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Listed
Presence
Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-10-09
Paul D. Drew
Federal Grant PI
High Impact
Professor and Chair
Also affiliated: National Institutes of Health (1994–1997); University of Arkansas Medical Center (2021); National Human Genome Research Institute (1997); National Institute of Neurological Disorders and Stroke (1993–1997); National Institute of Allergy and Infectious Diseases (1993); University of Maryland, College Park (1986–1990)
Neurobiology & Developmental Science, College of Medicine
39 h-index
86 pubs
4,767 cited
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Paul D. Drew's research program investigates the impact of ethanol exposure on neurodevelopment and neuroinflammation, with a particular focus on Fetal Alcohol Spectrum Disorders (FASD). His work utilizes animal models, specifically mice, to study the molecular and cellular mechanisms underlying these effects. Drew's laboratory has explored how ethanol influences the immune cells of the brain, such as microglia, and their role in neuroinflammatory processes relevant to FASD.
His funded research projects examine the dynamic interactions between the neuroimmune system and the onset and progression of FASD, the role of oligodendrocyte-lineage cells in FASD, and how neuroinflammation contributes to cognitive deficits associated with prenatal alcohol exposure. Drew has published extensively on these topics, with his work detailing ethanol's effects on cerebellar and hippocampal neuroinflammation, myelination, and gene expression in developing mouse models. His scholarship metrics include an h-index of 39 and over 4,700 citations across 86 publications.
Drew leads a research group at the University of Arkansas for Medical Sciences, where he holds the position of Professor and Chair of Neurobiology & Developmental Science in the College of Medicine. He has secured federal funding totaling over $1.3 million from the NIH/National Institute on Alcohol Abuse and Alcoholism for his work on FASD. His key collaborators are primarily within the University of Arkansas for Medical Sciences, including James C. Douglas, Cynthia J.M. Kane, Tonya Rafferty, and Kalee N. Holloway.
Research Overview
Drew Lab Research: Multiple Sclerosis Fetal Alcohol Spectrum Disorders Neuroimmunology Innate and Adaptive Immunity
Metrics
- h-index: 39
- Publications: 86
- Citations: 4,767
Positions
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Professor and Chair 1996–presentUniversity of Arkansas for Medical Sciences Neurobiology & Developmental Science, College of Medicine Institutional directory
Selected Publications
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Early Postnatal Ethanol Exposure Has Long-Term Behavioral Consequences in Female Mice (2026)
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Targeting the Nlrp3 inflammasome as potential treatment for ethanol-induced non-communicable diseases (2024)
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Developmental Ethanol Exposure Impacts Purkinje Cells but Not Microglia in the Young Adult Cerebellum (2024)
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Ethanol Induces Neuroinflammation in a Chronic Plus Binge Mouse Model of Alcohol Use Disorder via TLR4 and MyD88-Dependent Signaling (2023)
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Developmental ethanol exposure has minimal impact on cerebellar microglial dynamics, morphology, and interactions with Purkinje cells during adolescence (2023)
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Ethanol-induced cerebellar transcriptomic changes in a postnatal model of fetal alcohol spectrum disorders: Focus on disease onset (2023)
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Cerebellar Transcriptomic Analysis in a Chronic plus Binge Mouse Model of Alcohol Use Disorder Demonstrates Ethanol-Induced Neuroinflammation and Altered Glial Gene Expression (2023)
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Effects of chronic and binge ethanol administration on mouse cerebellar and hippocampal neuroinflammation (2022)
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Neuroimaging predictors of longitudinal disability and cognition outcomes in multiple sclerosis patients: A systematic review and meta-analysis (2021)
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Ethanol effects on cerebellar myelination in a postnatal mouse model of fetal alcohol spectrum disorders (2021)
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Ethanol modulation of hippocampal neuroinflammation, myelination, and neurodevelopment in a postnatal mouse model of fetal alcohol spectrum disorders (2021)
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Divergent and overlapping hippocampal and cerebellar transcriptome responses following developmental ethanol exposure during the secondary neurogenic period (2021)
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Microglia and astrocytes show limited, acute alterations in morphology and protein expression following a single developmental alcohol exposure (2021)
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Ethanol modulation of cerebellar neuroinflammation in a postnatal mouse model of fetal alcohol spectrum disorders (2021)
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Neuroinflammatory contribution of microglia and astrocytes in fetal alcohol spectrum disorders (2020)
Federal Grants 3 $1,392,941 total
NIH
Contact PI
May 2026 - Jan 2031
NIH
Contact PI
Sep 2018 - Jun 2024
Dynamic neuroimmune interactions in the onset and progression of FASD
NIH
Contact PI
Sep 2018 - Aug 2025
Grants & Funding
As listed on this researcher's institutional profile. Federal awards with verified records are shown above.
