William Brooks Gentry
Role not yet determined Is this you? Add your title
Also affiliated: Northwestern University (1993–1999); Eugene Applebaum College of Pharmacy and Health Sciences (2004); Arkansas Children's Hospital (2003); Pennsylvania State University (2011–2014); Mayo Clinic (2011); Wayne State University (2004); American Society of Anesthesiologists (1993); University of Mississippi (2004–2005); University of Chicago (1996–1999); InterveXion Therapeutics (United States) (2013–2025); Foundation for Anesthesia Education and Research (1993)
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
W. Brooks Gentry's research focuses on developing therapeutic interventions for methamphetamine use. His work has involved the creation and evaluation of monoclonal antibodies designed to neutralize the effects of methamphetamine. Recent publications detail the identification of candidate antibodies and their efficacy in preclinical studies, including assessments of cross-reactivity and impact on locomotor activity in animal models.
Gentry's scholarship metrics include a total of 62 publications and 2,564 citations, with an h-index of 28. He is recognized as a highly cited researcher. His collaborations include work with Michael D. Berquist and Melinda G. Gunnell at the University of Arkansas for Medical Sciences, with whom he shares multiple publications.
Metrics
- h-index: 28
- Publications: 61
- Citations: 2,601
Selected Publications
-
Comparison between a chimeric anti-methamphetamine monoclonal antibody and humanized antibodies on pharmacological effects of methamphetamine (2025)
-
Discovery and Development of an Anti-methamphetamine Monoclonal Antibody for Use in Treating Methamphetamine Abuse (2015)
-
Impact of CYP2D6 phenotype on response to methamphetamine in healthy volunteers (2015)
-
Customizing Monoclonal Antibodies for the Treatment of Methamphetamine Abuse (2014)
-
Pharmacological effects of two anti-methamphetamine monoclonal antibodies (2014)
-
Treatment with a Monoclonal Antibody against Methamphetamine and Amphetamine Reduces Maternal and Fetal Rat Brain Concentrations in Late Pregnancy (2014)
-
First human study of a chimeric anti-methamphetamine monoclonal antibody in healthy volunteers (2014)
-
Effects of prototypic calcium channel blockers in methadone-maintained humans responding under a naloxone discrimination procedure (2013)
-
Preclinical characterization of an anti-methamphetamine monoclonal antibody for human use (2013)
-
Randomized, placebo-controlled pilot trial of gabapentin during an outpatient, buprenorphine-assisted detoxification procedure. (2013)
-
Chronic anti-phencyclidine monoclonal antibody therapy decreases phencyclidine-induced in utero fetal mortality in pregnant rats (2011)
-
Gestation Time-Dependent Pharmacokinetics of Intravenous (+)-Methamphetamine in Rats (2011)
-
Use of GlideScope in airway management of a patient with osteogenesis imperfecta (2011)
-
The Fate and Function of Therapeutic Antiaddiction Monoclonal Antibodies across the Reproductive Cycle of Rats (2010)
-
Anti-(+)-Methamphetamine Monoclonal Antibody Antagonists Designed to Prevent the Progression of Human Diseases of Addiction (2010)
Collaboration Network
Top Collaborators
- Sex- and dose-dependency in the pharmacokinetics and pharmacodynamics of (+)-methamphetamine and its metabolite (+)-amphetamine in rats
- (+)-Methamphetamine-induced spontaneous behavior in rats depends on route of (+)METH administration
- Pharmacodynamic mechanisms of monoclonal antibody-based antagonism of (+)-methamphetamine in rats
- Safety and efficiency of an anti-(+)-methamphetamine monoclonal antibody in the protection against cardiovascular and central nervous system effects of (+)-methamphetamine in rats
- Development of active and passive human vaccines to treat methamphetamine addiction
Showing 5 of 19 shared publications
- Sex- and dose-dependency in the pharmacokinetics and pharmacodynamics of (+)-methamphetamine and its metabolite (+)-amphetamine in rats
- (+)-Methamphetamine-induced spontaneous behavior in rats depends on route of (+)METH administration
- Pharmacodynamic mechanisms of monoclonal antibody-based antagonism of (+)-methamphetamine in rats
- Safety and efficiency of an anti-(+)-methamphetamine monoclonal antibody in the protection against cardiovascular and central nervous system effects of (+)-methamphetamine in rats
- Monoclonal IgG affinity and treatment time alters antagonism of (+)-methamphetamine effects in rats
Showing 5 of 11 shared publications
- Cytochrome P450 phenotypic ratios for predicting herb‐drug interactions in humans
- Clinical Assessment of Effects of Botanical Supplementation on Cytochrome P450 Phenotypes in the Elderly
- Assessing the Clinical Significance of Botanical Supplementation on Human Cytochrome P450 3A Activity: Comparison of a Milk Thistle and Black Cohosh Product to Rifampin and Clarithromycin
- Supplementation With Goldenseal (Hydrastis canadensis), but not Kava Kava (Piper methysticum), Inhibits Human CYP3A Activity In Vivo
- Safety and efficiency of an anti-(+)-methamphetamine monoclonal antibody in the protection against cardiovascular and central nervous system effects of (+)-methamphetamine in rats
Showing 5 of 9 shared publications
- Cytochrome P450 phenotypic ratios for predicting herb‐drug interactions in humans
- In vivo effects of goldenseal, kava kava, black cohosh, and valerian on human cytochrome P450 1A2, 2D6, 2E1, and 3A4/5 phenotypes
- Clinical Assessment of Effects of Botanical Supplementation on Cytochrome P450 Phenotypes in the Elderly
- In vivo assessment of botanical supplementation on human cytochrome P450 phenotypes: , , milk thistle, and saw palmetto
- Assessing the Clinical Significance of Botanical Supplementation on Human Cytochrome P450 3A Activity: Comparison of a Milk Thistle and Black Cohosh Product to Rifampin and Clarithromycin
Showing 5 of 8 shared publications
- Cytochrome P450 phenotypic ratios for predicting herb‐drug interactions in humans
- In vivo effects of goldenseal, kava kava, black cohosh, and valerian on human cytochrome P450 1A2, 2D6, 2E1, and 3A4/5 phenotypes
- Clinical Assessment of Effects of Botanical Supplementation on Cytochrome P450 Phenotypes in the Elderly
- In vivo assessment of botanical supplementation on human cytochrome P450 phenotypes: , , milk thistle, and saw palmetto
- Assessing the Clinical Significance of Botanical Supplementation on Human Cytochrome P450 3A Activity: Comparison of a Milk Thistle and Black Cohosh Product to Rifampin and Clarithromycin
Showing 5 of 8 shared publications
- Randomized, placebo-controlled pilot trial of gabapentin during an outpatient, buprenorphine-assisted detoxification procedure.
