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Likely match
Presence
Current · Arkansas
Last published
2022
Sources
OpenAlex · ORCID
Refreshed
2026-10-06
K
Kenneth Hensley
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Also affiliated: University of Toledo Medical Center (2010–2015); NewYork–Presbyterian Hospital (2006); University of Kentucky (1993–2007); University of California, Los Angeles (2013); Cornell University (2006); Konkuk University (2006); Oklahoma Medical Research Foundation (1996–2010); National Institute on Aging (2006); P2D Bioscience (United States) (2013); VA Greater Los Angeles Healthcare System (2013); Weill Cornell Medicine (2006); University of Oklahoma Health Sciences Center (2000–2007); University of Oklahoma (2006–2007); University of Toledo (2009–2018)
58 h-index
168 pubs
12,199 cited
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Kenneth Hensley's research investigates the intersection of sulfur redox chemistry, cellular signal transduction, and proteostasis, with a focus on understanding and treating neurodegenerative diseases. His work has explored the therapeutic potential of specific compounds, such as lanthionine ketimine ethyl ester, in animal models. For instance, he has studied its capacity to accelerate remyelination in a mouse model of multiple sclerosis and its effects on the α-synucleinopathy mouse model. Additionally, his research has examined the inhibitory effects of phytochemicals, like hypoxoside derived from H. rooperii, on nitric oxide production in murine macrophages, a process relevant to immune response and inflammation.
Hensley is recognized as a highly cited researcher, with a significant publication record and citation count. His scholarly output includes 169 publications, garnering over 12,000 citations, and he holds an h-index of 58. He has collaborated with researchers such as T.M. do Nascimento Garcia and William Farrell at the University of Arkansas – Fort Smith on shared publications. His recent publications in 2021 and 2022 indicate ongoing activity in his research areas.
Metrics
- h-index: 58
- Publications: 168
- Citations: 12,199
Selected Publications
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Lanthionine Ketimine Ethyl Ester Accelerates Remyelination in a Mouse Model of Multiple Sclerosis (2022)
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Effects of Lanthionine Ketimine-5-Ethyl Ester on the α-Synucleinopathy Mouse Model (2022)
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Potent inhibition of LPS-induced nitric oxide production by the H. rooperii-derived phytochemical hypoxoside in murine macrophages (2022)
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At the intersection of sulfur redox chemistry, cellular signal transduction and proteostasis: A useful perspective from which to understand and treat neurodegeneration (2021)
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Stable knockout of lanthionine synthase C-like protein-1 (LanCL1) from HeLa cells indicates a role for LanCL1 in redox regulation of deubiquitinating enzymes (2020)
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Lanthionine ketimine ester improves outcome in an MPTP-induced mouse model of Parkinson's disease via suppressions of CRMP2 phosphorylation and microglial activation (2020)
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An overview of sulfur-containing compounds originating from natural metabolites: Lanthionine ketimine and its analogues (2019)
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Neuronal Conditional Knockout of Collapsin Response Mediator Protein 2 Ameliorates Disease Severity in a Mouse Model of Multiple Sclerosis (2019)
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Genetic suppression of collapsin response mediator protein 2 phosphorylation improves outcome in methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine‐induced Parkinson’s model mice (2018)
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CRISPR-Cas9 knockout of lanthionine synthase-like protein-1 (LanCL1) in HeLa cells renders the cells hypersensitive to oxidative stress despite inducing an upregulation of glutathione-dependent antioxidant defense mechanisms (2018)
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CSE derived sulfur metabolites regulates autophagy in ischemic endothelial cells (2018)
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Development and applications of solid-phase extraction and liquid chromatography-mass spectrometry methods for quantification of microcystins in urine, plasma, and serum (2018)
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Analysis of lanthionine ketimine ethyl ester in mouse serum, whole blood and tissues using ultrahigh‐pressure liquid chromatography/tandem mass spectrometry (2018)
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Multiple-step, one-pot synthesis of 2-substituted-3-phosphono-1-thia-4-aza-2-cyclohexene-5-carboxylates and their corresponding ethyl esters (2018)
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Lanthionine ketimine-5-ethyl ester provides neuroprotection in a zebrafish model of okadaic acid-induced Alzheimer's disease (2018)
Collaboration Network
Top Collaborators
Douglas L. Feinstein
University of Illinois Chicago (US)
4 shared publications
- Neuroprotective and neurotrophic effects of Lanthionine Ketimine Ester
- Lanthionine Ketimine Ethyl Ester Accelerates Remyelination in a Mouse Model of Multiple Sclerosis
- Neuronal Conditional Knockout of Collapsin Response Mediator Protein 2 Ameliorates Disease Severity in a Mouse Model of Multiple Sclerosis
- Analysis of lanthionine ketimine ethyl ester in mouse serum, whole blood and tissues using ultrahigh‐pressure liquid chromatography/tandem mass spectrometry
