Umesh D. Wankhade
Post Doctoral Researcher
Also affiliated: National Institutes of Health (2014–2017); Indian Veterinary Research Institute (2008); University of Arkansas Medical Center (2017–2022); National Institute of Diabetes and Digestive and Kidney Diseases (2013–2018); Arkansas Children's Nutrition Center (2016–2026); National Institutes of Health Clinical Center (2017); Arkansas Children's Research Institute (2021–2026); Virginia Tech (2007–2012)
Peds Pediatrics, College of Medicine
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Umesh D. Wankhade's research focuses on the intersection of diet, gut microbiota, and metabolic health, primarily utilizing mouse models. His work has investigated how specific dietary interventions, such as tryptophan deficiency or blueberry consumption, impact gut microbial composition and function, leading to changes in systemic inflammation, insulin resistance, and vascular complications.
Wankhade has also explored the role of specific molecular pathways and metabolites in metabolic regulation. His research includes examining how compounds like hippuric acid influence bone resorption and how the fungus Cordyceps affects ceramide biosynthesis and hepatic steatosis. Furthermore, his work has touched upon the potential roles of proteins like globins in adipose tissue function and the gut microbiota's connection to neurodegenerative diseases like Alzheimer's.
With an h-index of 24 and over 80 publications, Wankhade is recognized as a highly cited researcher. He collaborates extensively with colleagues at the University of Arkansas for Medical Sciences, including Henry A. Paz, Sree V. Chintapalli, and James D. Sikes, and leads a research group.
Metrics
- h-index: 24
- Publications: 83
- Citations: 1,963
Positions
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Director 2025–presentArkansas Children's Research Institute Animal Research ORCID
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Post Doctoral Researcher 2010–presentNational Institutes of Health NIDDK ORCID
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Post Doctoral Researcher publications 2016–2026University of Arkansas for Medical Sciences Peds Pediatrics, College of Medicine Institutional directory
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Graduate Research Assistant 2006–2010Virginia Polytechnic Institute and State University Human Nutrition, Food and Exercise ORCID
Selected Publications
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Osteocytic Lipocalin-2 regulates bone formation locally through iron-dependent ferroptosis and Wnt suppression (2026)
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Hormones, heat, and health: a comprehensive review of sex-based differences in brown and beige fat biology (2025)
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Dietary Prebiotics Modulate Omeprazole‐Induced Alterations in the Gut Microbial Signature (2025)
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Impact of short-term housing temperature alteration on metabolic parameters and adipose tissue in female mice (2025)
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Shared and distinct adaptations to early‐life exercise training based on inborn fitness (2025)
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Maternal high-fat diet-induced obesity in offspring: Unraveling adipose tissue dysfunction mediated by increased heat shock proteins (2025)
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The Transgenerational Inheritance of Obesity: Maternal High-Fat Diet Drives Inflammatory Transcriptomic Signatures in Offspring Adipose Tissue (2025)
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Lipocalin-2 Regulates Osteocyte Ferroptosis and Osteocyte-Osteoblast Crosstalk via Wnt Signaling to Control Bone Formation (2025)
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Gut microbes metabolize strawberry phytochemicals and mediate their beneficial effects on vascular inflammation (2025)
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Shared and distinct adaptations to early-life exercise training based on inborn fitness (2024)
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Impact of maternal high‐fat diet on offspring gut microbiota during short‐term high‐fat diet exposure in mice (2024)
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Maternal High-Fat Diet-Induced Obesity in Offspring: Unraveling Adipose Tissue Dysfunction Mediated by Increased Heat Shock Proteins (2024)
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Maternal Obesity Alters Adipogenic Potential and Mitochondrial Function in Mesenchymal Stem Cells From Infants Born to Mothers With Overweight or Obesity (2024)
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Effects of Statin and Annatto-extracted Tocotrienol Supplementation on Glucose Homeostasis, Bone Microstructure, and Gut Microbiota Composition in Obese Mice (2024)
