John Talpos Source Confirmed

Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.

High Impact

Primary Investigator

National Center for Toxicological Research

faculty

21 h-index 51 pubs 1,618 cited

Research Areas

Neuroscience and Neuropharmacology Research Pharmacological Effects and Toxicity Studies Carcinogens and Genotoxicity Assessment Birth, Development, and Health Anesthesia and Pain Management SARS-CoV-2 and COVID-19 Research Molecular Biology Techniques and Applications

Links

ORCID Research Group

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OverviewAI-generated summary

John Talpos's research program investigates the toxicological effects of various substances on biological systems, with a particular focus on neurotoxicity and genotoxicity. His work utilizes advanced methodologies, including New Approach Methods (NAMs) and in vitro models, to assess potential risks. Recent publications explore the assessment of developmental neurotoxicity, the genotoxicity of compounds using primary hepatocytes, and the establishment of neural stem cells from primate brains for toxicity testing.

Talpos's research also delves into the neurological impacts of specific pharmaceuticals and environmental factors. He has studied the effects of long-term methylphenidate treatment in nonhuman primates, including its discontinuation and neurochemical consequences, as well as the development of primate models to evaluate the effects of ketamine and surgical stress on the neonatal brain. Furthermore, his group is investigating potential desflurane-induced neurotoxicity using primate neural stem cell models.

Talpos leads a research group and has a notable publication record, evidenced by an h-index of 21 and over 1,600 citations. His collaborations include established researchers at the National Center for Toxicological Research, such as William Slikker, Leah E. Latham, Shuliang Liu, and Merle G. Paule.

Metrics

  • h-index: 21
  • Publications: 51
  • Citations: 1,618

Selected Publications

  • Pharmacokinetics of cannabidiol and its metabolites in rhesus monkeys and New Zealand White rabbits (2025) DOI
  • Assessing potential desflurane-induced neurotoxicity using nonhuman primate neural stem cell models (2025) DOI
  • State of the science on assessing developmental neurotoxicity using new approach methods (2024) DOI
  • Establishment of neural stem cells from fetal monkey brain for neurotoxicity testing (2023) DOI
  • Development of a primate model to evaluate the effects of ketamine and surgical stress on the neonatal brain (2023) DOI
  • Discontinuation of methylphenidate after long-term exposure in nonhuman primates (2023) DOI
  • Rodent models of anesthesia-induced developmental neurotoxicity☆ (2022) DOI
  • The effects of long-term methylphenidate administration and withdrawal on progressive ratio responding and T2 MRI in the male rhesus monkey (2022) DOI
  • Genotoxicity evaluation using primary hepatocytes isolated from rhesus macaque (Macaca mulatta) (2021) DOI
  • MicroPET/CT assessment of neurochemical effects in the brain after long-term methylphenidate treatment in nonhuman primates (2021) DOI
  • Can SARS-CoV-2 infect the central nervous system via the olfactory bulb or the blood-brain barrier? (2021) DOI

Collaborators

Researchers in the database who share publications

William Slikker National Center for Toxicological Research 4 shared publications Leah E. Latham National Center for Toxicological Research 3 shared publications Shuliang Liu National Center for Toxicological Research 3 shared publications Merle G. Paule National Center for Toxicological Research 3 shared publications Tucker A. Patterson National Center for Toxicological Research 2 shared publications Susan M. Burks National Center for Toxicological Research 2 shared publications Manuel Alejandro Ramirez-Lee National Center for Toxicological Research 2 shared publications Scott M. Apana University of Arkansas for Medical Sciences 2 shared publications

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