Robert W. Williams
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professor and chair
Faculty Researcher
Upstream record may be merged OpenAlex, the source of these figures, lists 154 institutions in 17 countries for this author record — a pattern that usually means it combines several researchers with similar names. The totals above may include work by other people.
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Robert W. Williams' research program focuses on quantitative genetics, genomics, and the development of computational tools for biological research. He has published extensively on the genetics of complex traits in model organisms, including work on longevity in heterogeneous mouse populations and the genetic basis of mutation spectrum variation. His work also includes the development of platforms and methods for experimental precision medicine, such as the extended BXD mouse family, which facilitates high-throughput genetic studies.
Williams is also involved in the development of bioinformatics tools. This includes work on building pangenome graphs, which are essential for representing genetic diversity within a species, and creating scalable, accessible, and reproducible reference genome assembly and evaluation pipelines within the Galaxy framework. His research extends to ecological modeling, with publications on designing surveys for wildlife populations and modeling ship strike risk to marine mammals.
With an h-index of 96 and over 880 publications, Williams has a significant scholarly record. He has collaborated with researchers such as Mary A. Phillips from the University of Arkansas for Medical Sciences, with whom he shares multiple publications. He maintains an active lab website to disseminate his research.
Metrics
- h-index: 96
- Publications: 880
- Citations: 37,533
Selected Publications
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Open problems in ageing science: a roadmap for biogerontology (2025)
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Progress, challenges and future directions in marine organic-walled dinoflagellate cyst research: New insights from an international workshop (2025)
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The Duke Mouse Brain Atlas: MRI and light sheet microscopy stereotaxic atlas of the mouse brain (2025)
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Inbred rat heredity and sex affect oral oxycodone self-administration and augmented intake in long sessions: correlations with anxiety and novelty-seeking (2025)
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Male and female behavioral variability and morphine response in C57BL/6J, DBA/2J, and their BXD progeny following chronic stress exposure (2024)
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Building pangenome graphs (2024)
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A revamped rat reference genome improves the discovery of genetic diversity in laboratory rats (2024)
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GenomeMUSter mouse genetic variation service enables multitrait, multipopulation data integration and analysis (2024)
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Scalable, accessible and reproducible reference genome assembly and evaluation in Galaxy (2024)
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ACNP 62nd Annual Meeting: Poster Abstracts P251 – P500 (2023)
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Increased development of T-bet+CD11c+ B cells predisposes to lupus in females: Analysis in BXD2 mouse and genetic crosses (2023)
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A rapid workflow for neuron counting in combined light sheet microscopy and magnetic resonance histology (2023)
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DNA methylation networks underlying mammalian traits (2023)
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Universal DNA methylation age across mammalian tissues (2023)
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IGFBPL1 is a master driver of microglia homeostasis and resolution of neuroinflammation in glaucoma and brain tauopathy (2023)
Collaboration Network
Top Collaborators
- A platform for experimental precision medicine: The extended BXD mouse family
- Building pangenome graphs
- Building pangenome graphs
- A natural mutator allele shapes mutation spectrum variation in mice
- Merged magnetic resonance and light sheet microscopy of the whole mouse brain
Showing 5 of 14 shared publications
- A platform for experimental precision medicine: The extended BXD mouse family
- A natural mutator allele shapes mutation spectrum variation in mice
- Multiomic profiling of the liver across diets and age in a diverse mouse population
- IGFBPL1 is a master driver of microglia homeostasis and resolution of neuroinflammation in glaucoma and brain tauopathy
- Genetic susceptibility to diabetic kidney disease is linked to promoter variants of XOR