Travis T. Denton
Gleason (United States) (US)
3 shared publications
- Lanthionine Ketimine Ethyl Ester Accelerates Remyelination in a Mouse Model of Multiple Sclerosis
- Multiple-step, one-pot synthesis of 2-substituted-3-phosphono-1-thia-4-aza-2-cyclohexene-5-carboxylates and their corresponding ethyl esters
- An overview of sulfur-containing compounds originating from natural metabolites: Lanthionine ketimine and its analogues
Toshio Ohshima
Waseda University (JP)
3 shared publications
- Genetic suppression of collapsin response mediator protein 2 phosphorylation improves outcome in methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine‐induced Parkinson’s model mice
- Lanthionine ketimine ester improves outcome in an MPTP-induced mouse model of Parkinson's disease via suppressions of CRMP2 phosphorylation and microglial activation
- Effects of Lanthionine Ketimine-5-Ethyl Ester on the α-Synucleinopathy Mouse Model
Natalia Marangoni
University of Illinois Chicago (US)
2 shared publications
- Neuroprotective and neurotrophic effects of Lanthionine Ketimine Ester
- Neuronal Conditional Knockout of Collapsin Response Mediator Protein 2 Ameliorates Disease Severity in a Mouse Model of Multiple Sclerosis
Kathy Kowal
University of Illinois Chicago (US)
2 shared publications
- Neuroprotective and neurotrophic effects of Lanthionine Ketimine Ester
- Neuronal Conditional Knockout of Collapsin Response Mediator Protein 2 Ameliorates Disease Severity in a Mouse Model of Multiple Sclerosis
Dunxin Shen
Washington State University Spokane (US)
2 shared publications
- Multiple-step, one-pot synthesis of 2-substituted-3-phosphono-1-thia-4-aza-2-cyclohexene-5-carboxylates and their corresponding ethyl esters
- An overview of sulfur-containing compounds originating from natural metabolites: Lanthionine ketimine and its analogues
Melissa Olcott
University of Arkansas – Fort Smith
2 shared publications
In database
- Stable knockout of lanthionine synthase C-like protein-1 (LanCL1) from HeLa cells indicates a role for LanCL1 in redox regulation of deubiquitinating enzymes
- CRISPR-Cas9 knockout of lanthionine synthase-like protein-1 (LanCL1) in HeLa cells renders the cells hypersensitive to oxidative stress despite inducing an upregulation of glutathione-dependent antioxidant defense mechanisms
Aaron Downey
University of Arkansas – Fort Smith
2 shared publications
In database
- Stable knockout of lanthionine synthase C-like protein-1 (LanCL1) from HeLa cells indicates a role for LanCL1 in redox regulation of deubiquitinating enzymes
- CRISPR-Cas9 knockout of lanthionine synthase-like protein-1 (LanCL1) in HeLa cells renders the cells hypersensitive to oxidative stress despite inducing an upregulation of glutathione-dependent antioxidant defense mechanisms
D. L. Spector
University of Arkansas – Fort Smith
2 shared publications
In database
- Stable knockout of lanthionine synthase C-like protein-1 (LanCL1) from HeLa cells indicates a role for LanCL1 in redox regulation of deubiquitinating enzymes
- CRISPR-Cas9 knockout of lanthionine synthase-like protein-1 (LanCL1) in HeLa cells renders the cells hypersensitive to oxidative stress despite inducing an upregulation of glutathione-dependent antioxidant defense mechanisms
Kentaro Togashi
Waseda University (JP)
2 shared publications
- Genetic suppression of collapsin response mediator protein 2 phosphorylation improves outcome in methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine‐induced Parkinson’s model mice
- Lanthionine ketimine ester improves outcome in an MPTP-induced mouse model of Parkinson's disease via suppressions of CRMP2 phosphorylation and microglial activation
Masaya Hasegawa
Waseda University (JP)
2 shared publications
- Genetic suppression of collapsin response mediator protein 2 phosphorylation improves outcome in methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine‐induced Parkinson’s model mice
- Lanthionine ketimine ester improves outcome in an MPTP-induced mouse model of Parkinson's disease via suppressions of CRMP2 phosphorylation and microglial activation
Jun Nagai
Waseda University (JP)
2 shared publications
- Genetic suppression of collapsin response mediator protein 2 phosphorylation improves outcome in methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine‐induced Parkinson’s model mice
- Lanthionine ketimine ester improves outcome in an MPTP-induced mouse model of Parkinson's disease via suppressions of CRMP2 phosphorylation and microglial activation
Daiki Masukawa
Yokohama City University (JP)
2 shared publications
- Genetic suppression of collapsin response mediator protein 2 phosphorylation improves outcome in methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine‐induced Parkinson’s model mice
- Lanthionine ketimine ester improves outcome in an MPTP-induced mouse model of Parkinson's disease via suppressions of CRMP2 phosphorylation and microglial activation
Yoshio Goshima
Yokohama City University (JP)
2 shared publications
- Genetic suppression of collapsin response mediator protein 2 phosphorylation improves outcome in methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine‐induced Parkinson’s model mice
- Lanthionine ketimine ester improves outcome in an MPTP-induced mouse model of Parkinson's disease via suppressions of CRMP2 phosphorylation and microglial activation
Sergey A. Kalinin
University of Illinois Chicago (US)
2 shared publications
- Lanthionine Ketimine Ethyl Ester Accelerates Remyelination in a Mouse Model of Multiple Sclerosis
- Neuronal Conditional Knockout of Collapsin Response Mediator Protein 2 Ameliorates Disease Severity in a Mouse Model of Multiple Sclerosis
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