Mark E. Hart
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Researcher
Also affiliated: University of North Texas (1996–2002); United States Food and Drug Administration (2008–2024); University of North Texas Health Science Center (1996–2002); Kansas State University (1992–1994); Czech Academy of Sciences, Institute of Microbiology (2006–2008); Mississippi State University (1987–1990)
Faculty Researcher
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Mark E. Hart's research focuses on the molecular mechanisms of bacterial pathogenesis, particularly in the context of *Staphylococcus aureus*. His work investigates bacterial gene regulation, protein function, and genetic mutations that influence virulence and enzymatic activity. Recent publications include studies on the microcalorimetric analysis of staphylococcal enterotoxin unfolding, the interaction between *Lactobacillus plantarum* and *Staphylococcus aureus*, and the impact of a specific mutation in the *hysA1* gene on hyaluronidase activity in *Staphylococcus aureus* UAMS-1.
Hart also contributes to bioinformatics and computational tools for genomic analysis. He co-authored a publication introducing CPGminer, an interactive dashboard designed to explore genomic features and taxonomy of prokaryotic genomes. His research group is active in the field, evidenced by his h-index of 20 and over 1,700 citations across 38 publications. Hart has collaborated with researchers at the National Center for Toxicological Research, including Seong‐Jae Kim and Sandeep Kondakala, on multiple shared publications.
Metrics
- h-index: 21
- Publications: 38
- Citations: 1,757
Selected Publications
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Directional and Strain-Specific Interaction Between Lactobacillus plantarum and Staphylococcus aureus (2024)
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CPGminer: An Interactive Dashboard to Explore the Genomic Features and Taxonomy of Complete Prokaryotic Genomes (2023)
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Microcalorimetric Investigations of Reversible Staphylococcal Enterotoxin Unfolding (2022)
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A naturally occurring point mutation in the hyaluronidase gene (<i>hysA1</i>) of <i>Staphylococcus aureus</i> UAMS-1 results in reduced enzymatic activity (2021)
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CYPminer: an automated cytochrome P450 identification, classification, and data analysis tool for genome data sets across kingdoms (2020)
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Virulence Characteristics of mecA-Positive Multidrug-Resistant Clinical Coagulase-Negative Staphylococci (2020)
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Reduced vancomycin susceptibility and increased macrophage survival in Staphylococcus aureus strains sequentially isolated from a bacteraemic patient during a short course of antibiotic therapy (2019)
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Draft Genome Sequences of Two Staphylococcus aureus Strains Isolated in Succession from a Case of Bacteremia (2017)
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Infection of Murine Macrophages by Salmonella enterica Serovar Heidelberg Blocks Murine Norovirus Infectivity and Virus-induced Apoptosis (2015)
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Current Issues in Foodborne Illness Caused by Staphylococcus aureus (2015)
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Staphylococcus aureus Hyaluronidase Is a CodY-Regulated Virulence Factor (2014)
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Staphylococcus aureus toxic shock syndrome toxin-1 (TSST-1) production and Lactobacillus species growth in a defined medium simulating vaginal secretions (2014)
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Hyaluronidase expression and biofilm involvement in Staphylococcus aureus UAMS-1 and its sarA, agr and sarA agr regulatory mutants (2013)
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Evaluation of Virulence and Antimicrobial Resistance in <i>Salmonella enterica</i> Serovar Enteritidis Isolates from Humans and Chicken- and Egg-Associated Sources (2013)
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Influenza Virus Primes Mice for Pneumonia From Staphylococcus aureus (2011)
Collaboration Network
Top Collaborators
- A naturally occurring point mutation in the hyaluronidase gene (<i>hysA1</i>) of <i>Staphylococcus aureus</i> UAMS-1 results in reduced enzymatic activity
- Directional and Strain-Specific Interaction Between Lactobacillus plantarum and Staphylococcus aureus
- Directional and Strain-Specific Interaction Between Lactobacillus plantarum and Staphylococcus aureus
- CPGminer: An Interactive Dashboard to Explore the Genomic Features and Taxonomy of Complete Prokaryotic Genomes
- Directional and Strain-Specific Interaction Between Lactobacillus plantarum and Staphylococcus aureus
- CPGminer: An Interactive Dashboard to Explore the Genomic Features and Taxonomy of Complete Prokaryotic Genomes
- Directional and Strain-Specific Interaction Between Lactobacillus plantarum and Staphylococcus aureus
- CPGminer: An Interactive Dashboard to Explore the Genomic Features and Taxonomy of Complete Prokaryotic Genomes
- A naturally occurring point mutation in the hyaluronidase gene (<i>hysA1</i>) of <i>Staphylococcus aureus</i> UAMS-1 results in reduced enzymatic activity
- A naturally occurring point mutation in the hyaluronidase gene (<i>hysA1</i>) of <i>Staphylococcus aureus</i> UAMS-1 results in reduced enzymatic activity
- Microcalorimetric Investigations of Reversible Staphylococcal Enterotoxin Unfolding
- Microcalorimetric Investigations of Reversible Staphylococcal Enterotoxin Unfolding
- Microcalorimetric Investigations of Reversible Staphylococcal Enterotoxin Unfolding
- Microcalorimetric Investigations of Reversible Staphylococcal Enterotoxin Unfolding
- Microcalorimetric Investigations of Reversible Staphylococcal Enterotoxin Unfolding
- CPGminer: An Interactive Dashboard to Explore the Genomic Features and Taxonomy of Complete Prokaryotic Genomes
- CPGminer: An Interactive Dashboard to Explore the Genomic Features and Taxonomy of Complete Prokaryotic Genomes
- CPGminer: An Interactive Dashboard to Explore the Genomic Features and Taxonomy of Complete Prokaryotic Genomes
- CPGminer: An Interactive Dashboard to Explore the Genomic Features and Taxonomy of Complete Prokaryotic Genomes
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