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Biography and Research Information
OverviewAI-generated summary
James C. Douglas's research program investigates the neuroinflammatory and neurodevelopmental effects of ethanol exposure, particularly in the context of Fetal Alcohol Spectrum Disorders (FASD) and Alcohol Use Disorder (AUD). He has published work examining ethanol's modulation of neuroinflammation in the cerebellum and hippocampus of mouse models. Specific studies have explored the roles of Toll-like receptor 4 (TLR4) and MyD88-dependent signaling in ethanol-induced neuroinflammation in chronic plus binge AUD models. Douglas's work also addresses the impact of developmental ethanol exposure on myelination and the transcriptome in the cerebellum and hippocampus during critical neurodevelopmental periods. His research network includes frequent collaborators from the University of Arkansas for Medical Sciences, such as Paul D. Drew, Cynthia J.M. Kane, and Tonya Rafferty, with whom he has co-authored multiple publications. Douglas's scholarly output includes 17 publications with an h-index of 13 and over 700 citations.
Metrics
- h-index: 13
- Publications: 18
- Citations: 719
Selected Publications
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Developmental Ethanol Exposure Impacts Purkinje Cells but Not Microglia in the Young Adult Cerebellum (2024)
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Ethanol Induces Neuroinflammation in a Chronic Plus Binge Mouse Model of Alcohol Use Disorder via TLR4 and MyD88-Dependent Signaling (2023)
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Developmental ethanol exposure has minimal impact on cerebellar microglial dynamics, morphology, and interactions with Purkinje cells during adolescence (2023)
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Ethanol-induced cerebellar transcriptomic changes in a postnatal model of fetal alcohol spectrum disorders: Focus on disease onset (2023)
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Effects of chronic and binge ethanol administration on mouse cerebellar and hippocampal neuroinflammation (2022)
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Ethanol effects on cerebellar myelination in a postnatal mouse model of fetal alcohol spectrum disorders (2021)
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Ethanol modulation of hippocampal neuroinflammation, myelination, and neurodevelopment in a postnatal mouse model of fetal alcohol spectrum disorders (2021)
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Divergent and overlapping hippocampal and cerebellar transcriptome responses following developmental ethanol exposure during the secondary neurogenic period (2021)
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Ethanol modulation of cerebellar neuroinflammation in a postnatal mouse model of fetal alcohol spectrum disorders (2021)
Collaboration Network
Top Collaborators
Paul D. Drew
University of Arkansas for Medical Sciences
9 shared publications
In database
- Ethanol modulation of cerebellar neuroinflammation in a postnatal mouse model of fetal alcohol spectrum disorders
- Ethanol Induces Neuroinflammation in a Chronic Plus Binge Mouse Model of Alcohol Use Disorder via TLR4 and MyD88-Dependent Signaling
- Ethanol modulation of hippocampal neuroinflammation, myelination, and neurodevelopment in a postnatal mouse model of fetal alcohol spectrum disorders
- Effects of chronic and binge ethanol administration on mouse cerebellar and hippocampal neuroinflammation
- Divergent and overlapping hippocampal and cerebellar transcriptome responses following developmental ethanol exposure during the secondary neurogenic period
Showing 5 of 9 shared publications
Cynthia J.M. Kane
University of Arkansas for Medical Sciences
7 shared publications
In database
- Ethanol modulation of cerebellar neuroinflammation in a postnatal mouse model of fetal alcohol spectrum disorders
- Ethanol Induces Neuroinflammation in a Chronic Plus Binge Mouse Model of Alcohol Use Disorder via TLR4 and MyD88-Dependent Signaling
- Ethanol modulation of hippocampal neuroinflammation, myelination, and neurodevelopment in a postnatal mouse model of fetal alcohol spectrum disorders
- Effects of chronic and binge ethanol administration on mouse cerebellar and hippocampal neuroinflammation
- Divergent and overlapping hippocampal and cerebellar transcriptome responses following developmental ethanol exposure during the secondary neurogenic period
Showing 5 of 7 shared publications
Tonya Rafferty
University of Arkansas for Medical Sciences
6 shared publications
In database
- Ethanol modulation of cerebellar neuroinflammation in a postnatal mouse model of fetal alcohol spectrum disorders
- Ethanol Induces Neuroinflammation in a Chronic Plus Binge Mouse Model of Alcohol Use Disorder via TLR4 and MyD88-Dependent Signaling
- Ethanol modulation of hippocampal neuroinflammation, myelination, and neurodevelopment in a postnatal mouse model of fetal alcohol spectrum disorders
- Effects of chronic and binge ethanol administration on mouse cerebellar and hippocampal neuroinflammation
- Ethanol effects on cerebellar myelination in a postnatal mouse model of fetal alcohol spectrum disorders
Showing 5 of 6 shared publications
