Match tier
Institution-verified
Presence
Current · Arkansas
Last published
2026
Sources
Institutional record
Refreshed
2026-10-09
S
Srinivas Ayyadevara
Sourced from institutional research profiles (UAMS TRI or ARA).
High Impact
Professor
Also affiliated: University of Rome Tor Vergata (2016); United States Department of Veterans Affairs (2017); University of Arkansas Medical Center (2016); Central Arkansas Veterans Healthcare System (2000–2026); Geriatric Research Education and Clinical Center (2024); John L. McClellan Memorial Veterans Hospital (2011–2026); Louisiana Tech University (1994)
32 h-index
93 pubs
5,636 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Srinivas Ayyadevara, a professor at the University of Arkansas for Medical Sciences, studies the biological mechanisms underlying aging and age-related diseases, with a particular focus on neurodegeneration and longevity. His research utilizes model organisms, including *Caenorhabditis elegans* and mice, to investigate pathways that influence lifespan and stress resistance. Ayyadevara has received funding from the National Institute on Aging for his work on common pathways involved in neurodegeneration and other age-progressive diseases.
His publications include studies on the role of lipid biosynthesis in stress resistance and longevity in *C. elegans*, the effects of aspirin on lifespan and functional decline in nematodes, and the influence of apolipoprotein E4 on autophagy. He has also investigated the development of small-molecule inhibitors for cancer treatment. Ayyadevara's work is supported by collaborations with researchers at the University of Arkansas for Medical Sciences, including Robert J. Shmookler Reis, Meenakshisundaram Balasubramaniam, Akshatha Ganne, and W. Sue T. Griffin. His scholarly output is reflected in an h-index of 32, with over 5,500 citations across 93 publications.
Metrics
- h-index: 32
- Publications: 93
- Citations: 5,636
Positions
-
Professor 2025–presentUniversity of Arkansas for Medical Sciences Geriatrics Institutional directory
-
Research Health Scientiat 2022–presentCentral Arkansas Veterans Healthcare System GRECC ORCID
Selected Publications
-
Abstract LB320: Inverse relationship between cancer and Alzheimer’s disease: Important interplay between autophagy and apoptosis signaling mechanisms (2026)
-
Development of an AI-Enhanced Workflow for Automated Quality Classification of Biomedical Fluorescence (2026)
-
The aggregate proteome of Caenorhabditis elegans mitochondria implicates shared mechanisms of aging and Alzheimer’s disease (2026)
-
Machine Learning–Enhanced Quantitative Structure-Activity Relationship Modeling for DNA Polymerase Inhibitor Discovery: Algorithm Development and Validation (2025)
-
When Two Worlds Collide: The Contribution and Association Between Genetics (APOEε4) and Neuroinflammation (IL-1β) in Alzheimer’s Neuropathogenesis (2025)
-
The Seminal Role of the Proinflammatory Cytokine IL-1β and Its Signaling Cascade in Glioblastoma Pathogenesis and the Therapeutic Effect of Interleukin-1β Receptor Antagonist (IL-1RA) and Tolcapone (2025)
-
DNA Polymerase Inhibitor Discovery Using Machine Learning-Enhanced QSAR Modeling (2025)
-
Altered protein homeostasis in cardiovascular diseases contributes to Alzheimer’s-like neuropathology (2025)
-
Abstract LB131: The role of the proinflammatory cytokine IL-1β and its signaling cascade in glioblastoma pathogenesis and the therapeutic effect of IL-1RA and Tolcapone as anticancer agents (2025)
-
Mitochondria in aging and age-associated diseases (2025)
-
Ezetimibe Lowers Risk of Alzheimer’s and Related Dementias over Sevenfold, Reducing Aggregation in Model Systems by Inhibiting 14-3-3G::Hexokinase Interaction (2024)
-
Model biological systems demonstrate the inducibility of pathways that strongly reduce cryoprotectant toxicity (2024)
-
Rescue of ApoE4-related lysosomal autophagic failure in Alzheimer’s disease by targeted small molecules (2024)
-
Alzheimer’s-specific brain amyloid interactome: Neural-network analysis of intra-aggregate crosslinking identifies novel drug targets (2023)
-
Myocardial infarction elevates endoplasmic reticulum stress and protein aggregation in heart as well as brain (2023)
Federal Grants 1 $374,971 total
NIH
Co-PI
Sep 2018 - May 2024
Inference of Common Pathways Underlying Neurodegeneration & Other Age-Progressive Diseases
Grants & Funding
As listed on this researcher's institutional profile. Federal awards with verified records are shown above.
