Match tier
Listed
Presence
Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-10-05
Brian D. Piccolo
High Impact
Assistant Professor, Tenure Track
Also affiliated: Agricultural Research Service (2015–2023); United States Department of Agriculture (2015–2022); University of Arkansas Medical Center (2018); Western Human Nutrition Research Center (2015–2020); Arkansas Children's Nutrition Center (2016–2026); Arkansas Children's Research Institute (2023–2026); University of California, Davis (2010–2020)
Peds Pediatrics, College of Medicine
25 h-index
94 pubs
1,903 cited
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Brian D. Piccolo's research focuses on the intricate relationships between diet, the gut microbiome, and host metabolism, particularly in the context of obesity and chronic disease. His work investigates how dietary components, such as resistant starch and whey protein, influence microbial communities and their metabolic byproducts.
Piccolo has published studies examining these interactions across various models, including rats, mice, infants, and pigs. His research has explored the impact of maternal diet on offspring liver steatosis and the sexually dimorphic programming of metabolic health. Furthermore, he has investigated the effects of neonatal diet on infant gut microbiota and metabolome profiles, comparing breast milk and formula feeding. His scholarship metrics include an h-index of 25, with 94 total publications and 1,899 total citations, designating him as a highly cited researcher.
His collaborations at the University of Arkansas for Medical Sciences include shared publications with Sree V. Chintapalli, Renny S. Lan, Lindsay Pack, and Michael Scott Robeson. Piccolo leads a research group dedicated to advancing this area of study.
Metrics
- h-index: 25
- Publications: 94
- Citations: 1,903
Positions
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Assistant Professor, Tenure Track 2019–presentUniversity of Arkansas for Medical Sciences Peds Pediatrics, College of Medicine Institutional directory
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Assistant Professor, Non-Tenure Track 2015–2019University of Arkansas for Medical Sciences Pediatrics ORCID
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Postdoctoral Fellow 2013–2014USDA-ARS Arkansas Children's Nutrition Center ORCID
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Postdoctoral Fellow 2012–2013University of California, Davis West Coast Metabolomics Center ORCID
Selected Publications
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From known chemical space to unannotated metabolites: a cluster-guided retention-time driven framework for biologically informed annotation (2026)
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Metabolic Functional Guilds Drive Fiber-Specific Xenometabolite Signatures From Human Gut Microbiota (2026)
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Integrating fingerprint prediction and physicochemical property filtering to annotate unknown metabolites from high-resolution MS/MS spectra (2026)
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Improvement of glucose homeostasis during leptin treatment does not alter the intestinal microbiome in male diabetic UC Davis type-2 diabetes mellitus rats (2026)
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Xenometabolomics reveals metabolic functional guilds unique to specific inulin subtypes in human gut microbiota cultures (2025)
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Beyond the Known Metabolome: Predictive Strategies for Dark Matter Discovery (2025)
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Fueling the fire: colonocyte metabolism and its effect on the colonic epithelia (2025)
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Novel odd-chain cyclopropane fatty acids: detection in a mammalian lipidome and uptake by hepatosplanchnic tissues (2024)
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Effects of Statin and Annatto-extracted Tocotrienol Supplementation on Glucose Homeostasis, Bone Microstructure, and Gut Microbiota Composition in Obese Mice (2024)
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Colonic epithelial hypoxia remains constant during the progression of diabetes in male UC Davis type 2 diabetes mellitus rats (2024)
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Physiological response to fetal intravenous lipid emulsion (2024)
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Parental cardiorespiratory fitness influences early life energetics and metabolic health (2023)
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Exercise training modifies xenometabolites in gut and circulation of lean and obese adults (2023)
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Olive- and Coconut-Oil-Enriched Diets Decreased Secondary Bile Acids and Regulated Metabolic and Transcriptomic Markers of Brain Injury in the Frontal Cortexes of NAFLD Pigs (2022)
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Dietary fat composition shapes bile acid metabolism and severity of liver injury in a pig model of pediatric NAFLD (2022)
Collaboration Network
Top Collaborators
Kartik Shankar
Arkansas Children's Nutrition Center (US)
22 shared publications
- Neonatal diet alters fecal microbiota and metabolome profiles at different ages in infants fed breast milk or formula
- Formula diet driven microbiota shifts tryptophan metabolism from serotonin to tryptamine in neonatal porcine colon
