762 CD28 costimulation induces PCK2 to support T cell effector function in metabolically hostile environments
- 685 EZH2 inhibition impairs CD8+ CAR-T cell persistence
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