Neha S. Dole

Federal Grant PI

Assistant Professor

UAMS

Last publication 2025 Last refreshed 2026-05-22

faculty

Physiology and Cell Biology, College of Medicine

nsdole@uams.edu

14 h-index 27 pubs 598 cited

Research Areas

Links

ORCID Lab Website UAMS TRI Profile

OverviewAI-generated summary

Neha S. Dole, Assistant Professor in the Department of Physiology and Cell Biology at the University of Arkansas for Medical Sciences, investigates the role of osteocytes in bone health and systemic metabolic regulation. Her research focuses on how these bone cells respond to mechanical stimuli and dietary factors, influencing bone quality and overall body function. Dole's work has explored the intricate signaling pathways within osteocytes, including the involvement of transforming growth factor beta (TGFβ) and microRNAs (miRNAs) such as miR-100 and miR-181a/b-1.

Her federally funded project, supported by a $140,899 grant from the NIH/National Institute of Diabetes and Digestive and Kidney Diseases, aims to unravel the role of osteocytes in metabolic dysfunction associated with obesity. This research investigates how factors like high-fat and high-carbohydrate diets impact bone fragility through TGF-β dependent mechanisms. Dole's publications also examine the effects of aging on osteocytic regulation of collagen integrity and bone quality, as well as the potential therapeutic benefits of agents like zoledronic acid in improving bone and muscle function.

Dole collaborates with researchers at the University of Arkansas for Medical Sciences, including Vivek Khanal, Madeline Carroll, Amy Y. Sato, and Ryan M. Allen, with whom she has co-authored multiple publications. Her scholarship metrics include an h-index of 13 and 27 total publications.

Metrics

h-index: 14
Publications: 27
Citations: 598

Selected Publications

Osteocytic Lipocalin-2 regulates bone formation locally through iron-dependent ferroptosis and Wnt suppression (2026)

DOI OpenAlex
Global Transcriptional Profiling of Adipose Tissue Uncovers Unique Sex-Dependent Mechanisms in Acute Obesity: Implications for Adipose-Heart Interorgan Crosstalk (2025)

DOI OpenAlex
Lipocalin-2 Regulates Osteocyte Ferroptosis and Osteocyte-Osteoblast Crosstalk via Wnt Signaling to Control Bone Formation (2025)

1 citation DOI OpenAlex
High-fat and high-carbohydrate diets increase bone fragility through TGF-β–dependent control of osteocyte function (2024)

13 citations DOI OpenAlex
miR181a/b-1 controls osteocyte metabolism and mechanical properties independently of bone morphology (2023)

1 citation DOI OpenAlex
The Multifaceted Effects of Osteocytic TGFβ Signaling on the Skeletal and Extraskeletal Functions of Bone (2023)

3 citations DOI OpenAlex

View all publications on OpenAlex →

Federal Grants 1 $140,899 total

NIH/National Institute of Diabetes and Digestive and Kidney Diseases Contact PI Sep 2021 - Jul 2026

Unraveling the role of osteocytes in metabolic dysfunction associated with obesity

National Institute of Diabetes and Digestive and Kidney Diseases $140,899 K01

Grants & Funding

Role of subchondral bone osteocytes in post-traumatic osteoarthritis US Department of Defense Principal Investigator
Unraveling the role of osteocytes in metabolic dysfunction associated with obesity NIH/Nat. Inst. of Diabetes & Digestive & Kidney Diseases Principal Investigator
Unraveling the role of osteocytes in metabolic dysfunction associated with obesity NIH/Nat. Inst. of Diabetes & Digestive & Kidney Diseases Principal Investigator
Vivek Khanal ASBMR 2025 President's Award American Society for Bone and Mineral Research Principal Investigator
Role of subchondral bone osteocytes in post-traumatic osteoarthritis US Department of Defense Principal Investigator
ABI P. Prather NIH T32 FY26 Y3 State of Arkansas Principal Investigator