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Gut Microbiota Depletion Using Antibiotics to Investigate Diet‐Derived Microbial Metabolites: An Efficient Strategy (2023)
Collaboration Network
Top Collaborators
- Enhanced offspring predisposition to steatohepatitis with maternal high-fat diet is associated with epigenetic and microbiome alterations
- High-fat, high-fructose, high-cholesterol feeding causes severe NASH and cecal microbiota dysbiosis in juvenile Ossabaw swine
- Maternal High-Fat Diet Programs Offspring Liver Steatosis in a Sexually Dimorphic Manner in Association with Changes in Gut Microbial Ecology in Mice
- Dietary supplementation with strawberry induces marked changes in the composition and functional potential of the gut microbiome in diabetic mice
- Gut microbiota are linked to increased susceptibility to hepatic steatosis in low-aerobic-capacity rats fed an acute high-fat diet
Showing 5 of 27 shared publications
- Enhanced offspring predisposition to steatohepatitis with maternal high-fat diet is associated with epigenetic and microbiome alterations
- High-fat, high-fructose, high-cholesterol feeding causes severe NASH and cecal microbiota dysbiosis in juvenile Ossabaw swine
- Maternal High-Fat Diet Programs Offspring Liver Steatosis in a Sexually Dimorphic Manner in Association with Changes in Gut Microbial Ecology in Mice
- Dietary supplementation with strawberry induces marked changes in the composition and functional potential of the gut microbiome in diabetic mice
- Sex-Specific Changes in Gut Microbiome Composition following Blueberry Consumption in C57BL/6J Mice
Showing 5 of 18 shared publications
- Enhanced offspring predisposition to steatohepatitis with maternal high-fat diet is associated with epigenetic and microbiome alterations
- Maternal High-Fat Diet Programs Offspring Liver Steatosis in a Sexually Dimorphic Manner in Association with Changes in Gut Microbial Ecology in Mice
- Sex-Specific Changes in Gut Microbiome Composition following Blueberry Consumption in C57BL/6J Mice
- Gut Microbiota Depletion Using Antibiotics to Investigate Diet‐Derived Microbial Metabolites: An Efficient Strategy
- Dose- and Time-Dependent Effect of Dietary Blueberries on Diabetic Vasculature Is Correlated with Gut Microbial Signature
Showing 5 of 16 shared publications
- Beige Adipose Tissue Identification and Marker Specificity—Overview
- Cordyceps inhibits ceramide biosynthesis and improves insulin resistance and hepatic steatosis
- Dietary Blueberry Ameliorates Vascular Complications in Diabetic Mice Possibly through NOX4 and Modulates Composition and Functional Diversity of Gut Microbes
- Blueberry intervention mitigates detrimental microbial metabolite trimethylamine N‐oxide by modulating gut microbes
- Gut Microbiota Depletion Using Antibiotics to Investigate Diet‐Derived Microbial Metabolites: An Efficient Strategy
Showing 5 of 16 shared publications
- Maternal High-Fat Diet Programs Offspring Liver Steatosis in a Sexually Dimorphic Manner in Association with Changes in Gut Microbial Ecology in Mice
- Dietary supplementation with strawberry induces marked changes in the composition and functional potential of the gut microbiome in diabetic mice
- Sex-Specific Changes in Gut Microbiome Composition following Blueberry Consumption in C57BL/6J Mice
- Xenometabolite signatures in the UC Davis type 2 diabetes mellitus rat model revealed using a metabolomics platform enriched with microbe-derived metabolites
- Dietary Blueberry Ameliorates Vascular Complications in Diabetic Mice Possibly through NOX4 and Modulates Composition and Functional Diversity of Gut Microbes
Showing 5 of 9 shared publications
- Dietary supplementation with strawberry induces marked changes in the composition and functional potential of the gut microbiome in diabetic mice
- Cordyceps inhibits ceramide biosynthesis and improves insulin resistance and hepatic steatosis
- Dietary Blueberry Ameliorates Vascular Complications in Diabetic Mice Possibly through NOX4 and Modulates Composition and Functional Diversity of Gut Microbes
- Blueberry intervention mitigates detrimental microbial metabolite trimethylamine N‐oxide by modulating gut microbes
- Gut Microbes Are Associated with the Vascular Beneficial Effects of Dietary Strawberry on Metabolic Syndrome‐Induced Vascular Inflammation
Showing 5 of 9 shared publications
- Cordyceps inhibits ceramide biosynthesis and improves insulin resistance and hepatic steatosis
- Dietary Blueberry Ameliorates Vascular Complications in Diabetic Mice Possibly through NOX4 and Modulates Composition and Functional Diversity of Gut Microbes
- Blueberry intervention mitigates detrimental microbial metabolite trimethylamine N‐oxide by modulating gut microbes
- Gut Microbes Are Associated with the Vascular Beneficial Effects of Dietary Strawberry on Metabolic Syndrome‐Induced Vascular Inflammation