- Maternal High-Fat Diet Programs Offspring Liver Steatosis in a Sexually Dimorphic Manner in Association with Changes in Gut Microbial Ecology in Mice
- Dietary supplementation with strawberry induces marked changes in the composition and functional potential of the gut microbiome in diabetic mice
- Obesity leads to distinct metabolomic signatures in follicular fluid of women undergoing in vitro fertilization
Showing 5 of 22 shared publications
Sean H. Adams
University of California, Davis
21 shared publications
In database
- Resistant starch alters gut microbiome and metabolomic profiles concurrent with amelioration of chronic kidney disease in rats
- Neonatal diet alters fecal microbiota and metabolome profiles at different ages in infants fed breast milk or formula
- Mice Fed a High-Fat Diet Supplemented with Resistant Starch Display Marked Shifts in the Liver Metabolome Concurrent with Altered Gut Bacteria
- Early Postnatal Diets Affect the Bioregional Small Intestine Microbiome and Ileal Metabolome in Neonatal Pigs
- Oxylipin Profiling of Alzheimer’s Disease in Nondiabetic and Type 2 Diabetic Elderly
Showing 5 of 21 shared publications
Sree V. Chintapalli
Arkansas Children's Nutrition Center
19 shared publications
In database
- Neonatal diet alters fecal microbiota and metabolome profiles at different ages in infants fed breast milk or formula
- Formula diet driven microbiota shifts tryptophan metabolism from serotonin to tryptamine in neonatal porcine colon
- Maternal High-Fat Diet Programs Offspring Liver Steatosis in a Sexually Dimorphic Manner in Association with Changes in Gut Microbial Ecology in Mice
- Dietary supplementation with strawberry induces marked changes in the composition and functional potential of the gut microbiome in diabetic mice
- Associations between maternal obesity and offspring gut microbiome in the first year of life
Showing 5 of 19 shared publications
Laxmi Yeruva
Arkansas Children's Nutrition Center
13 shared publications
In database
- Neonatal diet alters fecal microbiota and metabolome profiles at different ages in infants fed breast milk or formula
- Formula diet driven microbiota shifts tryptophan metabolism from serotonin to tryptamine in neonatal porcine colon
- Early Postnatal Diets Affect the Bioregional Small Intestine Microbiome and Ileal Metabolome in Neonatal Pigs
- Neonatal Diet Impacts Bioregional Microbiota Composition in Piglets Fed Human Breast Milk or Infant Formula
- Xenometabolite signatures in the UC Davis type 2 diabetes mellitus rat model revealed using a metabolomics platform enriched with microbe-derived metabolites
Showing 5 of 13 shared publications
Kelly E. Mercer
Arkansas Children's Hospital
12 shared publications
In database
- Neonatal diet alters fecal microbiota and metabolome profiles at different ages in infants fed breast milk or formula
- Formula diet driven microbiota shifts tryptophan metabolism from serotonin to tryptamine in neonatal porcine colon
- Maternal High-Fat Diet Programs Offspring Liver Steatosis in a Sexually Dimorphic Manner in Association with Changes in Gut Microbial Ecology in Mice
- Obesity leads to distinct metabolomic signatures in follicular fluid of women undergoing in vitro fertilization
- Early Postnatal Diets Affect the Bioregional Small Intestine Microbiome and Ileal Metabolome in Neonatal Pigs
Showing 5 of 12 shared publications
Lindsay Pack
Arkansas Children's Nutrition Center
11 shared publications
In database
- Neonatal diet alters fecal microbiota and metabolome profiles at different ages in infants fed breast milk or formula
- Obesity leads to distinct metabolomic signatures in follicular fluid of women undergoing in vitro fertilization
- Associations between maternal obesity and offspring gut microbiome in the first year of life
- Early Postnatal Diets Affect the Bioregional Small Intestine Microbiome and Ileal Metabolome in Neonatal Pigs
- Xenometabolite signatures in the UC Davis type 2 diabetes mellitus rat model revealed using a metabolomics platform enriched with microbe-derived metabolites
Showing 5 of 11 shared publications
Umesh D. Wankhade
Arkansas Children's Nutrition Center
8 shared publications
In database
- Maternal High-Fat Diet Programs Offspring Liver Steatosis in a Sexually Dimorphic Manner in Association with Changes in Gut Microbial Ecology in Mice
- Dietary supplementation with strawberry induces marked changes in the composition and functional potential of the gut microbiome in diabetic mice
- Sex-Specific Changes in Gut Microbiome Composition following Blueberry Consumption in C57BL/6J Mice
- Xenometabolite signatures in the UC Davis type 2 diabetes mellitus rat model revealed using a metabolomics platform enriched with microbe-derived metabolites
- Diabetes-associated alterations in the cecal microbiome and metabolome are independent of diet or environment in the UC Davis Type 2 Diabetes Mellitus Rat model
Showing 5 of 8 shared publications
Renny S. Lan
University of Arkansas for Medical Sciences
8 shared publications
In database
- Associations between maternal obesity and offspring gut microbiome in the first year of life
- Exercise training modifies xenometabolites in gut and circulation of lean and obese adults
- Net release and uptake of xenometabolites across intestinal, hepatic, muscle, and renal tissue beds in healthy conscious pigs
- Novel odd-chain cyclopropane fatty acids: detection in a mammalian lipidome and uptake by hepatosplanchnic tissues
