R
Ryan M. Allen
High Impact
Assistant Professor
faculty
20 h-index
58 pubs
2,236 cited
Research Areas
Biography and Research Information
OverviewAI-generated summary
Ryan M. Allen's research investigates the mechanisms by which extracellular vesicles, particularly those containing RNA, contribute to disease processes. His work has explored the role of VAP-A and CERT in the biogenesis of RNA-containing extracellular vesicles at ER membrane contact sites. Allen has also studied the impact of microbial small RNAs delivered via LDL on the development of atherosclerosis, specifically their influence on macrophage TLR8 activation. His publications also address the potential of circulating microRNAs (miRNAs) to improve the prediction of coronary atherosclerosis in patients with rheumatoid arthritis.
Further research by Allen has focused on the structural optimization of siRNA conjugates for albumin binding to achieve targeted cancer therapy, specifically MCL1-directed treatments. He has also investigated the physico-chemical principles governing high-density lipoprotein-small RNA binding interactions. Additionally, his work has examined how the depletion of METTL3 affects cellular and extracellular levels of miRNAs containing m6A consensus sequences, and has profiled the podocyte translatome during the development of diabetic nephropathy.
Metrics
- h-index: 20
- Publications: 58
- Citations: 2,236
Selected Publications
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Osteocytic Lipocalin-2 regulates bone formation locally through iron-dependent ferroptosis and Wnt suppression (2026)
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Plasminogen as a Ribonucleoprotein: Regulatory small RNA Cargo Modulates Fibrinolysis and Inflammation (2025)
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Lipocalin-2 Regulates Osteocyte Ferroptosis and Osteocyte-Osteoblast Crosstalk via Wnt Signaling to Control Bone Formation (2025)
Grants & Funding
Collaboration Network
Top Collaborators
Kasey C. Vickers
Vanderbilt University Medical Center (US)
20 shared publications
- VAP-A and its binding partner CERT drive biogenesis of RNA-containing extracellular vesicles at ER membrane contact sites
- Structural optimization of siRNA conjugates for albumin binding achieves effective MCL1-directed cancer therapy
- LDL delivery of microbial small RNAs drives atherosclerosis through macrophage TLR8
- Plasma miRNAs improve the prediction of coronary atherosclerosis in patients with rheumatoid arthritis
- Profile of Podocyte Translatome During Development of Type 2 and Type 1 Diabetic Nephropathy Using Podocyte-Specific TRAP mRNA RNA-seq
Showing 5 of 20 shared publications
Danielle L. Michell
Vanderbilt University Medical Center (US)
16 shared publications
- Structural optimization of siRNA conjugates for albumin binding achieves effective MCL1-directed cancer therapy
- LDL delivery of microbial small RNAs drives atherosclerosis through macrophage TLR8
- Profile of Podocyte Translatome During Development of Type 2 and Type 1 Diabetic Nephropathy Using Podocyte-Specific TRAP mRNA RNA-seq
- Elucidation of physico-chemical principles of high-density lipoprotein–small RNA binding interactions
- Structural Optimization of siRNA Conjugates for Albumin Binding Achieves Effective MCL1-Targeted Cancer Therapy
Showing 5 of 16 shared publications
Quanhu Sheng
Vanderbilt University Medical Center (US)
15 shared publications
- LDL delivery of microbial small RNAs drives atherosclerosis through macrophage TLR8
- Plasma miRNAs improve the prediction of coronary atherosclerosis in patients with rheumatoid arthritis
- Profile of Podocyte Translatome During Development of Type 2 and Type 1 Diabetic Nephropathy Using Podocyte-Specific TRAP mRNA RNA-seq
- Elucidation of physico-chemical principles of high-density lipoprotein–small RNA binding interactions
- LDL delivery of microbial small RNAs drives atherosclerosis through macrophage TLR8
Showing 5 of 15 shared publications
Ashley Cavnar
Vanderbilt University Medical Center (US)
12 shared publications
- Structural optimization of siRNA conjugates for albumin binding achieves effective MCL1-directed cancer therapy
- LDL delivery of microbial small RNAs drives atherosclerosis through macrophage TLR8
- Elucidation of physico-chemical principles of high-density lipoprotein–small RNA binding interactions
- Structural Optimization of siRNA Conjugates for Albumin Binding Achieves Effective MCL1-Targeted Cancer Therapy
- LDL delivery of microbial small RNAs drives atherosclerosis through macrophage TLR8
Showing 5 of 12 shared publications
MacRae F. Linton
Vanderbilt University Medical Center (US)
12 shared publications
- LDL delivery of microbial small RNAs drives atherosclerosis through macrophage TLR8
- Elucidation of physico-chemical principles of high-density lipoprotein–small RNA binding interactions
- LDL delivery of microbial small RNAs drives atherosclerosis through macrophage TLR8
- Abstract 14320: High Density Lipoprotein Affinity and Transport of Small RNAs in Atherosclerosis
- Abstract 13914: Low-Density Lipoprotein Delivery of Microbial Small RNAs Drives Atherosclerosis Through Macrophage Toll-Like Receptor 8
Showing 5 of 12 shared publications
Chase Raby
Vanderbilt University Medical Center (US)
11 shared publications
- LDL delivery of microbial small RNAs drives atherosclerosis through macrophage TLR8
- Elucidation of physico-chemical principles of high-density lipoprotein–small RNA binding interactions
- LDL delivery of microbial small RNAs drives atherosclerosis through macrophage TLR8