- PPAR-alpha agonists as treatment for autoimmune demyelination National Multiple Sclerosis Society via The Ohio State University Research Foundation Principal Investigator
- PPAR-Agonist as Treatment for Autoimmune Demyelination (Subcontract from UT Southwestern Medical Center) National Multiple Sclerosis Society via University of Texas - Southwestern Principal Investigator
- LXR agonists as treatment for autoimmune demyelination National Multiple Sclerosis Society Principal Investigator
- PPAR-gamma Immune Regulation and Multiple Sclerosis NIH Principal Investigator
- Microglia modulate ethanol impact on CNS development. NIH Co-Investigator
- Alcohol Pathogenesis in CNS Microglial Cells NIH Co-Investigator
- Female Sex Steroids: Effects on Glia National Multiple Sclerosis Society Principal Investigator
- Mechanisms of Ethanol-Induced Neuroinflammation and Neurodegeneration NIH Principal Investigator
- DEAP Awards - P. Drew - UAMS VCRI - FY26 Role of Oligodendrocyte-Lineage Cells in FASD UAMS Division of Research and Innovation Principal Investigator
- CNS Development &Alcohol: Microglia-Neuron Interactions NIH Co-Investigator
- Regulation of Neuroimmune Responses in FASD Models NIH Co-Principal Investigator
- Neuroinflammatory Mechanisms in FASD: Development of Novel Therapeutic Strategies NIH Co-Investigator
- Early Events in Alzheimer Pathogenesis NIH Co-Investigator
- The role of the endothelial NPYR1-TRPC3-ET1 signaling axis in neurovascular coupling dysfunction NIH Co-Investigator
- Effects of Alcohol on Microglia and Innate Immunity NIH Principal Investigator
- Neuroscience Research Center Core Facility at UAMS NIH Principal Investigator
Collaboration Network
Top Collaborators
Cynthia J.M. Kane
University of Arkansas for Medical Sciences
23 shared publications
In database
- Pioglitazone Blocks Ethanol Induction of Microglial Activation and Immune Responses in the Hippocampus, Cerebellum, and Cerebral Cortex in a Mouse Model of Fetal Alcohol Spectrum Disorders
- Effects of Ethanol on Immune Response in the Brain: Region-Specific Changes in Adolescent Versus Adult Mice
- Protection of neurons and microglia against ethanol in a mouse model of fetal alcohol spectrum disorders by peroxisome proliferator-activated receptor-γ agonists
- Fetal Alcohol Spectrum Disorders and Neuroimmune Changes
- Neuroinflammatory contribution of microglia and astrocytes in fetal alcohol spectrum disorders
Showing 5 of 23 shared publications
James C. Douglas
University of Arkansas for Medical Sciences
18 shared publications
In database
- Pioglitazone Blocks Ethanol Induction of Microglial Activation and Immune Responses in the Hippocampus, Cerebellum, and Cerebral Cortex in a Mouse Model of Fetal Alcohol Spectrum Disorders
- Effects of Ethanol on Immune Response in the Brain: Region-Specific Changes in Adolescent Versus Adult Mice
- Protection of neurons and microglia against ethanol in a mouse model of fetal alcohol spectrum disorders by peroxisome proliferator-activated receptor-γ agonists
- Liver X receptor agonist regulation of Th17 lymphocyte function in autoimmunity
- Protection against alcohol-induced neuronal and cognitive damage by the PPARγ receptor agonist pioglitazone
Showing 5 of 18 shared publications
Janet A. Chavis
University of Arkansas for Medical Sciences (US)
17 shared publications
- Female sex steroids: effects upon microglial cell activation
- Peroxisome Proliferator-Activated Receptor α Agonists as Therapy for Autoimmune Disease
- Peroxisome proliferator-activated receptor-gamma agonists inhibit the activation of microglia and astrocytes: Implications for multiple sclerosis
- Agonists for the peroxisome proliferator‐activated receptor‐α and the retinoid X receptor inhibit inflammatory responses of microglia
- Ligands for the peroxisome proliferator-activated receptor-γ and the retinoid X receptor exert additive anti-inflammatory effects on experimental autoimmune encephalomyelitis
Showing 5 of 17 shared publications
Jihong Xu
University of Arkansas for Medical Sciences (US)
15 shared publications
- Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand
