Steven R. Post

Federal Grant PI High Impact

Vice Chair for Research

UAMS

Last publication 2026 Last refreshed 2026-05-22

faculty

Pathology, College of Medicine

spost@uams.edu

33 h-index 133 pubs 4,538 cited

Research Areas

Links

ORCID Lab Website Research Group UAMS TRI Profile

OverviewAI-generated summary

Steven R. Post's research focuses on the intersection of viral infections, cellular signaling, and cancer development. He investigates how viral reactivation, particularly of oncogenic herpesviruses like KSHV (Kaposi's sarcoma-associated herpesvirus), can be influenced by external factors such as antiviral drugs or SARS-CoV-2 infection. His work has explored the role of intracellular signaling pathways in promoting viral reactivation and the potential of specific agents, like Echinomycin, as therapeutic options for KSHV-related malignancies.

Additionally, Dr. Post's research extends to other oncogenic viruses and their therapeutic potential, including characterizing Morreton virus as a platform for liver cancer virotherapy and evaluating the repurposing of the MMR vaccine for cancer immunotherapy. He also examines the molecular mechanisms underlying cancer cell survival and disease progression, as seen in his work on the EIF4G1 network in non-small cell lung cancers. His scholarship metrics include an h-index of 33, 131 total publications, and 4,518 total citations. He has served as PI on a $324,563 NIH/National Cancer Institute grant studying how periodontal bacteria enhance oral KSHV pathogenesis and Kaposi's Sarcoma development in HIV+ patients.

Metrics

h-index: 33
Publications: 133
Citations: 4,538

Selected Publications

Detection of mitochondrial DNA mutations in T cells following 5-FU or cisplatin exposure (2026)

DOI OpenAlex
Class A Scavenger receptors promote tumor progression and induce a unique macrophage phenotype in a mouse model of spontaneous breast cancer (2026)

DOI OpenAlex
Evaluation of the Activity of Monensin and Its Analogs for Modulation of Stem-like Cell Functionality in 2D and 3D Breast Cancer Models (2025)

DOI OpenAlex
Multimodal reprogramming of the tumor microenvironment by MMR and dual checkpoint blockade in hepatocellular carcinoma models (2025)

DOI OpenAlex
Pancreatic tumor microenvironment reprogramming via alloantigen-expressing virotherapy elicits tumor rejection and improves immunotherapy response (2025)

DOI OpenAlex
Impact of New Hematopoietic Progenitor Cell Collection Goals on Apheresis and Cell Therapy Laboratory Services (2025)

DOI OpenAlex
Monensin and Its Analogs Exhibit Activity Against Breast Cancer Stem-Like Cells in an Organoid Model (2025)

DOI OpenAlex
Isolation of mitochondrial mutation-specific T cell receptors (2025)

4 citations DOI OpenAlex
Abstract 2987: Role of EIF4G1 network in non-small cell lung cancers (NSCLC) pathogenesis and development of targeted therapy (2025)

DOI OpenAlex
Abstract 945: Live attenuated MMR vaccines modulate tumor immune cell infiltration and synergize with standard of care to prolong survival in preclinical HCC models (2025)

DOI OpenAlex
Abstract 947: Engineering a synthetic oncolytic virus to overcome apoptotic resistance and induce immunogenic cell death in pancreatic ductal adenocarcinoma (2025)

DOI OpenAlex
Monensin and Its Analogs Offer a Multi-Targeted Approach to Enhancing Metastatic Breast Cancer Immunogenicity and Cell Death (Abstract ID: 163059) (2025)

DOI OpenAlex
474 Repositioning monensin: Enhancing anti-cancer activity and immune modulation in breast cancer cells (2025)

DOI OpenAlex
Alterations in Cellular Gene Expression Due to Co‐Infection With Kaposi's Sarcoma‐Associated Herpesvirus and SARS‐CoV‐2: Implications for Disease Severity (2024)

DOI OpenAlex
Enhancing immune response and survival in hepatocellular carcinoma with novel oncolytic Jurona virus and immune checkpoint blockade (2024)

4 citations DOI OpenAlex

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Federal Grants 1 $324,563 total

NIH/National Cancer Institute Contact PI Mar 2019 - Apr 2025

Periodontal bacteria enhance oral KSHV pathogenesis and Kaposi's Sarcoma development in HIV + patients

National Cancer Institute $324,563 R01

Research Interests

The goal of our research is to better understand the key role that macrophages play in the development and progression of chronic inflammatory diseases including cardiovascular disease and cancer. Our studies indicate that a specific macrophage receptor, the class A macrophage scavenger receptor (SR-A), may differentially function to enhance or diminish inflammation. Our ongoing studies seek to provide mechanistic details regarding the functional interactions between SR-A and inflammatory signaling pathways. Results of these studies will advance understanding of the pathologic role of macrophages in cardiovascular disease and cancer, and may indicate novel therapeutic approaches targeting the inflammatory responses in these disease.

Grants & Funding

No FP attached UAMS Internal Research Awards Principal Investigator
Impact of hemodynamics on efferocytosis in endothelial cells NIH/Nat. Heart, Lung & Blood Institute Co-Investigator
No FP attached UAMS Executive Breast Committee Principal Investigator
Diabetes Medicine Adherence in Marshallese Patients UAMS College of Medicine Principal Investigator
Periodontal bacteria enhance oral KSHV pathogenesis and Kaposi's Sarcoma development in HIV + patients - Continuation NIH/Nat. Cancer Institute Co-Investigator
Fibroblast-macrophage interactions induce a tumor-promoting microenvironment NIH/National Institutes of Health Principal Investigator
Regulation of Ras Signaling by Rlf in Hypertrophy NIH/Nat. Heart, Lung & Blood Institute Principal Investigator
Periodontal bacteria enhance oral KSHV pathogenesis and Kaposi's Sarcoma development in HIV + patients - Continuation NIH/Nat. Cancer Institute Principal Investigator