- Mechanisms of PCSK9 in endothelial aging NIH/Nat. Inst. on Aging
- Inference of Common Pathways Underlying Neurodegeneration & Other Age-Progressive Diseases - Continuation - Continuation NIH/Nat. Inst. on Aging
- Neuroinflammation, Protein Aggregates, ApoE4 Drug Targeting, and Autophagy Rescue NIH/Nat. Inst. on Aging
- Role of glutathione transferases in life span extension of C. elegans NIH
- Early Events in Alzheimer Pathogenesis NIH
- Neuroinflammation, Protein Aggregates, ApoE4 Drug Targeting, and Autophagy Rescue NIH
Collaboration Network
Top Collaborators
Robert J. Shmookler Reis
University of Arkansas at Little Rock
55 shared publications
In database
- Remarkable longevity and stress resistance of nematode PI3K‐null mutants
- Modulation of lipid biosynthesis contributes to stress resistance and longevity of C. elegans mutants
- Discrimination of Primer 3′-Nucleotide Mismatch by Taq DNA Polymerase during Polymerase Chain Reaction
- Apolipoprotein E4 inhibits autophagy gene products through direct, specific binding to CLEAR motifs
- Aspirin Inhibits Oxidant Stress, Reduces Age-Associated Functional Declines, and Extends Lifespan of Caenorhabditis elegans
Showing 5 of 55 shared publications
Meenakshisundaram Balasubramaniam
University of Arkansas for Medical Sciences
32 shared publications
In database
- Apolipoprotein E4 inhibits autophagy gene products through direct, specific binding to CLEAR motifs
- Proteins that mediate protein aggregation and cytotoxicity distinguish Alzheimer's hippocampus from normal controls
- Aspirin-Mediated Acetylation Protects Against Multiple Neurodegenerative Pathologies by Impeding Protein Aggregation
- Proteins in aggregates functionally impact multiple neurodegenerative disease models by forming proteasome‐blocking complexes
- Proteins that accumulate with age in human skeletal-muscle aggregates contribute to declines in muscle mass and function in Caenorhabditis elegans
Showing 5 of 32 shared publications
Akshatha Ganne
University of Arkansas for Medical Sciences
17 shared publications
In database
- Glial Fibrillary Acidic Protein: A Biomarker and Drug Target for Alzheimer’s Disease
- Intrinsically disordered proteins identified in the aggregate proteome serve as biomarkers of neurodegeneration
- “Protein aggregates” contain RNA and DNA, entrapped by misfolded proteins but largely rescued by slowing translational elongation
- Aggregate Interactome Based on Protein Cross-linking Interfaces Predicts Drug Targets to Limit Aggregation in Neurodegenerative Diseases
- A Novel Microtubule-Binding Drug Attenuates and Reverses Protein Aggregation in Animal Models of Alzheimer’s Disease
Showing 5 of 17 shared publications
Ramani Alla
Central Arkansas Veterans Healthcare System
11 shared publications
In database
- Remarkable longevity and stress resistance of nematode PI3K‐null mutants
- Modulation of lipid biosynthesis contributes to stress resistance and longevity of C. elegans mutants
- Proteins that mediate protein aggregation and cytotoxicity distinguish Alzheimer's hippocampus from normal controls
- A universal transcriptomic signature of age reveals the temporal scaling of Caenorhabditis elegans aging trajectories
- Aspirin-Mediated Acetylation Protects Against Multiple Neurodegenerative Pathologies by Impeding Protein Aggregation
Showing 5 of 11 shared publications
Nirjal Mainali
University of Arkansas for Medical Sciences
11 shared publications
In database
- Design and Synthesis of Novel Hybrid 8-Hydroxy Quinoline-Indole Derivatives as Inhibitors of Aβ Self-Aggregation and Metal Chelation-Induced Aβ Aggregation
- Mitochondria in aging and age-associated diseases
- Myocardial infarction elevates endoplasmic reticulum stress and protein aggregation in heart as well as brain
- Thiadiazolidinone (TDZD) Analogs Inhibit Aggregation-Mediated Pathology in Diverse Neurodegeneration Models, and Extend C. elegans Life- and Healthspan
- Ezetimibe Lowers Risk of Alzheimer’s and Related Dementias over Sevenfold, Reducing Aggregation in Model Systems by Inhibiting 14-3-3G::Hexokinase Interaction
Showing 5 of 11 shared publications
Samuel Kakraba
Tulane University (US)
