Match tier
Listed
Presence
Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-10-07
J
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
James C. Douglas investigates the effects of ethanol on the brain, particularly in the context of Fetal Alcohol Spectrum Disorders (FASD) and alcohol use disorder. His research utilizes mouse models to study neuroinflammation, focusing on the roles of microglia and immune responses in specific brain regions such as the hippocampus and cerebellum. Douglas has explored the protective effects of certain pharmacological agents, including peroxisome proliferator-activated receptor-γ (PPARγ) agonists like pioglitazone, against ethanol-induced neuronal and microglial damage. His work has also examined region-specific changes in immune responses to ethanol in adolescent versus adult mice, and the signaling pathways involved in ethanol-induced neuroinflammation, such as TLR4 and MyD88. Douglas has published approximately 20 papers, with an h-index of 14 and over 700 citations, and has collaborated with several colleagues at the University of Arkansas for Medical Sciences.
Metrics
- h-index: 14
- Publications: 18
- Citations: 740
Positions
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Biological Safety Officer publications 2009–2026University of Arkansas for Medical Sciences Institution web page
Selected Publications
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Early Postnatal Ethanol Exposure Has Long-Term Behavioral Consequences in Female Mice (2026)
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Developmental Ethanol Exposure Impacts Purkinje Cells but Not Microglia in the Young Adult Cerebellum (2024)
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Ethanol Induces Neuroinflammation in a Chronic Plus Binge Mouse Model of Alcohol Use Disorder via TLR4 and MyD88-Dependent Signaling (2023)
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Developmental ethanol exposure has minimal impact on cerebellar microglial dynamics, morphology, and interactions with Purkinje cells during adolescence (2023)
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Ethanol-induced cerebellar transcriptomic changes in a postnatal model of fetal alcohol spectrum disorders: Focus on disease onset (2023)
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Effects of chronic and binge ethanol administration on mouse cerebellar and hippocampal neuroinflammation (2022)
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Ethanol effects on cerebellar myelination in a postnatal mouse model of fetal alcohol spectrum disorders (2021)
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Ethanol modulation of hippocampal neuroinflammation, myelination, and neurodevelopment in a postnatal mouse model of fetal alcohol spectrum disorders (2021)
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Divergent and overlapping hippocampal and cerebellar transcriptome responses following developmental ethanol exposure during the secondary neurogenic period (2021)
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Ethanol modulation of cerebellar neuroinflammation in a postnatal mouse model of fetal alcohol spectrum disorders (2021)
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PPAR-γ agonists suppress neuroinflammation in a FASD animal model (2017)
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Protection against alcohol-induced neuronal and cognitive damage by the PPARγ receptor agonist pioglitazone (2017)
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Pioglitazone Blocks Ethanol Induction of Microglial Activation and Immune Responses in the Hippocampus, Cerebellum, and Cerebral Cortex in a Mouse Model of Fetal Alcohol Spectrum Disorders (2015)
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Effects of ethanol on immune response in the brain: region-specific changes in aged mice (2013)
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Effects of Ethanol on Immune Response in the Brain: Region-Specific Changes in Adolescent Versus Adult Mice (2013)
Collaboration Network
Top Collaborators
Paul D. Drew
University of Arkansas for Medical Sciences
18 shared publications
In database
- Pioglitazone Blocks Ethanol Induction of Microglial Activation and Immune Responses in the Hippocampus, Cerebellum, and Cerebral Cortex in a Mouse Model of Fetal Alcohol Spectrum Disorders
- Effects of Ethanol on Immune Response in the Brain: Region-Specific Changes in Adolescent Versus Adult Mice
- Protection of neurons and microglia against ethanol in a mouse model of fetal alcohol spectrum disorders by peroxisome proliferator-activated receptor-γ agonists
- Liver X receptor agonist regulation of Th17 lymphocyte function in autoimmunity
- Protection against alcohol-induced neuronal and cognitive damage by the PPARγ receptor agonist pioglitazone
Showing 5 of 18 shared publications
Cynthia J.M. Kane
University of Arkansas for Medical Sciences
13 shared publications
In database
- Pioglitazone Blocks Ethanol Induction of Microglial Activation and Immune Responses in the Hippocampus, Cerebellum, and Cerebral Cortex in a Mouse Model of Fetal Alcohol Spectrum Disorders
- Effects of Ethanol on Immune Response in the Brain: Region-Specific Changes in Adolescent Versus Adult Mice
- Protection of neurons and microglia against ethanol in a mouse model of fetal alcohol spectrum disorders by peroxisome proliferator-activated receptor-γ agonists
- Protection against alcohol-induced neuronal and cognitive damage by the PPARγ receptor agonist pioglitazone
- Effects of ethanol on immune response in the brain: region-specific changes in aged mice
Showing 5 of 13 shared publications
Kevin D. Phelan
University of Arkansas for Medical Sciences
6 shared publications
In database
- Pioglitazone Blocks Ethanol Induction of Microglial Activation and Immune Responses in the Hippocampus, Cerebellum, and Cerebral Cortex in a Mouse Model of Fetal Alcohol Spectrum Disorders
- Effects of Ethanol on Immune Response in the Brain: Region-Specific Changes in Adolescent Versus Adult Mice
