Match tier Listed
Presence Current · Arkansas
Last published 2026
Sources OpenAlex · ORCID
Refreshed 2026-08-15
Brian D. Piccolo profile photo

Brian D. Piccolo

High Impact

Assistant Professor, Tenure Track

Also affiliated: Arkansas Children's Hospital (2018–2024); Agricultural Research Service (2015–2020); United States Department of Agriculture (2020–2022); University of California System (2011); Joint Center for Structural Genomics (2015); Western Human Nutrition Research Center (2015–2020); Arkansas Children's Nutrition Center (2016–2026); University of California, Davis (2010–2020)

Faculty Researcher

Peds Pediatrics, College of Medicine

24 h-index 93 pubs 1,878 cited

  • Gastrointestinal Microbiome
  • Animals
  • Male
  • Humans
  • Female
  • Metabolome
  • Diet
  • Metabolomics
  • Obesity
  • Liver
  • Swine
  • Mice
  • Adult
  • Bacteria
  • Animals, Newborn

Biography and Research Information

OverviewAI-generated summary

Brian D. Piccolo's research focuses on the interplay between diet, the gut microbiome, and metabolic health, particularly in the context of obesity and liver disease. His work utilizes animal models, including mice, pigs, and rats, to investigate how dietary components and interventions influence microbial composition, bile acid metabolism, and disease progression. He has explored the effects of specific diets, such as blueberry, olive oil, and coconut oil, on vascular complications in diabetes and liver injury in models of non-alcoholic fatty liver disease (NAFLD).

Further investigations by Piccolo examine how dietary manipulations, like iron deficiency or varying fat compositions, impact gut health and enteric infections. His research also extends to human studies, analyzing how diet and exercise affect the gut microbiome and circulating metabolites in adults. He has published on the associations between maternal diet, body composition, and offspring gut microbiome in the first year of life, highlighting the importance of early life nutrition.

Piccolo holds an Assistant Professor position in the Department of Pediatrics at the University of Arkansas for Medical Sciences. His scholarship metrics include an h-index of 24 and over 1,700 citations across 90 publications. He leads a research group and collaborates with several colleagues at his institution, including Sree V. Chintapalli, Renny S. Lan, Sean H. Adams, and Lindsay Pack.

Metrics

  • h-index: 24
  • Publications: 93
  • Citations: 1,878

Selected Publications

  • Metabolic Functional Guilds Drive Fiber-Specific Xenometabolite Signatures From Human Gut Microbiota (2026)
    Current Developments in Nutrition DOI OpenAlex
  • Integrating fingerprint prediction and physicochemical property filtering to annotate unknown metabolites from high-resolution MS/MS spectra (2026)
    Microchemical Journal DOI OpenAlex
  • Xenometabolomics reveals metabolic functional guilds unique to specific inulin subtypes in human gut microbiota cultures (2025)
    mSystems 3 citations DOI OpenAlex
  • Beyond the Known Metabolome: Predictive Strategies for Dark Matter Discovery (2025)
    Current Developments in Nutrition DOI OpenAlex
  • Fueling the fire: colonocyte metabolism and its effect on the colonic epithelia (2025)
    Critical Reviews in Food Science and Nutrition 12 citations DOI OpenAlex
  • Novel odd-chain cyclopropane fatty acids: detection in a mammalian lipidome and uptake by hepatosplanchnic tissues (2024)
    Journal of Lipid Research 5 citations DOI OpenAlex
  • Effects of Statin and Annatto-extracted Tocotrienol Supplementation on Glucose Homeostasis, Bone Microstructure, and Gut Microbiota Composition in Obese Mice (2024)
    In Vivo 5 citations DOI OpenAlex
  • Colonic epithelial hypoxia remains constant during the progression of diabetes in male UC Davis type 2 diabetes mellitus rats (2024)
    BMJ Open Diabetes Research & Care 4 citations DOI OpenAlex
  • Physiological response to fetal intravenous lipid emulsion (2024)
    Clinical Science 3 citations DOI OpenAlex
  • Parental cardiorespiratory fitness influences early life energetics and metabolic health (2023)
    Physiological Genomics 4 citations DOI OpenAlex
  • Exercise training modifies xenometabolites in gut and circulation of lean and obese adults (2023)
    Physiological Reports 15 citations DOI OpenAlex
  • Olive- and Coconut-Oil-Enriched Diets Decreased Secondary Bile Acids and Regulated Metabolic and Transcriptomic Markers of Brain Injury in the Frontal Cortexes of NAFLD Pigs (2022)
    Brain Sciences 10 citations DOI OpenAlex
  • Dietary fat composition shapes bile acid metabolism and severity of liver injury in a pig model of pediatric NAFLD (2022)
    American Journal of Physiology-Endocrinology and Metabolism 21 citations DOI OpenAlex
  • C‐section increases cecal abundance of the archetypal bile acid and glucocorticoid modifying <i>Lachnoclostridium [clostridium] scindens</i> in mice (2022)
    Physiological Reports 4 citations DOI OpenAlex
  • Iron deficient diets modify the gut microbiome and reduce the severity of enteric infection in a mouse model of S. Typhimurium-induced enterocolitis (2022)
    The Journal of Nutritional Biochemistry 17 citations DOI OpenAlex

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Collaboration Network

102 Collaborators 30 Institutions 3 Countries

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