Showing 5 of 14 shared publications
- A platform for experimental precision medicine: The extended BXD mouse family
- Gene-by-environment modulation of lifespan and weight gain in the murine BXD family
- Gabra2 is a genetic modifier of Dravet syndrome in mice
- Whole genome sequencing of nearly isogenic WMI and WLI inbred rats identifies genes potentially involved in depression and stress reactivity
- Identification of cyclin D1 as a major modulator of 3-nitropropionic acid-induced striatal neurodegeneration
Showing 5 of 12 shared publications
- Building pangenome graphs
- Building pangenome graphs
- GeneCup: mining PubMed and GWAS catalog for gene–keyword relationships
- Deep sequencing of a large family of isogenic mice enables complex variants discovery and accurate phenotype mapping
- Artificial Intelligence Models for Cell Type and Subtype Identification Based on Single-Cell RNA Sequencing Data in Vision Science
Showing 5 of 7 shared publications
- A platform for experimental precision medicine: The extended BXD mouse family
- Sex- and age-dependent genetics of longevity in a heterogeneous mouse population
- Gene-by-environment modulation of lifespan and weight gain in the murine BXD family
- Multiomic profiling of the liver across diets and age in a diverse mouse population
- A natural mutator allele shapes mutation spectrum variation in mice
- A natural mutator allele shapes mutation spectrum variation in mice
- Deep sequencing of a large family of isogenic mice enables complex variants discovery and accurate phenotype mapping
- A novel quantitative trait locus implicates <i>Msh3</i> in the propensity for genome-wide short tandem repeat expansions in mice
- A natural mutator allele shapes mutation spectrum variation in mice
- A natural mutator allele shapes mutation spectrum variation in mice
- Deep sequencing of a large family of isogenic mice enables complex variants discovery and accurate phenotype mapping
- A novel quantitative trait locus implicates <i>Msh3</i> in the propensity for genome-wide short tandem repeat expansions in mice
- Merged magnetic resonance and light sheet microscopy of the whole mouse brain
- HiDiver: A Suite of Methods to Merge Magnetic Resonance Histology, Light Sheet Microscopy, and Complete Brain Delineations
- A rapid workflow for neuron counting in combined light sheet microscopy and magnetic resonance histology
- The Duke Mouse Brain Atlas: MRI and light sheet microscopy stereotaxic atlas of the mouse brain
- Merged magnetic resonance and light sheet microscopy of the whole mouse brain
- HiDiver: A Suite of Methods to Merge Magnetic Resonance Histology, Light Sheet Microscopy, and Complete Brain Delineations
- A rapid workflow for neuron counting in combined light sheet microscopy and magnetic resonance histology
- The Duke Mouse Brain Atlas: MRI and light sheet microscopy stereotaxic atlas of the mouse brain
- A revamped rat reference genome improves the discovery of genetic diversity in laboratory rats
- GeneCup: mining PubMed and GWAS catalog for gene–keyword relationships
- Deep sequencing of a large family of isogenic mice enables complex variants discovery and accurate phenotype mapping
- A revamped rat reference genome improves the discovery of genetic diversity in laboratory rats
- Building pangenome graphs
- Building pangenome graphs
- Deep sequencing of a large family of isogenic mice enables complex variants discovery and accurate phenotype mapping
- A novel quantitative trait locus implicates <i>Msh3</i> in the propensity for genome-wide short tandem repeat expansions in mice
- A revamped rat reference genome improves the discovery of genetic diversity in laboratory rats
- Deep sequencing of a large family of isogenic mice enables complex variants discovery and accurate phenotype mapping
- A revamped rat reference genome improves the discovery of genetic diversity in laboratory rats
- A novel quantitative trait locus implicates <i>Msh3</i> in the propensity for genome-wide short tandem repeat expansions in mice
- Building pangenome graphs
- Building pangenome graphs
- A revamped rat reference genome improves the discovery of genetic diversity in laboratory rats
- A revamped rat reference genome improves the discovery of genetic diversity in laboratory rats
- IGFBPL1 is a master driver of microglia homeostasis and resolution of neuroinflammation in glaucoma and brain tauopathy
- Genetic Dissection of the Regulatory Mechanisms of Ace2 in the Infected Mouse Lung
- Characterizing modifier genes of cardiac fibrosis phenotype in hypertrophic cardiomyopathy
- Gene-by-environment modulation of lifespan and weight gain in the murine BXD family
- Genetic Dissection of the Regulatory Mechanisms of Ace2 in the Infected Mouse Lung
- Characterizing modifier genes of cardiac fibrosis phenotype in hypertrophic cardiomyopathy
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