Priyangi A. Malaviarachchi
Researcher
Also affiliated: Winthrop Rockefeller Foundation (2009–2010); PDL BioPharma (United States) (2006)
Faculty Researcher
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Priyangi A. Malaviarachchi investigates host-pathogen interactions and immune responses, with a focus on infectious diseases affecting the lungs and reproductive tract. Her research utilizes *ex vivo* human precision-cut lung slices to study SARS-CoV-2 pathogenesis and evaluate antiviral drug efficacy. Malaviarachchi has also explored the role of specific immune mediators, such as Interleukin-17, in pulmonary inflammation during pneumonic plague and examined how interferon-gamma and antibodies contribute to immunity against *Chlamydia* infections, including their impact on female reproductive tract reinfections.
Her work extends to understanding disease severity in specific populations, as demonstrated by research on SARS-CoV-2 infection in a mouse model of Down Syndrome. Malaviarachchi also investigates the complex interplay of viral co-infections, examining alterations in cellular gene expression due to co-infection with Kaposi's Sarcoma-Associated Herpesvirus and SARS-CoV-2. She has published 24 papers, accumulating 465 citations, and holds an h-index of 8. Her collaborations include work with Srijon K. Banerjee, Lin‐Xi Li, Miguel A. B. Mercado, and Wuying Du at the University of Arkansas for Medical Sciences.
Metrics
- h-index: 8
- Publications: 24
- Citations: 468
Selected Publications
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Nicotine and cotinine enhance SARS-CoV-2 entry through distinct but complementary mechanisms in human respiratory epithelial cells (2026)
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Alterations in Cellular Gene Expression Due to Co‐Infection With Kaposi's Sarcoma‐Associated Herpesvirus and SARS‐CoV‐2: Implications for Disease Severity (2024)
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An <i>ex vivo</i> human precision-cut lung slice platform provides insight into SARS-CoV-2 pathogenesis and antiviral drug efficacy (2024)
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SARS-CoV-2 Infection Causes Heightened Disease Severity and Mortality in a Mouse Model of Down Syndrome (2024)
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Pulmonary Expression of Interleukin-17 Contributes to Neutrophil Infiltration into the Lungs during Pneumonic Plague (2023)
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An <i>ex vivo</i> human precision-cut lung slice platform provides insight into SARS-CoV-2 pathogenesis and antiviral drug efficacy (2023)
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IFNγ and Antibody Synergize To Enhance Protective Immunity against Chlamydia Dissemination and Female Reproductive Tract Reinfections (2022)
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IFNγ and antibody synergize to enhance protective immunity against <i>Chlamydia</i> dissemination and female reproductive tract reinfections (2022)
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Innate IFN-γ Is Essential for Systemic Chlamydia muridarum Control in Mice, While CD4 T Cell-Dependent IFN-γ Production Is Highly Redundant in the Female Reproductive Tract (2020)
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Innate IFNγ is essential for systemic <i>Chlamydia</i> control while CD4 T cell-dependent IFNγ production is highly redundant in the female reproductive tract (2020)
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Antibody, but not B‐cell–dependent antigen presentation, plays an essential role in preventing <i>Chlamydia</i> systemic dissemination in mice (2020)
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PTEN is indispensable for cells to respond to MAPK inhibitors in myeloid leukemia (2018)
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Myeloma-Derived Exosomes and Soluble Factors Suppress Natural Killer Cell Function (2016)
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Stem Cell-like Characteristics of MM Plasma Cells Vary By ROS Levels: Implications for Targeted Therapy (2015)
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Low BCL11A Expression in the Myeloma Microenvironment at Diagnosis Is Associated with Early Development of MDS Cytogenetic Abnormalities and Poor Overall Survival (2014)
