Match tier
Confirmed
Presence
Current · Arkansas
Last published
2025
Sources
OpenAlex · ORCID
Refreshed
2026-10-05
M
Michael L. Blackburn
Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.
High Impact
Research Associate III
Also affiliated: University of Washington (2003–2004); University of Arkansas Medical Center (2020–2024); VA Puget Sound Health Care System (2003–2008); Arkansas Children's Nutrition Center (2008–2025)
26 h-index
76 pubs
2,218 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Michael L. Blackburn's research focuses on the physiological and molecular mechanisms underlying bone health, metabolism, and related conditions, primarily utilizing mouse and rat models. His work investigates the impact of dietary factors, such as high-fat diets and phenolic acids, on bone development and the prevention of bone loss, particularly in contexts of sex-steroid deficiency. Blackburn has explored the role of specific genes and cellular processes, including Nox4 expression in osteo-progenitors and the function of Ezh2 in myeloid cells, in regulating bone formation and resorption.
Further research includes examining the metabolic physiology of myoglobin knockout mice, exploring potential roles for globins in adipose tissue, and assessing the impact of soy-based formulas on reproductive health in piglets. He also investigates genetic factors, such as GPR109A, in ameliorating bone loss. Blackburn's scholarship metrics include an h-index of 26, with 77 total publications and 2,165 total citations, designating him as a highly cited researcher. He collaborates with researchers from the University of Arkansas at Fayetteville and the University of Arkansas for Medical Sciences, including Jin‐Ran Chen, Oxana P. Lazarenko, Perry C. Caviness, and Umesh D. Wankhade, and leads a research group.
Metrics
- h-index: 26
- Publications: 76
- Citations: 2,218
Positions
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Research Associate III 2006–presentArkansas Children's Nutrition Center ORCID
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Research Associate III publications 2005–2025University of Arkansas for Medical Sciences ORCID
Selected Publications
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Soy Isoflavones Prevent Bone Quality Loss Induced by High‐Fat Diet in Rats Through Epigenetic Modifications (2025)
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Sex dependent effects of GPR109A gene deletion in myeloid cells on bone development in mice (2025)
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Cystatin M/E Ameliorates Multiple Myeloma-Induced Hyper Osteolytic Bone Resorption (2025)
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Cystatin M/E ameliorates bone resorption through increasing osteoclastic cell estrogen influx (2024)
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Phenolic acids prevent sex-steroid deficiency-induced bone loss and bone marrow adipogenesis in mice (2024)
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Decreased bone resorption in Ezh2 myeloid cell conditional knockout mouse model (2023)
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Maternal high-fat diet modifies epigenetic marks H3K27me3 and H3K27ac in bone to regulate offspring osteoblastogenesis in mice (2022)
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Nox4 expression in osteo-progenitors controls bone development in mice during early life (2022)
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GPR109A gene deletion ameliorates gonadectomy-induced bone loss in mice (2022)
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Metabolic physiology and skeletal muscle phenotypes in male and female myoglobin knockout mice (2021)
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On the potential role of globins in brown adipose tissue: a novel conceptual model and studies in myoglobin knockout mice (2021)
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Short‐Term Increased Physical Activity During Early Life Affects High‐Fat Diet–Induced Bone Loss in Young Adult Mice (2021)
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Ezh2 mediates epigenetic regulation of osteoclastogenesis and bone remodeling in mice (2021)
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Carnitine palmitoyltransferase 2 knockout potentiates palmitate-induced insulin resistance in C2C12myotubes (2020)
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Increased Physical Activity During Early Life Exacerbates High Fat Diet-Induced Bone Loss in Adult Mice (2020)
Collaboration Network
Top Collaborators
Jin‐Ran Chen
University of Arkansas Medical Center
33 shared publications
In database
- Dietary-induced serum phenolic acids promote bone growth via p38 MAPK/β-catenin canonical Wnt signaling
- Maternal Obesity Promotes a Proinflammatory Signature in Rat Uterus and Blastocyst
