James C. Douglas

Researcher

University of Arkansas for Medical Sciences

faculty

13 h-index 17 pubs 700 cited

Research Areas

Neuroscience and Neuropharmacology Research Immune Response and Inflammation Birth, Development, and Health Pharmacological Effects and Toxicity Studies Substance Abuse Treatment and Outcomes Neurological disorders and treatments Maternal and Perinatal Health Interventions

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OverviewAI-generated summary

James C. Douglas investigates the effects of ethanol exposure on neurodevelopment and neuroinflammation, primarily in mouse models. His research has explored how ethanol impacts the cerebellum and hippocampus, focusing on mechanisms involving Toll-like receptor 4 (TLR4) and MyD88-dependent signaling. Douglas's work also examines the consequences of developmental ethanol exposure on myelination, gene expression patterns, and microglial cell dynamics within the brain. He has published on these topics, including studies on fetal alcohol spectrum disorders and alcohol use disorder.

Douglas collaborates with several researchers at the University of Arkansas for Medical Sciences, including Paul D. Drew, Cynthia J.M. Kane, Tonya Rafferty, and Victoria M. Niedzwiedz‐Massey. His scholarly output includes 17 publications with an h-index of 13 and over 700 citations. His recent activity indicates ongoing research in this field.

Metrics

h-index: 13
Publications: 17
Citations: 700

Selected Publications

Developmental Ethanol Exposure Impacts Purkinje Cells but Not Microglia in the Young Adult Cerebellum (2024) DOI
Ethanol Induces Neuroinflammation in a Chronic Plus Binge Mouse Model of Alcohol Use Disorder via TLR4 and MyD88-Dependent Signaling (2023) DOI
Developmental ethanol exposure has minimal impact on cerebellar microglial dynamics, morphology, and interactions with Purkinje cells during adolescence (2023) DOI
Ethanol-induced cerebellar transcriptomic changes in a postnatal model of fetal alcohol spectrum disorders: Focus on disease onset (2023) DOI
Effects of chronic and binge ethanol administration on mouse cerebellar and hippocampal neuroinflammation (2022) DOI
Ethanol effects on cerebellar myelination in a postnatal mouse model of fetal alcohol spectrum disorders (2021) DOI
Ethanol modulation of hippocampal neuroinflammation, myelination, and neurodevelopment in a postnatal mouse model of fetal alcohol spectrum disorders (2021) DOI
Divergent and overlapping hippocampal and cerebellar transcriptome responses following developmental ethanol exposure during the secondary neurogenic period (2021) DOI
Ethanol modulation of cerebellar neuroinflammation in a postnatal mouse model of fetal alcohol spectrum disorders (2021) DOI