Collaboration Network
Top Collaborators
- An <i>ex vivo</i> human precision-cut lung slice platform provides insight into SARS-CoV-2 pathogenesis and antiviral drug efficacy
- Pulmonary Expression of Interleukin-17 Contributes to Neutrophil Infiltration into the Lungs during Pneumonic Plague
- An <i>ex vivo</i> human precision-cut lung slice platform provides insight into SARS-CoV-2 pathogenesis and antiviral drug efficacy
- SARS-CoV-2 Infection Causes Heightened Disease Severity and Mortality in a Mouse Model of Down Syndrome
- An <i>ex vivo</i> human precision-cut lung slice platform provides insight into SARS-CoV-2 pathogenesis and antiviral drug efficacy
- Pulmonary Expression of Interleukin-17 Contributes to Neutrophil Infiltration into the Lungs during Pneumonic Plague
- An <i>ex vivo</i> human precision-cut lung slice platform provides insight into SARS-CoV-2 pathogenesis and antiviral drug efficacy
- An <i>ex vivo</i> human precision-cut lung slice platform provides insight into SARS-CoV-2 pathogenesis and antiviral drug efficacy
- An <i>ex vivo</i> human precision-cut lung slice platform provides insight into SARS-CoV-2 pathogenesis and antiviral drug efficacy
- SARS-CoV-2 Infection Causes Heightened Disease Severity and Mortality in a Mouse Model of Down Syndrome
- IFNγ and Antibody Synergize To Enhance Protective Immunity against Chlamydia Dissemination and Female Reproductive Tract Reinfections
- IFNγ and antibody synergize to enhance protective immunity against <i>Chlamydia</i> dissemination and female reproductive tract reinfections
- IFNγ and Antibody Synergize To Enhance Protective Immunity against Chlamydia Dissemination and Female Reproductive Tract Reinfections
- IFNγ and antibody synergize to enhance protective immunity against <i>Chlamydia</i> dissemination and female reproductive tract reinfections
- IFNγ and Antibody Synergize To Enhance Protective Immunity against Chlamydia Dissemination and Female Reproductive Tract Reinfections
- IFNγ and antibody synergize to enhance protective immunity against <i>Chlamydia</i> dissemination and female reproductive tract reinfections
- An <i>ex vivo</i> human precision-cut lung slice platform provides insight into SARS-CoV-2 pathogenesis and antiviral drug efficacy
- An <i>ex vivo</i> human precision-cut lung slice platform provides insight into SARS-CoV-2 pathogenesis and antiviral drug efficacy
- An <i>ex vivo</i> human precision-cut lung slice platform provides insight into SARS-CoV-2 pathogenesis and antiviral drug efficacy
- An <i>ex vivo</i> human precision-cut lung slice platform provides insight into SARS-CoV-2 pathogenesis and antiviral drug efficacy
- An <i>ex vivo</i> human precision-cut lung slice platform provides insight into SARS-CoV-2 pathogenesis and antiviral drug efficacy
- An <i>ex vivo</i> human precision-cut lung slice platform provides insight into SARS-CoV-2 pathogenesis and antiviral drug efficacy
- An <i>ex vivo</i> human precision-cut lung slice platform provides insight into SARS-CoV-2 pathogenesis and antiviral drug efficacy
- An <i>ex vivo</i> human precision-cut lung slice platform provides insight into SARS-CoV-2 pathogenesis and antiviral drug efficacy
- Pulmonary Expression of Interleukin-17 Contributes to Neutrophil Infiltration into the Lungs during Pneumonic Plague
- SARS-CoV-2 Infection Causes Heightened Disease Severity and Mortality in a Mouse Model of Down Syndrome
- An <i>ex vivo</i> human precision-cut lung slice platform provides insight into SARS-CoV-2 pathogenesis and antiviral drug efficacy
- Alterations in Cellular Gene Expression Due to Co‐Infection With Kaposi's Sarcoma‐Associated Herpesvirus and SARS‐CoV‐2: Implications for Disease Severity
- IFNγ and antibody synergize to enhance protective immunity against <i>Chlamydia</i> dissemination and female reproductive tract reinfections
- IFNγ and Antibody Synergize To Enhance Protective Immunity against Chlamydia Dissemination and Female Reproductive Tract Reinfections
- An <i>ex vivo</i> human precision-cut lung slice platform provides insight into SARS-CoV-2 pathogenesis and antiviral drug efficacy
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