- Peroxisome proliferator-activated receptor-gamma agonists inhibit the activation of microglia and astrocytes: Implications for multiple sclerosis
- Agonists for the peroxisome proliferator‐activated receptor‐α and the retinoid X receptor inhibit inflammatory responses of microglia
- Effects of Ethanol on Immune Response in the Brain: Region-Specific Changes in Adolescent Versus Adult Mice
- 9-Cis-retinoic acid suppresses inflammatory responses of microglia and astrocytes
Showing 5 of 15 shared publications
Michael K. Racke
The Ohio State University Wexner Medical Center (US)
13 shared publications
- Peroxisome Proliferator-Activated Receptor-γ Agonist 15-Deoxy-Δ12,1412,14-Prostaglandin J2 Ameliorates Experimental Autoimmune Encephalomyelitis
- Peroxisome Proliferator-Activated Receptor α Agonists as Therapy for Autoimmune Disease
- Agonists for the peroxisome proliferator‐activated receptor‐α and the retinoid X receptor inhibit inflammatory responses of microglia
- Ligands for the peroxisome proliferator-activated receptor-γ and the retinoid X receptor exert additive anti-inflammatory effects on experimental autoimmune encephalomyelitis
- Peroxisome proliferator-activated receptor-α and retinoid X receptor agonists inhibit inflammatory responses of astrocytes
Showing 5 of 13 shared publications
Kevin D. Phelan
University of Arkansas for Medical Sciences
8 shared publications
In database
- Pioglitazone Blocks Ethanol Induction of Microglial Activation and Immune Responses in the Hippocampus, Cerebellum, and Cerebral Cortex in a Mouse Model of Fetal Alcohol Spectrum Disorders
- Effects of Ethanol on Immune Response in the Brain: Region-Specific Changes in Adolescent Versus Adult Mice
- Protection of neurons and microglia against ethanol in a mouse model of fetal alcohol spectrum disorders by peroxisome proliferator-activated receptor-γ agonists
- Effects of ethanol on immune response in the brain: region-specific changes in aged mice
- Neuroimmune mechanisms in fetal alcohol spectrum disorder
Showing 5 of 8 shared publications
Tonya Rafferty
University of Arkansas for Medical Sciences
7 shared publications
In database
- Ethanol Induces Neuroinflammation in a Chronic Plus Binge Mouse Model of Alcohol Use Disorder via TLR4 and MyD88-Dependent Signaling
- Ethanol modulation of cerebellar neuroinflammation in a postnatal mouse model of fetal alcohol spectrum disorders
- Effects of chronic and binge ethanol administration on mouse cerebellar and hippocampal neuroinflammation
- Ethanol modulation of hippocampal neuroinflammation, myelination, and neurodevelopment in a postnatal mouse model of fetal alcohol spectrum disorders
- Ethanol effects on cerebellar myelination in a postnatal mouse model of fetal alcohol spectrum disorders
Showing 5 of 7 shared publications
Gail Wagoner
University of Arkansas for Medical Sciences
6 shared publications
In database
- Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand
- Effects of Ethanol on Immune Response in the Brain: Region-Specific Changes in Adolescent Versus Adult Mice
- Liver X receptor agonist regulation of Th17 lymphocyte function in autoimmunity
- The Synthetic Peroxisome Proliferator-Activated Receptor-γ Agonist Ciglitazone Attenuates Neuroinflammation and Accelerates Encapsulation in Bacterial Brain Abscesses
- Effects of ethanol on immune response in the brain: region-specific changes in aged mice
Showing 5 of 6 shared publications
Amy E. Lovett‐Racke
6 shared publications
- Peroxisome Proliferator-Activated Receptor-γ Agonist 15-Deoxy-Δ12,1412,14-Prostaglandin J2 Ameliorates Experimental Autoimmune Encephalomyelitis
- Peroxisome Proliferator-Activated Receptor α Agonists as Therapy for Autoimmune Disease
- Ligands for the peroxisome proliferator-activated receptor-γ and the retinoid X receptor exert additive anti-inflammatory effects on experimental autoimmune encephalomyelitis
- Transcriptional Modulation of the Immune Response by Peroxisome Proliferator-Activated Receptor-α Agonists in Autoimmune Disease
- PPAR Alpha Regulation of the Immune Response and Autoimmune Encephalomyelitis
Showing 5 of 6 shared publications
Ania K. Majewska
University of Rochester Medicine (US)
6 shared publications
