Umesh D. Wankhade
High Impact
Post Doctoral Researcher
postdoc
Peds Pediatrics, College of Medicine
24 h-index
82 pubs
1,863 cited
Research Areas
Biography and Research Information
OverviewAI-generated summary
Umesh D. Wankhade's research focuses on the interplay between diet, gut microbiota, and metabolic health, utilizing animal models to investigate disease mechanisms. His work has explored how specific dietary interventions, such as tryptophan deficiency and blueberry consumption, impact the gut microbiome and influence systemic inflammation, insulin resistance, and vascular complications in mice. He has also investigated the role of specific molecules, like hippuric acid and ceramides, in metabolic processes, including bone resorption and hepatic steatosis.
His research extends to understanding the gut microbiome's role in neurological conditions, with recent work examining its dysbiosis in Alzheimer's disease models. Wankhade also studies adipose tissue, including beige adipose tissue identification and the potential role of globins in brown adipose tissue function. He has published 80 papers, accumulating 1,835 citations and an h-index of 24, and is recognized as a highly cited researcher. He leads a research group and collaborates with researchers at the University of Arkansas for Medical Sciences and the University of Arkansas at Fayetteville.
Metrics
- h-index: 24
- Publications: 82
- Citations: 1,863
Selected Publications
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Osteocytic Lipocalin-2 regulates bone formation locally through iron-dependent ferroptosis and Wnt suppression (2026)
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Hormones, heat, and health: a comprehensive review of sex-based differences in brown and beige fat biology (2025)
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Dietary Prebiotics Modulate Omeprazole‐Induced Alterations in the Gut Microbial Signature (2025)
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Impact of short-term housing temperature alteration on metabolic parameters and adipose tissue in female mice (2025)
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Shared and distinct adaptations to early‐life exercise training based on inborn fitness (2025)
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Maternal high-fat diet-induced obesity in offspring: Unraveling adipose tissue dysfunction mediated by increased heat shock proteins (2025)
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The Transgenerational Inheritance of Obesity: Maternal High-Fat Diet Drives Inflammatory Transcriptomic Signatures in Offspring Adipose Tissue (2025)
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Lipocalin-2 Regulates Osteocyte Ferroptosis and Osteocyte-Osteoblast Crosstalk via Wnt Signaling to Control Bone Formation (2025)
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Gut microbes metabolize strawberry phytochemicals and mediate their beneficial effects on vascular inflammation (2025)
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Shared and distinct adaptations to early-life exercise training based on inborn fitness (2024)
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Impact of maternal high‐fat diet on offspring gut microbiota during short‐term high‐fat diet exposure in mice (2024)
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Maternal High-Fat Diet-Induced Obesity in Offspring: Unraveling Adipose Tissue Dysfunction Mediated by Increased Heat Shock Proteins (2024)
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Maternal Obesity Alters Adipogenic Potential and Mitochondrial Function in Mesenchymal Stem Cells From Infants Born to Mothers With Overweight or Obesity (2024)
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Effects of Statin and Annatto-extracted Tocotrienol Supplementation on Glucose Homeostasis, Bone Microstructure, and Gut Microbiota Composition in Obese Mice (2024)
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Gut Microbiota Depletion Using Antibiotics to Investigate Diet‐Derived Microbial Metabolites: An Efficient Strategy (2023)
Grants & Funding
- No FP attached UAMS ACHRI Flow Through Principal Investigator
- No FP attached UAMS ACHRI Flow Through Principal Investigator
- No FP attached UAMS ACHRI Flow Through Principal Investigator
Collaboration Network
Top Collaborators
Henry A. Paz
Arkansas Children's Hospital
22 shared publications
In database
- Beige Adipose Tissue Identification and Marker Specificity—Overview
- Cordyceps inhibits ceramide biosynthesis and improves insulin resistance and hepatic steatosis
- Dietary Blueberry Ameliorates Vascular Complications in Diabetic Mice Possibly through NOX4 and Modulates Composition and Functional Diversity of Gut Microbes
- Blueberry intervention mitigates detrimental microbial metabolite trimethylamine N‐oxide by modulating gut microbes
- Gut Microbiota Depletion Using Antibiotics to Investigate Diet‐Derived Microbial Metabolites: An Efficient Strategy
Showing 5 of 22 shared publications
