Behjatolah Monzavi‐Karbassi
Associate Professor
Also affiliated: Russian Academy of Sciences (1998); University of Arkansas Medical Center (2005–2016); Institute of Molecular Genetics (1998); University of Pennsylvania (1999–2003)
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Behjatolah Monzavi‐Karbassi's research focuses on tumor-associated carbohydrate antigens and their role in cancer, particularly breast cancer metastasis. His work investigates how molecules like chondroitin sulfates contribute to aggressive cancer cell phenotypes and the formation of P-selectin ligands, which are implicated in cancer cell adhesion and spread. He has also explored the potential of peptide mimotopes as surrogate antigens for carbohydrate targets in vaccine development, aiming to elicit functional antibody responses against tumor-associated carbohydrates.
Monzavi‐Karbassi is the Principal Investigator on a National Cancer Institute grant totaling $178,819, studying "SR-A as a therapeutic target in breast cancer." His publications include work on the immune surveillance of tumor-associated glycans and the induction of anti-carbohydrate antibodies through DNA immunization with carbohydrate mimotopes. He has also investigated the metabolic influence of fructose on breast tumor cell aggression. His scholarship metrics include an h-index of 24, with 78 total publications and 1,627 total citations, designating him as a highly cited researcher.
Metrics
- h-index: 24
- Publications: 79
- Citations: 1,627
Positions
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Associate Professor publications 2003–2026University of Arkansas for Medical Sciences Pathology ORCID
Selected Publications
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Class A scavenger receptors promote tumor progression and induce a unique macrophage phenotype in a mouse model of spontaneous breast cancer (2026)
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Abstract PO5-02-05: Assessing Vaccine-Mediated Cellular Immune Responses in Patients Receiving Combined Vaccine and Chemotherapy Treatment (2024)
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Abstract 3860: Characterizing peripheral immune correlates of tumor response in breast cancer patients immunized with the P10s-PADRE vaccine (2024)
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Abstract 186: Tumor exosome-macrophage interactions: The role of tumor-associated glycans and scavenger receptor class A (2024)
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The Tumor Microenvironment and Immune Response in Breast Cancer (2024)
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Abstract 700: Induction of cancer-specific T-cell responses in patients immunized with P10s-PADRE vaccine (2023)
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Feeding Soy Protein Concentrates with Low and High Isoflavones Alters 9 and 18 Weeks Serum Isoflavones and Inflammatory Protein Levels in Lean and Obese Zucker Rats (2023)
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VT68.2: An Antibody to Chondroitin Sulfate Proteoglycan 4 (CSPG4) Displays Reactivity against a Tumor-Associated Carbohydrate Antigen (2023)
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Feeding Obese Zucker Rats With Soy Protein Concentrate With High Isoflavones Compared to Low Isoflavones Leads to a Significant Reduction of Serum Tumor Necrosis Factor-α (2022)
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Abstract P2-14-15: Timing of the immunization defines immune signature of a peptide cancer vaccine combined with Neoadjuvant chemotherapy in HR+ breast cancer patients (2022)
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P10s-PADRE vaccine combined with neoadjuvant chemotherapy in ER-positive breast cancer patients induces humoral and cellular immune responses (2021)
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Association of DNA-Methylation Profiles With Immune Responses Elicited in Breast Cancer Patients Immunized With a Carbohydrate-Mimicking Peptide: A Pilot Study (2020)
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Carbohydrate (Chondroitin 4) Sulfotransferase-11-Mediated Induction of Epithelial-Mesenchymal Transition and Generation of Cancer Stem Cells (2020)
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Macrophage Class A Scavenger Receptors Bind Tumor‐Associated Carbohydrate Antigens and Promote Breast Cancer Growth and Metastases in Mice (2020)
