M
Mohammad A. Alam Data-verified
Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.
Federal Grant PI
High Impact
Professor
faculty
22 h-index
74 pubs
1,080 cited
Research Areas
Links
Biography and Research Information
OverviewAI-generated summary
Mohammad A. Alam's research focuses on the design, synthesis, and evaluation of novel pyrazole derivatives as antibacterial agents, particularly against resistant bacterial strains. His work investigates the structure-activity relationships of these compounds, aiming to develop potent inhibitors of bacterial growth and virulence factors, such as fatty acid biosynthesis. Recent publications highlight the development of pyrazole derivatives targeting Gram-positive bacteria, including *Staphylococcus aureus* and *Acinetobacter baumannii*, as well as chimeric thiazolo-nootkatone derivatives with broad antimicrobial activity.
Alam also directs research on the functional genomics of oral pathogens, specifically *Streptococcus mutans*, with the goal of understanding their mechanisms of infection and developing targeted interventions. His laboratory is equipped with advanced instrumentation, including an X-ray diffractometer and a 400 MHz Nuclear Magnetic Resonance (NMR) spectrometer, acquired through federal grants from the National Institutes of Health (NIH) and the National Science Foundation (NSF). These grants, totaling over $1.3 million, support research in materials science, biomaterials, and molecular biology. Alam has an h-index of 22, with 74 publications and over 1,000 citations, and collaborates with researchers at Arkansas State University, including Subrata Roy, David F. Gilmore, Alexei G. Basnakian, and Shailesh Budhathoki.
Metrics
- h-index: 22
- Publications: 74
- Citations: 1,080
Selected Publications
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Design, Synthesis, and Development of 4-[2-[3,5-Bis(trifluoromethyl)anilino]thiazolo-4-yl]phenol as a Dual Inhibitor of Fatty Acid Biosynthesis (FASII) to Clear MRSA Infection (2026)
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High-level production of antibacterial pentacyclic triterpenoids from hairy root cultures of Bixa orellana via abiotic elicitation (2026)
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Correction: Thiazole-fused androstenone and ethisterone derivatives: potent β- and γ-actin cytoskeleton inhibitors to treat melanoma tumors (2025)
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Enhanced Production of Anti-Inflammatory and Antibacterial Prenylated Isoflavonoids in Pigeon Pea (<i>Cajanus cajan</i>) Hairy Root Cultures (2025)
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Production of Malheuran A, a Geranylated Flavonoid with Antimicrobial and Anti-Inflammatory Activities, in Hairy Root Cultures of Dalea purpurea (2025)
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Thiazole-fused androstenone and ethisterone derivatives: potent β- and γ-actin cytoskeleton inhibitors to treat melanoma tumors (2024)
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Synthesis of Thiazole‐Fused Diosgenin Derivatives as Potential Therapeutic Agents (2024)
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Editorial: Five-membered heterocycles: synthesis and applications (2024)
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Efficient Synthesis of Thiazole-Fused Bisnoralcohol Derivatives as Potential Therapeutic Agents (2024)
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Domino Reaction Protocol to Synthesize Benzothiophene-Derived Chemical Entities as Potential Therapeutic Agents (2024)
