Match tier
Listed
Presence
Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-10-05
R
Reza Hakkak
High Impact
Associate Dean for Research
Also affiliated: Arkansas Children's Hospital (1993–2021); University of Arkansas Medical Center (2006–2020); Arkansas Children's Nutrition Center (1999–2002); Arkansas Department of Agriculture (2017); Arkansas Children's Research Institute (1995–2026)
Dietetics and Nutrition, College of Health Profession
24 h-index
207 pubs
1,899 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Reza Hakkak's research focuses on the influence of nutrition on cancer prevention and promotion, with a particular emphasis on the links between obesity and breast cancer. His work also investigates the effects of various diets on chemical carcinogenesis and liver steatosis.
Dr. Hakkak has published over 65 research articles and more than 220 abstracts and presentations. His research has been supported by funding from the Susan G. Komen Foundation, the USDA, and the Arkansas Biosciences Institute. He holds multiple professorial appointments at the University of Arkansas for Medical Sciences, including in the Departments of Dietetics and Nutrition, Pediatrics, and Health Policy and Management, and serves as Associate Dean for Research in the College of Health Professions.
His scholarly contributions are reflected in an h-index of 24 and over 1,800 citations from a total of 207 publications. Dr. Hakkak has collaborated with researchers such as Soheila Korourian, Melisa Kozaczek, Michael Scott Robeson, and Elisabet Børsheim.
Metrics
- h-index: 24
- Publications: 207
- Citations: 1,899
Positions
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Professor and Chair 1987–presentUniversity of Arkansas for Medical Sciences Dietetics and Nutrition ORCID
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Associate Dean for Research publications 1993–2026University of Arkansas for Medical Sciences Dietetics and Nutrition, College of Health Profession Institutional directory
Selected Publications
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Metformin Attenuates Oxidative Stress and Inflammatory Responses in Obesity-Associated Nonalcoholic Fatty Liver Disease (NAFLD) (2025)
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The effect of obesity and dietary soy protein with different isoflavone levels on fecal microbial composition in lean and obese Zucker rats over 9- and 18-week periods (2025)
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Obesity-Associated NAFLD Coexists with a Chronic Inflammatory Kidney Condition That Is Partially Mitigated by Short-Term Oral Metformin (2025)
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Obesity and Dietary Soy Protein With Different Isoflavone Levels Alter Fecal Microbial Composition in Zucker Rats Over 9- and 18-Week Periods (2025)
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Unrecognized Effects of Metformin to Reduce Proteasomal Stress and Macrophage Infiltration in Kidneys of Obese Rats with NAFLD (Abstract ID: 166383) (2025)
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Dietary soy protein reverses obesity-induced liver steatosis and alters fecal microbial composition independent of isoflavone level (2024)
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Soy Protein Concentrate With Low and High Isoflavones Can Reverse Non-alcoholic Fatty Liver Disease Caused by Obesity and Alter Gut Microbial Composition (2024)
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Soy Protein Concentrate Diets Reduce Liver Lipopolysaccharide-Binding Protein Expression and Liver Inflammation in Obese Zucker Rats With Liver Steatosis (2024)
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Soy Protein Concentrate Diets Inversely Affect LPS-Binding Protein Expression in Colon and Liver, Reduce Liver Inflammation, and Increase Fecal LPS Excretion in Obese Zucker Rats (2024)
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Abstract 759: Soy protein diet changes metabolic profile in liver of 7,12-dimethylbenz(α)anthracene (DMBA)-induced mammary tumors in obese zucker rats (2024)
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Feeding soy protein concentrates with low or high isoflavone decreases liver inflammation by reducing lipopolysaccharide translocation (2023)
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Long-Term Feeding Soy Protein Concentrates Protect Against Hepatic Steatosis Independent of Isoflavone Levels (2023)
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Effect of Metformin Treatment on Serum Metabolic Profile Changes in Lean and Obese Zucker Rat Model for Fatty Liver Disease (2023)
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Feeding Soy Protein Concentrates with Low and High Isoflavones Alters 9 and 18 Weeks Serum Isoflavones and Inflammatory Protein Levels in Lean and Obese Zucker Rats (2023)
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Diet Containing Soy Protein Concentrate With Low and High Isoflavones for 9 Weeks Protects Against Non-alcoholic Fatty Liver Steatosis Using Obese Zucker Rats (2022)
Collaboration Network
Top Collaborators
Soheila Korourian
University of Arkansas for Medical Sciences
37 shared publications
In database
- The Health Consequences of Early Soy Consumption
- Dietary Saturated Fat Reduces Alcoholic Hepatotoxicity in Rats by Altering Fatty Acid Metabolism and Membrane Composition
- Obesity promotes 7,12-dimethylbenz(a)anthracene-induced mammary tumor development in female zucker rats
- Soy protein isolate consumption protects against azoxymethane-induced colon tumors in male rats
- Short-Term Soy Protein Isolate Feeding Prevents Liver Steatosis and Reduces Serum ALT and AST Levels in Obese Female Zucker Rats
Showing 5 of 37 shared publications
Thomas M. Badger
Arkansas Children's Hospital
15 shared publications
In database
- The Health Consequences of Early Soy Consumption
- Dietary Saturated Fat Reduces Alcoholic Hepatotoxicity in Rats by Altering Fatty Acid Metabolism and Membrane Composition
- Soy protein isolate consumption protects against azoxymethane-induced colon tumors in male rats
- Dietary whey protein protects against azoxymethane-induced colon tumors in male rats.
