Match tier
Confirmed
Presence
Current · Arkansas
Last published
2022
Sources
OpenAlex · ORCID
Refreshed
2026-10-05
W
William H. Tolleson
Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.
High Impact
Research Chemist
Also affiliated: Qingdao University (2020); Center for Food Safety and Applied Nutrition (2006); United States Food and Drug Administration (1996–2022); University of South Carolina (1991–1994); Tianjin Medical University General Hospital (2015); Instituto Superior Técnico (2002–2004); Centro de Química Estrutural (2002–2004); Tianjin Medical University (2015)
32 h-index
64 pubs
2,569 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
William H. Tolleson, a Research Chemist at the National Center for Toxicological Research, has a research focus that includes the characterization of cytochrome P450 (CYP)-overexpressing HepG2 cells for evaluating drug and chemical-induced liver toxicity. His work also involves microcalorimetric investigations of protein unfolding, specifically in the context of staphylococcal enterotoxins. Tolleson has published 66 papers, accumulating over 2,500 citations and an h-index of 32, designating him as a highly cited researcher. His collaborations include work with researchers from his own institution, such as Odbert A. Triplett and Nan Mei, as well as Mark E. Hart from the University of Arkansas for Medical Sciences. Tolleson's most recent publication was in 2022, indicating his continued activity in research.
Metrics
- h-index: 32
- Publications: 64
- Citations: 2,569
Positions
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Research Chemist 1994–presentNational Center for Toxicological Research Division of Biochemical Toxicology ORCID
Selected Publications
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Microcalorimetric Investigations of Reversible Staphylococcal Enterotoxin Unfolding (2022)
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Characterization of cytochrome P450s (CYP)-overexpressing HepG2 cells for assessing drug and chemical-induced liver toxicity (2021)
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Long noncoding RNA LINC00844-mediated molecular network regulates expression of drug metabolizing enzymes and nuclear receptors in human liver cells (2020)
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Coordinated Regulation of UGT2B15 Expression by Long Noncoding RNA LINC00574 and hsa-miR-129-5p in HepaRG Cells (2020)
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Regulation of cytochrome P450 expression by microRNAs and long noncoding RNAs: Epigenetic mechanisms in environmental toxicology and carcinogenesis (2019)Journal of Environmental Science and Health Part A Environmental Science and Engineering and Toxicology 4 citations OpenAlex
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MicroRNAs hsa-miR-495-3p and hsa-miR-486-5p suppress basal and rifampicin-induced expression of human sulfotransferase 2A1 (SULT2A1) by facilitating mRNA degradation (2019)
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Immunomagnetic Capture of Big Six Shiga Toxin–Producing Escherichia coli Strains in Apple Juice with Detection by Multiplex Real-Time PCR Eliminates Interference from the Food Matrix (2019)
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Regulation of cytochrome P450 expression by microRNAs and long noncoding RNAs: Epigenetic mechanisms in environmental toxicology and carcinogenesis (2019)
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MicroRNA-Dependent Gene Regulation of the Human Cytochrome P450 (2019)
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Primary and secondary pyrrolic metabolites of pyrrolizidine alkaloids form DNA adducts in human A549 cells (2018)
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Mechanistic ecotoxicology and environmental toxicology (2018)
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Mechanistic biomarkers of liver toxicity and carcinogenesis (2018)
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Mitochondrial dysfunction induced by leflunomide and its active metabolite (2018)
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Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans (2017)
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The expression, induction and pharmacological activity of CYP1A2 are post-transcriptionally regulated by microRNA hsa-miR-132-5p (2017)
Collaboration Network
Top Collaborators
Baitang Ning
National Center for Toxicological Research
16 shared publications
In database
- Development of HepG2-derived cells expressing cytochrome P450s for assessing metabolism-associated drug-induced liver toxicity
