Serguei Liachenko Data-verified

Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.

Director of Bioimaging

NCTR

Last publication 2025 Last refreshed 2026-05-16

faculty

18 h-index 52 pubs 930 cited

Research Areas

Links

ORCID Lab Website Research Group

OverviewAI-generated summary

Serguei Liachenko's research focuses on the development and application of advanced imaging techniques, particularly Magnetic Resonance Imaging (MRI) and Magnetic Resonance Spectroscopy (MRS), for the quantitative assessment of neurotoxicity in animal models. His work investigates the use of these non-invasive methods to identify and track biomarkers of neurological damage following exposure to various chemical agents. Liachenko has published research on the impact of agents such as trimethyltin and gadodiamide on rat brains, utilizing T2 mapping and other quantitative MRI approaches to detect and measure neurotoxic effects. His investigations also extend to the long-term effects of pharmacological agents, like methylphenidate, on brain structure and function in non-human primates.

Liachenko's role as Director of Bioimaging at the National Center for Toxicological Research facilitates collaborations with colleagues such as Merle G. Paule, William Slikker, Natalya Sadovova, and Sumit Sarkar. His research program aims to advance regulatory science by providing quantitative, in vivo methods for evaluating the safety of chemical substances and pharmaceuticals. With an h-index of 18 and over 900 citations across 52 publications, his work contributes to the understanding of neurotoxicity mechanisms and the development of objective assessment tools.

Metrics

h-index: 18
Publications: 52
Citations: 930

Selected Publications

Biomarkers of Neurotoxicity and Disease (2025)

1 citation DOI OpenAlex
In vivo mapping of rat brain partial white matter content using hexachlorophene-induced neurotoxicity model (2024)

1 citation DOI OpenAlex
Performance of the prospective T2 MRI biomarker of neurotoxicity in a trimethyltin model in rats at 7 T (2023)

1 citation DOI OpenAlex
The effects of long-term methylphenidate administration and withdrawal on progressive ratio responding and T2 MRI in the male rhesus monkey (2022)

2 citations DOI OpenAlex
Optimization of Detection of Gadodiamide Brain Retention in Rats Using Quantitative <scp>T<sub>2</sub></scp> Mapping and Intraperitoneal Administration (2022)

2 citations DOI OpenAlex
Circulating biomarkers of neurotoxicity: Proteomics approach reveals fluidic endpoints of central nervous system toxicity in a rodent model of neurotoxicity (2021)

DOI OpenAlex
Global Neurotoxicity: Quantitative Analysis of Rat Brain Toxicity Following Exposure to Trimethyltin (2021)

5 citations DOI OpenAlex