Richard C. Kurten
Professor
Also affiliated: Arkansas Children's Hospital (2004–2024); Baylor College of Medicine (1987–1997); Johannes Gutenberg University Mainz (2000); Medical College of Wisconsin (2010); University of Arkansas Medical Center (2004–2022); University of California San Diego (1995–2024); Central Arkansas Veterans Healthcare System (2002); Baylor School (1987); Klinik und Poliklinik für Strahlentherapie und Radioonkologie (2008); La Jolla Bioengineering Institute (2024); Applied BioPhysics (United States) (2015); Arkansas Children's Nutrition Center (2019–2023); Institute of Molecular Biology and Biophysics (2005–2010); Arkansas Department of Agriculture (2008); Heinrich Heine University Düsseldorf (2008); Rogers (United States) (2023); Michigan State University (1987); Texas A&M University (1984–1987); Stanford University (1988)
Formerly Arkansas Affiliated with UAMS through 2024.
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Richard C. Kurten's research focuses on understanding the molecular and cellular mechanisms underlying various physiological and pathological processes, with a particular emphasis on respiratory and gastrointestinal diseases. His work has investigated the role of specific proteins and cytokines in conditions such as eosinophilic esophagitis and asthma. For instance, he has studied how mucins are packaged within secretory granules and how the cytokine TNFSF14/LIGHT influences inflammation and remodeling in murine models of eosinophilic esophagitis. His investigations also extend to the function of ORMDL3 in airway smooth muscle, impacting hypertrophy, hyperplasia, and contractility.
Further contributions from Kurten's lab include the development and utilization of research platforms to study infectious diseases. He has been involved in establishing an *ex vivo* human precision-cut lung slice platform to gain insights into SARS-CoV-2 pathogenesis and to evaluate antiviral drug efficacy. His research has also explored the effects of viral infections, such as rhinovirus, on human airways and smooth muscle function. Additionally, his work has examined the impact of neurotransmitter system-targeting drugs on the growth of pathogens like *Coxiella burnetii* in human cells.
Kurten holds a notable scholarly record, with an h-index of 32, reflecting 123 total publications that have garnered 3,640 citations. He is recognized as a highly cited researcher. His collaborative network includes Joshua L. Kennedy, Priyangi A. Malaviarachchi, Duah Alkam, and Srijon K. Banerjee, all affiliated with the University of Arkansas for Medical Sciences, with whom he has co-authored multiple publications.
Metrics
- h-index: 32
- Publications: 123
- Citations: 3,682
Positions
-
Professor publications 1997–2024University of Arkansas for Medical Sciences Institution web page
Selected Publications
-
An ex vivo human precision-cut lung slice platform provides insight into SARS-CoV-2 pathogenesis and antiviral drug efficacy (2024)
-
Mechanotransduction-induced interplay between phospholamban and yes-activated protein induces smooth muscle cell hypertrophy (2024)
-
Rhinovirus C15 Attenuates Relaxation and cAMP Production in Human Airways and Smooth Muscle (2023)
-
An ex vivo human precision-cut lung slice platform provides insight into SARS-CoV-2 pathogenesis and antiviral drug efficacy (2023)
-
A Deficiency in the Cytokine TNFSF14/LIGHT Limits Inflammation and Remodeling in Murine Eosinophilic Esophagitis (2022)
-
Mucin Expression in Human Precision-Cut Lung Slices (2022)
-
Mucins MUC5AC and MUC5B Are Variably Packaged in the Same and in Separate Secretory Granules (2022)
-
Reduced AIBP expression in bronchial epithelial cells of asthmatic patients: Potential therapeutic target (2022)
-
Esophageal Fibroblasts are the Players in the Interferon Response in Eosinophilic Esophagitis (2022)
-
LIGHT controls distinct homeostatic and inflammatory gene expression profiles in esophageal fibroblasts via differential HVEM and LTβR-mediated mechanisms (2021)
-
Neurotransmitter System-Targeting Drugs Antagonize Growth of the Q Fever Agent, Coxiella burnetii, in Human Cells (2021)
-
ORMDL3 expression in ASM regulates hypertrophy, hyperplasia via TPM1 and TPM4, and contractility (2021)
-
Integrative Proteomics and Phosphoproteomics of Asthmatic Airways following RV Infection (2021)
-
A unique esophageal extracellular matrix proteome alters normal fibroblast function in severe eosinophilic esophagitis (2021)