9 shared publications
- Aspirin-Mediated Acetylation Protects Against Multiple Neurodegenerative Pathologies by Impeding Protein Aggregation
- Design and Synthesis of Novel Hybrid 8-Hydroxy Quinoline-Indole Derivatives as Inhibitors of Aβ Self-Aggregation and Metal Chelation-Induced Aβ Aggregation
- Aggregate Interactome Based on Protein Cross-linking Interfaces Predicts Drug Targets to Limit Aggregation in Neurodegenerative Diseases
- A Novel Microtubule-Binding Drug Attenuates and Reverses Protein Aggregation in Animal Models of Alzheimer’s Disease
- Thiadiazolidinone (TDZD) Analogs Inhibit Aggregation-Mediated Pathology in Diverse Neurodegeneration Models, and Extend C. elegans Life- and Healthspan
Showing 5 of 9 shared publications
John J. Thaden
University of Arkansas for Medical Sciences (US)
7 shared publications
- Remarkable longevity and stress resistance of nematode PI3K‐null mutants
- Modulation of lipid biosynthesis contributes to stress resistance and longevity of C. elegans mutants
- Discrimination of Primer 3′-Nucleotide Mismatch by Taq DNA Polymerase during Polymerase Chain Reaction
- Genetic Mapping of Quantitative Trait Loci Governing Longevity of Caenorhabditis elegans in Recombinant-Inbred Progeny of a Bergerac-BO × RC301 Interstrain Cross
- Genetic Loci Modulating Fitness and Life Span in Caenorhabditis elegans: Categorical Trait Interval Mapping in CL2a × Bergerac-BO Recombinant-Inbred Worms
Showing 5 of 7 shared publications
W. Sue T. Griffin
Central Arkansas Veterans Healthcare System
7 shared publications
In database
- Proteins that mediate protein aggregation and cytotoxicity distinguish Alzheimer's hippocampus from normal controls
- Rescue of ApoE4-related lysosomal autophagic failure in Alzheimer’s disease by targeted small molecules
- The Seminal Role of the Proinflammatory Cytokine IL-1β and Its Signaling Cascade in Glioblastoma Pathogenesis and the Therapeutic Effect of Interleukin-1β Receptor Antagonist (IL-1RA) and Tolcapone
- Glial Fibrillary Acidic Protein: A Biomarker and Drug Target for Alzheimer's Disease
- Abstract LB131: The role of the proinflammatory cytokine IL-1β and its signaling cascade in glioblastoma pathogenesis and the therapeutic effect of IL-1RA and Tolcapone as anticancer agents
Showing 5 of 7 shared publications
Steven W. Barger
Central Arkansas Veterans Healthcare System
6 shared publications
In database
- Apolipoprotein E4 inhibits autophagy gene products through direct, specific binding to CLEAR motifs
- Proteins that mediate protein aggregation and cytotoxicity distinguish Alzheimer's hippocampus from normal controls
- A Novel Microtubule-Binding Drug Attenuates and Reverses Protein Aggregation in Animal Models of Alzheimer’s Disease
- Rescue of ApoE4-related lysosomal autophagic failure in Alzheimer’s disease by targeted small molecules
- Thiadiazolidinone (TDZD) Analogs Inhibit Aggregation-Mediated Pathology in Diverse Neurodegeneration Models, and Extend C. elegans Life- and Healthspan
Showing 5 of 6 shared publications
Narsimha Reddy Penthala
University of Arkansas for Medical Sciences
6 shared publications
In database
- Design and Synthesis of Novel Hybrid 8-Hydroxy Quinoline-Indole Derivatives as Inhibitors of Aβ Self-Aggregation and Metal Chelation-Induced Aβ Aggregation
- Aggregate Interactome Based on Protein Cross-linking Interfaces Predicts Drug Targets to Limit Aggregation in Neurodegenerative Diseases
- A Novel Microtubule-Binding Drug Attenuates and Reverses Protein Aggregation in Animal Models of Alzheimer’s Disease
- Novel hydroxybenzylamine-deoxyvasicinone hybrids as anticholinesterase therapeutics for Alzheimer’s disease
- Thiadiazolidinone (TDZD) Analogs Inhibit Aggregation-Mediated Pathology in Diverse Neurodegeneration Models, and Extend C. elegans Life- and Healthspan
Showing 5 of 6 shared publications
Peter A. Crooks
University of Arkansas for Medical Sciences
6 shared publications
In database
- Design and Synthesis of Novel Hybrid 8-Hydroxy Quinoline-Indole Derivatives as Inhibitors of Aβ Self-Aggregation and Metal Chelation-Induced Aβ Aggregation
- Aggregate Interactome Based on Protein Cross-linking Interfaces Predicts Drug Targets to Limit Aggregation in Neurodegenerative Diseases
