Srinivas Ayyadevara
Sourced from institutional research profiles (UAMS TRI or ARA).
Professor
Also affiliated: University of Rome Tor Vergata (2016); United States Department of Veterans Affairs (2017); British Geriatrics Society (2005–2012); University of Arkansas Medical Center (2015–2023); Auguste-Viktoria-Klinik (2010); Central Arkansas Veterans Healthcare System (2000–2026); Geriatric Research Education and Clinical Center (2009–2024); Institute on Aging (2016–2026); Department of Veterans Affairs (2010); John L. McClellan Memorial Veterans Hospital (2014–2026); Reynolds American (United States) (2017); Arkansas Department of Agriculture (2015); Institute of Pharmacology (2005); Louisiana Tech University (1994)
Faculty Researcher
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Srinivas Ayyadevara's research program investigates the molecular mechanisms underlying aging and age-associated neurodegenerative diseases, with a particular focus on Alzheimer's disease. His work examines the role of protein aggregation, mitochondrial function, and cellular stress pathways in these processes. Ayyadevara has explored the potential of specific molecules as therapeutic targets for Alzheimer's disease, including novel hydroxybenzylamine-deoxyvasicinone hybrids and small molecules designed to rescue lysosomal autophagic failure. His laboratory also studies the composition of protein aggregates, noting their potential to contain RNA and DNA and the impact of translational elongation on their resolution.
His research utilizes various model organisms, including *Caenorhabditis elegans* and mice, to understand fundamental biological processes related to aging and disease. Ayyadevara has received NIH funding to investigate common pathways underlying neurodegeneration and other age-progressive diseases. His scholarly output includes publications on glial fibrillary acidic protein as a biomarker and drug target for Alzheimer's disease, as well as the identification of intrinsically disordered proteins in the aggregate proteome as biomarkers of neurodegeneration. He maintains a high citation count, with an h-index of 31 and over 5,000 citations across his 91 publications, designating him as a highly cited researcher. Key collaborators include Robert J. Shmookler Reis, Meenakshisundaram Balasubramaniam, Akshatha Ganne, and Nirjal Mainali, all from the University of Arkansas for Medical Sciences.
Metrics
- h-index: 31
- Publications: 91
- Citations: 5,481
Selected Publications
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Abstract LB320: Inverse relationship between cancer and Alzheimer’s disease: Important interplay between autophagy and apoptosis signaling mechanisms (2026)
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Development of an AI-Enhanced Workflow for Automated Quality Classification of Biomedical Fluorescence (2026)
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The aggregate proteome of Caenorhabditis elegans mitochondria implicates shared mechanisms of aging and Alzheimer’s disease (2026)
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Machine Learning–Enhanced Quantitative Structure-Activity Relationship Modeling for DNA Polymerase Inhibitor Discovery: Algorithm Development and Validation (2025)
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When Two Worlds Collide: The Contribution and Association Between Genetics (APOEε4) and Neuroinflammation (IL-1β) in Alzheimer’s Neuropathogenesis (2025)
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The Seminal Role of the Proinflammatory Cytokine IL-1β and Its Signaling Cascade in Glioblastoma Pathogenesis and the Therapeutic Effect of Interleukin-1β Receptor Antagonist (IL-1RA) and Tolcapone (2025)
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Altered protein homeostasis in cardiovascular diseases contributes to Alzheimer’s-like neuropathology (2025)
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Abstract LB131: The role of the proinflammatory cytokine IL-1β and its signaling cascade in glioblastoma pathogenesis and the therapeutic effect of IL-1RA and Tolcapone as anticancer agents (2025)
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Mitochondria in aging and age-associated diseases (2025)
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Ezetimibe Lowers Risk of Alzheimer’s and Related Dementias over Sevenfold, Reducing Aggregation in Model Systems by Inhibiting 14-3-3G::Hexokinase Interaction (2024)
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Model biological systems demonstrate the inducibility of pathways that strongly reduce cryoprotectant toxicity (2024)
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Rescue of ApoE4-related lysosomal autophagic failure in Alzheimer’s disease by targeted small molecules (2024)
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Alzheimer’s-specific brain amyloid interactome: Neural-network analysis of intra-aggregate crosslinking identifies novel drug targets (2023)
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Myocardial infarction elevates endoplasmic reticulum stress and protein aggregation in heart as well as brain (2023)
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Thiadiazolidinone (TDZD) Analogs Inhibit Aggregation-Mediated Pathology in Diverse Neurodegeneration Models, and Extend C. elegans Life- and Healthspan (2023)
Federal Grants 1 $374,971 total
Inference of Common Pathways Underlying Neurodegeneration & Other Age-Progressive Diseases
Grants & Funding
As listed on this researcher's institutional profile. Federal awards with verified records are shown above.
