Match tier
Likely match
Presence
Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-10-06
T
Thomas E. Goodwin
This is a likely match — the affiliation was inferred from OpenAlex, ORCID, and web sources but has not been fully confirmed. Treat with appropriate caution.
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Also affiliated: Australian National University (2006); University of Minnesota (1998); Oregon Health & Science University (2002); University of Oregon (2009); Wright State University (1998); St. Olaf College (2009); Georgia Southern University (2007); University of Rochester (1998); Rice University (1977); Texas A&M University (1978–1981); Technische Universität Braunschweig (2002)
22 h-index
102 pubs
1,495 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Thomas E. Goodwin's research program focuses on cancer therapy, specifically investigating novel drug targets and combination therapies for hematological malignancies and solid tumors. He has published work on dihydroorotate dehydrogenase (DHODH) inhibitors, such as Hosu-53, examining their efficacy as monotherapies and in augmenting targeted treatments like CD47 blockade in acute myeloid leukemia (AML) and multiple myeloma. His work also explores the impact of DHODH inhibition on T cell metabolism, particularly in the context of graft-versus-host disease (GvHD) and graft-versus-leukemia (GvL) responses following hematopoietic stem cell transplantation.
In addition to his work on cancer therapeutics, Goodwin has also investigated animal communication, specifically studying how olfactory cues encode identity and group membership in African elephants. This research utilizes analytical techniques such as gas chromatography-mass spectrometry. His scholarly output includes over 100 publications and he holds an h-index of 22 with over 1,400 citations, reflecting a highly cited researcher designation. Goodwin leads a research group and collaborates with other researchers at Hendrix College.
Metrics
- h-index: 22
- Publications: 102
- Citations: 1,495
Selected Publications
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Abstract 7905: Dihydroorotate dehydrogenase (DHODH) inhibition as a promising therapeutic strategy with synergistic targeting of ROR1 in small cell lung cancer (2026)
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Abstract 6902: Promising therapeutic effects of pyrimidine synthesis inhibition by a novel dihydroorotate dehydrogenase inhibitor in small cell lung cancer (2025)
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DHODH inhibition alters T cell metabolism limiting acute graft-versus-host disease while retaining graft-versus-leukemia response (2025)
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DHODH Inhibition Modulates T Cell Metabolism, Selectively Impairs Effector T Cell Response, Limiting Gvhd While Preserving GVL. (2025)
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Pyrimidine depletion enhances targeted and immune therapy combinations in acute myeloid leukemia (2024)
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The Potent Dihydroorotate Dehydrogenase Inhibitor, Hosu-53, Exhibits Compelling Monotherapy Efficacy in Multiple Myeloma and Augments CD47 Targeted Therapy (2023)
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Hosu-53, a Novel Potent Dihydroorotate Dehydrogenase Inhibitor Accentuates CD47 Blockade Therapy Resulting in Long Term Survival in Acute Myeloid Leukemia (2022)
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Preclinical Development of Hosu-53, a Novel Potent Dihydroorotate Dehydrogenase Inhibitor with Impressive Single Agent Efficacy and Combination Approaches in Hematological Malignancy (2022)
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A pachyderm perfume: odour encodes identity and group membership in African elephants (2022)
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Abstract 1060: Introducing a novel DHODH inhibitor with superior in vivo activity as monotherapy or in novel combination regimen with immunotherapy for hematological malignancies (2022)
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Learning Organic Chemistry from Bark Beetle Pheromone Biosynthesis (2019)
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P-Mail: The Information Highway of Nocturnal, but Not Diurnal or Cathemeral, Strepsirrhines (2019)
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Concentration‐dependent chemosensory responses towards pheromones are influenced by receiver attributes in Asian elephants (2018)
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Stereospecific Metabolism of R- and S-Warfarin by Human Hepatic Cytosolic Reductases (2017)
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Reproductive endocrine patterns and volatile urinary compounds of Arctictis binturong: discovering why bearcats smell like popcorn (2016)
Collaboration Network
Top Collaborators
Bruce A. Schulte
Hendrix College (US)
17 shared publications