- Ethanol modulation of cerebellar neuroinflammation in a postnatal mouse model of fetal alcohol spectrum disorders
- Microglia and astrocytes show limited, acute alterations in morphology and protein expression following a single developmental alcohol exposure
- Ethanol-induced cerebellar transcriptomic changes in a postnatal model of fetal alcohol spectrum disorders: Focus on disease onset
- Developmental ethanol exposure has minimal impact on cerebellar microglial dynamics, morphology, and interactions with Purkinje cells during adolescence
- Developmental Ethanol Exposure Impacts Purkinje Cells but Not Microglia in the Young Adult Cerebellum
Showing 5 of 6 shared publications
Jennifer W. Johnson
University of Arkansas for Medical Sciences
5 shared publications
In database
- Pioglitazone Blocks Ethanol Induction of Microglial Activation and Immune Responses in the Hippocampus, Cerebellum, and Cerebral Cortex in a Mouse Model of Fetal Alcohol Spectrum Disorders
- Effects of Ethanol on Immune Response in the Brain: Region-Specific Changes in Adolescent Versus Adult Mice
- Effects of ethanol on immune response in the brain: region-specific changes in aged mice
- Ethanol modulation of cerebellar neuroinflammation in a postnatal mouse model of fetal alcohol spectrum disorders
- Effects of chronic and binge ethanol administration on mouse cerebellar and hippocampal neuroinflammation
Paul D. Storer
University of Arkansas for Medical Sciences (US)
5 shared publications
- Peroxisome proliferator-activated receptor-gamma agonists inhibit the activation of microglia and astrocytes: Implications for multiple sclerosis
- Agonists for the peroxisome proliferator‐activated receptor‐α and the retinoid X receptor inhibit inflammatory responses of microglia
- Peroxisome proliferator-activated receptor agonist regulation of glial activation: Relevance to CNS inflammatory disorders
- Cyclopentenone prostaglandins PGA2 and 15-deoxy-?12,14 PGJ2 suppress activation of murine microglia and astrocytes: Implications for multiple sclerosis
- Hormone regulation of microglial cell activation: relevance to multiple sclerosis
Kalee N. Holloway
University of Arkansas for Medical Sciences
5 shared publications
In database
- Ethanol Induces Neuroinflammation in a Chronic Plus Binge Mouse Model of Alcohol Use Disorder via TLR4 and MyD88-Dependent Signaling
- Effects of chronic and binge ethanol administration on mouse cerebellar and hippocampal neuroinflammation
- Divergent and overlapping hippocampal and cerebellar transcriptome responses following developmental ethanol exposure during the secondary neurogenic period
- Ethanol-induced cerebellar transcriptomic changes in a postnatal model of fetal alcohol spectrum disorders: Focus on disease onset
- Cerebellar Transcriptomic Analysis in a Chronic plus Binge Mouse Model of Alcohol Use Disorder Demonstrates Ethanol-Induced Neuroinflammation and Altered Glial Gene Expression
Rehana Z. Hussain
4 shared publications
- Peroxisome Proliferator-Activated Receptor-γ Agonist 15-Deoxy-Δ12,1412,14-Prostaglandin J2 Ameliorates Experimental Autoimmune Encephalomyelitis
- Peroxisome Proliferator-Activated Receptor α Agonists as Therapy for Autoimmune Disease
- Ligands for the peroxisome proliferator-activated receptor-γ and the retinoid X receptor exert additive anti-inflammatory effects on experimental autoimmune encephalomyelitis
- Transcriptional Modulation of the Immune Response by Peroxisome Proliferator-Activated Receptor-α Agonists in Autoimmune Disease
Asim Diab
The University of Texas Southwestern Medical Center (US)
4 shared publications
- Peroxisome Proliferator-Activated Receptor-γ Agonist 15-Deoxy-Δ12,1412,14-Prostaglandin J2 Ameliorates Experimental Autoimmune Encephalomyelitis
- Peroxisome Proliferator-Activated Receptor α Agonists as Therapy for Autoimmune Disease
- Ligands for the peroxisome proliferator-activated receptor-γ and the retinoid X receptor exert additive anti-inflammatory effects on experimental autoimmune encephalomyelitis
- Nuclear Receptors and Autoimmune Disease: The Potential of PPAR Agonists to Treat Multiple Sclerosis
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