- Mechanisms of PCSK9 in endothelial aging NIH/Nat. Inst. on Aging
- Inference of Common Pathways Underlying Neurodegeneration & Other Age-Progressive Diseases - Continuation - Continuation NIH/Nat. Inst. on Aging
- Neuroinflammation, Protein Aggregates, ApoE4 Drug Targeting, and Autophagy Rescue NIH/Nat. Inst. on Aging
- Role of glutathione transferases in life span extension of C. elegans NIH
- Early Events in Alzheimer Pathogenesis NIH
- Neuroinflammation, Protein Aggregates, ApoE4 Drug Targeting, and Autophagy Rescue NIH
Collaboration Network
Top Collaborators
- Glial Fibrillary Acidic Protein: A Biomarker and Drug Target for Alzheimer’s Disease
- “Protein aggregates” contain RNA and DNA, entrapped by misfolded proteins but largely rescued by slowing translational elongation
- Novel hydroxybenzylamine-deoxyvasicinone hybrids as anticholinesterase therapeutics for Alzheimer’s disease
- Rescue of ApoE4-related lysosomal autophagic failure in Alzheimer’s disease by targeted small molecules
- Mitochondria in aging and age-associated diseases
Showing 5 of 17 shared publications
- Glial Fibrillary Acidic Protein: A Biomarker and Drug Target for Alzheimer’s Disease
- “Protein aggregates” contain RNA and DNA, entrapped by misfolded proteins but largely rescued by slowing translational elongation
- Novel hydroxybenzylamine-deoxyvasicinone hybrids as anticholinesterase therapeutics for Alzheimer’s disease
- Rescue of ApoE4-related lysosomal autophagic failure in Alzheimer’s disease by targeted small molecules
- Mitochondria in aging and age-associated diseases
Showing 5 of 15 shared publications
- Glial Fibrillary Acidic Protein: A Biomarker and Drug Target for Alzheimer’s Disease
- “Protein aggregates” contain RNA and DNA, entrapped by misfolded proteins but largely rescued by slowing translational elongation
- Rescue of ApoE4-related lysosomal autophagic failure in Alzheimer’s disease by targeted small molecules
- Myocardial infarction elevates endoplasmic reticulum stress and protein aggregation in heart as well as brain
- Machine-learning analysis of intrinsically disordered proteins identifies key factors that contribute to neurodegeneration-related aggregation
Showing 5 of 11 shared publications
- Mitochondria in aging and age-associated diseases
- Myocardial infarction elevates endoplasmic reticulum stress and protein aggregation in heart as well as brain
- Thiadiazolidinone (TDZD) Analogs Inhibit Aggregation-Mediated Pathology in Diverse Neurodegeneration Models, and Extend C. elegans Life- and Healthspan
- Physiological Consequences of Targeting 14-3-3 and Its Interacting Partners in Neurodegenerative Diseases
- Alzheimer’s-specific brain amyloid interactome: Neural-network analysis of intra-aggregate crosslinking identifies novel drug targets
Showing 5 of 8 shared publications
- Rescue of ApoE4-related lysosomal autophagic failure in Alzheimer’s disease by targeted small molecules
- The Seminal Role of the Proinflammatory Cytokine IL-1β and Its Signaling Cascade in Glioblastoma Pathogenesis and the Therapeutic Effect of Interleukin-1β Receptor Antagonist (IL-1RA) and Tolcapone
- Glial Fibrillary Acidic Protein: A Biomarker and Drug Target for Alzheimer's Disease
- Abstract LB131: The role of the proinflammatory cytokine IL-1β and its signaling cascade in glioblastoma pathogenesis and the therapeutic effect of IL-1RA and Tolcapone as anticancer agents
- When Two Worlds Collide: The Contribution and Association Between Genetics (APOEε4) and Neuroinflammation (IL-1β) in Alzheimer’s Neuropathogenesis