- Micrornas as Pharmacogenomic Biomarkers for Drug Efficacy and Drug Safety Assessment
- Regulation of cytochrome P450 expression by microRNAs and long noncoding RNAs: Epigenetic mechanisms in environmental toxicology and carcinogenesis
- MicroRNA hsa-miR-29a-3p modulates CYP2C19 in human liver cells
- The expression, induction and pharmacological activity of CYP1A2 are post-transcriptionally regulated by microRNA hsa-miR-132-5p
Showing 5 of 16 shared publications
Lei Guo
National Center for Toxicological Research
16 shared publications
In database
- Development of HepG2-derived cells expressing cytochrome P450s for assessing metabolism-associated drug-induced liver toxicity
- Micrornas as Pharmacogenomic Biomarkers for Drug Efficacy and Drug Safety Assessment
- Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans
- Regulation of cytochrome P450 expression by microRNAs and long noncoding RNAs: Epigenetic mechanisms in environmental toxicology and carcinogenesis
- Mitochondrial dysfunction induced by leflunomide and its active metabolite
Showing 5 of 16 shared publications
Dianke Yu
National Center for Toxicological Research (US)
14 shared publications
- Micrornas as Pharmacogenomic Biomarkers for Drug Efficacy and Drug Safety Assessment
- Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans
- Regulation of cytochrome P450 expression by microRNAs and long noncoding RNAs: Epigenetic mechanisms in environmental toxicology and carcinogenesis
- MicroRNA hsa-miR-29a-3p modulates CYP2C19 in human liver cells
- The expression, induction and pharmacological activity of CYP1A2 are post-transcriptionally regulated by microRNA hsa-miR-132-5p
Showing 5 of 14 shared publications
Si Chen
National Center for Toxicological Research
12 shared publications
In database
- Development of HepG2-derived cells expressing cytochrome P450s for assessing metabolism-associated drug-induced liver toxicity
- Micrornas as Pharmacogenomic Biomarkers for Drug Efficacy and Drug Safety Assessment
- Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans
- Regulation of cytochrome P450 expression by microRNAs and long noncoding RNAs: Epigenetic mechanisms in environmental toxicology and carcinogenesis
- The expression, induction and pharmacological activity of CYP1A2 are post-transcriptionally regulated by microRNA hsa-miR-132-5p
Showing 5 of 12 shared publications
Paul C. Howard
National Center for Toxicological Research
10 shared publications
In database
- Apoptotic and anti-proliferative effects of fumonisin B1 in human keratinocytes, fibroblasts, esophageal epithelial cells and hepatoma cells
- The Mycotoxin Fumonisin Induces Apoptosis in Cultured Human Cells and in Livers and Kidneys of Rats
- Photodecomposition and Phototoxicity of Natural Retinoids
- Renal Effects of Fumonisin Mycotoxins in Animals
- Fumonisin B1 induces apoptosis in cultured human keratinocytes through sphinganine accumulation and ceramide depletion.
Showing 5 of 10 shared publications
Weida Tong
National Center for Toxicological Research
8 shared publications
In database
- Regulation of cytochrome P450 expression by microRNAs and long noncoding RNAs: Epigenetic mechanisms in environmental toxicology and carcinogenesis
- The expression, induction and pharmacological activity of CYP1A2 are post-transcriptionally regulated by microRNA hsa-miR-132-5p
- A systematic evaluation of microRNAs in regulating human hepatic CYP2E1
- Long noncoding RNA LINC00844-mediated molecular network regulates expression of drug metabolizing enzymes and nuclear receptors in human liver cells
- MicroRNAs hsa-miR-495-3p and hsa-miR-486-5p suppress basal and rifampicin-induced expression of human sulfotransferase 2A1 (SULT2A1) by facilitating mRNA degradation
Showing 5 of 8 shared publications
Nan Mei
National Center for Toxicological Research
7 shared publications
In database
- Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans
- MicroRNA hsa-miR-29a-3p modulates CYP2C19 in human liver cells
- The expression, induction and pharmacological activity of CYP1A2 are post-transcriptionally regulated by microRNA hsa-miR-132-5p
- Activation of the Nrf2 signaling pathway in usnic acid-induced toxicity in HepG2 cells
- Characterization of cytochrome P450s (CYP)-overexpressing HepG2 cells for assessing drug and chemical-induced liver toxicity
Showing 5 of 7 shared publications
William B. Melchior
National Center for Toxicological Research (US)
7 shared publications
- Apoptotic and anti-proliferative effects of fumonisin B1 in human keratinocytes, fibroblasts, esophageal epithelial cells and hepatoma cells
- Fumonisin B1 induces apoptosis in cultured human keratinocytes through sphinganine accumulation and ceramide depletion.
