Merle G. Paule

This is a likely match — the affiliation was inferred from OpenAlex, ORCID, and web sources but has not been fully confirmed. Treat with appropriate caution.

High Impact

Researcher

NCTR primary Hendrix College UAMS

Also affiliated: Centers for Disease Control and Prevention (2015); Arkansas Children's Hospital (1991–2012); American Institute of Certified Public Accountants (2016); United States Food and Drug Administration (2003–2023); Mayo Clinic (2018); Center for Drug Evaluation and Research (2015–2016); School of the Art Institute of Chicago (2018); National Institute for Occupational Safety and Health (2015); Economie Publique (2018); Zimmer Biomet (United States) (2003); Food and Drug Administration (2003–2008); National Research Council Canada (1986); University of California, Davis (1980–1982)

Faculty Researcher

53 h-index 336 pubs 10,817 cited

Research Areas

Biomedical Subjects

Links

ORCID

OverviewAI-generated summary

Merle G. Paule's research investigates the effects of various exposures on neurodevelopment and behavior across different species. A significant portion of this work focuses on the impacts of prenatal exposures, such as trace element and metal mixtures, on learning deficits and reward motivation in children. Studies have examined sex-specific associations between prenatal lead exposure and cognitive performance. Paule has also conducted research on the neurochemical and behavioral effects of methylphenidate treatment in nonhuman primates, including assessments of its impact on brain micro-PET/CT imaging and withdrawal effects. Further research includes quantitative analysis of rat brain toxicity following exposure to trimethyltin.

Paule's work often involves animal models, including rats and rhesus monkeys, to understand dose-response relationships and long-term consequences of exposures. Collaborations with researchers at the National Center for Toxicological Research, including John J. Chelonis, Serguei Liachenko, John Talpos, and William Slikker, have resulted in shared publications in these areas. With an h-index of 52 and over 10,700 citations, Paule is recognized as a highly cited researcher.

Metrics

h-index: 53
Publications: 336
Citations: 10,817

Selected Publications

Retraction notice to “On the early toxic effect of quinolinic acid: Involvement of RAGE” [Neurosci. Lett. 474(2) (2010) 74–78] (2024)

DOI OpenAlex
Performance of the prospective T2 MRI biomarker of neurotoxicity in a trimethyltin model in rats at 7 T (2023)

1 citation DOI OpenAlex
Discontinuation of methylphenidate after long-term exposure in nonhuman primates (2023)

3 citations DOI OpenAlex
The effects of long-term methylphenidate administration and withdrawal on progressive ratio responding and T2 MRI in the male rhesus monkey (2022)

2 citations DOI OpenAlex
Prenatal trace elements mixture is associated with learning deficits on a behavioral acquisition task among young children (2022)

New Directions for Child and Adolescent Development 17 citations DOI OpenAlex
Sexually dimorphic associations between prenatal blood lead exposure and performance on a behavioral testing battery in children (2022)

Neurotoxicology and Teratology 13 citations DOI OpenAlex
Prenatal metal mixture concentrations and reward motivation in children (2021)

NeuroToxicology 15 citations DOI OpenAlex
Sexually dimorphic associations between prenatal blood lead exposure and temporal processing in 6- to 7-year-old children in Mexico City (2021)

DOI OpenAlex
MicroPET/CT assessment of neurochemical effects in the brain after long-term methylphenidate treatment in nonhuman primates (2021)

7 citations DOI OpenAlex
Global Neurotoxicity: Quantitative Analysis of Rat Brain Toxicity Following Exposure to Trimethyltin (2021)

5 citations DOI OpenAlex
General anaesthesia during infancy reduces white matter micro-organisation in developing rhesus monkeys (2021)

British Journal of Anaesthesia 23 citations DOI OpenAlex
Quantitative Neurotoxicology: An Assessment of the Neurotoxic Profile of Kainic Acid in Sprague Dawley Rats (2020)

International Journal of Toxicology 12 citations DOI OpenAlex
An Alternative In Vitro Method for Examining Nanoparticle-Induced Cytotoxicity (2019)

International Journal of Toxicology 11 citations DOI OpenAlex
Cytotoxicity profile of pristine graphene on brain microvascular endothelial cells (2019)

Journal of Applied Toxicology 12 citations DOI OpenAlex
Performance on the Operant Test Battery in young children exposed to procedures requiring general anaesthesia: the MASK study (2019)

British Journal of Anaesthesia 31 citations DOI OpenAlex