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Listed
Presence
Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-08-20
Paul D. Drew
Federal Grant PI
High Impact
Professor and Chair
Also affiliated: National Institutes of Health (1994–1997); National Institute of Neurological Disorders and Stroke (1993–1997); Arkansas Department of Health (2009); University of Maryland, College Park (1986–1990)
Faculty Researcher
Neurobiology & Developmental Science, College of Medicine
39 h-index
86 pubs
4,733 cited
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Paul D. Drew's research program investigates the impact of ethanol exposure on neurodevelopment and neuroinflammation, with a particular focus on Fetal Alcohol Spectrum Disorders (FASD). His work utilizes animal models, specifically mice, to study the molecular and cellular mechanisms underlying these effects. Drew's laboratory has explored how ethanol influences the immune cells of the brain, such as microglia, and their role in neuroinflammatory processes relevant to FASD.
His funded research projects examine the dynamic interactions between the neuroimmune system and the onset and progression of FASD, the role of oligodendrocyte-lineage cells in FASD, and how neuroinflammation contributes to cognitive deficits associated with prenatal alcohol exposure. Drew has published extensively on these topics, with his work detailing ethanol's effects on cerebellar and hippocampal neuroinflammation, myelination, and gene expression in developing mouse models. His scholarship metrics include an h-index of 39 and over 4,700 citations across 86 publications.
Drew leads a research group at the University of Arkansas for Medical Sciences, where he holds the position of Professor and Chair of Neurobiology & Developmental Science in the College of Medicine. He has secured federal funding totaling over $1.3 million from the NIH/National Institute on Alcohol Abuse and Alcoholism for his work on FASD. His key collaborators are primarily within the University of Arkansas for Medical Sciences, including James C. Douglas, Cynthia J.M. Kane, Tonya Rafferty, and Kalee N. Holloway.
Research Overview
Drew Lab Research: Multiple Sclerosis Fetal Alcohol Spectrum Disorders Neuroimmunology Innate and Adaptive Immunity
Metrics
- h-index: 39
- Publications: 86
- Citations: 4,733
Selected Publications
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Early Postnatal Ethanol Exposure Has Long-Term Behavioral Consequences in Female Mice (2026)
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Targeting the Nlrp3 inflammasome as potential treatment for ethanol-induced non-communicable diseases (2024)
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Developmental Ethanol Exposure Impacts Purkinje Cells but Not Microglia in the Young Adult Cerebellum (2024)
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Ethanol Induces Neuroinflammation in a Chronic Plus Binge Mouse Model of Alcohol Use Disorder via TLR4 and MyD88-Dependent Signaling (2023)
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Developmental ethanol exposure has minimal impact on cerebellar microglial dynamics, morphology, and interactions with Purkinje cells during adolescence (2023)
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Ethanol-induced cerebellar transcriptomic changes in a postnatal model of fetal alcohol spectrum disorders: Focus on disease onset (2023)
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Cerebellar Transcriptomic Analysis in a Chronic plus Binge Mouse Model of Alcohol Use Disorder Demonstrates Ethanol-Induced Neuroinflammation and Altered Glial Gene Expression (2023)
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Effects of chronic and binge ethanol administration on mouse cerebellar and hippocampal neuroinflammation (2022)
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Neuroimaging predictors of longitudinal disability and cognition outcomes in multiple sclerosis patients: A systematic review and meta-analysis (2021)
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Ethanol effects on cerebellar myelination in a postnatal mouse model of fetal alcohol spectrum disorders (2021)
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Ethanol modulation of hippocampal neuroinflammation, myelination, and neurodevelopment in a postnatal mouse model of fetal alcohol spectrum disorders (2021)
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Divergent and overlapping hippocampal and cerebellar transcriptome responses following developmental ethanol exposure during the secondary neurogenic period (2021)
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Microglia and astrocytes show limited, acute alterations in morphology and protein expression following a single developmental alcohol exposure (2021)
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Ethanol modulation of cerebellar neuroinflammation in a postnatal mouse model of fetal alcohol spectrum disorders (2021)
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Neuroinflammatory contribution of microglia and astrocytes in fetal alcohol spectrum disorders (2020)
Federal Grants 3 $1,392,941 total
NIH
Contact PI
May 2026 - Jan 2031
NIH
Contact PI
Sep 2018 - Jun 2024
Dynamic neuroimmune interactions in the onset and progression of FASD
NIH
Contact PI
Sep 2018 - Aug 2025
Grants & Funding
As listed on this researcher's institutional profile. Federal awards with verified records are shown above.
