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Biography and Research Information
OverviewAI-generated summary
Mário G. Ferruzzi's research investigates the bioaccessibility and biological activity of dietary bioactive compounds, with a particular focus on polyphenols and carotenoids. His work examines how food processing techniques, such as spray-drying and freeze-drying, and the formation of protein-polyphenol aggregates affect the delivery and absorption of these compounds in both in vitro and in vivo models. This includes studies using animal models like rats and _C. elegans_ to understand the effects of specific dietary components on gut microbiota, phenolic metabolism, and antioxidant activity.
Ferruzzi's research group also explores the characteristics of food matrices, including foaming and sensory properties of protein-polyphenol particles. His recent publications address the structural requirements of flavonoids for enzyme inhibition and the antioxidant potential of edible insects. He has also contributed to broader discussions on the U.S. food system, including perspectives on ultra-processed foods and human health. Ferruzzi is a highly cited researcher with a substantial publication record and collaborates with colleagues at the University of Arkansas for Medical Sciences.
Metrics
- h-index: 71
- Publications: 404
- Citations: 15,890
Selected Publications
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Associations Between Serum Gut-Derived Tryptophan Metabolites and Cardiovascular Health Markers in Adolescents with Obesity (2025)
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Impact of flavan-3-ols on blood pressure and endothelial function in diverse populations: a systematic review and meta-analysis of randomized controlled trials (2025)
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Comparison of the capillary and venous blood plasma lipidomes: validation of self-collected blood for plasma lipidomics (2025)
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Identification and functional characterization of BAHD acyltransferases associated with anthocyanin acylation in blueberry (2025)
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Dietary modulation of human milk bioactives is associated with maternal FUT2 secretor phenotype: an exploratory analysis of carotenoids and polyphenol metabolites (2024)
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Toward a science-based classification of processed foods to support meaningful research and effective health policies (2024)
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Gut microbes differ in postmenopausal women responding to prunes to maintain hip bone mineral density (2024)
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Genotype and ripening method affect carotenoid content and bio-accessibility in banana (2024)
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Perspective: A Research Roadmap about Ultra-Processed Foods and Human Health for the United States Food System: Proceedings from an Interdisciplinary, Multi-Stakeholder Workshop (2023)
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Perspective: Challenges and Future Directions in Clinical Research with Nuts and Berries (2023)
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Protective Effects of Polyphenol-Rich Extracts against Neurotoxicity Elicited by Paraquat or Rotenone in Cellular Models of Parkinson’s Disease (2023)
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Trait stacking simultaneously enhances provitamin A carotenoid and mineral bioaccessibility in biofortified <i>Sorghum bicolor</i> (2023)
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Optimization of Mass Spectrometric Parameters in Data Dependent Acquisition for Untargeted Metabolomics on the Basis of Putative Assignments (2023)
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Moderate consumption of freeze-dried blueberry powder increased net bone calcium retention compared with no treatment in healthy postmenopausal women: a randomized crossover trial (2023)
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Crop, Host, and Gut Microbiome Variation Influence Precision Nutrition: An Example of Blueberries (2023)
Collaboration Network
Top Collaborators
Mary Ann Lila
North Carolina State University (US)
13 shared publications
- Foaming and sensory characteristics of protein-polyphenol particles in a food matrix
- Spray-dried and freeze-dried protein-spinach particles; effect of drying technique and protein type on the bioaccessibility of carotenoids, chlorophylls, and phenolics
- Boosting the Bioaccessibility of Dietary Bioactives by Delivery as Protein–Polyphenol Aggregate Particles
- High-density linkage map construction and identification of loci regulating fruit quality traits in blueberry
- Dissecting the genetic basis of bioactive metabolites and fruit quality traits in blueberries (Vaccinium corymbosum L.)
