John Talpos Data-verified

Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.

High Impact

Primary Investigator

NCTR

Last publication 2025 Last refreshed 2026-05-23

faculty

21 h-index 51 pubs 1,633 cited

Research Areas

Links

ORCID Research Group

OverviewAI-generated summary

John Talpos' research focuses on the neurotoxicological effects of various agents and conditions, particularly in nonhuman primate and rodent models. His work investigates the potential for substances like SARS-CoV-2, ketamine, and desflurane to impact the central nervous system. Talpos has explored the use of novel methods, including neural stem cell models derived from fetal monkey brains, to assess developmental neurotoxicity and screen for potential adverse effects.

His research also encompasses the evaluation of pharmacological agents, such as methylphenidate, examining its long-term effects and discontinuation outcomes in nonhuman primates using microPET/CT imaging to assess neurochemical changes. Furthermore, Talpos has contributed to genotoxicity evaluations, utilizing primary hepatocytes from rhesus macaques. He leads a research group and has a publication record that includes 51 papers, with a total of 1,624 citations and an h-index of 21. His collaborations include multiple shared publications with researchers at the National Center for Toxicological Research, such as William Slikker, Leah E. Latham, Shuliang Liu, and Merle G. Paule.

Metrics

h-index: 21
Publications: 51
Citations: 1,633

Selected Publications

Pharmacokinetics of cannabidiol and its metabolites in rhesus monkeys and New Zealand White rabbits (2025)

DOI OpenAlex
Assessing potential desflurane-induced neurotoxicity using nonhuman primate neural stem cell models (2025)

2 citations DOI OpenAlex
State of the science on assessing developmental neurotoxicity using new approach methods (2024)

8 citations DOI OpenAlex
Establishment of neural stem cells from fetal monkey brain for neurotoxicity testing (2023)

3 citations DOI OpenAlex
Development of a primate model to evaluate the effects of ketamine and surgical stress on the neonatal brain (2023)

3 citations DOI OpenAlex
Discontinuation of methylphenidate after long-term exposure in nonhuman primates (2023)

3 citations DOI OpenAlex
Rodent models of anesthesia-induced developmental neurotoxicity☆ (2022)

DOI OpenAlex
The effects of long-term methylphenidate administration and withdrawal on progressive ratio responding and T2 MRI in the male rhesus monkey (2022)

2 citations DOI OpenAlex
Genotoxicity evaluation using primary hepatocytes isolated from rhesus macaque (Macaca mulatta) (2021)

5 citations DOI OpenAlex
MicroPET/CT assessment of neurochemical effects in the brain after long-term methylphenidate treatment in nonhuman primates (2021)

7 citations DOI OpenAlex
Can SARS-CoV-2 infect the central nervous system via the olfactory bulb or the blood-brain barrier? (2021)

102 citations DOI OpenAlex