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Construction of an arrayed CRISPRi library as a resource for essential gene function studies in <i>Streptococcus mutans</i> (2023)
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Pyrazole: an Emerging Privileged Scaffold in Drug Discovery (2023)
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Development and Antibacterial Properties of 4-[4-(Anilinomethyl)-3-phenylpyrazol-1-yl]benzoic Acid Derivatives as Fatty Acid Biosynthesis Inhibitors (2023)
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List of contributors (2023)
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Thiazole, a privileged scaffold in drug discovery (2023)
Federal Grants 3 $1,379,507 total
NIH/National Institute of Dental and Craniofacial Research
Contact PI
Sep 2024 - Sep 2027
Systematic Functional Genomics Analysis of the Oral Pathogen Streptococcus Mutans
NSF
Co-PI
Sep 2024 - Aug 2027
NSF
PI
Aug 2021 - Jul 2024
Collaboration Network
Top Collaborators
Subrata Roy
Arkansas State University
11 shared publications
In database
- Design, synthesis, and antibacterial activity of<i>N</i>-(trifluoromethyl)phenyl substituted pyrazole derivatives
- Benign synthesis of fused-thiazoles with enone-based natural products and drugs for lead discovery
- Development and Antibacterial Properties of 4-[4-(Anilinomethyl)-3-phenylpyrazol-1-yl]benzoic Acid Derivatives as Fatty Acid Biosynthesis Inhibitors
- Synthesis of 3,5-Bis(trifluoromethyl)phenyl-Substituted Pyrazole Derivatives as Potent Growth Inhibitors of Drug-Resistant Bacteria
- Domino Reaction Protocol to Synthesize Benzothiophene-Derived Chemical Entities as Potential Therapeutic Agents
Showing 5 of 11 shared publications
David F. Gilmore
Arkansas State University
7 shared publications
In database
- Design, synthesis, and antibacterial activity of<i>N</i>-(trifluoromethyl)phenyl substituted pyrazole derivatives
- 4-4-(Anilinomethyl)-3-[4-(trifluoromethyl)phenyl]-1H-pyrazol-1-ylbenzoic acid derivatives as potent anti-gram-positive bacterial agents
- Synthesis of Chimeric Thiazolo‐Nootkatone Derivatives as Potent Antimicrobial Agents
- Development and Antibacterial Properties of 4-[4-(Anilinomethyl)-3-phenylpyrazol-1-yl]benzoic Acid Derivatives as Fatty Acid Biosynthesis Inhibitors
- Novel Pyrazoles As Potent Growth Inhibitors of Staphylococci, Enterococci and <i>Acinetobacter Baumannii</i> Bacteria
Showing 5 of 7 shared publications
Alexei G. Basnakian
Arkansas State University
7 shared publications
In database
- 4-4-(Anilinomethyl)-3-[4-(trifluoromethyl)phenyl]-1H-pyrazol-1-ylbenzoic acid derivatives as potent anti-gram-positive bacterial agents
- Antimelanoma activities of chimeric thiazole–androstenone derivatives
- Thiazole-fused androstenone and ethisterone derivatives: potent β- and γ-actin cytoskeleton inhibitors to treat melanoma tumors
- Author response for "Thiazole-fused Androstenone and Ethisterone Derivatives: Potent β- and γ-Actin Cytoskeleton Inhibitors to Treat Melanoma Tumors"
- Author response for "Thiazole-fused Androstenone and Ethisterone Derivatives: Potent β- and γ-Actin Cytoskeleton Inhibitors to Treat Melanoma Tumors"
Showing 5 of 7 shared publications
Shailesh Budhathoki
Arkansas State University
7 shared publications
In database
- Domino Reaction Protocol to Synthesize Benzothiophene-Derived Chemical Entities as Potential Therapeutic Agents
- Synthesis of Thiazole‐Fused Diosgenin Derivatives as Potential Therapeutic Agents
- Thiazole-fused androstenone and ethisterone derivatives: potent β- and γ-actin cytoskeleton inhibitors to treat melanoma tumors