- A functional quantitative polymerase chain reaction assay for ricin, Shiga toxin, and related ribosome-inactivating proteins
- Prolactin and Dehydroepiandrosterone Levels in Women with Systemic Lupus Erythematosus: The Role of the Extrapituitary Prolactin Promoter Polymorphism at −1149G/T
- Thermal inactivation reaction rates for ricin are influenced by pH and carbohydrates
Showing 5 of 7 shared publications
Bridgett Knox
National Center for Toxicological Research
7 shared publications
In database
- Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans
- The expression, induction and pharmacological activity of CYP1A2 are post-transcriptionally regulated by microRNA hsa-miR-132-5p
- MicroRNA hsa-miR-25-3p suppresses the expression and drug induction of CYP2B6 in human hepatocytes
- Modulation of ALDH5A1 and SLC22A7 by microRNA hsa-miR-29a-3p in human liver cells
- Long noncoding RNA LINC00844-mediated molecular network regulates expression of drug metabolizing enzymes and nuclear receptors in human liver cells
Showing 5 of 7 shared publications
Zhen Ren
National Center for Toxicological Research (US)
7 shared publications
- Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans
- Mitochondrial dysfunction induced by leflunomide and its active metabolite
- The expression, induction and pharmacological activity of CYP1A2 are post-transcriptionally regulated by microRNA hsa-miR-132-5p
- MicroRNA hsa-miR-25-3p suppresses the expression and drug induction of CYP2B6 in human hepatocytes
- Activation of the Nrf2 signaling pathway in usnic acid-induced toxicity in HepG2 cells
Showing 5 of 7 shared publications
Dongying Li
National Center for Toxicological Research
7 shared publications
In database
- Regulation of cytochrome P450 expression by microRNAs and long noncoding RNAs: Epigenetic mechanisms in environmental toxicology and carcinogenesis
- Characterization of cytochrome P450s (CYP)-overexpressing HepG2 cells for assessing drug and chemical-induced liver toxicity
- Long noncoding RNA LINC00844-mediated molecular network regulates expression of drug metabolizing enzymes and nuclear receptors in human liver cells
- MicroRNAs hsa-miR-495-3p and hsa-miR-486-5p suppress basal and rifampicin-induced expression of human sulfotransferase 2A1 (SULT2A1) by facilitating mRNA degradation
- Coordinated Regulation of UGT2B15 Expression by Long Noncoding RNA LINC00574 and hsa-miR-129-5p in HepaRG Cells
Showing 5 of 7 shared publications
Lauren S. Jackson
Center for Food Safety and Applied Nutrition (US)
6 shared publications
- Thermal Inactivation of Ricin Using Infant Formula as a Food Matrix
- Thermal Stability of Ricin in Orange and Apple Juices
- Chemical Inactivation of Protein Toxins on Food Contact Surfaces
- Thermal inactivation reaction rates for ricin are influenced by pH and carbohydrates
- Influence of yogurt fermentation and refrigerated storage on the stability of protein toxin contaminants
Showing 5 of 6 shared publications
Peter P. Fu
National Center for Toxicological Research (US)
5 shared publications
- Photodecomposition and Phototoxicity of Natural Retinoids
- Photoreaction, Phototoxicity, and Photocarcinogenicity of Retinoids
- Physiological Role of Retinyl Palmitate in the Skin
- Primary and secondary pyrrolic metabolites of pyrrolizidine alkaloids form DNA adducts in human A549 cells
- Metabolic Activation of Pyrrolizidine Alkaloids Leading to Phototoxicity and Photogenotoxicity in Human HaCaT Keratinocytes
Mona I. Churchwell
National Center for Toxicological Research
5 shared publications
In database
- Metabolism of Biochanin A and Formononetin by Human Liver Microsomes in Vitro
- Inhibition of Extrahepatic Human Cytochromes P450 1A1 and 1B1 by Metabolism of Isoflavones Found in Trifolium pratense (Red Clover)
- Identification of Ceramides in Human Cells Using Liquid Chromatography with detection by Atmospheric Pressure Chemical Ionization-Mass Spectrometry
- Effect of p53 Genotype on Gene Expression and DNA Adducts in ENU‐Exposed Mice
- Identification of Ceramides in Human Cells Using Liquid Chromatography with detection by Atmospheric Pressure Chemical Ionization‐Mass Spectrometry
Letha H. Couch
National Center for Toxicological Research (US)
5 shared publications
- Fumonisin B1 induces apoptosis in cultured human keratinocytes through sphinganine accumulation and ceramide depletion.
- Identification of Ceramides in Human Cells Using Liquid Chromatography with detection by Atmospheric Pressure Chemical Ionization-Mass Spectrometry
- Mitochondrial dysfunction induced by leflunomide and its active metabolite
- Activation of the Nrf2 signaling pathway in usnic acid-induced toxicity in HepG2 cells
- Identification of Ceramides in Human Cells Using Liquid Chromatography with detection by Atmospheric Pressure Chemical Ionization‐Mass Spectrometry
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