- Gut Microbiota Depletion Using Antibiotics to Investigate Diet‐Derived Microbial Metabolites: An Efficient Strategy
Showing 5 of 8 shared publications
- Impact of maternal high‐fat diet on offspring gut microbiota during short‐term high‐fat diet exposure in mice
- Gut Microbiome and Metabolome Modulation by Maternal High-Fat Diet and Thermogenic Challenge
- Maternal high-fat diet-induced obesity in offspring: Unraveling adipose tissue dysfunction mediated by increased heat shock proteins
- Shared and distinct adaptations to early‐life exercise training based on inborn fitness
- Maternal High-Fat Diet-Induced Obesity in Offspring: Unraveling Adipose Tissue Dysfunction Mediated by Increased Heat Shock Proteins
Showing 5 of 8 shared publications
- Dietary supplementation with strawberry induces marked changes in the composition and functional potential of the gut microbiome in diabetic mice
- Dietary Blueberry Ameliorates Vascular Complications in Diabetic Mice Possibly through NOX4 and Modulates Composition and Functional Diversity of Gut Microbes
- Blueberry intervention mitigates detrimental microbial metabolite trimethylamine N‐oxide by modulating gut microbes
- Gut Microbes Are Associated with the Vascular Beneficial Effects of Dietary Strawberry on Metabolic Syndrome‐Induced Vascular Inflammation
- Gut Microbiota Depletion Using Antibiotics to Investigate Diet‐Derived Microbial Metabolites: An Efficient Strategy
Showing 5 of 7 shared publications
- Sex-Specific Changes in Gut Microbiome Composition following Blueberry Consumption in C57BL/6J Mice
- GPR109A mediates the effects of hippuric acid on regulating osteoclastogenesis and bone resorption in mice
- 3‐(3‐Hydroxyphenyl)‐Propionic Acid (PPA) Suppresses Osteoblastic Cell Senescence to Promote Bone Accretion in Mice
- Nox4 Expression Is Not Required for OVX ‐Induced Osteoblast Senescence and Bone Loss in Mice
- Maternal high-fat diet modifies epigenetic marks H3K27me3 and H3K27ac in bone to regulate offspring osteoblastogenesis in mice
Showing 5 of 7 shared publications
- High-fat, high-fructose, high-cholesterol feeding causes severe NASH and cecal microbiota dysbiosis in juvenile Ossabaw swine
- Gut microbiota are linked to increased susceptibility to hepatic steatosis in low-aerobic-capacity rats fed an acute high-fat diet
- Soy compared with milk protein in a Western diet changes fecal microbiota and decreases hepatic steatosis in obese OLETF rats
- Cecal versus fecal microbiota in Ossabaw swine and implications for obesity
- Intrinsic High Aerobic Capacity in Male Rats Protects Against Diet-Induced Insulin Resistance
Showing 5 of 6 shared publications
- Sex-Specific Changes in Gut Microbiome Composition following Blueberry Consumption in C57BL/6J Mice
- GPR109A mediates the effects of hippuric acid on regulating osteoclastogenesis and bone resorption in mice
- 3‐(3‐Hydroxyphenyl)‐Propionic Acid (PPA) Suppresses Osteoblastic Cell Senescence to Promote Bone Accretion in Mice
- Nox4 Expression Is Not Required for OVX ‐Induced Osteoblast Senescence and Bone Loss in Mice
- Maternal high-fat diet modifies epigenetic marks H3K27me3 and H3K27ac in bone to regulate offspring osteoblastogenesis in mice
Showing 5 of 6 shared publications
- High-fat, high-fructose, high-cholesterol feeding causes severe NASH and cecal microbiota dysbiosis in juvenile Ossabaw swine
- Gut microbiota are linked to increased susceptibility to hepatic steatosis in low-aerobic-capacity rats fed an acute high-fat diet
- Soy compared with milk protein in a Western diet changes fecal microbiota and decreases hepatic steatosis in obese OLETF rats
- Cecal versus fecal microbiota in Ossabaw swine and implications for obesity
- Reduced Short‐chain Fatty Acid Producing Microbiota are Linked to Increased Energy Intake and Susceptibility to High Fat Diet Induced Hepatic Steatosis in Low Aerobic Capacity Rats
- Enhanced offspring predisposition to steatohepatitis with maternal high-fat diet is associated with epigenetic and microbiome alterations
- Maternal High-Fat Diet Programs Offspring Liver Steatosis in a Sexually Dimorphic Manner in Association with Changes in Gut Microbial Ecology in Mice
- Novel Browning Agents, Mechanisms, and Therapeutic Potentials of Brown Adipose Tissue
- Persistent influence of maternal obesity on offspring health: Mechanisms from animal models and clinical studies
- Maternal obesity during pregnancy uniquely programs offspring aortic and perivascular adipose tissue transcriptomes
- Gut microbiota are linked to increased susceptibility to hepatic steatosis in low-aerobic-capacity rats fed an acute high-fat diet
- Intrinsic High Aerobic Capacity in Male Rats Protects Against Diet-Induced Insulin Resistance
- Shared and distinct adaptations to early‐life exercise training based on inborn fitness
- Shared and distinct adaptations to early-life exercise training based on inborn fitness
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