I
Igor Koturbash
High Impact
Professor
faculty
Environmental Health Sciences, College of Public Health
44 h-index
155 pubs
6,149 cited
Research Areas
Biography and Research Information
OverviewAI-generated summary
Igor Koturbash, Professor of Environmental Health Sciences at the University of Arkansas for Medical Sciences, investigates the impact of environmental factors and lifestyle choices on human health, with a particular focus on genetic instability and epigenetic alterations. His research group has explored the effects of dietary interventions, such as methionine restriction, on immune cells in murine models, demonstrating how nutritional deficiencies can enhance genetic instability.
Dr. Koturbash's work also extends to human health, examining cytogenetic and epigenetic aberrations in populations exposed to environmental factors. He has contributed to understanding the hepatotoxicity of herbal dietary supplements and the potential interactions with other medications. Furthermore, his research has addressed the influence of the COVID-19 pandemic on supplement usage and self-medication practices within Arkansas.
With a h-index of 44 and over 6,110 citations from 152 publications, Dr. Koturbash is recognized as a highly cited researcher. He collaborates with colleagues at the University of Arkansas for Medical Sciences, including Marjan Boerma, Laura Ewing, Charles M. Skinner, and Rupak Pathak, on numerous shared publications. His research is supported by various funding agencies and aims to elucidate complex health challenges at the intersection of environment, diet, and genetics.
Metrics
- h-index: 44
- Publications: 155
- Citations: 6,149
Selected Publications
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Co-occurring substance use disorders and the compounding effect of kratom on serious mental illness, US, 2021–2023 (2026)
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From kratom to 7-hydroxymitragynine: evolution of a natural remedy into a public-health threat (2025)
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Exposure to a Single Dose of Space-Relevant Proton Radiation Alters the Intestinal One-Carbon Metabolism Pathway and Microbiome in Mice (2025)
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A Systematic and Ethnobotanical Review of Ashwagandha's (<scp><i>Withania Somnifera</i></scp>) Teratogenic and Abortifacient Potentials (2025)
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Sex-specific immune alterations in mice following long-term simulated microgravity and chronic irradiation (2025)
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A Combined Approach for Rapid Dereplication of Herb–Drug Interaction Causative Agents in Botanical Extracts─A Molecular Networking Strategy To Identify Potential Pregnane X Receptor (PXR) Modulators in Yohimbe (2024)
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Sex-specific effects on the heart from combined exposure to simulated galactic cosmic radiation and hindlimb unloading (2024)
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First-year evaluation of a campus-wide, cross-disciplinary scholarly writing development program supported by a center for biomedical research excellence (COBRE) (2024)
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DSHEA 1994 – Celebrating 30 Years of Dietary Supplement Regulation in the United States (2024)
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Developing a Screening Strategy to Identify Hepatotoxicity and Drug Interaction Potential of Botanicals (2024)
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Botanical-induced toxicity: Liver injury and botanical-drug interactions. A report on a society of Toxicology Annual Meeting symposium (2024)
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Phenibut: A drug with one too many “buts” (2024)
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Human quad liver-on-chip system as a tool toward bridging the gap between animals and humans regarding toxicology and pharmacology of a cannabidiol-rich cannabis extract (2024)
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Inter-strain variability in responses to a single administration of the cannabidiol-rich cannabis extract in mice (2024)
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A Phase I Trial of a Methionine Restricted Diet with Concurrent Radiation Therapy (2024)
Grants & Funding
- Analysis of hepatotoxicity of the OxyELITE Pro dietary supplement in a mouse model US Department of Justice Principal Investigator
- The Diversity Outbred: A Tool to Improve Preclinical Safety Testing and Pharmacog U.S. Food and Drug Administration Principal Investigator
- Analysis of hepatotoxicity of the OxyELITE Pro dietary supplement in a mouse model US Department of Justice Principal Investigator
- Integration of in-silico and in-vivo Models for Determining Preclinical Indicators and/or Integrated Biomarkers of Radiation-Induced Vascular Dysfunction National Aeronautics & Space Administration - Pass Through: Louisiana State University Principal Investigator