- Abstract 14320: High Density Lipoprotein Affinity and Transport of Small RNAs in Atherosclerosis
- Abstract 13914: Low-Density Lipoprotein Delivery of Microbial Small RNAs Drives Atherosclerosis Through Macrophage Toll-Like Receptor 8
Showing 5 of 11 shared publications
Danielle Contreras
Vanderbilt University Medical Center (US)
8 shared publications
- LDL delivery of microbial small RNAs drives atherosclerosis through macrophage TLR8
- Profile of Podocyte Translatome During Development of Type 2 and Type 1 Diabetic Nephropathy Using Podocyte-Specific TRAP mRNA RNA-seq
- Elucidation of physico-chemical principles of high-density lipoprotein–small RNA binding interactions
- LDL delivery of microbial small RNAs drives atherosclerosis through macrophage TLR8
- Abstract 13914: Low-Density Lipoprotein Delivery of Microbial Small RNAs Drives Atherosclerosis Through Macrophage Toll-Like Receptor 8
Showing 5 of 8 shared publications
Elizabeth M. Semler
Vanderbilt University Medical Center (US)
8 shared publications
- LDL delivery of microbial small RNAs drives atherosclerosis through macrophage TLR8
- Elucidation of physico-chemical principles of high-density lipoprotein–small RNA binding interactions
- LDL delivery of microbial small RNAs drives atherosclerosis through macrophage TLR8
- Abstract 14320: High Density Lipoprotein Affinity and Transport of Small RNAs in Atherosclerosis
- Abstract 13914: Low-Density Lipoprotein Delivery of Microbial Small RNAs Drives Atherosclerosis Through Macrophage Toll-Like Receptor 8
Showing 5 of 8 shared publications
Marisol Ramirez
Vanderbilt University Medical Center (US)
8 shared publications
- VAP-A and its binding partner CERT drive biogenesis of RNA-containing extracellular vesicles at ER membrane contact sites
- Elucidation of physico-chemical principles of high-density lipoprotein–small RNA binding interactions
- LDL delivery of microbial small RNAs drives atherosclerosis through macrophage TLR8
- Abstract 14320: High Density Lipoprotein Affinity and Transport of Small RNAs in Atherosclerosis
- Abstract 13914: Low-Density Lipoprotein Delivery of Microbial Small RNAs Drives Atherosclerosis Through Macrophage Toll-Like Receptor 8
Showing 5 of 8 shared publications
Mark Castleberry
Vanderbilt University (US)
7 shared publications
- LDL delivery of microbial small RNAs drives atherosclerosis through macrophage TLR8
- Elucidation of physico-chemical principles of high-density lipoprotein–small RNA binding interactions
- LDL delivery of microbial small RNAs drives atherosclerosis through macrophage TLR8
- Abstract 14320: High Density Lipoprotein Affinity and Transport of Small RNAs in Atherosclerosis
- Abstract 13914: Low-Density Lipoprotein Delivery of Microbial Small RNAs Drives Atherosclerosis Through Macrophage Toll-Like Receptor 8
Showing 5 of 7 shared publications
Wanying Zhu
Vanderbilt University Medical Center (US)
5 shared publications
- LDL delivery of microbial small RNAs drives atherosclerosis through macrophage TLR8
- Elucidation of physico-chemical principles of high-density lipoprotein–small RNA binding interactions
- LDL delivery of microbial small RNAs drives atherosclerosis through macrophage TLR8
- Physico-chemical principles of HDL-small RNA binding interactions
- Plasminogen as a Ribonucleoprotein: Regulatory small RNA Cargo Modulates Fibrinolysis and Inflammation
Carlisle R. DeJulius
Vanderbilt University (US)
5 shared publications
- Structural optimization of siRNA conjugates for albumin binding achieves effective MCL1-directed cancer therapy
- LDL delivery of microbial small RNAs drives atherosclerosis through macrophage TLR8
- Structural Optimization of siRNA Conjugates for Albumin Binding Achieves Effective MCL1-Targeted Cancer Therapy
- LDL delivery of microbial small RNAs drives atherosclerosis through macrophage TLR8
- Abstract 13914: Low-Density Lipoprotein Delivery of Microbial Small RNAs Drives Atherosclerosis Through Macrophage Toll-Like Receptor 8
Craig L. Duvall
Vanderbilt University (US)
5 shared publications
- Structural optimization of siRNA conjugates for albumin binding achieves effective MCL1-directed cancer therapy
- LDL delivery of microbial small RNAs drives atherosclerosis through macrophage TLR8
- Structural Optimization of siRNA Conjugates for Albumin Binding Achieves Effective MCL1-Targeted Cancer Therapy
- LDL delivery of microbial small RNAs drives atherosclerosis through macrophage TLR8
- Abstract 13914: Low-Density Lipoprotein Delivery of Microbial Small RNAs Drives Atherosclerosis Through Macrophage Toll-Like Receptor 8
Shilin Zhao
Vanderbilt University Medical Center (US)
4 shared publications
- LDL delivery of microbial small RNAs drives atherosclerosis through macrophage TLR8
- LDL delivery of microbial small RNAs drives atherosclerosis through macrophage TLR8
- Abstract 14320: High Density Lipoprotein Affinity and Transport of Small RNAs in Atherosclerosis
- Abstract 13914: Low-Density Lipoprotein Delivery of Microbial Small RNAs Drives Atherosclerosis Through Macrophage Toll-Like Receptor 8
Clark Massick
Vanderbilt University Medical Center (US)
4 shared publications
- Elucidation of physico-chemical principles of high-density lipoprotein–small RNA binding interactions
- Abstract 131: Plasminogen Oxidized Phospholipid Adducts Drive Macrophage Activation In Through TLR2
- Abstract Or141: Plasminogen small RNA cargo promotes immunogenicity and inhibits enzymatic activity.
- Plasminogen as a Ribonucleoprotein: Regulatory small RNA Cargo Modulates Fibrinolysis and Inflammation
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