Victoria M. Niedzwiedz‐Massey
University of Arkansas for Medical Sciences
4 shared publications
In database
- Ethanol modulation of cerebellar neuroinflammation in a postnatal mouse model of fetal alcohol spectrum disorders
- Ethanol modulation of hippocampal neuroinflammation, myelination, and neurodevelopment in a postnatal mouse model of fetal alcohol spectrum disorders
- Effects of chronic and binge ethanol administration on mouse cerebellar and hippocampal neuroinflammation
- Ethanol effects on cerebellar myelination in a postnatal mouse model of fetal alcohol spectrum disorders
Ania K. Majewska
University of Rochester (US)
4 shared publications
- Ethanol modulation of cerebellar neuroinflammation in a postnatal mouse model of fetal alcohol spectrum disorders
- Ethanol-induced cerebellar transcriptomic changes in a postnatal model of fetal alcohol spectrum disorders: Focus on disease onset
- Developmental ethanol exposure has minimal impact on cerebellar microglial dynamics, morphology, and interactions with Purkinje cells during adolescence
- Developmental Ethanol Exposure Impacts Purkinje Cells but Not Microglia in the Young Adult Cerebellum
Kalee N. Holloway
University of Arkansas for Medical Sciences
4 shared publications
In database
- Ethanol Induces Neuroinflammation in a Chronic Plus Binge Mouse Model of Alcohol Use Disorder via TLR4 and MyD88-Dependent Signaling
- Effects of chronic and binge ethanol administration on mouse cerebellar and hippocampal neuroinflammation
- Divergent and overlapping hippocampal and cerebellar transcriptome responses following developmental ethanol exposure during the secondary neurogenic period
- Ethanol-induced cerebellar transcriptomic changes in a postnatal model of fetal alcohol spectrum disorders: Focus on disease onset
Jennifer W. Johnson
University of Arkansas for Medical Sciences
2 shared publications
In database
- Ethanol modulation of cerebellar neuroinflammation in a postnatal mouse model of fetal alcohol spectrum disorders
- Effects of chronic and binge ethanol administration on mouse cerebellar and hippocampal neuroinflammation
MaKenna Y. Cealie
University of Rochester (US)
2 shared publications
- Developmental ethanol exposure has minimal impact on cerebellar microglial dynamics, morphology, and interactions with Purkinje cells during adolescence
- Developmental Ethanol Exposure Impacts Purkinje Cells but Not Microglia in the Young Adult Cerebellum
Erik VonKaenel
Pacific Northwest National Laboratory (US)
2 shared publications
- Developmental ethanol exposure has minimal impact on cerebellar microglial dynamics, morphology, and interactions with Purkinje cells during adolescence
- Developmental Ethanol Exposure Impacts Purkinje Cells but Not Microglia in the Young Adult Cerebellum
Matthew N. McCall
University of Rochester (US)
2 shared publications
- Developmental ethanol exposure has minimal impact on cerebellar microglial dynamics, morphology, and interactions with Purkinje cells during adolescence
- Developmental Ethanol Exposure Impacts Purkinje Cells but Not Microglia in the Young Adult Cerebellum
Kevin D. Phelan
University of Arkansas for Medical Sciences
1 shared publication
In database
- Ethanol modulation of cerebellar neuroinflammation in a postnatal mouse model of fetal alcohol spectrum disorders
Marisa R. Pinson
Texas A&M University (US)
1 shared publication
- Divergent and overlapping hippocampal and cerebellar transcriptome responses following developmental ethanol exposure during the secondary neurogenic period
Rajesh C. Miranda
Texas A&M University (US)
1 shared publication
- Divergent and overlapping hippocampal and cerebellar transcriptome responses following developmental ethanol exposure during the secondary neurogenic period
P.A.L. Wight
University of Arkansas for Medical Sciences
1 shared publication
In database
- Ethanol modulation of hippocampal neuroinflammation, myelination, and neurodevelopment in a postnatal mouse model of fetal alcohol spectrum disorders
Michael D. Berquist
University of Arkansas for Medical Sciences
1 shared publication
In database
- Effects of chronic and binge ethanol administration on mouse cerebellar and hippocampal neuroinflammation
Similar Researchers
Based on overlapping research topics
Kalee N. Holloway
University of Arkansas for Medical Sciences
Neuroinflammation and Neurodegeneration Mechanisms
Substance Abuse Treatment and Outcomes
Immune Response and Inflammation
Cynthia J.M. Kane
University of Arkansas for Medical Sciences
Prenatal Substance Exposure Effects
Substance Abuse Treatment and Outcomes
Immune Response and Inflammation
A. Harmsworth
Harding University Main Campus
Neuroinflammation and Neurodegeneration Mechanisms
Substance Abuse Treatment and Outcomes
Immune Response and Inflammation
A. R. Hamilton
University of Arkansas for Medical Sciences
Neuroinflammation and Neurodegeneration Mechanisms
Prenatal Substance Exposure Effects
Substance Abuse Treatment and Outcomes
Cécile Asher
University of Arkansas for Medical Sciences
Substance Abuse Treatment and Outcomes
Birth, Development, and Health
Genomics and Phylogenetic Studies
Jennifer W. Johnson
University of Arkansas for Medical Sciences
Substance Abuse Treatment and Outcomes
Birth, Development, and Health
Immune Response and Inflammation