Showing 5 of 13 shared publications
Colin D. Kay
Arkansas Children's Hospital
10 shared publications
In database
- Foaming and sensory characteristics of protein-polyphenol particles in a food matrix
- Spray-dried and freeze-dried protein-spinach particles; effect of drying technique and protein type on the bioaccessibility of carotenoids, chlorophylls, and phenolics
- Boosting the Bioaccessibility of Dietary Bioactives by Delivery as Protein–Polyphenol Aggregate Particles
- High-density linkage map construction and identification of loci regulating fruit quality traits in blueberry
- The high-fat diet and low-dose streptozotocin type-2 diabetes model induces hyperinsulinemia and insulin resistance in male but not female C57BL/6J mice
Showing 5 of 10 shared publications
Connie M. Weaver
San Diego State University (US)
8 shared publications
- Blueberry polyphenols alter gut microbiota & phenolic metabolism in rats
- Prunes preserve hip bone mineral density in a 12-month randomized controlled trial in postmenopausal women: the Prune Study
- (Poly)phenol toxicity <i>in vivo</i> following oral administration: A targeted narrative review of (poly)phenols from green tea, grape, and <scp>anthocyanin‐rich</scp> extracts
- Moderate consumption of freeze-dried blueberry powder increased net bone calcium retention compared with no treatment in healthy postmenopausal women: a randomized crossover trial
- Prune supplementation for 12 months alters the gut microbiome in postmenopausal women
Showing 5 of 8 shared publications
Bruce R. Hamaker
Purdue University West Lafayette (US)
8 shared publications
- Structural requirements of flavonoids for the selective inhibition of α-amylase versus α-glucosidase
- Perspective: A Research Roadmap about Ultra-Processed Foods and Human Health for the United States Food System: Proceedings from an Interdisciplinary, Multi-Stakeholder Workshop
- Dietary starch is weight reducing when distally digested in the small intestine
- Potential of moringa leaf and baobab fruit food-to-food fortification of wholegrain maize porridge to improve iron and zinc bioaccessibility
- Compositional analysis of phytochemicals and polysaccharides from Senegalese plant ingredients: Adansonia digitata (baobab), Moringa oleifera (moringa) and Hibsicus sabdariffa (hibiscus)
Showing 5 of 8 shared publications
Massimo Iorizzo
David H. Murdock Research Institute (US)
8 shared publications
- Foaming and sensory characteristics of protein-polyphenol particles in a food matrix
- Spray-dried and freeze-dried protein-spinach particles; effect of drying technique and protein type on the bioaccessibility of carotenoids, chlorophylls, and phenolics
- Boosting the Bioaccessibility of Dietary Bioactives by Delivery as Protein–Polyphenol Aggregate Particles
- High-density linkage map construction and identification of loci regulating fruit quality traits in blueberry
- Dissecting the genetic basis of bioactive metabolites and fruit quality traits in blueberries (Vaccinium corymbosum L.)
Showing 5 of 8 shared publications
Cindy H. Nakatsu
Purdue University West Lafayette (US)
6 shared publications
- Blueberry polyphenols alter gut microbiota & phenolic metabolism in rats
- Prunes preserve hip bone mineral density in a 12-month randomized controlled trial in postmenopausal women: the Prune Study
- Prune supplementation for 12 months alters the gut microbiome in postmenopausal women
- Rationale and study design of Randomized Controlled Trial of Dietary Supplementation with prune (dried plums) on bone density, geometry, and estimated bone strength in postmenopausal women: The Prune study
- Crop, Host, and Gut Microbiome Variation Influence Precision Nutrition: An Example of Blueberries
Showing 5 of 6 shared publications
Micaela Hayes
North Carolina State University (US)
6 shared publications
- Spray-dried and freeze-dried protein-spinach particles; effect of drying technique and protein type on the bioaccessibility of carotenoids, chlorophylls, and phenolics
- Influence of simulated food and oral processing on carotenoid and chlorophyll <i>in vitro</i> bioaccessibility among six spinach genotypes
- Design and Nutrient Analysis of a Carotenoid-Rich Food Product to Address Vitamin A and Protein Deficiency
- Bioaccessibility, gut microbial metabolism and intestinal transport of phenolics from 100% Concord grape juice and whole grapes are similar in a simulated digestion and fecal fermentation model
- Genotype and ripening method affect carotenoid content and bio-accessibility in banana
Showing 5 of 6 shared publications
Andrew P. Neilson
David H. Murdock Research Institute (US)
6 shared publications
- The high-fat diet and low-dose streptozotocin type-2 diabetes model induces hyperinsulinemia and insulin resistance in male but not female C57BL/6J mice
- Mechanism of off-color formation in potato chips fried in oil systems containing ascorbic acid as a stabilizer
- Bioaccessibility, gut microbial metabolism and intestinal transport of phenolics from 100% Concord grape juice and whole grapes are similar in a simulated digestion and fecal fermentation model
- Cocoa extract exerts sex-specific anti-diabetic effects in an aggressive type-2 diabetes model: A pilot study
- Bioaccessibility and intestinal cell uptake of carotenoids and chlorophylls differ in powdered spinach by the ingredient form as measured using <i>in vitro</i> gastrointestinal digestion and anaerobic fecal fermentation models
Showing 5 of 6 shared publications
Mary H. Grace
North Carolina State University (US)
6 shared publications
- Spray-dried and freeze-dried protein-spinach particles; effect of drying technique and protein type on the bioaccessibility of carotenoids, chlorophylls, and phenolics
- Boosting the Bioaccessibility of Dietary Bioactives by Delivery as Protein–Polyphenol Aggregate Particles
- Dissecting the genetic basis of bioactive metabolites and fruit quality traits in blueberries (Vaccinium corymbosum L.)