Chrissa Petersen
University of Utah (US)
12 shared publications
- Dietary Blueberry Ameliorates Vascular Complications in Diabetic Mice Possibly through NOX4 and Modulates Composition and Functional Diversity of Gut Microbes
- Blueberry intervention mitigates detrimental microbial metabolite trimethylamine N‐oxide by modulating gut microbes
- Gut Microbes Are Associated with the Vascular Beneficial Effects of Dietary Strawberry on Metabolic Syndrome‐Induced Vascular Inflammation
- Gut Microbiota Depletion Using Antibiotics to Investigate Diet‐Derived Microbial Metabolites: An Efficient Strategy
- Dose- and Time-Dependent Effect of Dietary Blueberries on Diabetic Vasculature Is Correlated with Gut Microbial Signature
Showing 5 of 12 shared publications
Ying Zhong
Arkansas Children's Hospital (US)
12 shared publications
- Gut Microbiota Depletion Using Antibiotics to Investigate Diet‐Derived Microbial Metabolites: An Efficient Strategy
- Dose- and Time-Dependent Effect of Dietary Blueberries on Diabetic Vasculature Is Correlated with Gut Microbial Signature
- Impact of maternal high‐fat diet on offspring gut microbiota during short‐term high‐fat diet exposure in mice
- Gut microbes metabolize strawberry phytochemicals and mediate their beneficial effects on vascular inflammation
- Gut Microbiome and Metabolome Modulation by Maternal High-Fat Diet and Thermogenic Challenge
Showing 5 of 12 shared publications
Adhini Kuppuswamy Satheesh Babu
University of Utah (US)
11 shared publications
- Cordyceps inhibits ceramide biosynthesis and improves insulin resistance and hepatic steatosis
- Dietary Blueberry Ameliorates Vascular Complications in Diabetic Mice Possibly through NOX4 and Modulates Composition and Functional Diversity of Gut Microbes
- Blueberry intervention mitigates detrimental microbial metabolite trimethylamine N‐oxide by modulating gut microbes
- Gut Microbes Are Associated with the Vascular Beneficial Effects of Dietary Strawberry on Metabolic Syndrome‐Induced Vascular Inflammation
- Gut Microbiota Depletion Using Antibiotics to Investigate Diet‐Derived Microbial Metabolites: An Efficient Strategy
Showing 5 of 11 shared publications
Kartik Shankar
University of Colorado Anschutz Medical Campus (US)
10 shared publications
- GPR109A mediates the effects of hippuric acid on regulating osteoclastogenesis and bone resorption in mice
- Dietary Blueberry Ameliorates Vascular Complications in Diabetic Mice Possibly through NOX4 and Modulates Composition and Functional Diversity of Gut Microbes
- Maternal high-fat diet modifies epigenetic marks H3K27me3 and H3K27ac in bone to regulate offspring osteoblastogenesis in mice
- Gut microbes metabolize strawberry phytochemicals and mediate their beneficial effects on vascular inflammation
- <scp>Short‐Term</scp> Increased Physical Activity During Early Life Affects High‐Fat <scp>Diet–Induced</scp> Bone Loss in Young Adult Mice
Showing 5 of 10 shared publications
Pon Velayutham Anandh Babu
University of Utah (US)
10 shared publications
- Cordyceps inhibits ceramide biosynthesis and improves insulin resistance and hepatic steatosis
- Dietary Blueberry Ameliorates Vascular Complications in Diabetic Mice Possibly through NOX4 and Modulates Composition and Functional Diversity of Gut Microbes
- Blueberry intervention mitigates detrimental microbial metabolite trimethylamine N‐oxide by modulating gut microbes
- Gut Microbes Are Associated with the Vascular Beneficial Effects of Dietary Strawberry on Metabolic Syndrome‐Induced Vascular Inflammation
- Gut Microbiota Depletion Using Antibiotics to Investigate Diet‐Derived Microbial Metabolites: An Efficient Strategy
Showing 5 of 10 shared publications
Sree V. Chintapalli
Arkansas Children's Nutrition Center
8 shared publications
In database
- GPR109A mediates the effects of hippuric acid on regulating osteoclastogenesis and bone resorption in mice
- Dietary Blueberry Ameliorates Vascular Complications in Diabetic Mice Possibly through NOX4 and Modulates Composition and Functional Diversity of Gut Microbes
- On the potential role of globins in brown adipose tissue: a novel conceptual model and studies in myoglobin knockout mice
- Gut Microbes Are Associated with the Vascular Beneficial Effects of Dietary Strawberry on Metabolic Syndrome‐Induced Vascular Inflammation
- Gut Microbiome and Metabolome Modulation by Maternal High-Fat Diet and Thermogenic Challenge
Showing 5 of 8 shared publications
James D. Sikes
8 shared publications
- Impact of maternal high‐fat diet on offspring gut microbiota during short‐term high‐fat diet exposure in mice
- Gut Microbiome and Metabolome Modulation by Maternal High-Fat Diet and Thermogenic Challenge
- Maternal high-fat diet-induced obesity in offspring: Unraveling adipose tissue dysfunction mediated by increased heat shock proteins
- Shared and distinct adaptations to early‐life exercise training based on inborn fitness
- Maternal High-Fat Diet-Induced Obesity in Offspring: Unraveling Adipose Tissue Dysfunction Mediated by Increased Heat Shock Proteins
