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Listed
Presence
Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-08-15
R
Reza Hakkak
High Impact
Associate Dean for Research
Also affiliated: Arkansas Children's Hospital (1993–2026); University of Arkansas Medical Center (2005–2014); University of Arkansas System (2021); Arkansas Department of Education (2017); Academy of Nutrition and Dietetics (2006–2019); Poultry Research Institute (2021); Cancer Research Center (2007–2014); Arkansas Children's Nutrition Center (1999–2023); Arkansas Department of Agriculture (2006–2020)
Faculty Researcher
Dietetics and Nutrition, College of Health Profession
24 h-index
207 pubs
1,892 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Reza Hakkak's research investigates the complex interplay between nutrition, obesity, and disease, with a particular focus on cancer prevention and promotion. His work utilizes animal models, primarily Zucker rats, to explore the metabolic and physiological effects of various dietary components and interventions. Recent studies have examined the impact of soy protein concentrate with differing isoflavone levels on non-alcoholic fatty liver steatosis, liver inflammation, and the translocation of lipopolysaccharide in obese rats. Additionally, his research has explored the effects of metformin on liver steatosis in obese rat models.
Dr. Hakkak's contributions extend to nutrition education and policy, drawing on his extensive experience as a professor and administrator within the University of Arkansas for Medical Sciences' College of Health Professions. He holds multiple professorships across departments including Dietetics and Nutrition, Pediatrics, and Health Policy and Management. His research has been supported by grants from organizations such as the Susan G. Komen Foundation, USDA, and the Arkansas Biosciences Institute. With over 65 research articles and 220 abstracts and presentations, Dr. Hakkak has established a significant publication record, complemented by an h-index of 24 and over 1,800 citations.
Metrics
- h-index: 24
- Publications: 207
- Citations: 1,892
Selected Publications
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Metformin Attenuates Oxidative Stress and Inflammatory Responses in Obesity-Associated Nonalcoholic Fatty Liver Disease (NAFLD) (2025)
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The effect of obesity and dietary soy protein with different isoflavone levels on fecal microbial composition in lean and obese Zucker rats over 9- and 18-week periods (2025)
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Obesity-Associated NAFLD Coexists with a Chronic Inflammatory Kidney Condition That Is Partially Mitigated by Short-Term Oral Metformin (2025)
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Obesity and Dietary Soy Protein With Different Isoflavone Levels Alter Fecal Microbial Composition in Zucker Rats Over 9- and 18-Week Periods (2025)
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Unrecognized Effects of Metformin to Reduce Proteasomal Stress and Macrophage Infiltration in Kidneys of Obese Rats with NAFLD (Abstract ID: 166383) (2025)
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Dietary soy protein reverses obesity-induced liver steatosis and alters fecal microbial composition independent of isoflavone level (2024)
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Soy Protein Concentrate With Low and High Isoflavones Can Reverse Non-alcoholic Fatty Liver Disease Caused by Obesity and Alter Gut Microbial Composition (2024)
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Soy Protein Concentrate Diets Reduce Liver Lipopolysaccharide-Binding Protein Expression and Liver Inflammation in Obese Zucker Rats With Liver Steatosis (2024)
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Soy Protein Concentrate Diets Inversely Affect LPS-Binding Protein Expression in Colon and Liver, Reduce Liver Inflammation, and Increase Fecal LPS Excretion in Obese Zucker Rats (2024)
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Abstract 759: Soy protein diet changes metabolic profile in liver of 7,12-dimethylbenz(<i>α</i>)anthracene (DMBA)-induced mammary tumors in obese zucker rats (2024)
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Feeding soy protein concentrates with low or high isoflavone decreases liver inflammation by reducing lipopolysaccharide translocation (2023)
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Long-Term Feeding Soy Protein Concentrates Protect Against Hepatic Steatosis Independent of Isoflavone Levels (2023)
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Effect of Metformin Treatment on Serum Metabolic Profile Changes in Lean and Obese Zucker Rat Model for Fatty Liver Disease (2023)
