Ryan M. Allen

OverviewAI-generated summary

Ryan M. Allen's research program focuses on the biogenesis and function of extracellular vesicles, particularly those containing RNA, and their role in disease processes. His work has investigated the mechanisms by which cellular components, such as VAP-A and CERT, drive the formation of RNA-containing extracellular vesicles at specific cellular locations. Allen has also explored the involvement of microbial small RNAs delivered via low-density lipoprotein (LDL) in driving atherosclerosis through macrophage activation. His research extends to the potential of plasma microRNAs for predicting coronary atherosclerosis, especially in individuals with rheumatoid arthritis.

Further investigations by Allen include the development and structural optimization of siRNA conjugates designed for albumin binding to achieve targeted cancer therapy, specifically against MCL1. He has also examined how the depletion of METTL3 impacts cellular and extracellular levels of miRNAs that contain m6A consensus sequences. Additionally, his group has worked to elucidate the physico-chemical principles governing the binding interactions between high-density lipoprotein and small RNA molecules. Allen leads an active research group and has a scholarly record marked by a h-index of 20 and over 2,200 citations across his 59 publications.

Metrics

• h-index: 20
• Publications: 59
• Citations: 2,204