- Team Leader for the Radiation Effects Team National Space Biomedical Research Institute - Pass Through: Baylor College of Medicine Co-Investigator
- Center for Studies of Host Response to Cancer Therapy NIH Co-Investigator
- Arkansas Center for Health Disparities (ARCHD): An NIMHD COE NIH Co-Investigator
- Effects of wood burning-associated smoke on satellite DNA NIH/Nat. Inst. for Occupational Safety & Health - Pass Through: University of Alabama at Birmingham Principal Investigator
Collaboration Network
Top Collaborators
Marjan Boerma
University of Arkansas for Medical Sciences
10 shared publications
In database
- Cytogenetic and epigenetic aberrations in peripheral lymphocytes of northwest Arkansas Marshallese
- A Review of Numerical Models of Radiation Injury and Repair Considering Subcellular Targets and the Extracellular Microenvironment
- Effects of proton and oxygen ion irradiation on cardiovascular function and structure in a rabbit model
- Sex-specific effects on the heart from combined exposure to simulated galactic cosmic radiation and hindlimb unloading
- A Review of Numerical Models of Radiation Injury and Repair Considering Subcellular Targets and the Extracellular Microenvironment
Showing 5 of 10 shared publications
Rupak Pathak
University of Arkansas for Medical Sciences
6 shared publications
In database
- Dietary Methionine Deficiency Enhances Genetic Instability in Murine Immune Cells
- Cytogenetic and epigenetic aberrations in peripheral lymphocytes of northwest Arkansas Marshallese
- Methods for induction and assessment of intestinal permeability in rodent models of radiation injury
- Sex-specific immune alterations in mice following long-term simulated microgravity and chronic irradiation
- Cytogenetic and epigenetic aberrations in peripheral lymphocytes of northwest Arkansas Marshallese
Showing 5 of 6 shared publications
Laura Ewing
University of Arkansas for Medical Sciences
6 shared publications
In database
- Cytogenetic and epigenetic aberrations in peripheral lymphocytes of northwest Arkansas Marshallese
- Effects of proton and oxygen ion irradiation on cardiovascular function and structure in a rabbit model
- Methods for induction and assessment of intestinal permeability in rodent models of radiation injury
- Human quad liver-on-chip system as a tool toward bridging the gap between animals and humans regarding toxicology and pharmacology of a cannabidiol-rich cannabis extract
- Inter-strain variability in responses to a single administration of the cannabidiol-rich cannabis extract in mice
Showing 5 of 6 shared publications
Charles M. Skinner
University of Arkansas for Medical Sciences
6 shared publications
In database
- Cytogenetic and epigenetic aberrations in peripheral lymphocytes of northwest Arkansas Marshallese
- Effects of proton and oxygen ion irradiation on cardiovascular function and structure in a rabbit model
- Human quad liver-on-chip system as a tool toward bridging the gap between animals and humans regarding toxicology and pharmacology of a cannabidiol-rich cannabis extract
- Inter-strain variability in responses to a single administration of the cannabidiol-rich cannabis extract in mice
- Cytogenetic and epigenetic aberrations in peripheral lymphocytes of northwest Arkansas Marshallese
Showing 5 of 6 shared publications
Bill J. Gurley
University of Mississippi (US)
6 shared publications
- Hepatotoxicity due to herbal dietary supplements: Past, present and the future
- Developing a Screening Strategy to Identify Hepatotoxicity and Drug Interaction Potential of Botanicals
- Human quad liver-on-chip system as a tool toward bridging the gap between animals and humans regarding toxicology and pharmacology of a cannabidiol-rich cannabis extract
- Phenibut: A drug with one too many “buts”
- A Combined Approach for Rapid Dereplication of Herb–Drug Interaction Causative Agents in Botanical Extracts─A Molecular Networking Strategy To Identify Potential Pregnane X Receptor (PXR) Modulators in Yohimbe
Showing 5 of 6 shared publications
Isabelle R. Miousse
University of Arkansas for Medical Sciences
5 shared publications
In database
- Dietary Methionine Deficiency Enhances Genetic Instability in Murine Immune Cells
- Climate Change and New Challenges for Rural Communities: Particulate Matter Matters
- Effects of proton and oxygen ion irradiation on cardiovascular function and structure in a rabbit model
- Methylsulfonylmethane Serves as a Donor of Methyl Groups for Methylation of DNA in Human Liver HepaRG Cells
- Exposure to a Single Dose of Space-Relevant Proton Radiation Alters the Intestinal One-Carbon Metabolism Pathway and Microbiome in Mice
Martin Hauer‐Jensen
University of Arkansas for Medical Sciences
5 shared publications
In database
- Dietary Methionine Deficiency Enhances Genetic Instability in Murine Immune Cells
- Cytogenetic and epigenetic aberrations in peripheral lymphocytes of northwest Arkansas Marshallese
- Methods for induction and assessment of intestinal permeability in rodent models of radiation injury
- Cytogenetic and epigenetic aberrations in peripheral lymphocytes of northwest Arkansas Marshallese
