Jacob L Edmondson

Researcher

University of Arkansas for Medical Sciences

faculty

3 h-index 13 pubs 122 cited

Research Areas

Cancer-related molecular mechanisms research Immune Cell Function and Interaction Cancer Immunotherapy and Biomarkers T-cell and B-cell Immunology Metabolism and Genetic Disorders Protein Structure and Dynamics Health and Medical Research Impacts

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Research Group

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OverviewAI-generated summary

Jacob L Edmondson's research investigates molecular mechanisms underlying immune responses and cancer progression. His recent publications focus on the role of specific proteins and pathways in enhancing anti-tumor immunity and improving the efficacy of cancer therapies, particularly in melanoma. He has explored how factors like ATF6 activation and NEK2 influence tumorigenesis and tumor progression, and how proteome turnover dynamics can identify E3 ligases that support T-cell persistence during exhaustion. Edmondson's work also delves into the metabolic plasticity of T cells, examining the function of PCK2 in supporting T-cell effector function in challenging microenvironments. His collaborations include work with Brian Koss, Daniel Fil, Megan R. Reed, and Billie Heflin at the University of Arkansas for Medical Sciences. Edmondson's scholarly output includes 13 publications with 122 citations and an h-index of 3.

Metrics

  • h-index: 3
  • Publications: 13
  • Citations: 122

Selected Publications

  • 691 ATF6 activation promotes ICB response in melanoma (2025) DOI
  • 762 CD28 costimulation induces PCK2 to support T cell effector function in metabolically hostile environments (2025) DOI
  • 277 Proteome turnover dynamics analysis uncovers E3 ligases that enhance T-cell persistence during exhaustion (2025) DOI
  • 1132 Enhancing melanoma therapy efficacy by protecting EZH2 activity in T cells (2024) DOI
  • 538 ATF6 activation in melanoma promotes anti-tumor immunity and improves ICB therapy response (2024) DOI
  • 319 Comprehensive analysis of proteome turnover dynamics during T cell exhaustion (2024) DOI
  • 932 Defining the role for PCK2 in T-cell metabolic plasticity (2024) DOI
  • Role of NEK2 in tumorigenesis and tumor progression (2024) DOI
  • Abstract 584: Synergistic action of ATF6 and EZH2 in sensing metabolic stress to boost anti-tumor immunity (2024) DOI
  • 536 EZH2 senses metabolic stress to restore MHC-I antigen presentation and ICB response in metastatic melanoma (2023) DOI

Collaborators

Researchers in the database who share publications

Brian Koss University of Arkansas for Medical Sciences 10 shared publications Daniel Fil University of Arkansas for Medical Sciences 8 shared publications Megan R. Reed University of Arkansas for Medical Sciences 5 shared publications Billie Heflin University of Arkansas for Medical Sciences 5 shared publications Katherine Wallis University of Arkansas for Medical Sciences 4 shared publications Lora J. Rogers University of Arkansas for Medical Sciences 4 shared publications Samuel G. Mackintosh University of Arkansas for Medical Sciences 2 shared publications Sam G Mackintosh University of Arkansas for Medical Sciences 2 shared publications

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