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Presence Current · Arkansas
Last published 2026
Sources OpenAlex · ORCID
Refreshed 2026-08-15

Randal S. Shelton

Researcher

Also affiliated: Winthrop Rockefeller Foundation (2019–2021)

Faculty Researcher

5 h-index 20 pubs 71 cited

  • Animals
  • Humans
  • Solanum lycopersicum
  • Nanotubes, Carbon
  • Mice
  • Multiple Myeloma
  • Immune Checkpoint Inhibitors
  • Carcinoma, Hepatocellular
  • Liver Neoplasms
  • Tumor Microenvironment
  • Agriculture
  • Plants
  • Risk Assessment
  • DNA-Binding Proteins
  • Transcription Factors

Biography and Research Information

OverviewAI-generated summary

Randal S. Shelton's research focuses on modifying the tumor microenvironment to enhance the effectiveness of cancer therapies. He investigates strategies for improving immune responses and survival rates in models of hepatocellular carcinoma and pancreatic cancer. His work includes exploring novel oncolytic viruses in combination with immune checkpoint blockade, as well as the multimodal reprogramming of the tumor microenvironment through various therapeutic approaches.

Shelton also studies the risk assessment of nanomaterials, specifically carbon nanotubes, for agricultural applications. His research extends to understanding cellular injury mechanisms, such as the role of Endonuclease G in kidney tubular epithelial cells during cisplatin injury. He has published 20 papers with an h-index of 4 and has collaborated extensively with Alexei G. Basnakian, Steven R. Post, Martin J. Cannon, and Mulu Z. Tesfay.

Metrics

  • h-index: 5
  • Publications: 20
  • Citations: 71

Selected Publications

  • Abstract 4378: Live attenuated MMR vaccines modulate tumor immune cell infiltration and synergize with standard of care to prolong survival in preclinical HCC models (2026)
    Cancer Research DOI OpenAlex
  • Pancreatic tumor microenvironment reprogramming via alloantigen-expressing virotherapy elicits tumor rejection and improves immunotherapy response (2026)
    Journal for ImmunoTherapy of Cancer DOI OpenAlex
  • Multimodal reprogramming of the tumor microenvironment by MMR and dual checkpoint blockade in hepatocellular carcinoma models (2025)
    Frontiers in Immunology 1 citation DOI OpenAlex
  • Abstract 945: Live attenuated MMR vaccines modulate tumor immune cell infiltration and synergize with standard of care to prolong survival in preclinical HCC models (2025)
    Cancer Research DOI OpenAlex
  • Enhancing Neoadjuvant Virotherapy’s Effectiveness by Targeting Stroma to Improve Resectability in Pancreatic Cancer (2024)
    Biomedicines 5 citations DOI OpenAlex
  • Abstract 5004: Oncolytic Jurona-driven systemic and intratumoral immunotherapy combined with immune checkpoint blockade boost immune response and survival in hepatocellular carcinoma models (2024)
    Cancer Research DOI OpenAlex
  • Endonuclease G (EndoG) Inhibits DNase I-Mediated Apoptosis and DNA Repair in Kidney Tubular Epithelial Cells During Cisplatin Injury (2023)
    Journal of the American Society of Nephrology DOI OpenAlex
  • Comprehensive Risk Assessment of Carbon Nanotubes Used for Agricultural Applications (2022)
    ACS Nano 23 citations DOI OpenAlex
  • PHF19 inhibition as a therapeutic target in multiple myeloma (2021)
    Current Research in Translational Medicine 9 citations DOI OpenAlex
  • The Role of PHF19 As a Promoter of Tumorigenicity and Therapeutic Target in Multiple Myeloma (2019)
    Blood DOI OpenAlex
  • Proliferation and Molecular Risk Score of Low Risk Myeloma Cells Are Increased in High Risk Microenvironment Via Augmented Bioavailability of Growth Factors (2018)
    Blood DOI OpenAlex
  • Sclerostin Antibody Treatment Stimulates Bone Formation to Normalize Bone Mass in Male Down Syndrome Mice (2017)
    JBMR Plus 19 citations DOI OpenAlex
  • Mesenchymal Stem Cells Preconditioned with Myeloma Cells from High-Risk Patients Support the Growth of Myeloma Cells from Low-Risk Patients (2016)
    Blood 3 citations DOI OpenAlex
  • Utility of an allograft tendon for scoliosis correction via the costo‐transverse foreman (2016)
    Journal of Orthopaedic Research® 2 citations DOI OpenAlex
  • Sustained Growth of Primary Myeloma Cells in Coculture with Whole Donor Bone Marrow Is Associated with Induced Secretion of the Microenvironmental Mediator of Cytokinesis, Hemicentin-1 (2014)
    Blood 1 citation DOI OpenAlex

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Collaboration Network

72 Collaborators 24 Institutions 2 Countries

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