- PPAR-alpha agonists as treatment for autoimmune demyelination National Multiple Sclerosis Society via The Ohio State University Research Foundation Principal Investigator
- PPAR-Agonist as Treatment for Autoimmune Demyelination (Subcontract from UT Southwestern Medical Center) National Multiple Sclerosis Society via University of Texas - Southwestern Principal Investigator
- LXR agonists as treatment for autoimmune demyelination National Multiple Sclerosis Society Principal Investigator
- PPAR-gamma Immune Regulation and Multiple Sclerosis NIH Principal Investigator
- Microglia modulate ethanol impact on CNS development. NIH Co-Investigator
- Alcohol Pathogenesis in CNS Microglial Cells NIH Co-Investigator
- Female Sex Steroids: Effects on Glia National Multiple Sclerosis Society Principal Investigator
- Mechanisms of Ethanol-Induced Neuroinflammation and Neurodegeneration NIH Principal Investigator
- DEAP Awards - P. Drew - UAMS VCRI - FY26 Role of Oligodendrocyte-Lineage Cells in FASD UAMS Division of Research and Innovation Principal Investigator
- CNS Development &Alcohol: Microglia-Neuron Interactions NIH Co-Investigator
- Regulation of Neuroimmune Responses in FASD Models NIH Co-Principal Investigator
- Neuroinflammatory Mechanisms in FASD: Development of Novel Therapeutic Strategies NIH Co-Investigator
- Early Events in Alzheimer Pathogenesis NIH Co-Investigator
- The role of the endothelial NPYR1-TRPC3-ET1 signaling axis in neurovascular coupling dysfunction NIH Co-Investigator
- Effects of Alcohol on Microglia and Innate Immunity NIH Principal Investigator
- Neuroscience Research Center Core Facility at UAMS NIH Principal Investigator
Collaboration Network
Top Collaborators
James C. Douglas
University of Arkansas for Medical Sciences
9 shared publications
In database
- Ethanol Induces Neuroinflammation in a Chronic Plus Binge Mouse Model of Alcohol Use Disorder via TLR4 and MyD88-Dependent Signaling
- Ethanol modulation of cerebellar neuroinflammation in a postnatal mouse model of fetal alcohol spectrum disorders
- Effects of chronic and binge ethanol administration on mouse cerebellar and hippocampal neuroinflammation
- Ethanol modulation of hippocampal neuroinflammation, myelination, and neurodevelopment in a postnatal mouse model of fetal alcohol spectrum disorders
- Divergent and overlapping hippocampal and cerebellar transcriptome responses following developmental ethanol exposure during the secondary neurogenic period
Showing 5 of 9 shared publications
Cynthia J.M. Kane
University of Arkansas for Medical Sciences
8 shared publications
In database
- Ethanol Induces Neuroinflammation in a Chronic Plus Binge Mouse Model of Alcohol Use Disorder via TLR4 and MyD88-Dependent Signaling
- Ethanol modulation of cerebellar neuroinflammation in a postnatal mouse model of fetal alcohol spectrum disorders
- Effects of chronic and binge ethanol administration on mouse cerebellar and hippocampal neuroinflammation
- Ethanol modulation of hippocampal neuroinflammation, myelination, and neurodevelopment in a postnatal mouse model of fetal alcohol spectrum disorders
- Divergent and overlapping hippocampal and cerebellar transcriptome responses following developmental ethanol exposure during the secondary neurogenic period
Showing 5 of 8 shared publications
Tonya Rafferty
University of Arkansas for Medical Sciences
7 shared publications
In database
- Ethanol Induces Neuroinflammation in a Chronic Plus Binge Mouse Model of Alcohol Use Disorder via TLR4 and MyD88-Dependent Signaling
- Ethanol modulation of cerebellar neuroinflammation in a postnatal mouse model of fetal alcohol spectrum disorders
- Effects of chronic and binge ethanol administration on mouse cerebellar and hippocampal neuroinflammation
- Ethanol modulation of hippocampal neuroinflammation, myelination, and neurodevelopment in a postnatal mouse model of fetal alcohol spectrum disorders
- Ethanol effects on cerebellar myelination in a postnatal mouse model of fetal alcohol spectrum disorders
Showing 5 of 7 shared publications
Ania K. Majewska
University of Rochester (US)
5 shared publications
- Ethanol modulation of cerebellar neuroinflammation in a postnatal mouse model of fetal alcohol spectrum disorders
- Microglia and astrocytes show limited, acute alterations in morphology and protein expression following a single developmental alcohol exposure
- Ethanol-induced cerebellar transcriptomic changes in a postnatal model of fetal alcohol spectrum disorders: Focus on disease onset
- Developmental ethanol exposure has minimal impact on cerebellar microglial dynamics, morphology, and interactions with Purkinje cells during adolescence
- Developmental Ethanol Exposure Impacts Purkinje Cells but Not Microglia in the Young Adult Cerebellum
Kalee N. Holloway
University of Arkansas for Medical Sciences
5 shared publications
In database
- Ethanol Induces Neuroinflammation in a Chronic Plus Binge Mouse Model of Alcohol Use Disorder via TLR4 and MyD88-Dependent Signaling
