Kimberly J. Krager Source Confirmed

Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.

High Impact

Researcher

University of Arkansas for Medical Sciences

faculty

20 h-index 71 pubs 2,772 cited

Research Areas

Bone Metabolism and Diseases Mitochondrial Function and Pathology Radiation Therapy and Dosimetry Cancer-related molecular mechanisms research Cardiovascular Function and Risk Factors Iron Metabolism and Disorders Immune Response and Inflammation Diversity and Career in Medicine

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OverviewAI-generated summary

Kimberly J. Krager's research investigates the molecular mechanisms underlying bone loss and radiation-induced damage, with a focus on mitochondrial function and cellular processes. Her work has explored the role of mitochondrial Sirt3 in age-related and estrogen deficiency-induced bone loss, as well as how transferrin receptor 1-mediated iron uptake influences bone mass through osteoclast mitochondria and the cytoskeleton. Krager has also studied the impact of ionizing radiation on bone, including simulated galactic cosmic rays, and their effects on mitochondrial metabolism in osteoclasts, leading to bone loss in mice.

Further investigations by Krager examine the activation of mitochondrial function in osteoclasts by ionizing radiation and its contribution to bone loss in young adult male mice. Her research extends to the cardiovascular system, exploring the role of Toll-like receptor 4 (TLR4) in radiation-induced heart disease and the sex-dependent effects of genetic upregulation of activated protein C on radiation exposure outcomes in various organs. Additionally, her work includes studying parthenolide-induced ferroptosis in hepatocellular carcinoma cells.

Metrics

  • h-index: 20
  • Publications: 71
  • Citations: 2,772

Selected Publications

  • SIRT3–IDH2 axis is a target of dietary fructose: implication of IDH2 as a key player in dietary carcinogen toxicity in mice colon (2025) DOI
  • Multimodal reprogramming of the tumor microenvironment by MMR and dual checkpoint blockade in hepatocellular carcinoma models (2025) DOI
  • Enhancing Rectal Cancer Radiosensitivity and Gut Protection through Methionine Restriction (2025) DOI
  • SIRT3-IDH2 axis is a target of dietary fructose: implication of IDH2 as a key player in dietary carcinogen toxicity in mice colon (2025) DOI
  • Tocotrienols Provide Radioprotection to Multiple Organ Systems through Complementary Mechanisms of Antioxidant and Signaling Effects (2023) DOI
  • TLR4—A Pertinent Player in Radiation-Induced Heart Disease? (2023) DOI
  • Abstract No. 106 Where are Women in Academic Interventional Radiology? (2023) DOI
  • Effect of Sirt3 on hippocampal MnSOD activity, mitochondrial function, physiology, and cognition in an aged murine model (2023) DOI
  • Effects of Whole and Partial Heart Irradiation on Collagen, Mast Cells, and Toll-like Receptor 4 in the Mouse Heart (2023) DOI
  • Effect of Sirt3 on Hippocampal MnSOD Activity, Mitochondrial Function, Physiology, And Cognition in an Aged Murine Model (2022) DOI
  • Effect of Sirt3 on Hippocampal MnSOD Activity, Mitochondrial Function, Physiology, and Cognition in an Aged Murine Model (2022) DOI
  • Hematopoietic cytoplasmic adaptor protein Hem1 promotes osteoclast fusion and bone resorption in mice (2022) DOI
  • Parthenolide induces rapid thiol oxidation that leads to ferroptosis in hepatocellular carcinoma cells (2022) DOI
  • Author response: Transferrin receptor 1-mediated iron uptake regulates bone mass in mice via osteoclast mitochondria and cytoskeleton (2022) DOI
  • Transferrin receptor 1-mediated iron uptake regulates bone mass in mice via osteoclast mitochondria and cytoskeleton (2022) DOI

Collaborators

Researchers in the database who share publications

Nükhet Aykin‐Burns University of Arkansas for Medical Sciences 24 shared publications Ha‐Neui Kim University of Arkansas for Medical Sciences 6 shared publications Francesca V. LoBianco University of Arkansas for Medical Sciences 6 shared publications Brian Koss University of Arkansas for Medical Sciences 4 shared publications Samuel G. Mackintosh University of Arkansas for Medical Sciences 4 shared publications Aaron J. Storey University of Arkansas for Medical Sciences 4 shared publications Samrat Roy Choudhury University of Arkansas for Medical Sciences 4 shared publications Charity L. Washam University of Arkansas for Medical Sciences 4 shared publications

Similar Researchers

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Bone Metabolism and Diseases Mitochondrial Function and Pathology Cancer-related molecular mechanisms research
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Enoch K. Larrey University of Arkansas for Medical Sciences
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Si Chen National Center for Toxicological Research
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Philip Palade University of Arkansas for Medical Sciences
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Wen Ling University of Arkansas for Medical Sciences
Bone Metabolism and Diseases Mitochondrial Function and Pathology Cancer-related molecular mechanisms research
Good match 3 shared topics