Donald J. Johann
Professor
University of Arkansas for Medical Sciences
faculty
Biomedical Informatics, College of Medicine
Research Areas
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Biography and Research Information
OverviewAI-generated summary
Donald J. Johann is a Professor of Biomedical Informatics at the University of Arkansas for Medical Sciences. His research focuses on the development and evaluation of technologies and methodologies for analyzing genomic data, particularly in the context of cancer diagnostics and precision oncology. He has published work on assessing the analytical validity of circulating tumor DNA sequencing assays and the performance of cancer gene panels for detecting small variants of low allele frequency. His research also addresses quality control for next-generation sequencing, including the impact of sample processing on data quality.
Johann's scholarship metrics include an h-index of 23, with 118 total publications and 2,426 total citations. He has served as PI on federal grants, including a $750,000 award from the NIH/National Institute of General Medical Sciences for an advanced next-generation sequencer. He leads a research group and collaborates with researchers at the University of Arkansas for Medical Sciences and the National Center for Toxicological Research, with multiple shared publications with Ikjae Shin, Erich A. Peterson, and Matthew A. Steliga, and Binsheng Gong.
Metrics
- h-index: 23
- Publications: 118
- Citations: 2,426
Selected Publications
- Lexicon for Clonal Hematopoiesis in Liquid Biopsy (2025) DOI
- Harnessing Native-Resolution 2D Embeddings for Lung Cancer Classification: A Feasibility Study with the RAD-DINO Self-supervised Foundation Model (2025) DOI
- EET-Based Therapeutics Mitigate Sorafenib-Associated Glomerular Cell Damage (2025) DOI
- Augmenting precision medicine via targeted RNA-Seq detection of expressed mutations (2025) DOI
- Recommended Clinical Context and Patient Context Data Elements for Liquid Biopsy Data Submitted to Data Repositories and Data Commons (2025) DOI
- Towards Preanalytical Best Practices for Liquid Biopsy Studies: A BLOODPAC Landscape Analysis (2024) DOI
- Targeted DNA-seq and RNA-seq of Reference Samples with Short-read and Long-read Sequencing (2024) DOI
- A Microdissection Protocol for Proteogenomic Analysis of Histological Sections to Advance Drug Development (2024) DOI
- Advancing drug development by leveraging microdissection for proteogenomic analysis of histological sections. (2024) DOI
- Abstract PO5-02-05: Assessing Vaccine-Mediated Cellular Immune Responses in Patients Receiving Combined Vaccine and Chemotherapy Treatment (2024) DOI
- Assessments of tumor mutational burden estimation by targeted panel sequencing: A comprehensive simulation analysis (2023) DOI
- Liquid biopsy based on circulating tumor DNA for lung cancer: A step toward prevention (2023) DOI
- Contrived Materials and a Data Set for the Evaluation of Liquid Biopsy Tests (2023) DOI
- An advanced molecular medicine case report of a rare human tumor using genomics, pathomics, and radiomics (2023) DOI
- Additional file 2 of Deep oncopanel sequencing reveals within block position-dependent quality degradation in FFPE processed samples (2022) DOI
Federal Grants 1 $750,000 total
Grants & Funding
- Scientific and methodological advancement in liquid biopsies to further the development of lung cancer-based precision medicine (Bio 3) U.S. Food and Drug Administration - Pass Through: Arkansas Research Alliance Principal Investigator
- Development and Validation of a Microdissection Method to Advance Precision Medicine in the Clinical Setting - Continuation - Continuation NIH/Nat. Cancer Institute Principal Investigator
- Financial Support for the Breast Cancer Intergroup Correlative Science Studies Breast Cancer Research Foundation - Pass Through: University of Michigan Principal Investigator
- NovaSeq X Plus, Advanced Next Generation Sequencer NIH/Office of the Director Principal Investigator
- NovaSeq X Plus, Advanced Next Generation Sequencer NIH/Office of the Director Principal Investigator
- Center for Studies of Host Response to Cancer Therapy NIH Co-Investigator
- Scientific and methodological advancement in liquid biopsies to further the development of lung cancer-based precision medicine U.S. Food and Drug Administration - Pass Through: Arkansas Research Alliance Principal Investigator
- Scientific and methodological advancement in liquid biopsies to further the development of lung cancer-based precision medicine U.S. Food and Drug Administration - Pass Through: Arkansas Research Alliance Principal Investigator
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