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Biography and Research Information
OverviewAI-generated summary
Katherine Wallis's research focuses on the intersection of diet, metabolism, and cancer treatment, particularly in the context of immune checkpoint inhibitors. Her work has investigated the effects of nutrient restriction, such as methionine depletion, on tumor response in preclinical models. This includes studies exploring how dietary interventions can enhance the efficacy of immunotherapies in cancers like colorectal cancer and melanoma.
Wallis has also examined specific molecular mechanisms underlying treatment response. Her publications include research on how resveratrol influences antigen presentation in melanoma and the activation of specific cellular pathways like ATF6 in promoting responses to immune checkpoint inhibitors. Additionally, her work has explored differences in cell death pathways triggered by the depletion of essential amino acids like methionine and cysteine. Her research network includes frequent collaborations with researchers at the University of Arkansas for Medical Sciences, such as Brian Koss and Daniel Fil.
Metrics
- h-index: 5
- Publications: 20
- Citations: 152
Selected Publications
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685 EZH2 inhibition impairs CD8+ CAR-T cell persistence (2025)
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691 ATF6 activation promotes ICB response in melanoma (2025)
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762 CD28 costimulation induces PCK2 to support T cell effector function in metabolically hostile environments (2025)
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236 Manipulating the DNA damage response to combat T cell exhaustion and improve immunotherapy response (2025)
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538 ATF6 activation in melanoma promotes anti-tumor immunity and improves ICB therapy response (2024)
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929 Proteomic analysis reveals differential modulation of the DNA damage response in exhausted T cells (2024)
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932 Defining the role for PCK2 in T-cell metabolic plasticity (2024)
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Abstract 3625: Metabolic phenotypes of doxorubicin-induced cardiotoxicity in breast cancer patients (2024)
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Resveratrol induces major histocompatibility complex class I antigen presentation in a STING-dependent and independent manner in melanoma (2023)
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Increased Response to Immune Checkpoint Inhibitors with Dietary Methionine Restriction in a Colorectal Cancer Model (2023)
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Increased response to immune checkpoint inhibitors with dietary methionine restriction (2023)
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Abstract P3-08-08: Establishment of a Breast Cancer Rat Model of Chemotherapy-Induced Cardiotoxicity (2023)
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Increased Response to Immune Checkpoint Inhibitors with Dietary Methionine Restriction (2023)
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Abstract 1577: Caloric restriction mimetics as adjuvant to immune checkpoint inhibitors for treatment of melanoma (2021)
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32219 Differences in cell death in methionine versus cysteine depletion (2021)
Collaboration Network
Top Collaborators
Brian Koss
University of Arkansas for Medical Sciences
9 shared publications
In database
- Resveratrol induces major histocompatibility complex class I antigen presentation in a STING-dependent and independent manner in melanoma
- Abstract 1577: Caloric restriction mimetics as adjuvant to immune checkpoint inhibitors for treatment of melanoma
- 932 Defining the role for PCK2 in T-cell metabolic plasticity
- 929 Proteomic analysis reveals differential modulation of the DNA damage response in exhausted T cells
- 538 ATF6 activation in melanoma promotes anti-tumor immunity and improves ICB therapy response
Showing 5 of 9 shared publications
Daniel Fil
University of Arkansas for Medical Sciences
8 shared publications
In database
- Resveratrol induces major histocompatibility complex class I antigen presentation in a STING-dependent and independent manner in melanoma
- 932 Defining the role for PCK2 in T-cell metabolic plasticity
- 929 Proteomic analysis reveals differential modulation of the DNA damage response in exhausted T cells
- 538 ATF6 activation in melanoma promotes anti-tumor immunity and improves ICB therapy response
- 236 Manipulating the DNA damage response to combat T cell exhaustion and improve immunotherapy response
Showing 5 of 8 shared publications
Isabelle R. Miousse
University of Arkansas for Medical Sciences
7 shared publications
In database
- Differences in cell death in methionine versus cysteine depletion
- Increased Response to Immune Checkpoint Inhibitors with Dietary Methionine Restriction in a Colorectal Cancer Model
- Increased Response to Immune Checkpoint Inhibitors with Dietary Methionine Restriction
- Increased response to immune checkpoint inhibitors with dietary methionine restriction
- Resveratrol induces major histocompatibility complex class I antigen presentation in a STING-dependent and independent manner in melanoma
Showing 5 of 7 shared publications
Alan J. Tackett