- Obesity Reduces Bone Density Associated with Activation of PPARγ and Suppression of Wnt/β-Catenin in Rapidly Growing Male Rats
- Feeding Blueberry Diets in Early Life Prevent Senescence of Osteoblasts and Bone Loss in Ovariectomized Adult Female Rats
- Ethanol Impairs Estrogen Receptor Signaling Resulting in Accelerated Activation of Senescence Pathways, Whereas Estradiol Attenuates the Effects of Ethanol in Osteoblasts
Showing 5 of 33 shared publications
Oxana P. Lazarenko
Arkansas Children's Nutrition Center
30 shared publications
In database
- Dietary-induced serum phenolic acids promote bone growth via p38 MAPK/β-catenin canonical Wnt signaling
- Obesity Reduces Bone Density Associated with Activation of PPARγ and Suppression of Wnt/β-Catenin in Rapidly Growing Male Rats
- Feeding Blueberry Diets in Early Life Prevent Senescence of Osteoblasts and Bone Loss in Ovariectomized Adult Female Rats
- Ethanol Impairs Estrogen Receptor Signaling Resulting in Accelerated Activation of Senescence Pathways, Whereas Estradiol Attenuates the Effects of Ethanol in Osteoblasts
- Inhibition of fetal bone development through epigenetic down‐regulation of HoxA10 in obese rats fed high‐fat diet
Showing 5 of 30 shared publications
Martin J. J. Ronis
Louisiana Cancer Research Center (US)
26 shared publications
- Dietary-induced serum phenolic acids promote bone growth via p38 MAPK/β-catenin canonical Wnt signaling
- Maternal Obesity Promotes a Proinflammatory Signature in Rat Uterus and Blastocyst
- Obesity Reduces Bone Density Associated with Activation of PPARγ and Suppression of Wnt/β-Catenin in Rapidly Growing Male Rats
- Maternal Obesity during Gestation Impairs Fatty Acid Oxidation and Mitochondrial SIRT3 Expression in Rat Offspring at Weaning
- Feeding Blueberry Diets in Early Life Prevent Senescence of Osteoblasts and Bone Loss in Ovariectomized Adult Female Rats
Showing 5 of 26 shared publications
Thomas M. Badger
Arkansas Children's Nutrition Center
25 shared publications
In database
- Dietary-induced serum phenolic acids promote bone growth via p38 MAPK/β-catenin canonical Wnt signaling
- Maternal Obesity Promotes a Proinflammatory Signature in Rat Uterus and Blastocyst
- Obesity Reduces Bone Density Associated with Activation of PPARγ and Suppression of Wnt/β-Catenin in Rapidly Growing Male Rats
- Maternal Obesity during Gestation Impairs Fatty Acid Oxidation and Mitochondrial SIRT3 Expression in Rat Offspring at Weaning
- Feeding Blueberry Diets in Early Life Prevent Senescence of Osteoblasts and Bone Loss in Ovariectomized Adult Female Rats
Showing 5 of 25 shared publications
Kartik Shankar
Arkansas Children's Nutrition Center (US)
20 shared publications
- Dietary-induced serum phenolic acids promote bone growth via p38 MAPK/β-catenin canonical Wnt signaling
- Maternal Obesity Promotes a Proinflammatory Signature in Rat Uterus and Blastocyst
- Obesity Reduces Bone Density Associated with Activation of PPARγ and Suppression of Wnt/β-Catenin in Rapidly Growing Male Rats
- Maternal Obesity during Gestation Impairs Fatty Acid Oxidation and Mitochondrial SIRT3 Expression in Rat Offspring at Weaning
- Feeding Blueberry Diets in Early Life Prevent Senescence of Osteoblasts and Bone Loss in Ovariectomized Adult Female Rats
Showing 5 of 20 shared publications
Kikumi D. Ono‐Moore
Arkansas Children's Nutrition Center (US)
8 shared publications
- Blood cytokine patterns suggest a modest inflammation phenotype in subjects with long‐chain fatty acid oxidation disorders
- On the potential role of globins in brown adipose tissue: a novel conceptual model and studies in myoglobin knockout mice
- Carnitine palmitoyltransferase 2 knockout potentiates palmitate-induced insulin resistance in C2C12myotubes
- Is palmitate truly proinflammatory? Experimental confounders and context-specificity
- Metabolic physiology and skeletal muscle phenotypes in male and female myoglobin knockout mice
Showing 5 of 8 shared publications
Sean H. Adams
Arkansas Children's Nutrition Center
8 shared publications
In database
- Blood cytokine patterns suggest a modest inflammation phenotype in subjects with long‐chain fatty acid oxidation disorders
- On the potential role of globins in brown adipose tissue: a novel conceptual model and studies in myoglobin knockout mice
- Carnitine palmitoyltransferase 2 knockout potentiates palmitate-induced insulin resistance in C2C12myotubes
- Is palmitate truly proinflammatory? Experimental confounders and context-specificity
- Metabolic physiology and skeletal muscle phenotypes in male and female myoglobin knockout mice
Showing 5 of 8 shared publications
Jennifer F. Chen
Arkansas Children's Nutrition Center
8 shared publications
In database
- Nox4 expression in osteo-progenitors controls bone development in mice during early life
