Serguei Liachenko

Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.

Director of Bioimaging

NCTR

Also affiliated: United States Food and Drug Administration (2015–2024); Center for Drug Evaluation and Research (2015); University of Pittsburgh (1998–2003); Pfizer (United States) (2006); Food and Drug Administration (2021); Stanford University (2009)

Faculty Researcher

18 h-index 52 pubs 945 cited

Research Areas

Biomedical Subjects

Links

ORCID Lab Website Research Group

OverviewAI-generated summary

Serguei Liachenko's research focuses on the development and application of advanced imaging techniques, particularly Magnetic Resonance Imaging (MRI) and Magnetic Resonance Spectroscopy (MRS), for the quantitative assessment of neurotoxicity in animal models. His work investigates the use of these non-invasive methods to identify and track biomarkers of neurological damage following exposure to various chemical agents. Liachenko has published research on the impact of agents such as trimethyltin and gadodiamide on rat brains, utilizing T2 mapping and other quantitative MRI approaches to detect and measure neurotoxic effects. His investigations also extend to the long-term effects of pharmacological agents, like methylphenidate, on brain structure and function in non-human primates.

Liachenko's role as Director of Bioimaging at the National Center for Toxicological Research facilitates collaborations with colleagues such as Merle G. Paule, William Slikker, Natalya Sadovova, and Sumit Sarkar. His research program aims to advance regulatory science by providing quantitative, in vivo methods for evaluating the safety of chemical substances and pharmaceuticals. With an h-index of 18 and over 900 citations across 52 publications, his work contributes to the understanding of neurotoxicity mechanisms and the development of objective assessment tools.

Metrics

h-index: 18
Publications: 52
Citations: 945

Selected Publications

Biomarkers of Neurotoxicity and Disease (2025)

Elsevier eBooks 1 citation DOI OpenAlex
In vivo mapping of rat brain partial white matter content using hexachlorophene-induced neurotoxicity model (2024)

Brain Research 1 citation DOI OpenAlex
Performance of the prospective T2 MRI biomarker of neurotoxicity in a trimethyltin model in rats at 7 T (2023)

Neurotoxicology and Teratology 1 citation DOI OpenAlex
The effects of long-term methylphenidate administration and withdrawal on progressive ratio responding and T2 MRI in the male rhesus monkey (2022)

Neurotoxicology and Teratology 2 citations DOI OpenAlex
Optimization of Detection of Gadodiamide Brain Retention in Rats Using Quantitative <scp>T<sub>2</sub></scp> Mapping and Intraperitoneal Administration (2022)

Journal of Magnetic Resonance Imaging 2 citations DOI OpenAlex
Circulating biomarkers of neurotoxicity: Proteomics approach reveals fluidic endpoints of central nervous system toxicity in a rodent model of neurotoxicity (2021)

Journal of Pharmacological and Toxicological Methods DOI OpenAlex
Global Neurotoxicity: Quantitative Analysis of Rat Brain Toxicity Following Exposure to Trimethyltin (2021)

International Journal of Toxicology 6 citations DOI OpenAlex
MicroCT Imaging of Heart Valve Tissue in Fluid (2020)

Experimental Mechanics 2 citations DOI OpenAlex
Quantitative Neurotoxicology: An Assessment of the Neurotoxic Profile of Kainic Acid in Sprague Dawley Rats (2020)

International Journal of Toxicology 12 citations DOI OpenAlex
Translational imaging in toxicology (2020)

Current Opinion in Toxicology 8 citations DOI OpenAlex
Sex differences in the effect of acute administration of nicotine on MRS-measured metabolic profile of the rat brain (2019)

Neuroscience Research 4 citations DOI OpenAlex
A Method for Sampling Rat Cerebrospinal Fluid with Minimal Blood Contamination: A Critical Tool for Biomarker Studies (2019)

Neuromethods DOI OpenAlex
A multi-center preclinical study of gadoxetate DCE-MRI in rats as a biomarker of drug induced inhibition of liver transporter function (2018)

PLoS ONE 23 citations DOI OpenAlex
Comparison of quantitative T2 and ADC mapping in the assessment of 3-nitropropionic acid-induced neurotoxicity in rats (2018)

NeuroToxicology 9 citations DOI OpenAlex
Changes in the metabolome and microRNA levels in biological fluids might represent biomarkers of neurotoxicity: A trimethyltin study (2017)

Experimental Biology and Medicine 22 citations DOI OpenAlex