-
The Yersinia pestis GTPase BipA Promotes Pathogenesis of Primary Pneumonic Plague (2020)
Collaboration Network
Top Collaborators
- EGF receptor downregulation depends on a trafficking motif in the distal tyrosine kinase domain
- Coordinating epidermal growth factor-induced motility promotes efficient wound closure
- Effects of rhinovirus 39 infection on airway hyperresponsiveness to carbachol in human airways precision cut lung slices
- Effects of the β‐agonist, isoprenaline, on the down‐regulation, functional responsiveness and trafficking of β2‐adrenergic receptors with N‐terminal polymorphisms
- Characterization of a panel of six β2-adrenergic receptor antibodies by indirect immunofluorescence microscopy
Showing 5 of 20 shared publications
- Group 2 innate lymphocytes (ILC2) are enriched in active eosinophilic esophagitis
- TGF-β1–induced PAI-1 contributes to a profibrotic network in patients with eosinophilic esophagitis
- Increased Production of LIGHT by T Cells in Eosinophilic Esophagitis Promotes Differentiation of Esophageal Fibroblasts Toward an Inflammatory Phenotype
- Interleukin 9 Alters Epithelial Barrier and E‐cadherin in Eosinophilic Esophagitis
- LIGHT controls distinct homeostatic and inflammatory gene expression profiles in esophageal fibroblasts via differential HVEM and LTβR-mediated mechanisms
Showing 5 of 19 shared publications
- Group 2 innate lymphocytes (ILC2) are enriched in active eosinophilic esophagitis
- TGF-β1–induced PAI-1 contributes to a profibrotic network in patients with eosinophilic esophagitis
- Increased Production of LIGHT by T Cells in Eosinophilic Esophagitis Promotes Differentiation of Esophageal Fibroblasts Toward an Inflammatory Phenotype
- Interleukin 9 Alters Epithelial Barrier and E‐cadherin in Eosinophilic Esophagitis
- A unique esophageal extracellular matrix proteome alters normal fibroblast function in severe eosinophilic esophagitis
Showing 5 of 16 shared publications
- Modulation of airway hyperresponsiveness by rhinovirus exposure
- Effects of rhinovirus 39 infection on airway hyperresponsiveness to carbachol in human airways precision cut lung slices
- Rhinovirus C15 Induces Airway Hyperresponsiveness via Calcium Mobilization in Airway Smooth Muscle
- An ex vivo human precision-cut lung slice platform provides insight into SARS-CoV-2 pathogenesis and antiviral drug efficacy
- Acetaminophen is both bronchodilatory and bronchoprotective in human precision cut lung slice airways
Showing 5 of 14 shared publications
- Virulent Coxiella burnetii pathotypes productively infect primary human alveolar macrophages
- Coxiella burnetii Type IV Secretion-Dependent Recruitment of Macrophage Autophagosomes
- Development of an Ex Vivo Tissue Platform To Study the Human Lung Response to Coxiella burnetii
- Coxiella burnetii Subverts p62/Sequestosome 1 and Activates Nrf2 Signaling in Human Macrophages
- Coxiella burnetiiexploits host cAMP-dependent protein kinase signalling to promote macrophage survival
Showing 5 of 11 shared publications
- GSDMB induces an asthma phenotype characterized by increased airway responsiveness and remodeling without lung inflammation
- Group 2 innate lymphocytes (ILC2) are enriched in active eosinophilic esophagitis
- TGF-β1–induced PAI-1 contributes to a profibrotic network in patients with eosinophilic esophagitis
- β2 integrins rather than β1 integrins mediate Alternaria-induced group 2 innate lymphoid cell trafficking to the lung
- Regulatory B cells and T follicular helper cells are reduced in allergic rhinitis
Showing 5 of 11 shared publications
- TGF-β1–induced PAI-1 contributes to a profibrotic network in patients with eosinophilic esophagitis
- Interleukin 9 Alters Epithelial Barrier and E‐cadherin in Eosinophilic Esophagitis
- Rigid substrate induces esophageal smooth muscle hypertrophy and eosinophilic esophagitis fibrotic gene expression
- TGFβ1 single-nucleotide polymorphism C-509T alters mucosal cell function in pediatric eosinophilic esophagitis
- Plasminogen Activator Inhibitor-1 as a Marker of Esophageal Functional Changes in Pediatric Eosinophilic Esophagitis
Showing 5 of 11 shared publications
- Group 2 innate lymphocytes (ILC2) are enriched in active eosinophilic esophagitis
- TGF-β1–induced PAI-1 contributes to a profibrotic network in patients with eosinophilic esophagitis
- Interleukin 9 Alters Epithelial Barrier and E‐cadherin in Eosinophilic Esophagitis