- Insect Pheromones and Precursors in Female African Elephant Urine
- Male African elephants, Loxodonta africana, can distinguish oestrous status via urinary signals
- Chemical Signals in Vertebrates 13
- Honest signalling through chemicals by elephants with applications for care and conservation
- Chemical Signals of Elephant Musth: Temporal Aspects of Microbially-Mediated Modifications
Showing 5 of 17 shared publications
L.E.L. Rasmussen
Hendrix College (US)
10 shared publications
- Insect Pheromones and Precursors in Female African Elephant Urine
- Male African elephants, Loxodonta africana, can distinguish oestrous status via urinary signals
- Honest signalling through chemicals by elephants with applications for care and conservation
- Characterization of interdigital glands in the Asian elephant (Elephas maximus)
- Assessing chemical communication in elephants
Showing 5 of 10 shared publications
Sandip Vibhute
The Ohio State University (US)
9 shared publications
- Pyrimidine depletion enhances targeted and immune therapy combinations in acute myeloid leukemia
- The Potent Dihydroorotate Dehydrogenase Inhibitor, Hosu-53, Exhibits Compelling Monotherapy Efficacy in Multiple Myeloma and Augments CD47 Targeted Therapy
- DHODH inhibition alters T cell metabolism limiting acute graft-versus-host disease while retaining graft-versus-leukemia response
- Abstract 1060: Introducing a novel DHODH inhibitor with superior in vivo activity as monotherapy or in novel combination regimen with immunotherapy for hematological malignancies
- Preclinical Development of Hosu-53, a Novel Potent Dihydroorotate Dehydrogenase Inhibitor with Impressive Single Agent Efficacy and Combination Approaches in Hematological Malignancy
Showing 5 of 9 shared publications
Ola A. Elgamal
University of Cincinnati (US)
8 shared publications
- Pyrimidine depletion enhances targeted and immune therapy combinations in acute myeloid leukemia
- The Potent Dihydroorotate Dehydrogenase Inhibitor, Hosu-53, Exhibits Compelling Monotherapy Efficacy in Multiple Myeloma and Augments CD47 Targeted Therapy
- DHODH inhibition alters T cell metabolism limiting acute graft-versus-host disease while retaining graft-versus-leukemia response
- Abstract 1060: Introducing a novel DHODH inhibitor with superior in vivo activity as monotherapy or in novel combination regimen with immunotherapy for hematological malignancies
- Preclinical Development of Hosu-53, a Novel Potent Dihydroorotate Dehydrogenase Inhibitor with Impressive Single Agent Efficacy and Combination Approaches in Hematological Malignancy
Showing 5 of 8 shared publications
Chad Bennett
The Ohio State University (US)
8 shared publications
- The Potent Dihydroorotate Dehydrogenase Inhibitor, Hosu-53, Exhibits Compelling Monotherapy Efficacy in Multiple Myeloma and Augments CD47 Targeted Therapy
- DHODH inhibition alters T cell metabolism limiting acute graft-versus-host disease while retaining graft-versus-leukemia response
- Abstract 1060: Introducing a novel DHODH inhibitor with superior in vivo activity as monotherapy or in novel combination regimen with immunotherapy for hematological malignancies
- Preclinical Development of Hosu-53, a Novel Potent Dihydroorotate Dehydrogenase Inhibitor with Impressive Single Agent Efficacy and Combination Approaches in Hematological Malignancy
- Hosu-53, a Novel Potent Dihydroorotate Dehydrogenase Inhibitor Accentuates CD47 Blockade Therapy Resulting in Long Term Survival in Acute Myeloid Leukemia
Showing 5 of 8 shared publications
Erin Hertlein
University of Cincinnati (US)
8 shared publications
- The Potent Dihydroorotate Dehydrogenase Inhibitor, Hosu-53, Exhibits Compelling Monotherapy Efficacy in Multiple Myeloma and Augments CD47 Targeted Therapy
- DHODH inhibition alters T cell metabolism limiting acute graft-versus-host disease while retaining graft-versus-leukemia response
- Abstract 1060: Introducing a novel DHODH inhibitor with superior in vivo activity as monotherapy or in novel combination regimen with immunotherapy for hematological malignancies
- Preclinical Development of Hosu-53, a Novel Potent Dihydroorotate Dehydrogenase Inhibitor with Impressive Single Agent Efficacy and Combination Approaches in Hematological Malignancy
- Hosu-53, a Novel Potent Dihydroorotate Dehydrogenase Inhibitor Accentuates CD47 Blockade Therapy Resulting in Long Term Survival in Acute Myeloid Leukemia
Showing 5 of 8 shared publications
Christine M. Drea
Duke University (US)
5 shared publications
- Night and day: the comparative study of strepsirrhine primates reveals socioecological and phylogenetic patterns in olfactory signals
- The “ S ecret” in Secretions: Methodological Considerations in Deciphering Primate Olfactory Communication
- Reproductive endocrine patterns and volatile urinary compounds of Arctictis binturong: discovering why bearcats smell like popcorn
- Chemical Differences Between Voided and Bladder Urine in the A ye‐ A ye ( D aubentonia madagascariensis): Implications for Olfactory Communication Studies