- Effects of chronic and binge ethanol administration on mouse cerebellar and hippocampal neuroinflammation
- Divergent and overlapping hippocampal and cerebellar transcriptome responses following developmental ethanol exposure during the secondary neurogenic period
- Ethanol-induced cerebellar transcriptomic changes in a postnatal model of fetal alcohol spectrum disorders: Focus on disease onset
- Cerebellar Transcriptomic Analysis in a Chronic plus Binge Mouse Model of Alcohol Use Disorder Demonstrates Ethanol-Induced Neuroinflammation and Altered Glial Gene Expression
Victoria M. Niedzwiedz‐Massey
University of Arkansas for Medical Sciences
4 shared publications
In database
- Ethanol modulation of cerebellar neuroinflammation in a postnatal mouse model of fetal alcohol spectrum disorders
- Effects of chronic and binge ethanol administration on mouse cerebellar and hippocampal neuroinflammation
- Ethanol modulation of hippocampal neuroinflammation, myelination, and neurodevelopment in a postnatal mouse model of fetal alcohol spectrum disorders
- Ethanol effects on cerebellar myelination in a postnatal mouse model of fetal alcohol spectrum disorders
MaKenna Y. Cealie
University of Rochester (US)
3 shared publications
- Microglia and astrocytes show limited, acute alterations in morphology and protein expression following a single developmental alcohol exposure
- Developmental ethanol exposure has minimal impact on cerebellar microglial dynamics, morphology, and interactions with Purkinje cells during adolescence
- Developmental Ethanol Exposure Impacts Purkinje Cells but Not Microglia in the Young Adult Cerebellum
Jennifer W. Johnson
University of Arkansas for Medical Sciences
2 shared publications
In database
- Ethanol modulation of cerebellar neuroinflammation in a postnatal mouse model of fetal alcohol spectrum disorders
- Effects of chronic and binge ethanol administration on mouse cerebellar and hippocampal neuroinflammation
Marisa R. Pinson
Texas A&M University (US)
2 shared publications
- Divergent and overlapping hippocampal and cerebellar transcriptome responses following developmental ethanol exposure during the secondary neurogenic period
- Cerebellar Transcriptomic Analysis in a Chronic plus Binge Mouse Model of Alcohol Use Disorder Demonstrates Ethanol-Induced Neuroinflammation and Altered Glial Gene Expression
Rajesh C. Miranda
Texas A&M University (US)
2 shared publications
- Divergent and overlapping hippocampal and cerebellar transcriptome responses following developmental ethanol exposure during the secondary neurogenic period
- Cerebellar Transcriptomic Analysis in a Chronic plus Binge Mouse Model of Alcohol Use Disorder Demonstrates Ethanol-Induced Neuroinflammation and Altered Glial Gene Expression
Erik VonKaenel
Pacific Northwest National Laboratory (US)
2 shared publications
- Developmental ethanol exposure has minimal impact on cerebellar microglial dynamics, morphology, and interactions with Purkinje cells during adolescence
- Developmental Ethanol Exposure Impacts Purkinje Cells but Not Microglia in the Young Adult Cerebellum
Matthew N. McCall
University of Rochester (US)
2 shared publications
- Developmental ethanol exposure has minimal impact on cerebellar microglial dynamics, morphology, and interactions with Purkinje cells during adolescence
- Developmental Ethanol Exposure Impacts Purkinje Cells but Not Microglia in the Young Adult Cerebellum
Kevin D. Phelan
University of Arkansas for Medical Sciences
1 shared publication
In database
- Ethanol modulation of cerebellar neuroinflammation in a postnatal mouse model of fetal alcohol spectrum disorders
Rebecca L. Lowery
University of Rochester (US)
1 shared publication
- Microglia and astrocytes show limited, acute alterations in morphology and protein expression following a single developmental alcohol exposure
Cassandra E. Lamantia
University of Rochester (US)
1 shared publication
- Microglia and astrocytes show limited, acute alterations in morphology and protein expression following a single developmental alcohol exposure
Similar Researchers
Based on overlapping research topics
James C. Douglas
University of Arkansas for Medical Sciences
Fetal Alcohol Spectrum Disorders
Neuroinflammation and Neurodegeneration Mechanisms
Disease Models, Animal
Jennifer W. Johnson
University of Arkansas for Medical Sciences
Neuroinflammation and Neurodegeneration Mechanisms
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Tonya Rafferty
University of Arkansas for Medical Sciences
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Victoria M. Niedzwiedz‐Massey
University of Arkansas for Medical Sciences
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Kalee N. Holloway
University of Arkansas for Medical Sciences
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Cynthia J.M. Kane
University of Arkansas for Medical Sciences
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