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Abstract P3-09-18: Immunization of breast cancer patients in combination with standard-of-care chemotherapy: Results of a phase Ib clinical trial (2020)
Federal Grants 1 $178,819 total
Collaboration Network
Top Collaborators
- Chondroitin sulfates play a major role in breast cancer metastasis: a role for CSPG4 and CHST11gene expression in forming surface P-selectin ligands in aggressive breast cancer cells
- Chondroitin sulfate glycosaminoglycans as major P‐selectin ligands on metastatic breast cancer cell lines
- Tumor-Associated Glycans and Immune Surveillance
- Targeting tumor-associated carbohydrate antigens: a phase I study of a carbohydrate mimetic-peptide vaccine in stage IV breast cancer subjects
- Adipocyte hypoxia promotes epithelial-mesenchymal transition-related gene expression and estrogen receptor-negative phenotype in breast cancer cells
Showing 5 of 49 shared publications
- Chondroitin sulfates play a major role in breast cancer metastasis: a role for CSPG4 and CHST11gene expression in forming surface P-selectin ligands in aggressive breast cancer cells
- Chondroitin sulfate glycosaminoglycans as major P‐selectin ligands on metastatic breast cancer cell lines
- Targeting tumor-associated carbohydrate antigens: a phase I study of a carbohydrate mimetic-peptide vaccine in stage IV breast cancer subjects
- Preclinical studies of carbohydrate mimetic peptide vaccines for breast cancer and melanoma
- Pre-diagnosis blood glucose and prognosis in women with breast cancer
Showing 5 of 33 shared publications
- Chondroitin sulfates play a major role in breast cancer metastasis: a role for CSPG4 and CHST11gene expression in forming surface P-selectin ligands in aggressive breast cancer cells
- Targeting tumor-associated carbohydrate antigens: a phase I study of a carbohydrate mimetic-peptide vaccine in stage IV breast cancer subjects
- Pre-diagnosis blood glucose and prognosis in women with breast cancer
- CHST11 gene expression and DNA methylation in breast cancer
- Moving a Carbohydrate Mimetic Peptide into the clinic
Showing 5 of 19 shared publications
- Tumor-Associated Glycans and Immune Surveillance
- Targeting tumor-associated carbohydrate antigens: a phase I study of a carbohydrate mimetic-peptide vaccine in stage IV breast cancer subjects
- Preclinical studies of carbohydrate mimetic peptide vaccines for breast cancer and melanoma
- Immune surveillance and immunotherapy: Lessons from carbohydrate mimotopes
- Multiple Antigenic Mimotopes of HIV Carbohydrate Antigens
Showing 5 of 17 shared publications
- Targeting tumor-associated carbohydrate antigens: a phase I study of a carbohydrate mimetic-peptide vaccine in stage IV breast cancer subjects
- Moving a Carbohydrate Mimetic Peptide into the clinic
- Harnessing benefit from targeting tumor associated carbohydrate antigens
- P10s-PADRE vaccine combined with neoadjuvant chemotherapy in ER-positive breast cancer patients induces humoral and cellular immune responses
- Breast cancer survival disparity between African American and Caucasian women in Arkansas: A race-by-grade analysis
Showing 5 of 13 shared publications
- Targeting tumor-associated carbohydrate antigens: a phase I study of a carbohydrate mimetic-peptide vaccine in stage IV breast cancer subjects
- Preclinical studies of carbohydrate mimetic peptide vaccines for breast cancer and melanoma
- Pre-diagnosis blood glucose and prognosis in women with breast cancer
- Moving a Carbohydrate Mimetic Peptide into the clinic
- Harnessing benefit from targeting tumor associated carbohydrate antigens
Showing 5 of 9 shared publications
- Chondroitin sulfate glycosaminoglycans as major P‐selectin ligands on metastatic breast cancer cell lines
- Preclinical studies of carbohydrate mimetic peptide vaccines for breast cancer and melanoma
- A Mimic of Tumor Rejection Antigen-Associated Carbohydrates Mediates an Antitumor Cellular Response
- Reduction of Spontaneous Metastases through Induction of Carbohydrate Cross-Reactive Apoptotic Antibodies
- Deficiency in surface expression of E‐selectin ligand promotes lung colonization in a mouse model of breast cancer
Showing 5 of 7 shared publications
- Chondroitin sulfates play a major role in breast cancer metastasis: a role for CSPG4 and CHST11gene expression in forming surface P-selectin ligands in aggressive breast cancer cells