University of Arkansas for Medical Sciences
7 shared publications
In database
- Increased Response to Immune Checkpoint Inhibitors with Dietary Methionine Restriction in a Colorectal Cancer Model
- Increased Response to Immune Checkpoint Inhibitors with Dietary Methionine Restriction
- Increased response to immune checkpoint inhibitors with dietary methionine restriction
- Resveratrol induces major histocompatibility complex class I antigen presentation in a STING-dependent and independent manner in melanoma
- Abstract 1577: Caloric restriction mimetics as adjuvant to immune checkpoint inhibitors for treatment of melanoma
Showing 5 of 7 shared publications
Lauren C. Morehead
University of Arkansas for Medical Sciences
6 shared publications
In database
- Differences in cell death in methionine versus cysteine depletion
- Increased Response to Immune Checkpoint Inhibitors with Dietary Methionine Restriction in a Colorectal Cancer Model
- Increased Response to Immune Checkpoint Inhibitors with Dietary Methionine Restriction
- Increased response to immune checkpoint inhibitors with dietary methionine restriction
- Resveratrol induces major histocompatibility complex class I antigen presentation in a STING-dependent and independent manner in melanoma
Showing 5 of 6 shared publications
Sydnye L. Shuttleworth
University of Arkansas for Medical Sciences
6 shared publications
In database
- 932 Defining the role for PCK2 in T-cell metabolic plasticity
- 929 Proteomic analysis reveals differential modulation of the DNA damage response in exhausted T cells
- 236 Manipulating the DNA damage response to combat T cell exhaustion and improve immunotherapy response
- 762 CD28 costimulation induces PCK2 to support T cell effector function in metabolically hostile environments
- 691 ATF6 activation promotes ICB response in melanoma
Showing 5 of 6 shared publications
Sarita Garg
University of Arkansas for Medical Sciences
4 shared publications
In database
- Increased Response to Immune Checkpoint Inhibitors with Dietary Methionine Restriction in a Colorectal Cancer Model
- Increased Response to Immune Checkpoint Inhibitors with Dietary Methionine Restriction
- Increased response to immune checkpoint inhibitors with dietary methionine restriction
- Resveratrol induces major histocompatibility complex class I antigen presentation in a STING-dependent and independent manner in melanoma
Billie Heflin
University of Arkansas for Medical Sciences
4 shared publications
In database
- Resveratrol induces major histocompatibility complex class I antigen presentation in a STING-dependent and independent manner in melanoma
- 538 ATF6 activation in melanoma promotes anti-tumor immunity and improves ICB therapy response
- 691 ATF6 activation promotes ICB response in melanoma
- 685 EZH2 inhibition impairs CD8+ CAR-T cell persistence
Jacob L Edmondson
University of Arkansas for Medical Sciences
4 shared publications
In database
- 932 Defining the role for PCK2 in T-cell metabolic plasticity
- 538 ATF6 activation in melanoma promotes anti-tumor immunity and improves ICB therapy response
- 762 CD28 costimulation induces PCK2 to support T cell effector function in metabolically hostile environments
- 691 ATF6 activation promotes ICB response in melanoma
Lora J. Rogers
University of Arkansas for Medical Sciences
4 shared publications
In database
- 932 Defining the role for PCK2 in T-cell metabolic plasticity
- 236 Manipulating the DNA damage response to combat T cell exhaustion and improve immunotherapy response
- 762 CD28 costimulation induces PCK2 to support T cell effector function in metabolically hostile environments
- 685 EZH2 inhibition impairs CD8+ CAR-T cell persistence
Jessica L Kelliher
University of Arkansas for Medical Sciences (US)
4 shared publications
- 932 Defining the role for PCK2 in T-cell metabolic plasticity
- 929 Proteomic analysis reveals differential modulation of the DNA damage response in exhausted T cells
- 236 Manipulating the DNA damage response to combat T cell exhaustion and improve immunotherapy response
- 762 CD28 costimulation induces PCK2 to support T cell effector function in metabolically hostile environments
Eric R. Siegel
University of Arkansas for Medical Sciences
3 shared publications
In database
- Increased Response to Immune Checkpoint Inhibitors with Dietary Methionine Restriction in a Colorectal Cancer Model
- Increased Response to Immune Checkpoint Inhibitors with Dietary Methionine Restriction
- Increased response to immune checkpoint inhibitors with dietary methionine restriction
Megan R. Reed
University of Arkansas for Medical Sciences
3 shared publications
In database
- 538 ATF6 activation in melanoma promotes anti-tumor immunity and improves ICB therapy response
- 691 ATF6 activation promotes ICB response in melanoma
- 685 EZH2 inhibition impairs CD8+ CAR-T cell persistence
Thomas A. Williams
University of Arkansas for Medical Sciences
3 shared publications
In database
- 236 Manipulating the DNA damage response to combat T cell exhaustion and improve immunotherapy response
- 762 CD28 costimulation induces PCK2 to support T cell effector function in metabolically hostile environments
- 685 EZH2 inhibition impairs CD8+ CAR-T cell persistence
Sam Makhoul
2 shared publications
- Abstract P3-08-08: Establishment of a Breast Cancer Rat Model of Chemotherapy-Induced Cardiotoxicity
- Abstract 3625: Metabolic phenotypes of doxorubicin-induced cardiotoxicity in breast cancer patients
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