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Feeding Soy Protein Concentrates with Low and High Isoflavones Alters 9 and 18 Weeks Serum Isoflavones and Inflammatory Protein Levels in Lean and Obese Zucker Rats (2023)
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Diet Containing Soy Protein Concentrate With Low and High Isoflavones for 9 Weeks Protects Against Non-alcoholic Fatty Liver Steatosis Using Obese Zucker Rats (2022)
Collaboration Network
Top Collaborators
Soheila Korourian
University of Arkansas for Medical Sciences
9 shared publications
In database
- Diet Containing Soy Protein Concentrate With Low and High Isoflavones for 9 Weeks Protects Against Non-alcoholic Fatty Liver Steatosis Using Obese Zucker Rats
- Effects of obesity and 10 weeks metformin treatment on liver steatosis
- Long-Term Feeding Soy Protein Concentrates Protect Against Hepatic Steatosis Independent of Isoflavone Levels
- Dietary soy protein reverses obesity-induced liver steatosis and alters fecal microbial composition independent of isoflavone level
- Effects of Obesity and Low and High Isoflavones in Soy Protein Concentrate Diet on Liver Steatosis
Showing 5 of 9 shared publications
Beverly J. Spray
Arkansas Children's Hospital (US)
8 shared publications
- Diet Containing Soy Protein Concentrate With Low and High Isoflavones for 9 Weeks Protects Against Non-alcoholic Fatty Liver Steatosis Using Obese Zucker Rats
- Feeding Soy Protein Concentrates with Low and High Isoflavones Alters 9 and 18 Weeks Serum Isoflavones and Inflammatory Protein Levels in Lean and Obese Zucker Rats
- Effects of obesity and 10 weeks metformin treatment on liver steatosis
- Long-Term Feeding Soy Protein Concentrates Protect Against Hepatic Steatosis Independent of Isoflavone Levels
- Dietary soy protein reverses obesity-induced liver steatosis and alters fecal microbial composition independent of isoflavone level
Showing 5 of 8 shared publications
Melisa Kozaczek
University of Arkansas for Medical Sciences
7 shared publications
In database
- Effects of obesity and 10 weeks metformin treatment on liver steatosis
- A Comparison of Short- and Long-Term Soy Protein Isolate Intake and Its Ability to Reduce Liver Steatosis in Obese Zucker Rats Through Modifications of Genes Involved in Inflammation and Lipid Transport
- Effects of Short- and Long-Term Soy Protein Feeding on Hepatic Cytochrome P450 Expression in Obese Nonalcoholic Fatty Liver Disease Rat Model
- Hepatic Proteomics Analysis of Nonalcoholic Fatty Liver Disease Obese Rat Model After Short- and Long-Term Soy Protein Isolate Feeding
- Liver Proteomics Analysis After Short- and Long-Term Soy Protein Isolate Feeding Using Obese Zucker Rat Model
Showing 5 of 7 shared publications
Walter Bottje
University of Arkansas System (US)
5 shared publications
- A Comparison of Short- and Long-Term Soy Protein Isolate Intake and Its Ability to Reduce Liver Steatosis in Obese Zucker Rats Through Modifications of Genes Involved in Inflammation and Lipid Transport
- Effects of Short- and Long-Term Soy Protein Feeding on Hepatic Cytochrome P450 Expression in Obese Nonalcoholic Fatty Liver Disease Rat Model
- Hepatic Proteomics Analysis of Nonalcoholic Fatty Liver Disease Obese Rat Model After Short- and Long-Term Soy Protein Isolate Feeding
- Liver Proteomics Analysis After Short- and Long-Term Soy Protein Isolate Feeding Using Obese Zucker Rat Model
- Effects of Short and Long-Term Soy Protein Isolate Intake on Hepatic Cytochrome P450 Expression in Obese Zucker Rats
Michael S. Robeson
University of Arkansas for Medical Sciences
5 shared publications
In database
- Short-Term Metformin Treatment Enriches Bacteroides dorei in an Obese Liver Steatosis Zucker Rat Model
- Dietary soy protein reverses obesity-induced liver steatosis and alters fecal microbial composition independent of isoflavone level
- Effects of Short-Term Metformin Treatment on Gut Microbiota Profile Using Female Obese Zucker Rat Model
- Soy Protein Concentrate With Low and High Isoflavones Can Reverse Non-alcoholic Fatty Liver Disease Caused by Obesity and Alter Gut Microbial Composition
- The effect of obesity and dietary soy protein with different isoflavone levels on fecal microbial composition in lean and obese Zucker rats over 9- and 18-week periods
David M. Irby
4 shared publications
- Diet Containing Soy Protein Concentrate with Low and High Isoflavones for 18 Weeks Protects Against Non-alcoholic Fatty Liver Diseases
- Effects of 8 Weeks Feeding Diet with Low and High Isoflavones Soy Protein Concentrate on Serum Isoflavones in Non-alcoholic Fatty Liver Disease (NAFLD) Rat Model
- Feeding Obese Zucker Rats With Soy Protein Concentrate With High Isoflavones Compared to Low Isoflavones Leads to a Significant Reduction of Serum Tumor Necrosis Factor-α
- Soy Protein Concentrate With Low and High Isoflavones Can Reverse Non-alcoholic Fatty Liver Disease Caused by Obesity and Alter Gut Microbial Composition