- Adipocyte hypoxia promotes epithelial-mesenchymal transition-related gene expression and estrogen receptor-negative phenotype in breast cancer cells
- CHST11 gene expression and DNA methylation in breast cancer
- Carbohydrate (Chondroitin 4) Sulfotransferase-11-Mediated Induction of Epithelial-Mesenchymal Transition and Generation of Cancer Stem Cells
- Abstract 4018: DNA methylation controls CHST11 gene expression in breast cancer
Showing 5 of 7 shared publications
- Feeding Soy Protein Concentrates with Low and High Isoflavones Alters 9 and 18 Weeks Serum Isoflavones and Inflammatory Protein Levels in Lean and Obese Zucker Rats
- VT68.2: An Antibody to Chondroitin Sulfate Proteoglycan 4 (CSPG4) Displays Reactivity against a Tumor-Associated Carbohydrate Antigen
- Feeding Obese Zucker Rats With Soy Protein Concentrate With High Isoflavones Compared to Low Isoflavones Leads to a Significant Reduction of Serum Tumor Necrosis Factor-α
- Abstract 700: Induction of cancer-specific T-cell responses in patients immunized with P10s-PADRE vaccine
- Abstract 3860: Characterizing peripheral immune correlates of tumor response in breast cancer patients immunized with the P10s-PADRE vaccine
Showing 5 of 6 shared publications
- Chondroitin sulfate glycosaminoglycans as major P‐selectin ligands on metastatic breast cancer cell lines
- Preclinical studies of carbohydrate mimetic peptide vaccines for breast cancer and melanoma
- Reduction of Spontaneous Metastases through Induction of Carbohydrate Cross-Reactive Apoptotic Antibodies
- Deficiency in surface expression of E‐selectin ligand promotes lung colonization in a mouse model of breast cancer
- Carbohydrate Mimetic Peptides Augment Carbohydrate-Reactive Immune Responses in the Absence of Immune Pathology
- Deficiency in surface expression of E‐selectin ligand promotes lung colonization in a mouse model of breast cancer
- VT68.2: An Antibody to Chondroitin Sulfate Proteoglycan 4 (CSPG4) Displays Reactivity against a Tumor-Associated Carbohydrate Antigen
- The Tumor Microenvironment and Immune Response in Breast Cancer
- Macrophage Class A Scavenger Receptors Bind Tumor‐Associated Carbohydrate Antigens and Promote Breast Cancer Growth and Metastases in Mice
- Abstract 186: Tumor exosome-macrophage interactions: The role of tumor-associated glycans and scavenger receptor class A
- Targeting tumor-associated carbohydrate antigens: a phase I study of a carbohydrate mimetic-peptide vaccine in stage IV breast cancer subjects
- Moving a Carbohydrate Mimetic Peptide into the clinic
- Harnessing benefit from targeting tumor associated carbohydrate antigens
- Unleashing natural killer cells upon immunization with a carbohydrate mimetic peptide vaccine.
- Abstract P3-09-18: Immunization of breast cancer patients in combination with standard-of-care chemotherapy: Results of a phase Ib clinical trial
- VT68.2: An Antibody to Chondroitin Sulfate Proteoglycan 4 (CSPG4) Displays Reactivity against a Tumor-Associated Carbohydrate Antigen
- The Tumor Microenvironment and Immune Response in Breast Cancer
- Macrophage Class A Scavenger Receptors Bind Tumor‐Associated Carbohydrate Antigens and Promote Breast Cancer Growth and Metastases in Mice
- Abstract 186: Tumor exosome-macrophage interactions: The role of tumor-associated glycans and scavenger receptor class A
- Class A scavenger receptors promote tumor progression and induce a unique macrophage phenotype in a mouse model of spontaneous breast cancer
- Chondroitin sulfate glycosaminoglycans as major P‐selectin ligands on metastatic breast cancer cell lines
- Reduction of Spontaneous Metastases through Induction of Carbohydrate Cross-Reactive Apoptotic Antibodies
- Characterization of the glycosylation profile of the human breast cancer cell line, MDA-231, and a bone colonizing variant
- Deficiency in surface expression of E‐selectin ligand promotes lung colonization in a mouse model of breast cancer
- CHST11 gene expression and DNA methylation in breast cancer
- Expression analysis of carbohydrate antigens in ductal carcinoma in situof the breast by lectin histochemistry
- Reduction of Spontaneous Metastases through Induction of Carbohydrate Cross-Reactive Apoptotic Antibodies
- Deficiency in surface expression of E‐selectin ligand promotes lung colonization in a mouse model of breast cancer
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