- Open-Label Pilot Study of Modafinil for Methamphetamine Dependence
- Behavioral effects of γ-hydroxybutyrate in humans
- Effects of prototypic calcium channel blockers in methadone-maintained humans responding under a naloxone discrimination procedure
- Impact of CYP2D6 phenotype on response to methamphetamine in healthy volunteers
- First human study of a chimeric anti-methamphetamine monoclonal antibody in healthy volunteers
- Preclinical characterization of an anti-methamphetamine monoclonal antibody for human use
- Pharmacological effects of two anti-methamphetamine monoclonal antibodies
- Discovery and Development of an Anti-methamphetamine Monoclonal Antibody for Use in Treating Methamphetamine Abuse
- Comparison between a chimeric anti-methamphetamine monoclonal antibody and humanized antibodies on pharmacological effects of methamphetamine
- First human study of a chimeric anti-methamphetamine monoclonal antibody in healthy volunteers
- Preclinical characterization of an anti-methamphetamine monoclonal antibody for human use
- Preclinical characterization of an anti-methamphetamine monoclonal antibody for human use
- Preclinical characterization of an anti-methamphetamine monoclonal antibody for human use
- Comparison between a chimeric anti-methamphetamine monoclonal antibody and humanized antibodies on pharmacological effects of methamphetamine
- Treatment with a Monoclonal Antibody against Methamphetamine and Amphetamine Reduces Maternal and Fetal Rat Brain Concentrations in Late Pregnancy
- Pharmacological effects of two anti-methamphetamine monoclonal antibodies
- Gestation Time-Dependent Pharmacokinetics of Intravenous (+)-Methamphetamine in Rats
- Impact of CYP2D6 phenotype on response to methamphetamine in healthy volunteers
- Pharmacokinetic and Functional Properties of Anti‐Methamphetamine Monoclonal Antibodies
- In vivo effects of goldenseal, kava kava, black cohosh, and valerian on human cytochrome P450 1A2, 2D6, 2E1, and 3A4/5 phenotypes
- In vivo assessment of botanical supplementation on human cytochrome P450 phenotypes: , , milk thistle, and saw palmetto
- Effect of goldenseal, black cohosh, kava kava, and valerian on human cytochrome p450 1A2, 2D6, 2E1, and 3A4 phenotypes
- Effect of botanical supplementation on cytochrome P450 phenotypes in the elderly
- Randomized, placebo-controlled pilot trial of gabapentin during an outpatient, buprenorphine-assisted detoxification procedure.
- Open-Label Pilot Study of Modafinil for Methamphetamine Dependence
- Effects of prototypic calcium channel blockers in methadone-maintained humans responding under a naloxone discrimination procedure
- Impact of CYP2D6 phenotype on response to methamphetamine in healthy volunteers
- In vivo effects of goldenseal, kava kava, black cohosh, and valerian on human cytochrome P450 1A2, 2D6, 2E1, and 3A4/5 phenotypes
- In vivo assessment of botanical supplementation on human cytochrome P450 phenotypes: , , milk thistle, and saw palmetto
- Effect of goldenseal, black cohosh, kava kava, and valerian on human cytochrome p450 1A2, 2D6, 2E1, and 3A4 phenotypes
- Preclinical characterization of an anti-methamphetamine monoclonal antibody for human use
- Preclinical characterization of an anti-methamphetamine monoclonal antibody for human use
- Preclinical characterization of an anti-methamphetamine monoclonal antibody for human use
- In vivo effects of goldenseal, kava kava, black cohosh, and valerian on human cytochrome P450 1A2, 2D6, 2E1, and 3A4/5 phenotypes
- In vivo assessment of botanical supplementation on human cytochrome P450 phenotypes: , , milk thistle, and saw palmetto
- Pharmacokinetic Mechanisms for Obtaining High Renal Coelimination of Phencyclidine and a Monoclonal Antiphencyclidine Antigen-Binding Fragment of Immunoglobulin G in the Rat
- Phencyclidine (PCP) distribution in rats: Unique time profiles of brain and testis accumulation1
Similar Researchers
Based on overlapping research topics