Wei Li
University of Arkansas for Medical Sciences (US)
4 shared publications
- Feeding Soy Protein Concentrates with Low and High Isoflavones Alters 9 and 18 Weeks Serum Isoflavones and Inflammatory Protein Levels in Lean and Obese Zucker Rats
- Soy Protein Concentrate Diets Inversely Affect LPS-Binding Protein Expression in Colon and Liver, Reduce Liver Inflammation, and Increase Fecal LPS Excretion in Obese Zucker Rats
- Long-Term Feeding Soy Protein Concentrates Protect Against Hepatic Steatosis Independent of Isoflavone Levels
- Feeding Obese Zucker Rats With Soy Protein Concentrate With High Isoflavones Compared to Low Isoflavones Leads to a Significant Reduction of Serum Tumor Necrosis Factor-α
Elisabet Børsheim
Arkansas Children's Hospital
4 shared publications
In database
- Diet Containing Soy Protein Concentrate With Low and High Isoflavones for 9 Weeks Protects Against Non-alcoholic Fatty Liver Steatosis Using Obese Zucker Rats
- Long-Term Feeding Soy Protein Concentrates Protect Against Hepatic Steatosis Independent of Isoflavone Levels
- Dietary soy protein reverses obesity-induced liver steatosis and alters fecal microbial composition independent of isoflavone level
- A Pilot Study Protocol: Glycemic Patterns in Obese Pregnancies Without Diabetes – Identifying Susceptible Periods for Intervention
Stepan Melnyk
3 shared publications
In database
- Metabolic Status of Lean and Obese Zucker Rats Based on Untargeted and Targeted Metabolomics Analysis of Serum
- Abstract 740: Obesity promotes liver pro-oxidative and DNA damage in mammary tumor of Zucker rats
- Abstract 759: Soy protein diet changes metabolic profile in liver of 7,12-dimethylbenz(<i>α</i>)anthracene (DMBA)-induced mammary tumors in obese zucker rats
Nathan C. Twaddle
National Center for Toxicological Research
3 shared publications
In database
- Feeding Soy Protein Concentrates with Low and High Isoflavones Alters 9 and 18 Weeks Serum Isoflavones and Inflammatory Protein Levels in Lean and Obese Zucker Rats
- Dietary soy protein reverses obesity-induced liver steatosis and alters fecal microbial composition independent of isoflavone level
- Effects of 8 Weeks Feeding Diet with Low and High Isoflavones Soy Protein Concentrate on Serum Isoflavones in Non-alcoholic Fatty Liver Disease (NAFLD) Rat Model
Wei Li
University of Arkansas for Medical Sciences (US)
3 shared publications
- Dietary soy protein reverses obesity-induced liver steatosis and alters fecal microbial composition independent of isoflavone level
- Obesity and Dietary Soy Protein With Different Isoflavone Levels Alter Fecal Microbial Composition in Zucker Rats Over 9- and 18-Week Periods
- The effect of obesity and dietary soy protein with different isoflavone levels on fecal microbial composition in lean and obese Zucker rats over 9- and 18-week periods
Christopher E. Randolph
Arkansas Children's Hospital
3 shared publications
In database
- Dietary soy protein reverses obesity-induced liver steatosis and alters fecal microbial composition independent of isoflavone level
- Obesity and Dietary Soy Protein With Different Isoflavone Levels Alter Fecal Microbial Composition in Zucker Rats Over 9- and 18-Week Periods
- The effect of obesity and dietary soy protein with different isoflavone levels on fecal microbial composition in lean and obese Zucker rats over 9- and 18-week periods
Neriman Gokden
University of Arkansas for Medical Sciences
3 shared publications
In database
- Unrecognized Effects of Metformin to Reduce Proteasomal Stress and Macrophage Infiltration in Kidneys of Obese Rats with NAFLD (Abstract ID: 166383)
- Obesity-Associated NAFLD Coexists with a Chronic Inflammatory Kidney Condition That Is Partially Mitigated by Short-Term Oral Metformin
- Metformin Attenuates Oxidative Stress and Inflammatory Responses in Obesity-Associated Nonalcoholic Fatty Liver Disease (NAFLD)
Nirmala Parajuli
University of Arkansas for Medical Sciences
3 shared publications
In database
- Unrecognized Effects of Metformin to Reduce Proteasomal Stress and Macrophage Infiltration in Kidneys of Obese Rats with NAFLD (Abstract ID: 166383)
- Obesity-Associated NAFLD Coexists with a Chronic Inflammatory Kidney Condition That Is Partially Mitigated by Short-Term Oral Metformin
- Metformin Attenuates Oxidative Stress and Inflammatory Responses in Obesity-Associated Nonalcoholic Fatty Liver Disease (NAFLD)
Byung‐Whi Kong
University of Arkansas System (US)
2 shared publications
- A Comparison of Short- and Long-Term Soy Protein Isolate Intake and Its Ability to Reduce Liver Steatosis in Obese Zucker Rats Through Modifications of Genes Involved in Inflammation and Lipid Transport
- Hepatic Proteomics Analysis of Nonalcoholic Fatty Liver Disease Obese Rat Model After Short- and Long-Term Soy Protein Isolate Feeding
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