Biography and Research Information
OverviewAI-generated summary
Ramani Atluri studies the molecular mechanisms underlying neurodegenerative diseases, with a particular focus on Alzheimer's disease. Research investigates the role of protein aggregates, RNA and DNA entrapment within these aggregates, and the impact of translational elongation rates on their formation. Atluri's work also examines rescue strategies for lysosomal autophagic failure associated with Apolipoprotein E4 (ApoE4) in Alzheimer's disease, exploring targeted small molecules. Further studies assess the potential of thiadiazolidinone (TDZD) analogs to inhibit aggregation-mediated pathology in various neurodegeneration models and extend lifespan in *C. elegans*. Additionally, research explores how ezetimibe may lower the risk of Alzheimer's and related dementias by reducing aggregation in model systems through inhibition of a specific protein interaction.
Metrics
- h-index: 4
- Publications: 4
- Citations: 77
Selected Publications
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Ezetimibe Lowers Risk of Alzheimer’s and Related Dementias over Sevenfold, Reducing Aggregation in Model Systems by Inhibiting 14-3-3G::Hexokinase Interaction (2024)
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Rescue of ApoE4-related lysosomal autophagic failure in Alzheimer’s disease by targeted small molecules (2024)
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Thiadiazolidinone (TDZD) Analogs Inhibit Aggregation-Mediated Pathology in Diverse Neurodegeneration Models, and Extend C. elegans Life- and Healthspan (2023)
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“Protein aggregates” contain RNA and DNA, entrapped by misfolded proteins but largely rescued by slowing translational elongation (2021)
Collaboration Network
Top Collaborators
Robert J. Shmookler Reis
Geriatric Research Education and Clinical Center
4 shared publications
In database
- “Protein aggregates” contain RNA and DNA, entrapped by misfolded proteins but largely rescued by slowing translational elongation
- Rescue of ApoE4-related lysosomal autophagic failure in Alzheimer’s disease by targeted small molecules
- Thiadiazolidinone (TDZD) Analogs Inhibit Aggregation-Mediated Pathology in Diverse Neurodegeneration Models, and Extend C. elegans Life- and Healthspan
- Ezetimibe Lowers Risk of Alzheimer’s and Related Dementias over Sevenfold, Reducing Aggregation in Model Systems by Inhibiting 14-3-3G::Hexokinase Interaction
Meenakshisundaram Balasubramaniam
Central Arkansas Veterans Healthcare System
4 shared publications
In database
- “Protein aggregates” contain RNA and DNA, entrapped by misfolded proteins but largely rescued by slowing translational elongation
- Rescue of ApoE4-related lysosomal autophagic failure in Alzheimer’s disease by targeted small molecules
- Thiadiazolidinone (TDZD) Analogs Inhibit Aggregation-Mediated Pathology in Diverse Neurodegeneration Models, and Extend C. elegans Life- and Healthspan
- Ezetimibe Lowers Risk of Alzheimer’s and Related Dementias over Sevenfold, Reducing Aggregation in Model Systems by Inhibiting 14-3-3G::Hexokinase Interaction
Srinivas Ayyadevara
University of Arkansas for Medical Sciences
4 shared publications
In database
- “Protein aggregates” contain RNA and DNA, entrapped by misfolded proteins but largely rescued by slowing translational elongation
- Rescue of ApoE4-related lysosomal autophagic failure in Alzheimer’s disease by targeted small molecules
- Thiadiazolidinone (TDZD) Analogs Inhibit Aggregation-Mediated Pathology in Diverse Neurodegeneration Models, and Extend C. elegans Life- and Healthspan
- Ezetimibe Lowers Risk of Alzheimer’s and Related Dementias over Sevenfold, Reducing Aggregation in Model Systems by Inhibiting 14-3-3G::Hexokinase Interaction
Akshatha Ganne
University of Arkansas for Medical Sciences
3 shared publications
In database
- “Protein aggregates” contain RNA and DNA, entrapped by misfolded proteins but largely rescued by slowing translational elongation
- Rescue of ApoE4-related lysosomal autophagic failure in Alzheimer’s disease by targeted small molecules
- Ezetimibe Lowers Risk of Alzheimer’s and Related Dementias over Sevenfold, Reducing Aggregation in Model Systems by Inhibiting 14-3-3G::Hexokinase Interaction
Nirjal Mainali
Institute on Aging
2 shared publications
In database
- Thiadiazolidinone (TDZD) Analogs Inhibit Aggregation-Mediated Pathology in Diverse Neurodegeneration Models, and Extend C. elegans Life- and Healthspan
- Ezetimibe Lowers Risk of Alzheimer’s and Related Dementias over Sevenfold, Reducing Aggregation in Model Systems by Inhibiting 14-3-3G::Hexokinase Interaction
Steven W. Barger
Central Arkansas Veterans Healthcare System
2 shared publications
In database
- Rescue of ApoE4-related lysosomal autophagic failure in Alzheimer’s disease by targeted small molecules
- Thiadiazolidinone (TDZD) Analogs Inhibit Aggregation-Mediated Pathology in Diverse Neurodegeneration Models, and Extend C. elegans Life- and Healthspan
Jay E. Johnson
University of Arkansas for Medical Sciences (US)
1 shared publication
- “Protein aggregates” contain RNA and DNA, entrapped by misfolded proteins but largely rescued by slowing translational elongation
Samuel Kakraba
University of Arkansas for Medical Sciences (US)
1 shared publication
- Thiadiazolidinone (TDZD) Analogs Inhibit Aggregation-Mediated Pathology in Diverse Neurodegeneration Models, and Extend C. elegans Life- and Healthspan
B. Suresh Kuarm
University of Arkansas for Medical Sciences
1 shared publication
In database
- Thiadiazolidinone (TDZD) Analogs Inhibit Aggregation-Mediated Pathology in Diverse Neurodegeneration Models, and Extend C. elegans Life- and Healthspan
Narsimha Reddy Penthala
University of Arkansas for Medical Sciences
1 shared publication
In database
- Thiadiazolidinone (TDZD) Analogs Inhibit Aggregation-Mediated Pathology in Diverse Neurodegeneration Models, and Extend C. elegans Life- and Healthspan
Sue Griffin
Central Arkansas Veterans Healthcare System (US)
1 shared publication
- Thiadiazolidinone (TDZD) Analogs Inhibit Aggregation-Mediated Pathology in Diverse Neurodegeneration Models, and Extend C. elegans Life- and Healthspan
Peter A. Crooks
University of Arkansas for Medical Sciences
1 shared publication
In database
- Thiadiazolidinone (TDZD) Analogs Inhibit Aggregation-Mediated Pathology in Diverse Neurodegeneration Models, and Extend C. elegans Life- and Healthspan
Narasimhappagari Jagadeesh
University of Arkansas for Medical Sciences
1 shared publication
In database
- Rescue of ApoE4-related lysosomal autophagic failure in Alzheimer’s disease by targeted small molecules
Ling Liu
University of Arkansas for Medical Sciences (US)
1 shared publication
- Rescue of ApoE4-related lysosomal autophagic failure in Alzheimer’s disease by targeted small molecules
Haarika Ayyadevara
University of Arkansas at Fayetteville
1 shared publication
In database
- Rescue of ApoE4-related lysosomal autophagic failure in Alzheimer’s disease by targeted small molecules
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