Paul M. Spring

Associate Professor and Director of Research

UAMS

Formerly Arkansas Affiliated with UA Little Rock, UAMS through 2011.

18 h-index 50 pubs 1,263 cited

Research Areas

Biomedical Subjects

Links

Lab Website

OverviewAI-generated summary

Paul M. Spring's research focuses on cancer treatment, particularly head and neck squamous cell carcinoma. His work investigates methods to enhance the efficacy of chemotherapy and radiation, including the potentiation of Paclitaxel by low-dose fractionated radiation in tumor cell lines with varying p53 status. He has also explored the mechanisms of drug resistance in head and neck cancers, examining the role of microRNA expression profiles and increased mitochondrial DNA. Additionally, Spring's research has touched upon targeting specific cellular pathways to improve drug cytotoxicity, such as enhancing cisplatin effects in hepatoma cells by targeting the hOGG1 enzyme to mitochondria. His publications also include investigations into the incidence of thyroid carcinoma found incidentally on PET scans and the safety and survival outcomes of novel neoadjuvant immunotherapy regimens for head and neck squamous cell cancer. Spring's scholarly contributions are reflected in an h-index of 18, with 50 publications and 1,263 citations.

Metrics

h-index: 18
Publications: 50
Citations: 1,263

Selected Publications

Novel neoadjuvant immunotherapy regimen safety and survival in head and neck squamous cell cancer (2011)

Head & Neck 58 citations DOI OpenAlex
MicroRNA expression profiles of head and neck squamous cell carcinoma with docetaxel‐induced multidrug resistance (2010)

Head & Neck 78 citations DOI OpenAlex
Markedly Elevated Serum Calcitonin Concentrations Associated with Initial Presentation But Not the Recurrent Presentation of Medullary Thyroid Carcinoma (2010)

Thyroid 1 citation DOI OpenAlex
In vivo , Noninvasive, Label-Free Detection and Eradication of Circulating Metastatic Melanoma Cells Using Two-Color Photoacoustic Flow Cytometry with a Diode Laser (2009)

Cancer Research 260 citations DOI OpenAlex
Gelatin sponge insertion into tympanostomy tubes: An in‐vitro study to evaluate postoperative obstruction (2009)

Otolaryngology DOI OpenAlex
Lack of P-Glycoprotein Expression by Low-Dose Fractionated Radiation Results from Loss of Nuclear Factor-κB and NF-Y Activation in Oral Carcinoma Cells (2008)

Molecular Cancer Research 34 citations DOI OpenAlex
Oral glutamine prevents DMBA-induced mammary carcinogenesis via upregulation of glutathione production (2008)

Nutrition 17 citations DOI OpenAlex
Conductive Interstitial Thermal Therapy (CITT) Device Evaluation in VX2 Rabbit Model (2007)

Technology in Cancer Research & Treatment 13 citations DOI OpenAlex
Targeting human 8-oxoguanine DNA glycosylase (hOGG1) to mitochondria enhances cisplatin cytotoxicity in hepatoma cells (2007)

Carcinogenesis 60 citations DOI OpenAlex
Long Term Results of a Phase II Trial of Hyperfractionated Radiation and Intraarterial Cisplatin (HYPERRADPLAT) on Stage III-IV Head and Neck Cancer With Bulky Primary Tumors (2007)

International Journal of Radiation Oncology*Biology*Physics DOI OpenAlex
Spatially Fractionated Radiation Therapy and Chemotherapy-IMRT for Locally Advanced Squamous Cell Carcinoma of the Head and Neck (2007)

International Journal of Radiation Oncology*Biology*Physics DOI OpenAlex
Incidence of Thyroid Carcinoma in Fluorodeoxyglucose Positron Emission Tomography‐Positive Thyroid Incidentalomas (2007)

Otolaryngology 71 citations DOI OpenAlex
Evaluation of the inferior and superior laryngeal nerve stumps for perineural spread in laryngeal cancer (2007)

Otolaryngology 6 citations DOI OpenAlex
Increased mitochondrial DNA induces acquired docetaxel resistance in head and neck cancer cells (2007)

Oncogene 70 citations DOI OpenAlex
Conductive interstitial thermal therapy device for surgical margin ablation:In vivoverification of a theoretical model (2007)

International Journal of Hyperthermia 20 citations DOI OpenAlex