Katherine Wallis

Research Assistant

University of Arkansas for Medical Sciences

grad_student

5 h-index 19 pubs 143 cited

Research Areas

Diet and metabolism studies Cancer Treatment and Pharmacology Immune Response and Inflammation Cancer Immunotherapy and Biomarkers Molecular Biology Techniques and Applications Metabolism and Genetic Disorders CAR-T cell therapy research

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OverviewAI-generated summary

Katherine Wallis's research focuses on the intersection of diet, metabolism, and cancer treatment, particularly investigating the role of nutrient restriction in enhancing the efficacy of immune checkpoint inhibitors. Her work has explored how dietary methionine restriction can increase response rates to these therapies in colorectal cancer and melanoma models. Wallis has also examined the mechanisms by which caloric restriction mimetics and specific compounds like resveratrol can influence anti-tumor immunity, including their impact on antigen presentation and T-cell function.

Her investigations have also delved into the cellular processes underlying nutrient deprivation, such as differences in cell death pathways when cells are deprived of methionine versus cysteine. Wallis has experience with various laboratory techniques, including cell culture, protein and nucleic acid extraction, Western blots, and Seahorse assays. She has also been involved in preclinical studies using tumor-bearing mouse models, performing injections, necropsies, and tissue collection. Her collaborations include researchers at the University of Arkansas for Medical Sciences, with whom she has co-authored multiple publications.

Metrics

h-index: 5
Publications: 19
Citations: 143

Selected Publications

685 EZH2 inhibition impairs CD8+ CAR-T cell persistence (2025) DOI
691 ATF6 activation promotes ICB response in melanoma (2025) DOI
762 CD28 costimulation induces PCK2 to support T cell effector function in metabolically hostile environments (2025) DOI
236 Manipulating the DNA damage response to combat T cell exhaustion and improve immunotherapy response (2025) DOI
538 ATF6 activation in melanoma promotes anti-tumor immunity and improves ICB therapy response (2024) DOI
929 Proteomic analysis reveals differential modulation of the DNA damage response in exhausted T cells (2024) DOI
932 Defining the role for PCK2 in T-cell metabolic plasticity (2024) DOI
Abstract 3625: Metabolic phenotypes of doxorubicin-induced cardiotoxicity in breast cancer patients (2024) DOI
Resveratrol induces major histocompatibility complex class I antigen presentation in a STING-dependent and independent manner in melanoma (2023) DOI
Increased Response to Immune Checkpoint Inhibitors with Dietary Methionine Restriction in a Colorectal Cancer Model (2023) DOI
Increased response to immune checkpoint inhibitors with dietary methionine restriction (2023) DOI
Abstract P3-08-08: Establishment of a Breast Cancer Rat Model of Chemotherapy-Induced Cardiotoxicity (2023) DOI
Increased Response to Immune Checkpoint Inhibitors with Dietary Methionine Restriction (2023) DOI
Abstract 1577: Caloric restriction mimetics as adjuvant to immune checkpoint inhibitors for treatment of melanoma (2021) DOI
32219 Differences in cell death in methionine versus cysteine depletion (2021) DOI