- Author response for "Thiazole-fused Androstenone and Ethisterone Derivatives: Potent β- and γ-Actin Cytoskeleton Inhibitors to Treat Melanoma Tumors"
- Author response for "Thiazole-fused Androstenone and Ethisterone Derivatives: Potent β- and γ-Actin Cytoskeleton Inhibitors to Treat Melanoma Tumors"
Showing 5 of 7 shared publications
Hansa Raj KC
Arkansas State University
6 shared publications
In database
- Design, synthesis, and antibacterial activity of<i>N</i>-(trifluoromethyl)phenyl substituted pyrazole derivatives
- Development and Antibacterial Properties of 4-[4-(Anilinomethyl)-3-phenylpyrazol-1-yl]benzoic Acid Derivatives as Fatty Acid Biosynthesis Inhibitors
- Novel Pyrazoles As Potent Growth Inhibitors of Staphylococci, Enterococci and <i>Acinetobacter Baumannii</i> Bacteria
- Development of 4-[4-(Anilinomethyl)-3-phenyl-pyrazol-1-yl] Benzoic Acid Derivatives as Potent Anti-Staphylococci and Anti-Enterococci Agents
- Synthesis of 3,5-Bis(trifluoromethyl)phenyl-Substituted Pyrazole Derivatives as Potent Growth Inhibitors of Drug-Resistant Bacteria
Showing 5 of 6 shared publications
Sanjay Adhikary
Arkansas State University
6 shared publications
In database
- In Vitro Antimelanoma Properties of Verbena officinalis Fractions
- Efficient Synthesis of Thiazole-Fused Bisnoralcohol Derivatives as Potential Therapeutic Agents
- Thiazole-fused androstenone and ethisterone derivatives: potent β- and γ-actin cytoskeleton inhibitors to treat melanoma tumors
- Author response for "Thiazole-fused Androstenone and Ethisterone Derivatives: Potent β- and γ-Actin Cytoskeleton Inhibitors to Treat Melanoma Tumors"
- Author response for "Thiazole-fused Androstenone and Ethisterone Derivatives: Potent β- and γ-Actin Cytoskeleton Inhibitors to Treat Melanoma Tumors"
Showing 5 of 6 shared publications
Ibrahim S. Alkhaibari
5 shared publications
- Synthesis of Chimeric Thiazolo‐Nootkatone Derivatives as Potent Antimicrobial Agents
- Benign synthesis of fused-thiazoles with enone-based natural products and drugs for lead discovery
- Novel Pyrazoles As Potent Growth Inhibitors of Staphylococci, Enterococci and <i>Acinetobacter Baumannii</i> Bacteria
- Synthesis of 3,5-Bis(trifluoromethyl)phenyl-Substituted Pyrazole Derivatives as Potent Growth Inhibitors of Drug-Resistant Bacteria
- CCDC 2035523: Experimental Crystal Structure Determination
Robert C. Shields
Arkansas State University
5 shared publications
In database
- Development and Antibacterial Properties of 4-[4-(Anilinomethyl)-3-phenylpyrazol-1-yl]benzoic Acid Derivatives as Fatty Acid Biosynthesis Inhibitors
- Construction of an arrayed CRISPRi library as a resource for essential gene function studies in <i>Streptococcus mutans</i>
- Production of Malheuran A, a Geranylated Flavonoid with Antimicrobial and Anti-Inflammatory Activities, in Hairy Root Cultures of Dalea purpurea
- Enhanced Production of Anti-Inflammatory and Antibacterial Prenylated Isoflavonoids in Pigeon Pea (<i>Cajanus cajan</i>) Hairy Root Cultures
- Design, Synthesis, and Development of 4-[2-[3,5-Bis(trifluoromethyl)anilino]thiazolo-4-yl]phenol as a Dual Inhibitor of Fatty Acid Biosynthesis (FASII) to Clear MRSA Infection
Mohamed Milad
Arkansas State University
5 shared publications
In database
- Thiazole-fused androstenone and ethisterone derivatives: potent β- and γ-actin cytoskeleton inhibitors to treat melanoma tumors
- Author response for "Thiazole-fused Androstenone and Ethisterone Derivatives: Potent β- and γ-Actin Cytoskeleton Inhibitors to Treat Melanoma Tumors"
- Author response for "Thiazole-fused Androstenone and Ethisterone Derivatives: Potent β- and γ-Actin Cytoskeleton Inhibitors to Treat Melanoma Tumors"