- Nox4 expression in osteo-progenitors controls bone development in mice during early life
- Phenolic acids prevent sex-steroid deficiency-induced bone loss and bone marrow adipogenesis in mice
- Phenolic acids prevent sex-steroid deficiency-induced bone loss and bone marrow adipogenesis in mice
- Soy Isoflavones Prevent Bone Quality Loss Induced by High‐Fat Diet in Rats Through Epigenetic Modifications
Showing 5 of 8 shared publications
Perry C. Caviness
Arkansas Children's Nutrition Center
6 shared publications
In database
- Maternal high-fat diet modifies epigenetic marks H3K27me3 and H3K27ac in bone to regulate offspring osteoblastogenesis in mice
- Decreased bone resorption in Ezh2 myeloid cell conditional knockout mouse model
- Phenolic acids prevent sex-steroid deficiency-induced bone loss and bone marrow adipogenesis in mice
- Soy Isoflavones Prevent Bone Quality Loss Induced by High‐Fat Diet in Rats Through Epigenetic Modifications
- Cystatin M/E Ameliorates Multiple Myeloma-Induced Hyper Osteolytic Bone Resorption
Showing 5 of 6 shared publications
Mario A. Cleves
Arkansas Children's Nutrition Center (US)
5 shared publications
- Formula feeding alters hepatic gene expression signature, iron and cholesterol homeostasis in the neonatal pig
- Uterine responses to feeding soy protein isolate and treatment with 17β-estradiol differ in ovariectomized female rats
- Estradiol and NADPH oxidase crosstalk regulates responses to high fat feeding in female mice
- Feeding soy protein isolate and treatment with estradiol have different effects on mammary gland morphology and gene expression in weanling male and female rats
- Influence of fat/carbohydrate ratio on progression of fatty liver disease and on development of osteopenia in male rats fed alcohol via total enteral nutrition (TEN)
Junhui Zou
University of Arkansas for Medical Sciences (US)
4 shared publications
- TLS-ERG Leukemia Fusion Protein Deregulates Cyclin-Dependent Kinase 1 and Blocks Terminal Differentiation of Myeloid Progenitor Cells
- Proper expression of helix–loop–helix protein Id2 is important to chondrogenic differentiation of ATDC5 cells
- Oncogenic TLS-ERG Fusion Protein Promotes Differentiation of Myeloid Progenitors into Myeloblasts but Blocks Their Terminal Differentiation.
- TLS-ERG Fusion Protein Blocks Terminal Differentiation of Myeloid Progenitor Cells through Deregulation of Cyclin-Dependent Kinase 1 (CDK1).
Jamie Badeaux
Arkansas Children's Nutrition Center (US)
4 shared publications
- The role of ethanol metabolism in development of alcoholic steatohepatitis in the rat
- Infant Formula Promotes Bone Growth in Neonatal Piglets by Enhancing Osteoblastogenesis through Bone Morphogenic Protein Signaling , ,
- Formula feeding alters hepatic gene expression signature, iron and cholesterol homeostasis in the neonatal pig
- Formula Feeding and Protein Source Alter Hepatic Gene Expression, Iron and Lipid Homeostasis in Neonatal Piglets
Umesh D. Wankhade
Arkansas Children's Nutrition Center
4 shared publications
In database
- 3‐(3‐Hydroxyphenyl)‐Propionic Acid (PPA) Suppresses Osteoblastic Cell Senescence to Promote Bone Accretion in Mice
- On the potential role of globins in brown adipose tissue: a novel conceptual model and studies in myoglobin knockout mice
- Maternal high-fat diet modifies epigenetic marks H3K27me3 and H3K27ac in bone to regulate offspring osteoblastogenesis in mice
- Short‐Term Increased Physical Activity During Early Life Affects High‐Fat Diet–Induced Bone Loss in Young Adult Mice
Eugénia Carvalho
Arkansas Children's Nutrition Center (US)
4 shared publications
- Neonatal diet impacts liver mitochondrial bioenergetics in piglets fed formula or human milk
- Short‐Term Increased Physical Activity During Early Life Affects High‐Fat Diet–Induced Bone Loss in Young Adult Mice
- Increased Physical Activity During Early Life Exacerbates High Fat Diet-Induced Bone Loss in Adult Mice
- Increased Physical Activity Ameliorates High Fat Diet‐Induced Bone Resorption in Mice
Elisabet Børsheim
Arkansas Children's Nutrition Center
4 shared publications
In database
- Neonatal diet impacts liver mitochondrial bioenergetics in piglets fed formula or human milk
- Short‐Term Increased Physical Activity During Early Life Affects High‐Fat Diet–Induced Bone Loss in Young Adult Mice
- Increased Physical Activity During Early Life Exacerbates High Fat Diet-Induced Bone Loss in Adult Mice
- Increased Physical Activity Ameliorates High Fat Diet‐Induced Bone Resorption in Mice
Similar Researchers
Based on overlapping research topics
Perry C. Caviness
University of Arkansas for Medical Sciences
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Christopher E. Randolph
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Oxana P. Lazarenko
University of Arkansas for Medical Sciences
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