- TGFβ1 single-nucleotide polymorphism C-509T alters mucosal cell function in pediatric eosinophilic esophagitis
- Plasminogen Activator Inhibitor-1 as a Marker of Esophageal Functional Changes in Pediatric Eosinophilic Esophagitis
Showing 5 of 10 shared publications
- TAS2R activation promotes airway smooth muscle relaxation despite β 2 -adrenergic receptor tachyphylaxis
- Modulation of airway hyperresponsiveness by rhinovirus exposure
- Effects of rhinovirus 39 infection on airway hyperresponsiveness to carbachol in human airways precision cut lung slices
- Mucins MUC5AC and MUC5B Are Variably Packaged in the Same and in Separate Secretory Granules
- The odorant receptor OR2W3 on airway smooth muscle evokes bronchodilation via a cooperative chemosensory tradeoff between TMEM16A and CFTR
Showing 5 of 9 shared publications
- Interleukin 9 Alters Epithelial Barrier and E‐cadherin in Eosinophilic Esophagitis
- LIGHT controls distinct homeostatic and inflammatory gene expression profiles in esophageal fibroblasts via differential HVEM and LTβR-mediated mechanisms
- A unique esophageal extracellular matrix proteome alters normal fibroblast function in severe eosinophilic esophagitis
- TGFβ1 single-nucleotide polymorphism C-509T alters mucosal cell function in pediatric eosinophilic esophagitis
- Development and Application of a Functional Human Esophageal Mucosa Explant Platform to Eosinophilic Esophagitis
Showing 5 of 9 shared publications
- TAS2R activation promotes airway smooth muscle relaxation despite β 2 -adrenergic receptor tachyphylaxis
- Modulation of airway hyperresponsiveness by rhinovirus exposure
- Effects of rhinovirus 39 infection on airway hyperresponsiveness to carbachol in human airways precision cut lung slices
- The odorant receptor OR2W3 on airway smooth muscle evokes bronchodilation via a cooperative chemosensory tradeoff between TMEM16A and CFTR
- Rhinovirus C15 Induces Airway Hyperresponsiveness via Calcium Mobilization in Airway Smooth Muscle
Showing 5 of 8 shared publications
- GSDMB induces an asthma phenotype characterized by increased airway responsiveness and remodeling without lung inflammation
- Group 2 innate lymphocytes (ILC2) are enriched in active eosinophilic esophagitis
- β2 integrins rather than β1 integrins mediate Alternaria-induced group 2 innate lymphoid cell trafficking to the lung
- Regulatory B cells and T follicular helper cells are reduced in allergic rhinitis
- Rigid substrate induces esophageal smooth muscle hypertrophy and eosinophilic esophagitis fibrotic gene expression
Showing 5 of 7 shared publications
- GSDMB induces an asthma phenotype characterized by increased airway responsiveness and remodeling without lung inflammation
- β2 integrins rather than β1 integrins mediate Alternaria-induced group 2 innate lymphoid cell trafficking to the lung
- Regulatory B cells and T follicular helper cells are reduced in allergic rhinitis
- Segmental allergen challenge increases levels of airway follistatin-like 1 in patients with asthma
- ORMDL3 expression in ASM regulates hypertrophy, hyperplasia via TPM1 and TPM4, and contractility
Showing 5 of 7 shared publications
- Virulent Coxiella burnetii pathotypes productively infect primary human alveolar macrophages
- Coxiella burnetii Type IV Secretion-Dependent Recruitment of Macrophage Autophagosomes
- Development of an Ex Vivo Tissue Platform To Study the Human Lung Response to Coxiella burnetii
- Coxiella burnetiiexploits host cAMP-dependent protein kinase signalling to promote macrophage survival
- Vasodilator-Stimulated Phosphoprotein Activity Is Required for Coxiella burnetii Growth in Human Macrophages
Showing 5 of 6 shared publications
- Effects of rhinovirus 39 infection on airway hyperresponsiveness to carbachol in human airways precision cut lung slices
- Effects Of Rhinovirus (RV) 39 Infection On Airway Hyper-Reactivity (AHR) To Histamine and Carbachol In Human Airways
- IL-25 Causes Airway Hyper-Responsiveness of Human Precision Cut Lung Slices from Donors with Asthma.
- IL-33 and IL-13 Receptors Are Upregulated in Precision Cut Lung Slices from Donors with Asthma during RV39 Infection
- Food-Induced Anaphylaxis: Visualization of Airway Contractility with Allergen Exposure in Precision Cut Lung Slices from a Donor with History of Fatal Anaphylaxis to Cashew
Showing 5 of 6 shared publications
Similar Researchers
Based on overlapping research topics