Match tier
Likely match
Presence
Formerly Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-10-05
B
Bill J. Gurley
This is a likely match — the affiliation was inferred from OpenAlex, ORCID, and web sources but has not been fully confirmed. Treat with appropriate caution.
Principal Scientist
Formerly Arkansas Affiliated with Arkansas State University, NCTR, University of Arkansas, UAMS through 2024; recent publications list United States Pharmacopeial Convention, University of Florida.
35 h-index
171 pubs
5,913 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Bill J. Gurley's research focuses on the complex interactions between dietary supplements, herbal products, and pharmaceutical drugs, particularly concerning their impact on human health and drug metabolism. He investigates how plant extracts and their constituents can modulate the activity of key drug-metabolizing enzymes, transporters, and nuclear receptors, which are critical for the safe and effective use of medications. His work also addresses the potential for hepatotoxicity arising from herbal dietary supplements and explores analytical challenges in ensuring the quality and safety of these products.
Gurley has published extensively on these topics, with recent work examining the modulatory effects of specific botanicals like Bulbine natalensis and Zingiber officinale on drug metabolism pathways. He also explores the broader landscape of herb-drug interactions for commonly used botanicals on the US market. His research network includes collaborators such as Igor Koturbash, Mitchell R. McGill, Charles M. Quick, and Eric U. Yee, all at the University of Arkansas for Medical Sciences, with whom he has co-authored multiple publications. Gurley's scholarship is evidenced by an h-index of 35 and over 5,900 citations across 171 publications.
Metrics
- h-index: 35
- Publications: 171
- Citations: 5,913
Positions
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Principal Scientist 2019–presentUniversity of Mississippi National Center for Natural Products Research ORCID
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Principal ScientistUniversity of Arkansas for Medical Sciences ORCID
Selected Publications
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Phenibut: A drug with one too many “buts” (2024)
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Human quad liver-on-chip system as a tool toward bridging the gap between animals and humans regarding toxicology and pharmacology of a cannabidiol-rich cannabis extract (2024)
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Inter-strain variability in responses to a single administration of the cannabidiol-rich cannabis extract in mice (2024)
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Pharmacokinetics (2023)
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Hepatotoxicity due to herbal dietary supplements: Past, present and the future (2022)
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Safety and Molecular-Toxicological Implications of Cannabidiol-Rich Cannabis Extract and Methylsulfonylmethane Co-Administration (2020)
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Potential Probiotic or Trigger of Gut Inflammation – The Janus-Faced Nature of Cannabidiol-Rich Cannabis Extract (2020)
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Effect of Aromatase Inhibition (Exemestane) on Urine Concentration of Osteoprotegerin in Healthy Postmenopausal Women (2019)
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The Potential for Pharmacokinetic Interactions Between Cannabis Products and Conventional Medications (2019)
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Paradoxical Patterns of Sinusoidal Obstruction Syndrome-Like Liver Injury in Aged Female CD-1 Mice Triggered by Cannabidiol-Rich Cannabis Extract and Acetaminophen Co-Administration (2019)
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Hepatotoxicity of a Cannabidiol-Rich Cannabis Extract in the Mouse Model (2019)
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Decaffeinated Green Tea Extract Does Not Elicit Hepatotoxic Effects and Modulates the Gut Microbiome in Lean B6C3F1 Mice (2019)
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Impact of obesity on the toxicity of a multi-ingredient dietary supplement, OxyELITE Pro™ (New Formula), using the novel NZO/HILtJ obese mouse model: Physiological and mechanistic assessments (2018)
Collaboration Network
Top Collaborators
Gary W. Barone
University of Arkansas for Medical Sciences
17 shared publications
In database
- Drug Interaction between St. John's Wort and Cyclosporine
- Clinical assessment of CYP2D6‐mediated herb–drug interactions in humans: Effects of milk thistle, black cohosh, goldenseal, kava kava, St. John's wort, and<i>Echinacea</i>
- Gauging the clinical significance of P‐glycoprotein‐mediated herb‐drug interactions: Comparative effects of St. John's wort, Echinacea, clarithromycin, and rifampin on digoxin pharmacokinetics