- “Protein aggregates” contain RNA and DNA, entrapped by misfolded proteins but largely rescued by slowing translational elongation
- Rescue of ApoE4-related lysosomal autophagic failure in Alzheimer’s disease by targeted small molecules
- Thiadiazolidinone (TDZD) Analogs Inhibit Aggregation-Mediated Pathology in Diverse Neurodegeneration Models, and Extend C. elegans Life- and Healthspan
- Ezetimibe Lowers Risk of Alzheimer’s and Related Dementias over Sevenfold, Reducing Aggregation in Model Systems by Inhibiting 14-3-3G::Hexokinase Interaction
- Mitochondria in aging and age-associated diseases
- Alzheimer’s-specific brain amyloid interactome: Neural-network analysis of intra-aggregate crosslinking identifies novel drug targets
- Ezetimibe Lowers Risk of Alzheimer’s and Related Dementias over Sevenfold, Reducing Aggregation in Model Systems by Inhibiting 14-3-3G::Hexokinase Interaction
- The aggregate proteome of Caenorhabditis elegans mitochondria implicates shared mechanisms of aging and Alzheimer’s disease
- Rescue of ApoE4-related lysosomal autophagic failure in Alzheimer’s disease by targeted small molecules
- The Seminal Role of the Proinflammatory Cytokine IL-1β and Its Signaling Cascade in Glioblastoma Pathogenesis and the Therapeutic Effect of Interleukin-1β Receptor Antagonist (IL-1RA) and Tolcapone
- Abstract LB131: The role of the proinflammatory cytokine IL-1β and its signaling cascade in glioblastoma pathogenesis and the therapeutic effect of IL-1RA and Tolcapone as anticancer agents
- When Two Worlds Collide: The Contribution and Association Between Genetics (APOEε4) and Neuroinflammation (IL-1β) in Alzheimer’s Neuropathogenesis
- Myocardial infarction elevates endoplasmic reticulum stress and protein aggregation in heart as well as brain
- Protein homeostasis in the aged and diseased heart
- Proteomic analysis of transcription factors involved in the alteration of ischemic mouse heart as modulated by MSC exosomes
- Myocardial infarction elevates endoplasmic reticulum stress and protein aggregation in heart as well as brain
- Proteomic Analysis of Transcription Factors Involved in the Alteration of Ischemic Mouse Heart as Modulated by MSC Exosomes
- Proteomic analysis of transcription factors involved in the alteration of ischemic mouse heart as modulated by MSC exosomes
- Novel hydroxybenzylamine-deoxyvasicinone hybrids as anticholinesterase therapeutics for Alzheimer’s disease
- Thiadiazolidinone (TDZD) Analogs Inhibit Aggregation-Mediated Pathology in Diverse Neurodegeneration Models, and Extend C. elegans Life- and Healthspan
- Novel hydroxybenzylamine-deoxyvasicinone hybrids as anticholinesterase therapeutics for Alzheimer’s disease
- Thiadiazolidinone (TDZD) Analogs Inhibit Aggregation-Mediated Pathology in Diverse Neurodegeneration Models, and Extend C. elegans Life- and Healthspan
- Proteomic Analysis of Transcription Factors Involved in the Alteration of Ischemic Mouse Heart as Modulated by MSC Exosomes
- Proteomic analysis of transcription factors involved in the alteration of ischemic mouse heart as modulated by MSC exosomes
- Proteomic Analysis of Transcription Factors Involved in the Alteration of Ischemic Mouse Heart as Modulated by MSC Exosomes
- Proteomic analysis of transcription factors involved in the alteration of ischemic mouse heart as modulated by MSC exosomes
- Proteomic Analysis of Transcription Factors Involved in the Alteration of Ischemic Mouse Heart as Modulated by MSC Exosomes
- Proteomic analysis of transcription factors involved in the alteration of ischemic mouse heart as modulated by MSC exosomes
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