- Protection of neurons and microglia against ethanol in a mouse model of fetal alcohol spectrum disorders by peroxisome proliferator-activated receptor-γ agonists
- Effects of ethanol on immune response in the brain: region-specific changes in aged mice
- Ethanol modulation of cerebellar neuroinflammation in a postnatal mouse model of fetal alcohol spectrum disorders
Showing 5 of 6 shared publications
Tonya Rafferty
University of Arkansas for Medical Sciences
6 shared publications
In database
- Ethanol Induces Neuroinflammation in a Chronic Plus Binge Mouse Model of Alcohol Use Disorder via TLR4 and MyD88-Dependent Signaling
- Ethanol modulation of cerebellar neuroinflammation in a postnatal mouse model of fetal alcohol spectrum disorders
- Ethanol effects on cerebellar myelination in a postnatal mouse model of fetal alcohol spectrum disorders
- Effects of chronic and binge ethanol administration on mouse cerebellar and hippocampal neuroinflammation
- Ethanol modulation of hippocampal neuroinflammation, myelination, and neurodevelopment in a postnatal mouse model of fetal alcohol spectrum disorders
Showing 5 of 6 shared publications
Jennifer W. Johnson
University of Arkansas for Medical Sciences
5 shared publications
In database
- Pioglitazone Blocks Ethanol Induction of Microglial Activation and Immune Responses in the Hippocampus, Cerebellum, and Cerebral Cortex in a Mouse Model of Fetal Alcohol Spectrum Disorders
- Effects of Ethanol on Immune Response in the Brain: Region-Specific Changes in Adolescent Versus Adult Mice
- Effects of ethanol on immune response in the brain: region-specific changes in aged mice
- Ethanol modulation of cerebellar neuroinflammation in a postnatal mouse model of fetal alcohol spectrum disorders
- Effects of chronic and binge ethanol administration on mouse cerebellar and hippocampal neuroinflammation
Ania K. Majewska
University of Rochester Medicine (US)
5 shared publications
- Ethanol modulation of cerebellar neuroinflammation in a postnatal mouse model of fetal alcohol spectrum disorders
- Ethanol-induced cerebellar transcriptomic changes in a postnatal model of fetal alcohol spectrum disorders: Focus on disease onset
- Developmental ethanol exposure has minimal impact on cerebellar microglial dynamics, morphology, and interactions with Purkinje cells during adolescence
- Developmental Ethanol Exposure Impacts Purkinje Cells but Not Microglia in the Young Adult Cerebellum
- Early Postnatal Ethanol Exposure Has Long-Term Behavioral Consequences in Female Mice
Jihong Xu
University of Arkansas for Medical Sciences (US)
4 shared publications
- Effects of Ethanol on Immune Response in the Brain: Region-Specific Changes in Adolescent Versus Adult Mice
- Liver X receptor agonist regulation of Th17 lymphocyte function in autoimmunity
- Effects of ethanol on immune response in the brain: region-specific changes in aged mice
- β-Lapachone ameliorization of experimental autoimmune encephalomyelitis
Gail Wagoner
University of Arkansas for Medical Sciences
4 shared publications
In database
- Effects of Ethanol on Immune Response in the Brain: Region-Specific Changes in Adolescent Versus Adult Mice
- Liver X receptor agonist regulation of Th17 lymphocyte function in autoimmunity
- Effects of ethanol on immune response in the brain: region-specific changes in aged mice
- β-Lapachone ameliorization of experimental autoimmune encephalomyelitis
Victoria M. Niedzwiedz‐Massey
University of Arkansas for Medical Sciences
4 shared publications
In database
- Ethanol modulation of cerebellar neuroinflammation in a postnatal mouse model of fetal alcohol spectrum disorders
- Ethanol effects on cerebellar myelination in a postnatal mouse model of fetal alcohol spectrum disorders
- Effects of chronic and binge ethanol administration on mouse cerebellar and hippocampal neuroinflammation
- Ethanol modulation of hippocampal neuroinflammation, myelination, and neurodevelopment in a postnatal mouse model of fetal alcohol spectrum disorders
Kalee N. Holloway
University of Arkansas for Medical Sciences
4 shared publications
In database
- Ethanol Induces Neuroinflammation in a Chronic Plus Binge Mouse Model of Alcohol Use Disorder via TLR4 and MyD88-Dependent Signaling
- Effects of chronic and binge ethanol administration on mouse cerebellar and hippocampal neuroinflammation
- Ethanol-induced cerebellar transcriptomic changes in a postnatal model of fetal alcohol spectrum disorders: Focus on disease onset
- Divergent and overlapping hippocampal and cerebellar transcriptome responses following developmental ethanol exposure during the secondary neurogenic period
MaKenna Y. Cealie
University of Rochester Medicine (US)
3 shared publications
- Developmental ethanol exposure has minimal impact on cerebellar microglial dynamics, morphology, and interactions with Purkinje cells during adolescence
- Developmental Ethanol Exposure Impacts Purkinje Cells but Not Microglia in the Young Adult Cerebellum
- Early Postnatal Ethanol Exposure Has Long-Term Behavioral Consequences in Female Mice
Erik VonKaenel
Pacific Northwest National Laboratory (US)
2 shared publications
- Developmental ethanol exposure has minimal impact on cerebellar microglial dynamics, morphology, and interactions with Purkinje cells during adolescence
- Developmental Ethanol Exposure Impacts Purkinje Cells but Not Microglia in the Young Adult Cerebellum
Matthew N. McCall
University of Rochester (US)
2 shared publications
- Developmental ethanol exposure has minimal impact on cerebellar microglial dynamics, morphology, and interactions with Purkinje cells during adolescence
- Developmental Ethanol Exposure Impacts Purkinje Cells but Not Microglia in the Young Adult Cerebellum
Patrick S. Phelan
University of Arkansas for Medical Sciences
1 shared publication
In database
- Effects of Ethanol on Immune Response in the Brain: Region-Specific Changes in Adolescent Versus Adult Mice
Lihong Han
University of Arkansas for Medical Sciences (US)
1 shared publication
- Protection of neurons and microglia against ethanol in a mouse model of fetal alcohol spectrum disorders by peroxisome proliferator-activated receptor-γ agonists
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