- Soy and Whey Proteins Downregulate DMBA-Induced Liver and Mammary Gland CYP1 Expression in Female Rats
Showing 5 of 15 shared publications
Martin J. J. Ronis
Arkansas Children's Hospital (US)
14 shared publications
- The Health Consequences of Early Soy Consumption
- Dietary Saturated Fat Reduces Alcoholic Hepatotoxicity in Rats by Altering Fatty Acid Metabolism and Membrane Composition
- Soy protein isolate consumption protects against azoxymethane-induced colon tumors in male rats
- Dietary whey protein protects against azoxymethane-induced colon tumors in male rats.
- Soy and Whey Proteins Downregulate DMBA-Induced Liver and Mammary Gland CYP1 Expression in Female Rats
Showing 5 of 14 shared publications
Tina Crook
University of Arkansas for Medical Sciences (US)
10 shared publications
- Relationship between level of HbA1C and breast cancer
- Demonstrating Impact Through Replicable Analysis: Implications of an Evaluation of Arkansas's Expanded Food and Nutrition Education Program
- Evaluating Effectiveness of the Arkansas Expanded Food and Nutrition Education Program on Changing Food Resource Management and Nutrition Practice Outcomes
- Relationship Between Level of HbA1C and Breast Cancer Outcomes
- Comparison of Selected Micronutrient Intakes Between Vegans and Omnivores Using Dietary Reference Intakes
Showing 5 of 10 shared publications
Melisa Kozaczek
Arkansas Children's Hospital
10 shared publications
In database
- Comparison of liver gene expression by RNAseq and PCR analysis after 8 weeks of feeding soy protein isolate- or casein-based diets in an obese liver steatosis rat model
- Long-Term Soy Protein Isolate Consumption Reduces Liver Steatosis Through Changes in Global Transcriptomics in Obese Zucker Rats
- Effects of obesity and 10 weeks metformin treatment on liver steatosis
- A Comparison of Short- and Long-Term Soy Protein Isolate Intake and Its Ability to Reduce Liver Steatosis in Obese Zucker Rats Through Modifications of Genes Involved in Inflammation and Lipid Transport
- Effects of Short- and Long-Term Soy Protein Feeding on Hepatic Cytochrome P450 Expression in Obese Nonalcoholic Fatty Liver Disease Rat Model
Showing 5 of 10 shared publications
Andrea Bell
Arkansas Children's Hospital (US)
9 shared publications
- Short-Term Soy Protein Isolate Feeding Prevents Liver Steatosis and Reduces Serum ALT and AST Levels in Obese Female Zucker Rats
- Dehydroepiandrosterone (DHEA) Feeding Protects Liver Steatosis in Obese Breast Cancer Rat Model
- Obesity and the Link to Chronic Disease Development
- A diet containing a high- versus low-daidzein level does not protect against liver steatosis in the obese Zucker rat model
- A diet containing high- versus low-daidzein does not affect bone density and osteogenic gene expression in the obese Zucker rat model
Showing 5 of 9 shared publications
Beverly J. Spray
Arkansas Children's Hospital (US)
9 shared publications
- Diet Containing Soy Protein Concentrate With Low and High Isoflavones for 9 Weeks Protects Against Non-alcoholic Fatty Liver Steatosis Using Obese Zucker Rats
- Feeding Soy Protein Concentrates with Low and High Isoflavones Alters 9 and 18 Weeks Serum Isoflavones and Inflammatory Protein Levels in Lean and Obese Zucker Rats
- Effects of obesity and 10 weeks metformin treatment on liver steatosis
- Dietary soy protein reverses obesity-induced liver steatosis and alters fecal microbial composition independent of isoflavone level
- Long-Term Feeding Soy Protein Concentrates Protect Against Hepatic Steatosis Independent of Isoflavone Levels
Showing 5 of 9 shared publications
Josh Phelps
University of Arkansas for Medical Sciences (US)
8 shared publications
- Demonstrating Impact Through Replicable Analysis: Implications of an Evaluation of Arkansas's Expanded Food and Nutrition Education Program
- Evaluating Effectiveness of the Arkansas Expanded Food and Nutrition Education Program on Changing Food Resource Management and Nutrition Practice Outcomes
- Relationship Between Level of HbA1C and Breast Cancer Outcomes
- Comparison of Selected Micronutrient Intakes Between Vegans and Omnivores Using Dietary Reference Intakes
- Eating Habits and Patterns of Female College Athletes
Showing 5 of 8 shared publications
Walter Bottje
University of Arkansas System (US)
8 shared publications
- Comparison of liver gene expression by RNAseq and PCR analysis after 8 weeks of feeding soy protein isolate- or casein-based diets in an obese liver steatosis rat model
- Long-Term Soy Protein Isolate Consumption Reduces Liver Steatosis Through Changes in Global Transcriptomics in Obese Zucker Rats
