Match tier
Confirmed
Presence
Current · Arkansas
Last published
2025
Sources
OpenAlex · ORCID
Refreshed
2026-08-08
J
John Talpos
Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.
High Impact
Primary Investigator
Also affiliated: United States Food and Drug Administration (2021–2024); Johnson & Johnson (United States) (2011); Janssen (Belgium) (2011–2017); University of Cambridge (2005–2010); Neurolixis (United States) (2025); Johnson & Johnson (Israel) (2012)
Faculty Researcher
21 h-index
51 pubs
1,650 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
John Talpos' research focuses on the neurotoxicological effects of various agents and conditions, particularly in nonhuman primate and rodent models. His work investigates the potential for substances like SARS-CoV-2, ketamine, and desflurane to impact the central nervous system. Talpos has explored the use of novel methods, including neural stem cell models derived from fetal monkey brains, to assess developmental neurotoxicity and screen for potential adverse effects.
His research also encompasses the evaluation of pharmacological agents, such as methylphenidate, examining its long-term effects and discontinuation outcomes in nonhuman primates using microPET/CT imaging to assess neurochemical changes. Furthermore, Talpos has contributed to genotoxicity evaluations, utilizing primary hepatocytes from rhesus macaques. He leads a research group and has a publication record that includes 51 papers, with a total of 1,624 citations and an h-index of 21. His collaborations include multiple shared publications with researchers at the National Center for Toxicological Research, such as William Slikker, Leah E. Latham, Shuliang Liu, and Merle G. Paule.
Metrics
- h-index: 21
- Publications: 51
- Citations: 1,650
Selected Publications
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Pharmacokinetics of cannabidiol and its metabolites in rhesus monkeys and New Zealand White rabbits (2025)
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Assessing potential desflurane-induced neurotoxicity using nonhuman primate neural stem cell models (2025)
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State of the science on assessing developmental neurotoxicity using new approach methods (2024)
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Establishment of neural stem cells from fetal monkey brain for neurotoxicity testing (2023)
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Development of a primate model to evaluate the effects of ketamine and surgical stress on the neonatal brain (2023)
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Discontinuation of methylphenidate after long-term exposure in nonhuman primates (2023)
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Rodent models of anesthesia-induced developmental neurotoxicity☆ (2022)
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The effects of long-term methylphenidate administration and withdrawal on progressive ratio responding and T2 MRI in the male rhesus monkey (2022)
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Genotoxicity evaluation using primary hepatocytes isolated from rhesus macaque (Macaca mulatta) (2021)
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MicroPET/CT assessment of neurochemical effects in the brain after long-term methylphenidate treatment in nonhuman primates (2021)
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Can SARS-CoV-2 infect the central nervous system via the olfactory bulb or the blood-brain barrier? (2021)
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This is your teen brain on drugs: In search of biological factors unique to dependence toxicity in adolescence (2020)
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Regions of the basal ganglia and primary olfactory system are most sensitive to neurodegeneration after extended sevoflurane anesthesia in the perinatal rat (2020)
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Acetyl-l-carnitine does not prevent neurodegeneration in a rodent model of prolonged neonatal anesthesia (2020)
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Sevoflurane exposure has minimal effect on cognitive function and does not alter microglial activation in adult monkeys (2018)
Collaboration Network
Top Collaborators
William Slikker
National Center for Toxicological Research
4 shared publications
In database
- MicroPET/CT assessment of neurochemical effects in the brain after long-term methylphenidate treatment in nonhuman primates
- Discontinuation of methylphenidate after long-term exposure in nonhuman primates
- Development of a primate model to evaluate the effects of ketamine and surgical stress on the neonatal brain
- Establishment of neural stem cells from fetal monkey brain for neurotoxicity testing
Merle G. Paule
National Center for Toxicological Research
3 shared publications
In database
- MicroPET/CT assessment of neurochemical effects in the brain after long-term methylphenidate treatment in nonhuman primates
- Discontinuation of methylphenidate after long-term exposure in nonhuman primates
- The effects of long-term methylphenidate administration and withdrawal on progressive ratio responding and T2 MRI in the male rhesus monkey
Cheng Wang
Neurolixis (United States)
3 shared publications
In database
- Development of a primate model to evaluate the effects of ketamine and surgical stress on the neonatal brain
- Establishment of neural stem cells from fetal monkey brain for neurotoxicity testing
- Assessing potential desflurane-induced neurotoxicity using nonhuman primate neural stem cell models
Fang Liu
Neurolixis (United States)
3 shared publications
In database
- Development of a primate model to evaluate the effects of ketamine and surgical stress on the neonatal brain
- Establishment of neural stem cells from fetal monkey brain for neurotoxicity testing
- Assessing potential desflurane-induced neurotoxicity using nonhuman primate neural stem cell models
Shuliang Liu
National Center for Toxicological Research
3 shared publications
In database
- Development of a primate model to evaluate the effects of ketamine and surgical stress on the neonatal brain
- Establishment of neural stem cells from fetal monkey brain for neurotoxicity testing
- Assessing potential desflurane-induced neurotoxicity using nonhuman primate neural stem cell models
Leah E. Latham
Neurolixis (United States)
3 shared publications
In database
- Development of a primate model to evaluate the effects of ketamine and surgical stress on the neonatal brain
- Establishment of neural stem cells from fetal monkey brain for neurotoxicity testing
- Assessing potential desflurane-induced neurotoxicity using nonhuman primate neural stem cell models
Susan M. Burks
National Center for Toxicological Research
2 shared publications
In database
- Can SARS-CoV-2 infect the central nervous system via the olfactory bulb or the blood-brain barrier?
- Genotoxicity evaluation using primary hepatocytes isolated from rhesus macaque (Macaca mulatta)
Manuel Alejandro Ramirez-Lee
National Center for Toxicological Research
2 shared publications
In database
- Can SARS-CoV-2 infect the central nervous system via the olfactory bulb or the blood-brain barrier?
- Rodent models of anesthesia-induced developmental neurotoxicity☆
Marc S. Berridge
University of Arkansas for Medical Sciences (US)
2 shared publications
- MicroPET/CT assessment of neurochemical effects in the brain after long-term methylphenidate treatment in nonhuman primates
- Discontinuation of methylphenidate after long-term exposure in nonhuman primates
Scott M. Apana
University of Arkansas for Medical Sciences
2 shared publications
In database
- MicroPET/CT assessment of neurochemical effects in the brain after long-term methylphenidate treatment in nonhuman primates
- Discontinuation of methylphenidate after long-term exposure in nonhuman primates
Tucker A. Patterson
Office of the Director
2 shared publications
In database
- Development of a primate model to evaluate the effects of ketamine and surgical stress on the neonatal brain
- Assessing potential desflurane-induced neurotoxicity using nonhuman primate neural stem cell models
Joseph P. Hanig
Center for Drug Evaluation and Research (US)
2 shared publications
- Establishment of neural stem cells from fetal monkey brain for neurotoxicity testing
- Assessing potential desflurane-induced neurotoxicity using nonhuman primate neural stem cell models
Héctor Rosas-Hernández
National Center for Toxicological Research
1 shared publication
In database
- Can SARS-CoV-2 infect the central nervous system via the olfactory bulb or the blood-brain barrier?
Elvis Cuevas
National Center for Toxicological Research (US)
1 shared publication
- Can SARS-CoV-2 infect the central nervous system via the olfactory bulb or the blood-brain barrier?
X. Zhang
United States Food and Drug Administration
1 shared publication
In database
- MicroPET/CT assessment of neurochemical effects in the brain after long-term methylphenidate treatment in nonhuman primates
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