Vijayalakshmi Sridharan

High Impact

Researcher

University of Arkansas for Medical Sciences

faculty

27 h-index 99 pubs 2,454 cited

Research Areas

Cardiovascular Function and Risk Factors Metabolomics and Mass Spectrometry Studies Radiation Therapy and Dosimetry Immune Response and Inflammation Pharmacological Effects and Toxicity Studies Diet and metabolism studies Health and Medical Research Impacts

Links

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OverviewAI-generated summary

Vijayalakshmi Sridharan's research investigates the biological effects of radiation, with a particular focus on cardiac function and metabolic alterations. Her work examines how different types of radiation, including simulated galactic cosmic radiation and low-dose oxygen ions, impact the structure and function of the mouse heart. Sridharan also studies the role of specific biological pathways, such as Toll-like receptor 4 (TLR4), in radiation-induced heart disease and explores the potential protective effects of compounds like Dantrolene against treatment-induced lymphostasis.

Her publications also delve into sex-dependent effects of genetic factors and radiation exposure on various tissues, including the heart, small intestine, and skin. Sridharan utilizes metabolomics to predict radiation-induced cardiac dysfunction and to track longitudinal metabolic changes in response to radiation. Her research network includes collaborators at the University of Arkansas for Medical Sciences, such as Marjan Boerma, Martin Hauer-Jensen, Benjamin J. Lieblong, and Ashley Nemec-Bakk, with whom she has co-authored multiple publications.

Sridharan holds a high-impact researcher designation, evidenced by her h-index of 27, 2,454 total citations, and 99 total publications. Her recent activity indicates ongoing contributions to her field.

Metrics

  • h-index: 27
  • Publications: 99
  • Citations: 2,454

Selected Publications

  • Changes in gut, microbiome, and cognition after doxorubicin, cyclophosphamide, and paclitaxel chemotherapy treatment (2026) DOI
  • Implications of cyclophosphamide, methotrexate, and 5-fluorouracil chemotherapy on hippocampal-dependent cognition and gut microbiome (2025) DOI
  • Exposure to a Single Dose of Space-Relevant Proton Radiation Alters the Intestinal One-Carbon Metabolism Pathway and Microbiome in Mice (2025) DOI
  • Long-term effects of combined exposures to simulated microgravity and galactic cosmic radiation on the mouse lung: sex-specific epigenetic reprogramming (2025) DOI
  • Sex-specific effects on the heart from combined exposure to simulated galactic cosmic radiation and hindlimb unloading (2024) DOI
  • Genetic Upregulation of Activated Protein C Mitigates Delayed Effects of Acute Radiation Exposure in the Mouse Plasma (2024) DOI
  • Genetic Upregulation of Activated Protein C Mitigates Delayed Effects of Acute Radiation Exposure in the Mouse Plasma (2024) DOI
  • A pooled analysis of nine studies in one institution to assess effects of whole heart irradiation in rat models (2023) DOI
  • TLR4—A Pertinent Player in Radiation-Induced Heart Disease? (2023) DOI
  • Urinary Metabolomics for the Prediction of Radiation-Induced Cardiac Dysfunction (2023) DOI
  • Effects of proton and oxygen ion irradiation on cardiovascular function and structure in a rabbit model (2023) DOI
  • Effects of Simulated 5-Ion Galactic Cosmic Radiation on Function and Structure of the Mouse Heart (2023) DOI
  • Effects of Whole and Partial Heart Irradiation on Collagen, Mast Cells, and Toll-like Receptor 4 in the Mouse Heart (2023) DOI
  • Low dose space radiation-induced effects on the mouse retina and blood-retinal barrier integrity (2022) DOI
  • Small animal models of localized heart irradiation (2022) DOI

Collaborators

Researchers in the database who share publications

Marjan Boerma University of Arkansas for Medical Sciences 16 shared publications Martin Hauer‐Jensen University of Arkansas for Medical Sciences 9 shared publications Benjamin J. Lieblong University of Arkansas for Medical Sciences 8 shared publications Ashley Nemec-Bakk University of Arkansas for Medical Sciences 6 shared publications Igor Koturbash University of Arkansas for Medical Sciences 4 shared publications Kimberly J. Krager University of Arkansas for Medical Sciences 4 shared publications Chase Swinton University of Arkansas for Medical Sciences 3 shared publications Rupak Pathak University of Arkansas for Medical Sciences 2 shared publications

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