Daniel Fil

Researcher

University of Arkansas for Medical Sciences

faculty

11 h-index 43 pubs 471 cited

Research Areas

Cancer-related molecular mechanisms research Immune Cell Function and Interaction Neuroscience and Neuropharmacology Research Pharmacological Effects and Toxicity Studies Diet and metabolism studies Cancer Treatment and Pharmacology T-cell and B-cell Immunology

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OverviewAI-generated summary

Daniel Fil's research focuses on molecular mechanisms underlying disease and therapeutic interventions. He has investigated the role of salinomycin analogs in targeting stem-like cells in breast cancer models and explored the neurobehavioral consequences of specific genetic mutations, such as the G127V mutant frataxin. His work also examines the intricate processes of immune cell function, including the impact of chemical inhibition on T cell activation and cytotoxicity, and the modulation of DNA damage response pathways in T cell exhaustion. Fil has also studied the mechanisms of major histocompatibility complex (MHC) class I antigen presentation in melanoma, including the influence of resveratrol and EZH2 loss. Additionally, his research has delved into the metabolic plasticity of T cells in glioblastoma, defining the role of PCK2. Fil has a notable publication record, with 43 total publications and 471 citations, and an h-index of 11. He collaborates with several researchers at the University of Arkansas for Medical Sciences, including Brian Koss, Lora J. Rogers, Katherine Wallis, and Billie Heflin.

Metrics

  • h-index: 11
  • Publications: 43
  • Citations: 471

Selected Publications

  • 685 EZH2 inhibition impairs CD8+ CAR-T cell persistence (2025) DOI
  • 691 ATF6 activation promotes ICB response in melanoma (2025) DOI
  • 762 CD28 costimulation induces PCK2 to support T cell effector function in metabolically hostile environments (2025) DOI
  • 236 Manipulating the DNA damage response to combat T cell exhaustion and improve immunotherapy response (2025) DOI
  • 277 Proteome turnover dynamics analysis uncovers E3 ligases that enhance T-cell persistence during exhaustion (2025) DOI
  • 392 Donor-intrinsic proteomic programs shape CAR-T cell persistence across a longitudinal killing assay (2025) DOI
  • Comprehensive Analysis of Proteome Turnover Dynamics During T Cell Exhaustion (2025) DOI
  • EZH2 loss during metabolic stress drives restoration of MHC class I machinery in melanoma (2025) DOI
  • 1132 Enhancing melanoma therapy efficacy by protecting EZH2 activity in T cells (2024) DOI
  • 538 ATF6 activation in melanoma promotes anti-tumor immunity and improves ICB therapy response (2024) DOI
  • 929 Proteomic analysis reveals differential modulation of the DNA damage response in exhausted T cells (2024) DOI
  • 932 Defining the role for PCK2 in T-cell metabolic plasticity (2024) DOI
  • Design and validation of cell-based potency assays for frataxin supplementation treatments (2024) DOI
  • Abstract 584: Synergistic action of ATF6 and EZH2 in sensing metabolic stress to boost anti-tumor immunity (2024) DOI
  • 536 EZH2 senses metabolic stress to restore MHC-I antigen presentation and ICB response in metastatic melanoma (2023) DOI

Collaborators

Researchers in the database who share publications

Brian Koss University of Arkansas for Medical Sciences 20 shared publications Lora J. Rogers University of Arkansas for Medical Sciences 12 shared publications Katherine Wallis University of Arkansas for Medical Sciences 8 shared publications Billie Heflin University of Arkansas for Medical Sciences 8 shared publications Megan R. Reed University of Arkansas for Medical Sciences 8 shared publications Jacob L Edmondson University of Arkansas for Medical Sciences 8 shared publications Lauren C. Morehead University of Arkansas for Medical Sciences 3 shared publications Sydnye L. Shuttleworth University of Arkansas for Medical Sciences 3 shared publications

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