Neha S. Dole

Federal Grant PI

Assistant Professor

University of Arkansas for Medical Sciences

faculty

Physiology and Cell Biology, College of Medicine

nsdole@uams.edu

13 h-index 27 pubs 569 cited

Research Areas

Bone Metabolism and Diseases Diet and metabolism studies Osteoporosis research MicroRNA in disease regulation Receptor Mechanisms and Signaling Cellular Mechanics and Interactions Metabolism and Genetic Disorders Muscle Physiology and Disorders

Links

ORCID Lab Website UAMS TRI Profile

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OverviewAI-generated summary

Neha S. Dole investigates the role of osteocytes, the most abundant cells in bone, in maintaining skeletal health and their connection to broader metabolic functions. Her research explores how mechanical forces, such as fluid shear stress, influence osteocyte signaling pathways, including those involving TGFβ family receptors and microRNAs like miR-100. Dole's work also examines the detrimental effects of aging and diet on bone quality, specifically how high-fat and high-carbohydrate diets compromise bone integrity through osteocyte dysfunction, and how aging impairs the osteocytic regulation of collagen integrity.

Dole is a Principal Investigator on a grant from the NIH/National Institute of Diabetes and Digestive and Kidney Diseases, totaling $140,899, focused on unraveling the role of osteocytes in metabolic dysfunction associated with obesity. Her publications also address the effects of Zoledronic acid on bone quality and muscle function, and the regulation of osteocyte ferroptosis and osteocyte-osteoblast crosstalk by Lipocalin-2 via Wnt signaling. She has also published on how miR181a/b-1 controls osteocyte metabolism and mechanical properties.

Metrics

  • h-index: 13
  • Publications: 27
  • Citations: 569

Selected Publications

  • Global Transcriptional Profiling of Adipose Tissue Uncovers Unique Sex-Dependent Mechanisms in Acute Obesity: Implications for Adipose-Heart Interorgan Crosstalk (2025) DOI
  • Lipocalin-2 Regulates Osteocyte Ferroptosis and Osteocyte-Osteoblast Crosstalk via Wnt Signaling to Control Bone Formation (2025) DOI
  • High-fat and high-carbohydrate diets increase bone fragility through TGF-β–dependent control of osteocyte function (2024) DOI
  • miR181a/b-1 controls osteocyte metabolism and mechanical properties independently of bone morphology (2023) DOI
  • The Multifaceted Effects of Osteocytic TGFβ Signaling on the Skeletal and Extraskeletal Functions of Bone (2023) DOI

Federal Grants 1 $140,899 total

NIH/National Institute of Diabetes and Digestive and Kidney Diseases Contact PI Sep 2021 - Jul 2026

Unraveling the role of osteocytes in metabolic dysfunction associated with obesity

National Institute of Diabetes and Digestive and Kidney Diseases $140,899 K01

Grants & Funding

  • Role of subchondral bone osteocytes in post-traumatic osteoarthritis US Department of Defense Principal Investigator
  • Unraveling the role of osteocytes in metabolic dysfunction associated with obesity NIH/Nat. Inst. of Diabetes & Digestive & Kidney Diseases Principal Investigator
  • Unraveling the role of osteocytes in metabolic dysfunction associated with obesity NIH/Nat. Inst. of Diabetes & Digestive & Kidney Diseases Principal Investigator
  • Vivek Khanal ASBMR 2025 President's Award American Society for Bone and Mineral Research Principal Investigator
  • Role of subchondral bone osteocytes in post-traumatic osteoarthritis US Department of Defense Principal Investigator
  • ABI P. Prather NIH T32 FY26 Y3 State of Arkansas Principal Investigator

Collaborators

Researchers in the database who share publications

Madeline Carroll University of Arkansas for Medical Sciences 2 shared publications Amy Y. Sato University of Arkansas for Medical Sciences 1 shared publication Ryan M. Allen University of Arkansas for Medical Sciences 1 shared publication Umesh D. Wankhade University of Arkansas for Medical Sciences 1 shared publication Jayden Carter University of Arkansas for Medical Sciences 1 shared publication Rushita A. Bagchi University of Arkansas for Medical Sciences 1 shared publication Shahnaz Ibrahim University of Arkansas for Medical Sciences 1 shared publication Marguerite K. Shepard University of Arkansas for Medical Sciences 1 shared publication

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