William W. Greenfield

Professor

UAMS

Also affiliated: Arkansas Children's Hospital (2014); University of Arkansas Medical Center (2015–2021); Arkansas Department of Health (2021–2024)

Obstetrics & Gynecology, College of Medicine

11 h-index 28 pubs 415 cited

Research Areas

Biomedical Subjects

Links

ORCID Lab Website Research Group UAMS TRI Profile

OverviewAI-generated summary

Dr. William W. Greenfield's research focuses on human papillomavirus (HPV) and its association with cervical intraepithelial neoplasia and cervical cancer. He has investigated the impact of therapeutic HPV vaccines, examining immune responses, viral load reduction, and cross-protection mechanisms. His work includes clinical trials, such as a phase I dose-escalation study of a peptide-based HPV therapeutic vaccine with a novel adjuvant for women with cervical intraepithelial neoplasia 2/3. Dr. Greenfield has also explored the relationship between HPV type 16 viral load, CD4+ and CD8+ T-cell responses, and favorable clinical trends in affected patients. Additionally, his research interests extend to the cervical microbiome's role in vaccine response and has included a study on low-grade fibromyxoid sarcoma presenting as a primary ovarian neoplasm. He has also contributed to research on improving perinatal regionalization and lowering infant mortality through telemedicine collaboration.

Research Overview

Dr. William Greenfield completed his medical degree at Meharry Medical College in Nashville, Tennessee, completed an internship at Baylor College of Medicine in Houston, Texas, and his residency in Obstetrics and Gynecology at the University of Arkansas for Medical Sciences in Little Rock. Before attending medical school, he received a pharmacy degree from Auburn University. His clinical interests are in obstetrics and gynecology. He is trained in daVinci Robotic Surgery. He has made presentations nationally, regionally and locally on topics in his field. Dr. Greenfield currently serves as the Arkansas Section Chair for the American Congress of Obstetrics and Gynecology, and is a member of several professional organizations including:Arkansas Medical SocietyAmerican Medical AssociationAmerican Society of Colposcopy and Cervical PathologyDr. Greenfield enjoys both his obstetric and gynecologic patients. He likes to help educate his patients and guide them to make informed decisions about their healthcare.

Metrics

h-index: 11
Publications: 28
Citations: 415

Positions

Professor publications 2007–2026

University of Arkansas for Medical Sciences Obstetrics & Gynecology, College of Medicine Institutional directory

Selected Publications

Maternity Care Team Members’ Perspectives on Barriers and Facilitators to Integrating Doulas into the Hospital Setting (2026)

MCN The American Journal of Maternal/Child Nursing DOI OpenAlex
Personal Birth Experiences and Clinician Attitudes About Cesarean Birth: A Cross‐Sectional Study With Female Labor and Delivery Unit Staff (2026)

Birth DOI OpenAlex
A Randomized Double-Blind Phase 2 Clinical Trial Treating Cervical Intraepithelial Neoplasia 2/3 with PepCan or Candida (2025)

medRxiv 3 citations DOI OpenAlex
Immune responses in a phase 2 clinical trial of peptide-based therapeutic human papillomavirus vaccine, PepCan, versus Candida adjuvant alone in treating cervical intraepithelial neoplasia 2/3. (2024)

Journal of Clinical Oncology 1 citation DOI OpenAlex
Public Maternal Health Dashboards in the United States: Descriptive Assessment (2024)

Journal of Medical Internet Research 2 citations DOI OpenAlex
Maternal Mortality Review Committee findings: awareness and recommended dissemination strategies in Arkansas (2024)

AJOG Global Reports DOI OpenAlex
A peptide-based human papillomavirus therapeutic vaccine, PepCan, or Candida adjuvant alone in treatment of cervical intraepithelial neoplasia 2/3 (CIN2/3). (2023)

Journal of Clinical Oncology 2 citations DOI OpenAlex
Quarantine and isolation facility: A State Health Department’s response to the COVID-19 pandemic (2021)

American Journal of Disaster Medicine 1 citation DOI OpenAlex
Evaluation of DNA extraction protocols from liquid-based cytology specimens for studying cervical microbiota (2021)

PLoS ONE 11 citations DOI OpenAlex
Evaluation of DNA extraction protocols from liquid-based cytology specimens for studying cervical microbiota (2020)

bioRxiv (Cold Spring Harbor Laboratory) 4 citations DOI OpenAlex
Cervical Microbiome and Response to a Human Papillomavirus Therapeutic Vaccine for Treating High-Grade Cervical Squamous Intraepithelial Lesion (2019)

Integrative Cancer Therapies 16 citations DOI OpenAlex
Cervical microbiome role in outcomes of therapeutic HPV vaccination for cervical intraepithelial neoplasia. (2018)

Journal of Clinical Oncology 3 citations DOI OpenAlex
Human papillomavirus type 16 viral load is decreased following a therapeutic vaccination (2016)

Cancer Immunology Immunotherapy 63 citations DOI OpenAlex
A phase I dose-escalation clinical trial of a peptide-based human papillomavirus therapeutic vaccine with candida skin test reagent as a novel vaccine adjuvant for treating women with biopsy-proven cervical intraepithelial neoplasia 2/3. (2015)

Journal of Clinical Oncology DOI OpenAlex
A novel use of a statewide telecolposcopy network for recruitment of participants in a Phase I clinical trial of a human papillomavirus therapeutic vaccine (2015)

Clinical Trials 12 citations DOI OpenAlex

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Grants & Funding

As listed on this researcher's institutional profile.

DP24-004, PRC, Core: Health Promotion and Disease Prevention Research Centers NIH Co-Investigator
Understanding and Enhancing T-Cell Responses to High Risk Human Papillomaviruses-Renewal NIH Co-Investigator
The Arkansas Perinatal Quality Collaborative Centers for Disease Control & Prevention Co-Principal Investigator