- Correction: Thiazole-fused androstenone and ethisterone derivatives: potent β- and γ-actin cytoskeleton inhibitors to treat melanoma tumors
- Design, Synthesis, and Development of 4-[2-[3,5-Bis(trifluoromethyl)anilino]thiazolo-4-yl]phenol as a Dual Inhibitor of Fatty Acid Biosynthesis (FASII) to Clear MRSA Infection
Alan J. Tackett
University of Arkansas for Medical Sciences
4 shared publications
In database
- Thiazole-fused androstenone and ethisterone derivatives: potent β- and γ-actin cytoskeleton inhibitors to treat melanoma tumors
- Author response for "Thiazole-fused Androstenone and Ethisterone Derivatives: Potent β- and γ-Actin Cytoskeleton Inhibitors to Treat Melanoma Tumors"
- Author response for "Thiazole-fused Androstenone and Ethisterone Derivatives: Potent β- and γ-Actin Cytoskeleton Inhibitors to Treat Melanoma Tumors"
- Correction: Thiazole-fused androstenone and ethisterone derivatives: potent β- and γ-actin cytoskeleton inhibitors to treat melanoma tumors
Nathan L. Avaritt
University of Arkansas for Medical Sciences
4 shared publications
In database
- Thiazole-fused androstenone and ethisterone derivatives: potent β- and γ-actin cytoskeleton inhibitors to treat melanoma tumors
- Author response for "Thiazole-fused Androstenone and Ethisterone Derivatives: Potent β- and γ-Actin Cytoskeleton Inhibitors to Treat Melanoma Tumors"
- Author response for "Thiazole-fused Androstenone and Ethisterone Derivatives: Potent β- and γ-Actin Cytoskeleton Inhibitors to Treat Melanoma Tumors"
- Correction: Thiazole-fused androstenone and ethisterone derivatives: potent β- and γ-actin cytoskeleton inhibitors to treat melanoma tumors
Rawan Alnufaie
3 shared publications
In database
- Synthesis of Chimeric Thiazolo‐Nootkatone Derivatives as Potent Antimicrobial Agents
- Benign synthesis of fused-thiazoles with enone-based natural products and drugs for lead discovery
- CCDC 2035523: Experimental Crystal Structure Determination
Justin Roberts
Arkansas State University
3 shared publications
In database
- Development and Antibacterial Properties of 4-[4-(Anilinomethyl)-3-phenylpyrazol-1-yl]benzoic Acid Derivatives as Fatty Acid Biosynthesis Inhibitors
- Construction of an arrayed CRISPRi library as a resource for essential gene function studies in <i>Streptococcus mutans</i>
- Design, Synthesis, and Development of 4-[2-[3,5-Bis(trifluoromethyl)anilino]thiazolo-4-yl]phenol as a Dual Inhibitor of Fatty Acid Biosynthesis (FASII) to Clear MRSA Infection
S. Chowdhury
Arkansas State University
3 shared publications
In database
- Thiazole-fused androstenone and ethisterone derivatives: potent β- and γ-actin cytoskeleton inhibitors to treat melanoma tumors
- Author response for "Thiazole-fused Androstenone and Ethisterone Derivatives: Potent β- and γ-Actin Cytoskeleton Inhibitors to Treat Melanoma Tumors"
- Correction: Thiazole-fused androstenone and ethisterone derivatives: potent β- and γ-actin cytoskeleton inhibitors to treat melanoma tumors
Gaurav Gajurel
Arkansas State University
3 shared publications
In database
- Production of Malheuran A, a Geranylated Flavonoid with Antimicrobial and Anti-Inflammatory Activities, in Hairy Root Cultures of Dalea purpurea
- Enhanced Production of Anti-Inflammatory and Antibacterial Prenylated Isoflavonoids in Pigeon Pea (<i>Cajanus cajan</i>) Hairy Root Cultures
- Design, Synthesis, and Development of 4-[2-[3,5-Bis(trifluoromethyl)anilino]thiazolo-4-yl]phenol as a Dual Inhibitor of Fatty Acid Biosynthesis (FASII) to Clear MRSA Infection
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