Showing 5 of 8 shared publications
J. David Symons
University of Utah (US)
6 shared publications
- Dietary Blueberry Ameliorates Vascular Complications in Diabetic Mice Possibly through NOX4 and Modulates Composition and Functional Diversity of Gut Microbes
- Gut Microbes Are Associated with the Vascular Beneficial Effects of Dietary Strawberry on Metabolic Syndrome‐Induced Vascular Inflammation
- Gut microbes metabolize strawberry phytochemicals and mediate their beneficial effects on vascular inflammation
- Front Cover: Dietary Blueberry Ameliorates Vascular Complications in Diabetic Mice Possibly through NOX4 and Modulates Composition and Functional Diversity of Gut Microbes
- Dietary Blueberries Improve Vascular Inflammation and Alter the Composition of the Gut Microbiome in Aged Mice
Showing 5 of 6 shared publications
Jin‐Ran Chen
5 shared publications
In database
- GPR109A mediates the effects of hippuric acid on regulating osteoclastogenesis and bone resorption in mice
- Maternal high-fat diet modifies epigenetic marks H3K27me3 and H3K27ac in bone to regulate offspring osteoblastogenesis in mice
- <scp>Short‐Term</scp> Increased Physical Activity During Early Life Affects High‐Fat <scp>Diet–Induced</scp> Bone Loss in Young Adult Mice
- Author response for "Short‐Term Increased Physical Activity during Early Life Affects High Fat Diet‐Induced Bone Loss in Young Adult Mice"
- Maternal high-fat diet modifies epigenetic marks H3K27me3 and H3K27ac in bone to regulate offspring osteoblastogenesis in mice
Oxana P. Lazarenko
5 shared publications
In database
- GPR109A mediates the effects of hippuric acid on regulating osteoclastogenesis and bone resorption in mice
- Maternal high-fat diet modifies epigenetic marks H3K27me3 and H3K27ac in bone to regulate offspring osteoblastogenesis in mice
- <scp>Short‐Term</scp> Increased Physical Activity During Early Life Affects High‐Fat <scp>Diet–Induced</scp> Bone Loss in Young Adult Mice
- Author response for "Short‐Term Increased Physical Activity during Early Life Affects High Fat Diet‐Induced Bone Loss in Young Adult Mice"
- Maternal high-fat diet modifies epigenetic marks H3K27me3 and H3K27ac in bone to regulate offspring osteoblastogenesis in mice
Anna‐Claire Pilkington
University of Arkansas for Medical Sciences
5 shared publications
In database
- Beige Adipose Tissue Identification and Marker Specificity—Overview
- Gut Microbiome and Metabolome Modulation by Maternal High-Fat Diet and Thermogenic Challenge
- Beta‐adrenergic agonist induces unique transcriptomic signature in inguinal white adipose tissue
- Transcriptome profile of white, brown and beige adipose tissue
- Maternal High-Fat Diet-Induced Obesity in Offspring: Unraveling Adipose Tissue Dysfunction Mediated by Increased Heat Shock Proteins
Michael L. Blackburn
5 shared publications
In database
- On the potential role of globins in brown adipose tissue: a novel conceptual model and studies in myoglobin knockout mice
- Maternal high-fat diet modifies epigenetic marks H3K27me3 and H3K27ac in bone to regulate offspring osteoblastogenesis in mice
- <scp>Short‐Term</scp> Increased Physical Activity During Early Life Affects High‐Fat <scp>Diet–Induced</scp> Bone Loss in Young Adult Mice
- Author response for "Short‐Term Increased Physical Activity during Early Life Affects High Fat Diet‐Induced Bone Loss in Young Adult Mice"
- Maternal high-fat diet modifies epigenetic marks H3K27me3 and H3K27ac in bone to regulate offspring osteoblastogenesis in mice
Madison Putich
University of Utah (US)
5 shared publications
- Gut Microbes Are Associated with the Vascular Beneficial Effects of Dietary Strawberry on Metabolic Syndrome‐Induced Vascular Inflammation
- Dose- and Time-Dependent Effect of Dietary Blueberries on Diabetic Vasculature Is Correlated with Gut Microbial Signature
- Dose and Time Dependent Effect of Dietary Blueberries on Diabetic Vasculature is Associated with Gut Microbes
- Dietary Blueberries Improve Vascular Inflammation and Alter the Composition of the Gut Microbiome in Aged Mice
- Back Cover: Gut Microbes Are Associated with the Vascular Beneficial Effects of Dietary Strawberry on Metabolic Syndrome‐Induced Vascular Inflammation
Kartik Shankar
Southern Plains Agricultural Research Center (US)
5 shared publications
- Effects of Statin and Annatto-extracted Tocotrienol Supplementation on Glucose Homeostasis, Bone Microstructure, and Gut Microbiota Composition in Obese Mice
- Maternal high-fat diet-induced obesity in offspring: Unraveling adipose tissue dysfunction mediated by increased heat shock proteins
- Transcriptome profile of white, brown and beige adipose tissue
- Maternal Obesity Alters Adipogenic Potential and Mitochondrial Function in Mesenchymal Stem Cells From Infants Born to Mothers With Overweight or Obesity
- Maternal High-Fat Diet-Induced Obesity in Offspring: Unraveling Adipose Tissue Dysfunction Mediated by Increased Heat Shock Proteins
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