- Protective effects of polyphenol-rich extracts against neurotoxicity elicited by paraquat or rotenone in cellular models of Parkinson’s disease
- Protective Effects of Polyphenol-Rich Extracts against Neurotoxicity Elicited by Paraquat or Rotenone in Cellular Models of Parkinson’s Disease
Showing 5 of 6 shared publications
Hawi Debelo
David H. Murdock Research Institute (US)
5 shared publications
- Estimation of nutritional postharvest losses along food value chains: A case study of three key food security commodities in sub-Saharan Africa
- Compositional analysis of phytochemicals and polysaccharides from Senegalese plant ingredients: Adansonia digitata (baobab), Moringa oleifera (moringa) and Hibsicus sabdariffa (hibiscus)
- Co-extruded wheat/okra composite blends result in soft, cohesive and resilient crumbs rich in health-promoting compounds
- Effects of Concord grape juice flavor intensity and phenolic compound content on glycemia, appetite and cognitive function in adults with excess body weight: a randomized double-blind crossover trial
- Trait stacking simultaneously enhances provitamin A carotenoid and mineral bioaccessibility in biofortified <i>Sorghum bicolor</i>
Dennis P. Cladis
Virginia Tech (US)
4 shared publications
- Blueberry polyphenols alter gut microbiota & phenolic metabolism in rats
- (Poly)phenol toxicity <i>in vivo</i> following oral administration: A targeted narrative review of (poly)phenols from green tea, grape, and <scp>anthocyanin‐rich</scp> extracts
- Moderate consumption of freeze-dried blueberry powder increased net bone calcium retention compared with no treatment in healthy postmenopausal women: a randomized crossover trial
- Crop, Host, and Gut Microbiome Variation Influence Precision Nutrition: An Example of Blueberries
Abigayle M. R. Simpson
Purdue University West Lafayette (US)
4 shared publications
- Blueberry polyphenols alter gut microbiota & phenolic metabolism in rats
- Prune supplementation for 12 months alters the gut microbiome in postmenopausal women
- Rationale and study design of Randomized Controlled Trial of Dietary Supplementation with prune (dried plums) on bone density, geometry, and estimated bone strength in postmenopausal women: The Prune study
- Gut microbes differ in postmenopausal women responding to prunes to maintain hip bone mineral density
James E. Simon
Rutgers, The State University of New Jersey (US)
4 shared publications
- Protective effects of polyphenol-rich extracts against neurotoxicity elicited by paraquat or rotenone in cellular models of Parkinson’s disease
- Protective Effects of Polyphenol-Rich Extracts against Neurotoxicity Elicited by Paraquat or Rotenone in Cellular Models of Parkinson’s Disease
- Dissolution Study on Grape Polyphenol Hard Gelatin Capsule Dietary Supplements
- Chemical, Manufacturing, and Standardization Controls of Grape Polyphenol Dietary Supplements in Support of a Clinical Study: Mass Uniformity, Polyphenol Dosage, and Profiles
Qingli Wu
Rutgers, The State University of New Jersey (US)
4 shared publications
- Protective effects of polyphenol-rich extracts against neurotoxicity elicited by paraquat or rotenone in cellular models of Parkinson’s disease
- Protective Effects of Polyphenol-Rich Extracts against Neurotoxicity Elicited by Paraquat or Rotenone in Cellular Models of Parkinson’s Disease
- Dissolution Study on Grape Polyphenol Hard Gelatin Capsule Dietary Supplements
- Chemical, Manufacturing, and Standardization Controls of Grape Polyphenol Dietary Supplements in Support of a Clinical Study: Mass Uniformity, Polyphenol Dosage, and Profiles
Mary Jane De Souza
Pennsylvania State University (US)
4 shared publications
- Prunes preserve hip bone mineral density in a 12-month randomized controlled trial in postmenopausal women: the Prune Study
- Prune supplementation for 12 months alters the gut microbiome in postmenopausal women
- Rationale and study design of Randomized Controlled Trial of Dietary Supplementation with prune (dried plums) on bone density, geometry, and estimated bone strength in postmenopausal women: The Prune study
- Gut microbes differ in postmenopausal women responding to prunes to maintain hip bone mineral density
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