- Exposure to a Single Dose of Space-Relevant Proton Radiation Alters the Intestinal One-Carbon Metabolism Pathway and Microbiome in Mice
Jeffrey S. Willey
Wake Forest University (US)
5 shared publications
- A Review of Numerical Models of Radiation Injury and Repair Considering Subcellular Targets and the Extracellular Microenvironment
- Sex-specific effects on the heart from combined exposure to simulated galactic cosmic radiation and hindlimb unloading
- A Review of Numerical Models of Radiation Injury and Repair Considering Subcellular Targets and the Extracellular Microenvironment
- Long-term effects of combined exposures to simulated microgravity and galactic cosmic radiation on the mouse lung: sex-specific epigenetic reprogramming
- Exposure to a Single Dose of Space-Relevant Proton Radiation Alters the Intestinal One-Carbon Metabolism Pathway and Microbiome in Mice
Reid D. Landes
University of Arkansas for Medical Sciences (US)
4 shared publications
- Cytogenetic and epigenetic aberrations in peripheral lymphocytes of northwest Arkansas Marshallese
- Effects of proton and oxygen ion irradiation on cardiovascular function and structure in a rabbit model
- Cytogenetic and epigenetic aberrations in peripheral lymphocytes of northwest Arkansas Marshallese
- First-year evaluation of a campus-wide, cross-disciplinary scholarly writing development program supported by a center for biomedical research excellence (COBRE)
Mitchell R. McGill
University of Arkansas for Medical Sciences
4 shared publications
In database
- Hepatotoxicity due to herbal dietary supplements: Past, present and the future
- Human quad liver-on-chip system as a tool toward bridging the gap between animals and humans regarding toxicology and pharmacology of a cannabidiol-rich cannabis extract
- Natural Products That Protect Against Acetaminophen Hepatotoxicity: A Call for Increased Rigor in Preclinical Studies of Dietary Supplements
- Methylsulfonylmethane Serves as a Donor of Methyl Groups for Methylation of DNA in Human Liver HepaRG Cells
Kirsten Clement
University of Arkansas for Medical Sciences
4 shared publications
In database
- Human quad liver-on-chip system as a tool toward bridging the gap between animals and humans regarding toxicology and pharmacology of a cannabidiol-rich cannabis extract
- Inter-strain variability in responses to a single administration of the cannabidiol-rich cannabis extract in mice
- Long-term effects of combined exposures to simulated microgravity and galactic cosmic radiation on the mouse lung: sex-specific epigenetic reprogramming
- Methylsulfonylmethane Serves as a Donor of Methyl Groups for Methylation of DNA in Human Liver HepaRG Cells
Vijayalakshmi Sridharan
University of Arkansas for Medical Sciences
4 shared publications
In database
- Effects of proton and oxygen ion irradiation on cardiovascular function and structure in a rabbit model
- Sex-specific effects on the heart from combined exposure to simulated galactic cosmic radiation and hindlimb unloading
- Long-term effects of combined exposures to simulated microgravity and galactic cosmic radiation on the mouse lung: sex-specific epigenetic reprogramming
- Exposure to a Single Dose of Space-Relevant Proton Radiation Alters the Intestinal One-Carbon Metabolism Pathway and Microbiome in Mice
Wayne Newhauser
Mary Bird Perkins Cancer Center (US)
4 shared publications
- A Review of Numerical Models of Radiation Injury and Repair Considering Subcellular Targets and the Extracellular Microenvironment
- Sex-specific effects on the heart from combined exposure to simulated galactic cosmic radiation and hindlimb unloading
- A Review of Numerical Models of Radiation Injury and Repair Considering Subcellular Targets and the Extracellular Microenvironment
- Long-term effects of combined exposures to simulated microgravity and galactic cosmic radiation on the mouse lung: sex-specific epigenetic reprogramming
Jacqueline P. Williams
University of Rochester Medical Center (US)
4 shared publications
- A Review of Numerical Models of Radiation Injury and Repair Considering Subcellular Targets and the Extracellular Microenvironment
- Sex-specific effects on the heart from combined exposure to simulated galactic cosmic radiation and hindlimb unloading
- A Review of Numerical Models of Radiation Injury and Repair Considering Subcellular Targets and the Extracellular Microenvironment
- Long-term effects of combined exposures to simulated microgravity and galactic cosmic radiation on the mouse lung: sex-specific epigenetic reprogramming
Jeffery C. Chancellor
Texas Medical Center (US)
4 shared publications
- A Review of Numerical Models of Radiation Injury and Repair Considering Subcellular Targets and the Extracellular Microenvironment
- Sex-specific effects on the heart from combined exposure to simulated galactic cosmic radiation and hindlimb unloading
- A Review of Numerical Models of Radiation Injury and Repair Considering Subcellular Targets and the Extracellular Microenvironment
- Long-term effects of combined exposures to simulated microgravity and galactic cosmic radiation on the mouse lung: sex-specific epigenetic reprogramming
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