- EFFECT OF MILK THISTLE (SILYBUM MARIANUM) AND BLACK COHOSH (CIMICIFUGA RACEMOSA) SUPPLEMENTATION ON DIGOXIN PHARMACOKINETICS IN HUMANS
- Sirolimus-induced thrombotic microangiopathy in a renal transplant recipient
Showing 5 of 17 shared publications
David Williams
Arkansas Children's Nutrition Center (US)
16 shared publications
- Cytochrome P450 phenotypic ratios for predicting herb‐drug interactions in humans
- Clinical Assessment of Effects of Botanical Supplementation on Cytochrome P450 Phenotypes in the Elderly
- Clinical assessment of CYP2D6‐mediated herb–drug interactions in humans: Effects of milk thistle, black cohosh, goldenseal, kava kava, St. John's wort, and<i>Echinacea</i>
- Gauging the clinical significance of P‐glycoprotein‐mediated herb‐drug interactions: Comparative effects of St. John's wort, Echinacea, clarithromycin, and rifampin on digoxin pharmacokinetics
- EFFECT OF MILK THISTLE (SILYBUM MARIANUM) AND BLACK COHOSH (CIMICIFUGA RACEMOSA) SUPPLEMENTATION ON DIGOXIN PHARMACOKINETICS IN HUMANS
Showing 5 of 16 shared publications
Martha A. Hubbard
University of Arkansas for Medical Sciences (US)
14 shared publications
- Cytochrome P450 phenotypic ratios for predicting herb‐drug interactions in humans
- In vivo effects of goldenseal, kava kava, black cohosh, and valerian on human cytochrome P450 1A2, 2D6, 2E1, and 3A4/5 phenotypes
- Clinical Assessment of Effects of Botanical Supplementation on Cytochrome P450 Phenotypes in the Elderly
- In vivo assessment of botanical supplementation on human cytochrome P450 phenotypes: , , milk thistle, and saw palmetto
- Clinical assessment of CYP2D6‐mediated herb–drug interactions in humans: Effects of milk thistle, black cohosh, goldenseal, kava kava, St. John's wort, and<i>Echinacea</i>
Showing 5 of 14 shared publications
Igor Koturbash
University of Arkansas for Medical Sciences
12 shared publications
In database
- Hepatotoxicity of a Cannabidiol-Rich Cannabis Extract in the Mouse Model
- MicroRNAs as biomarkers for liver injury: Current knowledge, challenges and future prospects
- Hepatotoxicity due to herbal dietary supplements: Past, present and the future
- Paradoxical Patterns of Sinusoidal Obstruction Syndrome-Like Liver Injury in Aged Female CD-1 Mice Triggered by Cannabidiol-Rich Cannabis Extract and Acetaminophen Co-Administration
- Potential Probiotic or Trigger of Gut Inflammation – The Janus-Faced Nature of Cannabidiol-Rich Cannabis Extract
Showing 5 of 12 shared publications
Laura Ewing
University of Arkansas for Medical Sciences
10 shared publications
In database
- Hepatotoxicity of a Cannabidiol-Rich Cannabis Extract in the Mouse Model
- MicroRNAs as biomarkers for liver injury: Current knowledge, challenges and future prospects
- Paradoxical Patterns of Sinusoidal Obstruction Syndrome-Like Liver Injury in Aged Female CD-1 Mice Triggered by Cannabidiol-Rich Cannabis Extract and Acetaminophen Co-Administration
- Potential Probiotic or Trigger of Gut Inflammation – The Janus-Faced Nature of Cannabidiol-Rich Cannabis Extract
- Safety assessment of the dietary supplement OxyELITE™ Pro (New Formula) in inbred and outbred mouse strains
Showing 5 of 10 shared publications
Sameh R. Abul‐Ezz
University of Arkansas for Medical Sciences (US)
9 shared publications
- Drug Interaction between St. John's Wort and Cyclosporine
- Sirolimus-induced thrombotic microangiopathy in a renal transplant recipient
- St John's wort: a hidden risk for transplant patients
- St John's Wort: A Hidden Risk for Transplant Patients
- The Tolerability of Newer Immunosuppressive Medications in a Patient with Acute Intermittent Porphyria
Showing 5 of 9 shared publications
Charles M. Skinner
University of Arkansas for Medical Sciences
9 shared publications
In database
- Hepatotoxicity of a Cannabidiol-Rich Cannabis Extract in the Mouse Model
- Paradoxical Patterns of Sinusoidal Obstruction Syndrome-Like Liver Injury in Aged Female CD-1 Mice Triggered by Cannabidiol-Rich Cannabis Extract and Acetaminophen Co-Administration
- Potential Probiotic or Trigger of Gut Inflammation – The Janus-Faced Nature of Cannabidiol-Rich Cannabis Extract
- Safety assessment of the dietary supplement OxyELITE™ Pro (New Formula) in inbred and outbred mouse strains
- Decaffeinated Green Tea Extract Does Not Elicit Hepatotoxic Effects and Modulates the Gut Microbiome in Lean B6C3F1 Mice
Showing 5 of 9 shared publications
W. Brooks Gentry
University of Mississippi
8 shared publications
In database
- Cytochrome P450 phenotypic ratios for predicting herb‐drug interactions in humans
- In vivo effects of goldenseal, kava kava, black cohosh, and valerian on human cytochrome P450 1A2, 2D6, 2E1, and 3A4/5 phenotypes
- Clinical Assessment of Effects of Botanical Supplementation on Cytochrome P450 Phenotypes in the Elderly
