Narasimhappagari Jagadeesh

Researcher

University of Arkansas for Medical Sciences

faculty

6 h-index 17 pubs 93 cited

Research Areas

Cancer-related molecular mechanisms research Neurological disorders and treatments Neuroinflammation and Neurodegeneration Mechanisms Microbial infections and disease research Immune Response and Inflammation Alzheimer's disease research and treatments Glioma Diagnosis and Treatment Synthesis and biological activity

Is this your profile? Verify and claim your profile

OverviewAI-generated summary

Narasimhappagari Jagadeesh's research focuses on investigating the molecular mechanisms underlying various diseases and exploring potential therapeutic interventions. His work has examined the role of specific lectins, such as those from *Aspergillus niger* and *Adenia hondala*, in inducing apoptosis and necrosis in cancer cells, suggesting their potential as anti-cancer agents. Jagadeesh has also investigated the pathogenesis of neurological disorders, including Alzheimer's disease and glioblastoma. His publications explore the contribution of genetic factors like APOEε4 and inflammatory cytokines like IL-1β to Alzheimer's neuropathogenesis, and the potential therapeutic effects of IL-1β receptor antagonists and other compounds in glioblastoma. He has also studied the role of fungal lectins in causing infections, such as mycotic keratitis. Jagadeesh's research network includes collaborators from the University of Arkansas for Medical Sciences, including W. Sue T. Griffin, Srinivas Ayyadevara, and Meenakshisundaram Balasubramaniam, with whom he has co-authored multiple publications.

Metrics

  • h-index: 6
  • Publications: 17
  • Citations: 93

Selected Publications

  • When Two Worlds Collide: The Contribution and Association Between Genetics (APOEε4) and Neuroinflammation (IL-1β) in Alzheimer’s Neuropathogenesis (2025) DOI
  • The Seminal Role of the Proinflammatory Cytokine IL-1β and Its Signaling Cascade in Glioblastoma Pathogenesis and the Therapeutic Effect of Interleukin-1β Receptor Antagonist (IL-1RA) and Tolcapone (2025) DOI
  • Abstract LB131: The role of the proinflammatory cytokine IL-1β and its signaling cascade in glioblastoma pathogenesis and the therapeutic effect of IL-1RA and Tolcapone as anticancer agents (2025) DOI
  • Rescue of ApoE4-related lysosomal autophagic failure in Alzheimer’s disease by targeted small molecules (2024) DOI

Collaborators

Researchers in the database who share publications

W. Sue T. Griffin University of Arkansas for Medical Sciences 4 shared publications Srinivas Ayyadevara University of Arkansas for Medical Sciences 4 shared publications Meenakshisundaram Balasubramaniam University of Arkansas for Medical Sciences 4 shared publications Orwa Aboud University of Arkansas for Medical Sciences 2 shared publications Robert J. Shmookler Reis University of Arkansas for Medical Sciences 1 shared publication Akshatha Ganne University of Arkansas for Medical Sciences 1 shared publication Steven W. Barger University of Arkansas for Medical Sciences 1 shared publication Haarika Ayyadevara University of Arkansas at Fayetteville 1 shared publication

Similar Researchers

Based on overlapping research topics

W. Sue T. Griffin University of Arkansas for Medical Sciences
Cancer-related molecular mechanisms research Neuroinflammation and Neurodegeneration Mechanisms Immune Response and Inflammation
Good match 5 shared topics
Rachel Hendrix University of Arkansas for Medical Sciences
Cancer-related molecular mechanisms research Neurological disorders and treatments Microbial infections and disease research
Good match 4 shared topics
Sarah Assem University of Arkansas for Medical Sciences
Cancer-related molecular mechanisms research Neurological disorders and treatments Microbial infections and disease research
Good match 4 shared topics
Yamin Meng University of Arkansas for Medical Sciences
Cancer-related molecular mechanisms research Neurological disorders and treatments Microbial infections and disease research
Good match 4 shared topics
Karthika Veerapaneni University of Arkansas for Medical Sciences
Neurological disorders and treatments Neuroinflammation and Neurodegeneration Mechanisms Alzheimer's disease research and treatments
Good match 3 shared topics
Saima Fawad University of Arkansas for Medical Sciences
Cancer-related molecular mechanisms research Microbial infections and disease research Immune Response and Inflammation
Good match 3 shared topics