- Colonic epithelial hypoxia remains constant during the progression of diabetes in male UC Davis type 2 diabetes mellitus rats
Showing 5 of 8 shared publications
James L. Graham
University of California, Davis (US)
7 shared publications
- Plasma amino acid and metabolite signatures tracking diabetes progression in the UCD-T2DM rat model
- Xenometabolite signatures in the UC Davis type 2 diabetes mellitus rat model revealed using a metabolomics platform enriched with microbe-derived metabolites
- Diabetes-associated alterations in the cecal microbiome and metabolome are independent of diet or environment in the UC Davis Type 2 Diabetes Mellitus Rat model
- Progression of diabetes is associated with changes in the ileal transcriptome and ileal‐colon morphology in the UC Davis Type 2 Diabetes Mellitus rat
- Colonic epithelial hypoxia remains constant during the progression of diabetes in male UC Davis type 2 diabetes mellitus rats
Showing 5 of 7 shared publications
Aline Andres
Arkansas Children's Nutrition Center
7 shared publications
In database
- Neonatal diet alters fecal microbiota and metabolome profiles at different ages in infants fed breast milk or formula
- Maternal High-Fat Diet Programs Offspring Liver Steatosis in a Sexually Dimorphic Manner in Association with Changes in Gut Microbial Ecology in Mice
- Maternal adiposity alters the human milk metabolome: associations between nonglucose monosaccharides and infant adiposity
- Obesity leads to distinct metabolomic signatures in follicular fluid of women undergoing in vitro fertilization
- Associations between maternal obesity and offspring gut microbiome in the first year of life
Showing 5 of 7 shared publications
Kimber L. Stanhope
University of California, Davis (US)
6 shared publications
- Plasma amino acid and metabolite signatures tracking diabetes progression in the UCD-T2DM rat model
- Xenometabolite signatures in the UC Davis type 2 diabetes mellitus rat model revealed using a metabolomics platform enriched with microbe-derived metabolites
- Diabetes-associated alterations in the cecal microbiome and metabolome are independent of diet or environment in the UC Davis Type 2 Diabetes Mellitus Rat model
- Progression of diabetes is associated with changes in the ileal transcriptome and ileal‐colon morphology in the UC Davis Type 2 Diabetes Mellitus rat
- Colonic epithelial hypoxia remains constant during the progression of diabetes in male UC Davis type 2 diabetes mellitus rats
Showing 5 of 6 shared publications
Peter J. Havel
University of California, Davis (US)
6 shared publications
- Plasma amino acid and metabolite signatures tracking diabetes progression in the UCD-T2DM rat model
- Xenometabolite signatures in the UC Davis type 2 diabetes mellitus rat model revealed using a metabolomics platform enriched with microbe-derived metabolites
- Diabetes-associated alterations in the cecal microbiome and metabolome are independent of diet or environment in the UC Davis Type 2 Diabetes Mellitus Rat model
- Progression of diabetes is associated with changes in the ileal transcriptome and ileal‐colon morphology in the UC Davis Type 2 Diabetes Mellitus rat
- Colonic epithelial hypoxia remains constant during the progression of diabetes in male UC Davis type 2 diabetes mellitus rats
Showing 5 of 6 shared publications
Anne K. Bowlin
Arkansas Children's Nutrition Center
6 shared publications
In database
- Neonatal diet alters fecal microbiota and metabolome profiles at different ages in infants fed breast milk or formula
- Formula diet driven microbiota shifts tryptophan metabolism from serotonin to tryptamine in neonatal porcine colon
- Early Postnatal Diets Affect the Bioregional Small Intestine Microbiome and Ileal Metabolome in Neonatal Pigs
- Neonatal Diet Impacts Bioregional Microbiota Composition in Piglets Fed Human Breast Milk or Infant Formula
- Human Breast-Milk Feeding Enhances the Humoral and Cell-Mediated Immune Response in Neonatal Piglets
Showing 5 of 6 shared publications
Thomas M. Badger
Arkansas Children's Nutrition Center
5 shared publications
In database
- Neonatal diet alters fecal microbiota and metabolome profiles at different ages in infants fed breast milk or formula
- Formula diet driven microbiota shifts tryptophan metabolism from serotonin to tryptamine in neonatal porcine colon
- Early Postnatal Diets Affect the Bioregional Small Intestine Microbiome and Ileal Metabolome in Neonatal Pigs
- Human Breast-Milk Feeding Enhances the Humoral and Cell-Mediated Immune Response in Neonatal Piglets
- Early Diet Has Differential Effects on the Small Intestine Microbiome by Region in Neonatal Piglets
Tanya LeRoith
Virginia Tech (US)
5 shared publications
- Formula diet driven microbiota shifts tryptophan metabolism from serotonin to tryptamine in neonatal porcine colon
- Human Breast-Milk Feeding Enhances the Humoral and Cell-Mediated Immune Response in Neonatal Piglets
- Progression of diabetes is associated with changes in the ileal transcriptome and ileal‐colon morphology in the UC Davis Type 2 Diabetes Mellitus rat
- Colonic epithelial hypoxia remains constant during the progression of diabetes in male UC Davis type 2 diabetes mellitus rats
- Improvement of glucose homeostasis during leptin treatment does not alter the intestinal microbiome in male diabetic UC Davis type-2 diabetes mellitus rats
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