John C. Talpos

Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.

High Impact

Primary Investigator

NCTR

Also affiliated: United States Food and Drug Administration (2021–2024); Johnson & Johnson (United States) (2011); Janssen (Belgium) (2011–2017); University of Cambridge (2005–2010); Johnson & Johnson (Israel) (2012)

21 h-index 50 pubs 1,659 cited

Research Areas

Biomedical Subjects

Links

ORCID Research Group

OverviewAI-generated summary

John C. Talpos leads a research group focused on understanding the neurobiological underpinnings of cognitive disorders, particularly in the context of schizophrenia and autism spectrum disorders. His work investigates the role of NMDA receptors in cognition and disease models, exploring the validity of the NMDA receptor hypofunction hypothesis. Talpos has published research on operant conditioning and cognitive tasks, including novel touchscreen-automated tests for assessing memory impairments in rodents. These tasks are designed to be sensitive to pharmacological manipulation, aiding in the screening of potential drug treatments for cognitive deficits associated with neurodegenerative diseases and schizophrenia. His research also extends to evaluating behavioral and cognitive domains relevant to autism spectrum disorders in rodent models.

His publications include investigations into biased mGlu 5 -positive allosteric modulators, assessing their in vivo efficacy without potentiating NMDAR currents. Talpos has also examined the role of 5-HT receptors in impulsivity and has explored potential routes of SARS-CoV-2 infection within the central nervous system. He has collaborated with researchers Leah E. Latham, Fang Liu, Shuliang Liu, and Merle G. Paule, all from the National Center for Toxicological Research, on multiple publications. Talpos is recognized as a highly cited researcher, with an h-index of 21 and over 1,600 citations across his 50 publications.

Metrics

h-index: 21
Publications: 50
Citations: 1,659

Positions

Primary Investigator 2016–present

National Center for Toxicological Research Neurotoxicology ORCID
Senior Scientist 2009–2015

Janssen Pharmaceutica NV ORCID
Post-Doc 2007–2009

Eli Lilly ORCID

Selected Publications

Pharmacokinetics of cannabidiol and its metabolites in rhesus monkeys and New Zealand White rabbits (2025)

Toxicological Sciences DOI OpenAlex
Assessing potential desflurane-induced neurotoxicity using nonhuman primate neural stem cell models (2025)

Experimental Biology and Medicine 2 citations DOI OpenAlex
State of the science on assessing developmental neurotoxicity using new approach methods (2024)

ALTEX 9 citations DOI OpenAlex
Establishment of neural stem cells from fetal monkey brain for neurotoxicity testing (2023)

Experimental Biology and Medicine 3 citations DOI OpenAlex
Development of a primate model to evaluate the effects of ketamine and surgical stress on the neonatal brain (2023)

Experimental Biology and Medicine 4 citations DOI OpenAlex
Discontinuation of methylphenidate after long-term exposure in nonhuman primates (2023)

Neurotoxicology and Teratology 3 citations DOI OpenAlex
Rodent models of anesthesia-induced developmental neurotoxicity☆ (2022)

Elsevier eBooks DOI OpenAlex
The effects of long-term methylphenidate administration and withdrawal on progressive ratio responding and T2 MRI in the male rhesus monkey (2022)

Neurotoxicology and Teratology 2 citations DOI OpenAlex
Genotoxicity evaluation using primary hepatocytes isolated from rhesus macaque (Macaca mulatta) (2021)

Toxicology 6 citations DOI OpenAlex
MicroPET/CT assessment of neurochemical effects in the brain after long-term methylphenidate treatment in nonhuman primates (2021)

Neurotoxicology and Teratology 7 citations DOI OpenAlex
Can SARS-CoV-2 infect the central nervous system via the olfactory bulb or the blood-brain barrier? (2021)

Brain Behavior and Immunity 103 citations DOI OpenAlex
This is your teen brain on drugs: In search of biological factors unique to dependence toxicity in adolescence (2020)

Neurotoxicology and Teratology 23 citations DOI OpenAlex
Regions of the basal ganglia and primary olfactory system are most sensitive to neurodegeneration after extended sevoflurane anesthesia in the perinatal rat (2020)

Neurotoxicology and Teratology 8 citations DOI OpenAlex
Acetyl-l-carnitine does not prevent neurodegeneration in a rodent model of prolonged neonatal anesthesia (2020)

Neurotoxicology and Teratology 6 citations DOI OpenAlex
Sevoflurane exposure has minimal effect on cognitive function and does not alter microglial activation in adult monkeys (2018)

NeuroToxicology 21 citations DOI OpenAlex