- In vivo assessment of botanical supplementation on human cytochrome P450 phenotypes: , , milk thistle, and saw palmetto
- Assessing the Clinical Significance of Botanical Supplementation on Human Cytochrome P450 3A Activity: Comparison of a Milk Thistle and Black Cohosh Product to Rifampin and Clarithromycin
Showing 5 of 8 shared publications
Beverley L. Ketel
University of Arkansas for Medical Sciences (US)
8 shared publications
- Drug Interaction between St. John's Wort and Cyclosporine
- St John's wort: a hidden risk for transplant patients
- St John's Wort: A Hidden Risk for Transplant Patients
- The Tolerability of Newer Immunosuppressive Medications in a Patient with Acute Intermittent Porphyria
- Drug Interaction Between St. Johnʼs Wort and Cyclosporine
Showing 5 of 8 shared publications
Mahmoud A. ElSohly
University of Mississippi (US)
8 shared publications
- Hepatotoxicity of a Cannabidiol-Rich Cannabis Extract in the Mouse Model
- Paradoxical Patterns of Sinusoidal Obstruction Syndrome-Like Liver Injury in Aged Female CD-1 Mice Triggered by Cannabidiol-Rich Cannabis Extract and Acetaminophen Co-Administration
- Potential Probiotic or Trigger of Gut Inflammation – The Janus-Faced Nature of Cannabidiol-Rich Cannabis Extract
- Safety assessment of the dietary supplement OxyELITE™ Pro (New Formula) in inbred and outbred mouse strains
- Safety and Molecular-Toxicological Implications of Cannabidiol-Rich Cannabis Extract and Methylsulfonylmethane Co-Administration
Showing 5 of 8 shared publications
Meredith L Lightfoot
University of Arkansas for Medical Sciences (US)
7 shared publications
- Drug Interaction between St. John's Wort and Cyclosporine
- St John's wort: a hidden risk for transplant patients
- St John's Wort: A Hidden Risk for Transplant Patients
- Drug Interaction Between St. Johnʼs Wort and Cyclosporine
- Pretransplant evaluation of a patient with acute intermittent porphyria
Showing 5 of 7 shared publications
Stephanie F. Gardner
University of Arkansas for Medical Sciences (US)
6 shared publications
- Cytochrome P450 phenotypic ratios for predicting herb‐drug interactions in humans
- Clinical Assessment of Effects of Botanical Supplementation on Cytochrome P450 Phenotypes in the Elderly
- Pharmacokinetics and Cardiovascular Effects of Ma‐Huang (<i>Ephedra sinica</i>) in Normotensive Adults
- Ephedrine-type alkaloid content of nutritional supplements containing ephedra sinica (ma-huang) as determined by high performance liquid chromatography
- Ephedrine Pharmacokinetics After the Ingestion of Nutritional Supplements Containing Ephedra sinica (ma huang)
Showing 5 of 6 shared publications
Mitchell R. McGill
Office of Dietary Supplements
6 shared publications
In database
- Hepatotoxicity of a Cannabidiol-Rich Cannabis Extract in the Mouse Model
- Hepatotoxicity due to herbal dietary supplements: Past, present and the future
- Paradoxical Patterns of Sinusoidal Obstruction Syndrome-Like Liver Injury in Aged Female CD-1 Mice Triggered by Cannabidiol-Rich Cannabis Extract and Acetaminophen Co-Administration
- Decaffeinated Green Tea Extract Does Not Elicit Hepatotoxic Effects and Modulates the Gut Microbiome in Lean B6C3F1 Mice
- Safety and Molecular-Toxicological Implications of Cannabidiol-Rich Cannabis Extract and Methylsulfonylmethane Co-Administration
Showing 5 of 6 shared publications
Charles M. Quick
University of Arkansas for Medical Sciences
6 shared publications
In database
- Hepatotoxicity of a Cannabidiol-Rich Cannabis Extract in the Mouse Model
- Paradoxical Patterns of Sinusoidal Obstruction Syndrome-Like Liver Injury in Aged Female CD-1 Mice Triggered by Cannabidiol-Rich Cannabis Extract and Acetaminophen Co-Administration
- Potential Probiotic or Trigger of Gut Inflammation – The Janus-Faced Nature of Cannabidiol-Rich Cannabis Extract
- Safety and Molecular-Toxicological Implications of Cannabidiol-Rich Cannabis Extract and Methylsulfonylmethane Co-Administration
- Human quad liver-on-chip system as a tool toward bridging the gap between animals and humans regarding toxicology and pharmacology of a cannabidiol-rich cannabis extract
Showing 5 of 6 shared publications
Larry Walker
University of Mississippi (US)
6 shared publications
- Hepatotoxicity of a Cannabidiol-Rich Cannabis Extract in the Mouse Model
- Paradoxical Patterns of Sinusoidal Obstruction Syndrome-Like Liver Injury in Aged Female CD-1 Mice Triggered by Cannabidiol-Rich Cannabis Extract and Acetaminophen Co-Administration
- Potential Probiotic or Trigger of Gut Inflammation – The Janus-Faced Nature of Cannabidiol-Rich Cannabis Extract
- Safety and Molecular-Toxicological Implications of Cannabidiol-Rich Cannabis Extract and Methylsulfonylmethane Co-Administration
- Human quad liver-on-chip system as a tool toward bridging the gap between animals and humans regarding toxicology and pharmacology of a cannabidiol-rich cannabis extract
Showing 5 of 6 shared publications
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