- P-Mail: The Information Highway of Nocturnal, but Not Diurnal or Cathemeral, Strepsirrhines
Linda P. Desrochers
Hendrix College
5 shared publications
In database
- Stereospecific Metabolism of R- and S-Warfarin by Human Hepatic Cytosolic Reductases
- Prooxidant and antioxidant properties of salicylaldehyde isonicotinoyl hydrazone iron chelators in HepG2 cells
- Multiple UDP-glucuronosyltransferases in human liver microsomes glucuronidate both R- and S-7-hydroxywarfarin into two metabolites
- Hemiterpenoids and Pyrazines in the Odoriferous Urine of the Maned Wolf (Chrysocyon brachyurus)
- Learning Organic Chemistry from Bark Beetle Pheromone Biosynthesis
Christopher C. Coss
The Ohio State University (US)
5 shared publications
- Pyrimidine depletion enhances targeted and immune therapy combinations in acute myeloid leukemia
- Abstract 1060: Introducing a novel DHODH inhibitor with superior in vivo activity as monotherapy or in novel combination regimen with immunotherapy for hematological malignancies
- Preclinical Development of Hosu-53, a Novel Potent Dihydroorotate Dehydrogenase Inhibitor with Impressive Single Agent Efficacy and Combination Approaches in Hematological Malignancy
- Abstract 6902: Promising therapeutic effects of pyrimidine synthesis inhibition by a novel dihydroorotate dehydrogenase inhibitor in small cell lung cancer
- Abstract 7905: Dihydroorotate dehydrogenase (DHODH) inhibition as a promising therapeutic strategy with synergistic targeting of ROR1 in small cell lung cancer
Helen Loizi
Georgia Southern University (US)
4 shared publications
- Sexual dimorphism in the performance of chemosensory investigatory behaviours by African elephants (Loxodonta africana)
- Assessing chemical communication in elephants
- Chemical analysis of preovulatory female african elephant urine: A search for putative pheromones
- From Exploration to Selective Information Gathering: The Development of Chemosensory Investigation in Male African Elephants (Loxodonta africana)
Javier delBarco‐Trillo
University College Cork (IE)
4 shared publications
- Night and day: the comparative study of strepsirrhine primates reveals socioecological and phylogenetic patterns in olfactory signals
- The “ S ecret” in Secretions: Methodological Considerations in Deciphering Primate Olfactory Communication
- Chemical Differences Between Voided and Bladder Urine in the A ye‐ A ye ( D aubentonia madagascariensis): Implications for Olfactory Communication Studies
- P-Mail: The Information Highway of Nocturnal, but Not Diurnal or Cathemeral, Strepsirrhines
Susheela Tridandapani
Florida College (US)
4 shared publications
- Pyrimidine depletion enhances targeted and immune therapy combinations in acute myeloid leukemia
- The Potent Dihydroorotate Dehydrogenase Inhibitor, Hosu-53, Exhibits Compelling Monotherapy Efficacy in Multiple Myeloma and Augments CD47 Targeted Therapy
- Abstract 1060: Introducing a novel DHODH inhibitor with superior in vivo activity as monotherapy or in novel combination regimen with immunotherapy for hematological malignancies
- Hosu-53, a Novel Potent Dihydroorotate Dehydrogenase Inhibitor Accentuates CD47 Blockade Therapy Resulting in Long Term Survival in Acute Myeloid Leukemia
Jeffrey Patrick
The Ohio State University (US)
4 shared publications
- Pyrimidine depletion enhances targeted and immune therapy combinations in acute myeloid leukemia
- The Potent Dihydroorotate Dehydrogenase Inhibitor, Hosu-53, Exhibits Compelling Monotherapy Efficacy in Multiple Myeloma and Augments CD47 Targeted Therapy
- Preclinical Development of Hosu-53, a Novel Potent Dihydroorotate Dehydrogenase Inhibitor with Impressive Single Agent Efficacy and Combination Approaches in Hematological Malignancy
- Hosu-53, a Novel Potent Dihydroorotate Dehydrogenase Inhibitor Accentuates CD47 Blockade Therapy Resulting in Long Term Survival in Acute Myeloid Leukemia
John C. Byrd
University of Cincinnati (US)
4 shared publications
- The Potent Dihydroorotate Dehydrogenase Inhibitor, Hosu-53, Exhibits Compelling Monotherapy Efficacy in Multiple Myeloma and Augments CD47 Targeted Therapy
- Preclinical Development of Hosu-53, a Novel Potent Dihydroorotate Dehydrogenase Inhibitor with Impressive Single Agent Efficacy and Combination Approaches in Hematological Malignancy
- Hosu-53, a Novel Potent Dihydroorotate Dehydrogenase Inhibitor Accentuates CD47 Blockade Therapy Resulting in Long Term Survival in Acute Myeloid Leukemia
- Abstract 6902: Promising therapeutic effects of pyrimidine synthesis inhibition by a novel dihydroorotate dehydrogenase inhibitor in small cell lung cancer
Kathryn R. Bagley
Georgia Southern University (US)
3 shared publications
- Male African elephants, Loxodonta africana, can distinguish oestrous status via urinary signals
- Assessing chemical communication in elephants
- From Exploration to Selective Information Gathering: The Development of Chemosensory Investigation in Male African Elephants (Loxodonta africana)
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