Carrie L. Moland

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High Impact

Researcher

NCTR

Also affiliated: United States Food and Drug Administration (2004–2022); Northrop Grumman (United States) (2003); Procter & Gamble (United States) (2003)

Faculty Researcher

28 h-index 47 pubs 3,396 cited

Research Areas

Biomedical Subjects

OverviewAI-generated summary

Carrie L. Moland's research focuses on investigating the mechanisms and biomarkers of drug-induced cardiotoxicity, particularly in relation to the chemotherapeutic agent doxorubicin. Her work utilizes animal models, specifically mice and rats, to study gene expression changes and identify potential early indicators of cardiac damage. Recent publications have explored the delayed-onset and chronic effects of doxorubicin on the heart, including subclinical cardiotoxicity in mice.

Further research by Moland has examined sex-related differences in doxorubicin-induced cardiotoxicity, investigating the role of specific molecular pathways such as the apelin-APJ system. Additionally, her studies have identified microRNA-34a-5p as a potential circulating biomarker for early detection of doxorubicin-induced chronic cardiotoxicity. Moland's scholarship includes 47 publications and an h-index of 28, with her work being highly cited. She has collaborated with researchers at the National Center for Toxicological Research on multiple shared publications.

Metrics

h-index: 28
Publications: 47
Citations: 3,396

Selected Publications

Potential role of the apelin‐APJ pathway in sex‐related differential cardiotoxicity induced by doxorubicin in mice (2022)

Journal of Applied Toxicology 7 citations DOI OpenAlex
MicroRNA‐34a‐5p as a promising early circulating preclinical biomarker of doxorubicin‐induced chronic cardiotoxicity (2022)

Journal of Applied Toxicology 14 citations DOI OpenAlex
Doxorubicin‐induced delayed‐onset subclinical cardiotoxicity in mice (2021)

Journal of Applied Toxicology 15 citations DOI OpenAlex
Candidate early predictive plasma protein markers of doxorubicin-induced chronic cardiotoxicity in B6C3F1 mice (2018)

Toxicology and Applied Pharmacology 23 citations DOI OpenAlex
Sex and age differences in the expression of liver microRNAs during the life span of F344 rats (2017)

Biology of Sex Differences 33 citations DOI OpenAlex
Sex-related differential susceptibility to doxorubicin-induced cardiotoxicity in B6C3F1 mice (2016)

Toxicology and Applied Pharmacology 40 citations DOI OpenAlex
Early metabolomics changes in heart and plasma during chronic doxorubicin treatment in B6C3F<sub>1</sub> mice (2016)

Journal of Applied Toxicology 40 citations DOI OpenAlex
Early transcriptional changes in cardiac mitochondria during chronic doxorubicin exposure and mitigation by dexrazoxane in mice (2016)

Toxicology and Applied Pharmacology 34 citations DOI OpenAlex
Reproductive hormone levels and differential mitochondria-related oxidative gene expression as potential mechanisms for gender differences in cardiosensitivity to Doxorubicin in tumor-bearing spontaneously hypertensive rats (2015)

Cancer Chemotherapy and Pharmacology 30 citations DOI OpenAlex
Age and sex differences in kidney microRNA expression during the life span of F344 rats (2015)

Biology of Sex Differences 85 citations DOI OpenAlex
Sexual Dimorphism in the Expression of Mitochondria-Related Genes in Rat Heart at Different Ages (2015)

PLoS ONE 83 citations DOI OpenAlex
Human Sex Hormone-Binding Globulin Binding Affinities of 125 Structurally Diverse Chemicals and Comparison with Their Binding to Androgen Receptor, Estrogen Receptor, and α-Fetoprotein (2014)

Toxicological Sciences 85 citations DOI OpenAlex
Early biomarkers of doxorubicin-induced heart injury in a mouse model (2014)

Toxicology and Applied Pharmacology 96 citations DOI OpenAlex
A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages (2014)

Nature Communications 435 citations DOI OpenAlex
Sex differences in kidney gene expression during the life cycle of F344 rats (2013)

Biology of Sex Differences 55 citations DOI OpenAlex