- A Comparison of Short- and Long-Term Soy Protein Isolate Intake and Its Ability to Reduce Liver Steatosis in Obese Zucker Rats Through Modifications of Genes Involved in Inflammation and Lipid Transport
- Effects of Short- and Long-Term Soy Protein Feeding on Hepatic Cytochrome P450 Expression in Obese Nonalcoholic Fatty Liver Disease Rat Model
- Hepatic Proteomics Analysis of Nonalcoholic Fatty Liver Disease Obese Rat Model After Short- and Long-Term Soy Protein Isolate Feeding
Showing 5 of 8 shared publications
Huawei Zeng
United States Department of Agriculture (US)
7 shared publications
- Butyrate Inhibits Cancerous HCT116 Colon Cell Proliferation but to a Lesser Extent in Noncancerous NCM460 Colon Cells
- Advanced liver steatosis accompanies an increase in hepatic inflammation, colonic, secondary bile acids and Lactobacillaceae/Lachnospiraceae bacteria in C57BL/6 mice fed a high-fat diet
- Short- and Long-Term Soy Diet Versus Casein Protects Liver Steatosis Independent of the Arginine Content
- A diet containing a high- versus low-daidzein level does not protect against liver steatosis in the obese Zucker rat model
- Butyrate Plays Differential Roles in Cellular Signaling in Cancerous HCT116 and Noncancerous NCM460 Colon Cells
Showing 5 of 7 shared publications
Stepan Melnyk
Arkansas Children's Nutrition Center
7 shared publications
In database
- Metabolic Status of Lean and Obese Zucker Rats Based on Untargeted and Targeted Metabolomics Analysis of Serum
- Effects of Obesity on Pro-Oxidative Conditions and DNA Damage in Liver of DMBA-Induced Mammary Carcinogenesis Models
- Abstract 759: Soy protein diet changes metabolic profile in liver of 7,12-dimethylbenz(α)anthracene (DMBA)-induced mammary tumors in obese zucker rats
- Effect of obesity on liver metabolic and morphological profile in Zucker rats
- Liver steatosis and redox status alterations in obese Zucker rats
Showing 5 of 7 shared publications
P.A. Carroll
University of Arkansas for Medical Sciences (US)
5 shared publications
- Nutrigenetics: Development of a Standardized Patient Case to Prepare Dietetic Interns for the Future in Nutritional Counseling
- Nutrient Intakes of Individuals Consuming a Gluten-Free Diet Compared to Intakes of the General American Population and Healthy Eating Guidelines
- Student Behavior Outcomes of an Expanded Nutrition Curriculum in Culinary School of Apprenticeship
- Impact of Food Record Keeping and Other Contributing Factors to Weight Loss Success: Results from Fhe Managing Overweight and Obesity in Veterans Everywhere (MOVE!) Level 2 Program
- Dietary Glycemic Load and Insulin Sensitivity in the Elderly
Polly Carroll
University of Arkansas for Medical Sciences (US)
5 shared publications
- Relationship of body mass index with asthma indicators in Head Start children
- Sustainable Agriculture: An Educational Approach for the Promotion of Locally Grown Produce
- Diabetes education lowers HbA1c and weight in a veteran population with Type 2 Diabetes
- Associations of dietary intake and physical activity with intramyocellular lipid content in older men and women
- The effectiveness of diabetes education on the lipid profile and HbA1c in a proactive veteran population with Type 2 Diabetes Mellitus
Margaret M. Harris
University of Arkansas for Medical Sciences (US)
5 shared publications
- Impact of Food Record Keeping and Other Contributing Factors to Weight Loss Success: Results from Fhe Managing Overweight and Obesity in Veterans Everywhere (MOVE!) Level 2 Program
- Dietary Glycemic Load and Insulin Sensitivity in the Elderly
- Diabetes education lowers HbA1c and weight in a veteran population with Type 2 Diabetes
- Associations of dietary intake and physical activity with intramyocellular lipid content in older men and women
- The effectiveness of diabetes education on the lipid profile and HbA1c in a proactive veteran population with Type 2 Diabetes Mellitus
J. Craig Rowlands
Arkansas Children's Hospital (US)
5 shared publications
- The Health Consequences of Early Soy Consumption
- Soy and Whey Proteins Downregulate DMBA-Induced Liver and Mammary Gland CYP1 Expression in Female Rats
- Altered Expression and Glucocorticoid-Inducibility of Hepatic CYP3A and CYP2B Enzymes in Male Rats Fed Diets Containing Soy Protein Isolate
- Inducibility of Hepatic CYP1A Enzymes by 3-Methylcholanthrene and Isosafrole Differs in Male Rats Fed Diets Containing Casein, Soy Protein Isolate or Whey from Conception to Adulthood
- Chronic Intragastric Infusion of Ethanol-Containing Diets Induces CYP3A9 While Decreasing CYP3A2 in Male Rats
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