- A Novel Microtubule-Binding Drug Attenuates and Reverses Protein Aggregation in Animal Models of Alzheimer’s Disease
- Novel hydroxybenzylamine-deoxyvasicinone hybrids as anticholinesterase therapeutics for Alzheimer’s disease
- Thiadiazolidinone (TDZD) Analogs Inhibit Aggregation-Mediated Pathology in Diverse Neurodegeneration Models, and Extend C. elegans Life- and Healthspan
Showing 5 of 6 shared publications
Puneet Bharill
Central Arkansas Veterans Healthcare System (US)
5 shared publications
- Modulation of lipid biosynthesis contributes to stress resistance and longevity of C. elegans mutants
- Aspirin Inhibits Oxidant Stress, Reduces Age-Associated Functional Declines, and Extends Lifespan of Caenorhabditis elegans
- Positive Feedback between Transcriptional and Kinase Suppression in Nematodes with Extraordinary Longevity and Stress Resistance
- Extreme-longevity mutations orchestrate silencing of multiple signaling pathways
- Extreme Depletion of PIP3 Accompanies the Increased Life Span and Stress Tolerance of PI3K-null C. elegans Mutants
Sue Griffin
Central Arkansas Veterans Healthcare System
5 shared publications
In database
- Aggregate Interactome Based on Protein Cross-linking Interfaces Predicts Drug Targets to Limit Aggregation in Neurodegenerative Diseases
- Thiadiazolidinone (TDZD) Analogs Inhibit Aggregation-Mediated Pathology in Diverse Neurodegeneration Models, and Extend C. elegans Life- and Healthspan
- The aggregate proteome of Caenorhabditis elegans mitochondria implicates shared mechanisms of aging and Alzheimer’s disease
- P2‐181: IL‐1β INFLUENCES AUTOPHAGY BY MEDIATING UPREGULATION OF PARKIN AND PARKIN NEDDYLATION IN CELL CULTURE AND ANIMAL MODELS, AND MIMICS THE PATTERN SEEN IN AD BRAIN
- Aggregate Interactome Based on Protein-Crosslinking Interfaces Predicts Drug Targets to Limit Aggregation in Neurodegenerative Diseases
Sonu Pahal
University of Arkansas at Little Rock
5 shared publications
In database
- Mitochondria in aging and age-associated diseases
- Ezetimibe Lowers Risk of Alzheimer’s and Related Dementias over Sevenfold, Reducing Aggregation in Model Systems by Inhibiting 14-3-3G::Hexokinase Interaction
- Alzheimer’s-specific brain amyloid interactome: Neural-network analysis of intra-aggregate crosslinking identifies novel drug targets
- The aggregate proteome of Caenorhabditis elegans mitochondria implicates shared mechanisms of aging and Alzheimer’s disease
- Altered protein homeostasis in cardiovascular diseases contributes to Alzheimer’s-like neuropathology
David A. Alagpulinsa
University of Arkansas Medical Center (US)
4 shared publications
- A Small-Molecule Inhibitor of RAD51 Reduces Homologous Recombination and Sensitizes Multiple Myeloma Cells to Doxorubicin
- A Cyclin-Dependent Kinase Inhibitor, Dinaciclib, Impairs Homologous Recombination and Sensitizes Multiple Myeloma Cells to PARP Inhibition
- A peptide nucleic acid targeting nuclearRAD51sensitizes multiple myeloma cells to melphalan treatment
- Abstract 2400: Dinaciclib, an inhibitor of cyclin-dependent kinases (CDKs), impairs homologous recombination, abrogates G2 checkpoint arrest and sensitizes myeloma cells to PARP inhibition
Similar Researchers
Based on overlapping research topics
Vivek Yadala
University of Arkansas for Medical Sciences
Neurological disorders and treatments
Disease Mechanisms Research
Cancer Treatment and Pharmacology
Erika Horta
University of Arkansas for Medical Sciences
Neurological disorders and treatments
Disease Mechanisms Research
Cancer Treatment and Pharmacology
ML Calvert
University of Arkansas for Medical Sciences
Neurological disorders and treatments
Disease Mechanisms Research
Medical Research
Robert Kiss
University of Arkansas for Medical Sciences
Disease Mechanisms Research
Cancer Treatment and Pharmacology
Medical Research
Vicki Klimberg
University of Arkansas for Medical Sciences
Disease Mechanisms Research
Cancer Treatment and Pharmacology
Medical Research
Anna Lee Jarrett
University of Arkansas at Fayetteville
Neurological disorders and treatments
Disease Mechanisms Research
Medical Research